|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Medical management of gastric cancer:A 2014 update显示文摘Gastric cancer represents a serious health problem on a global scale. It is the second leading cause of cancer-related death worldwide. Novel therapeutic targets are desperately needed because the meager improvement in the cure rate of about 10% realized by adjunctive treatments to surgery is unacceptable as > 50% patients with localized gastric cancer succumb to their disease. Either postoperative chemoradiotherapy(United States),pre-and post-operative chemotherapy(Europe),and adjuvant chemotherapy after a D2 resection(Asia) can all be regarded as standards of care in the localized gastric cancer management. In metastatic disease the addition of trastuzumab to chemotherapy is standard of care in Her2 positive disease. In the HER2 negative population,the treatments remain limited.In the first line setting,the standard of care is a combination of fluoropyrimidine and platinum containing chemotherapy,with or without epirubicin or docetaxel.The results of targeted therapy trials have by and large been disappointing,but none of these trials looked at an appropriately enriched population.Finally there is a meager overall survival benefit in treating patients with metastatic disease in the second line setting,with either irinotecan,docetaxel or ramucirumab however none of these drugs have been compared head to head in a well-powered randomized controlled trial. | Elena Elimova Hironori Shiozaki Roopma Wadhwa Kazuki Sudo Qiongrong Chen Jeannelyn S Estrella Mariela A Blum Brian Badgwell Prajnan Das Shumei Song Jaffer A Ajani | 2014 | World Journal of Gastroenterology2014，20，38： | 10 |
| 2 | The IBI1 Receptor ofβ-Aminobutyric Acid Interacts with VOZ Transcription Factors to Regulate Abscisic Acid Signaling and Callose-Associated Defense显示文摘Extemal and internal signals can prime the plant immune system for a faster and/or stronger response to pathogen attack.β-aminobutyric acid(BABA)is an endogenous stress metabolite that induces broad-spectrum disease resistance in plants.BABA perception in Arabidopsis is mediated by the aspartyl tRNA synthetase IBI1,which activates priming of multiple immune responses,including callose-associated cell wall defenses that are under control by abscisic acid(ABA).However,the immediate signaling components after BABA perception by IBI1,as well as the regulatory role of ABA therein,remain unknown.Here,we have studied the early signaling events controlling IBI1-dependent BABA-induced resistance(BABAIR),using untargeted transcriptome and protein interaction analyses.Transcriptome analysis revealed that IBI1-dependent expression of BABA-IR against the biotrophic oomycete Hyaloperonospora arabidopsidis is associated with suppression of ABA-inducible abiotic stress genes.Protein interaction studies identified the VOZ1 and VOZ2 transcription factors(TFs)as IBI1-interacting partners,which are transcrip-tionally induced by ABA but suppress pathogen-induced expression of ABA-dependent genes.Furthermore,we show that VOZ TFs require nuclear localization for their contribution to BABA-IR by mediating augmented expression of callose-associated defense.Collectively,our study indicates that the IBI1-VOZ signaling module channels pathogen-induced ABA signaling toward cell wall defense while simultaneously suppressing abiotic stress-responsive genes. | Roland E.Schwarzenbacher Grace Wardell Joost Stassen Emily Guest Peijun Zhang Estrella Luna Jurriaan Ton | 2020 | Molecular Plant2020，13，10： | 4 |
| 3 | Towards high-power, high-coherence, integrated photonic mm Wave platform with microcavity solitons显示文摘Millimetre-wave(mmWave)technology continues to draw great interest due to its broad applications in wireless communications,radar,and spectroscopy.Compared to pure electronic solutions,photonic-based mmWave generation provides wide bandwidth,low power dissipation,and remoting through low-loss fibres.However,at high frequencies,two major challenges exist for the photonic system:the power roll-off of the photodiode,and the large signal linewidth derived directly from the lasers.Here,we demonstrate a new photonic mmWave platform combining integrated microresonator solitons and high-speed photodiodes to address the challenges in both power and coherence.The solitons,being inherently mode-locked,are measured to provide 5.8 dB additional gain through constructive interference among mmWave beatnotes,and the absolute mmWave power approaches the theoretical limit of conventional heterodyne detection at 100 GHz.In our free-running system,the soliton is capable of reducing the mmWave linewidth by two orders of magnitude from that of the pump laser.Our work leverages microresonator solitons and high-speed modified uni-traveling carrier photodiodes to provide a viable path to chip-scale,high-power,low-noise,high-frequency sources for mmWave applications. | Beichen Wang Jesse SMorgan Keye Sun Mandana Jahanbozorgi Zijiao Yang Madison Woodson Steven Estrella Andreas Beling Xu Yi | 2021 | Light(Science & Applications)2021，10，1： | 3 |
| 4 | Low-grade neuroendocrine tumors arising in intestinal adenomas: evidence for alterations in the adenomatous polyposis coli/ β -catenin pathway显示文摘 | Jeannelyn S. Estrella Melissa W. Taggart Asif Rashid Susan C. Abraham | 2014 | Human Pathology2014，，： | 2 |
| 5 | Home country macroeconomic factors and outward FDI of China and India显示文摘 | Paz Estrella Tolentino | 2010 | Journal of International Management2010，，2： | 2 |
| 6 | Efficient metallization of magnetite concentrate by reduction with agave bagasse as a source of reducing agents显示文摘The reduction behavior and metallization degree of magnetite concentrate with agave bagasse were investigated in an inert atmosphere.The effects of temperature,biomass content,and residence time on reduction experiments and metallization degree were investigated by X-ray diffraction and scanning electron microscopy.Compared with other types of biomass,agave bagasse had lower contents of nitrogen,sulfur,and ash.X-ray diffraction analysis showed that the metallization degree improved with increasing temperature and biomass content.Complete metallization was achieved at 1100℃ for 30 min with 65:35 and 50:50 ratios of the magnetite concentrate to the agave bagasse.These results demonstrate that agave bagasse promotes the efficient metallization of magnetite concentrate without the external addition of a reducing agent.Therefore,this biomass is a technical suitable alternative to replace fossil fuels in steelmaking. | Diana Cholico-González NoemíOrtiz Lara Mario Alberto Sánchez Miranda Ricardo Morales Estrella Ramiro Escudero García Carlos ALeón Patiño | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，4： | 2 |
| 7 | Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction显示文摘In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases.However,it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividing state.Here,we describe a versatile in vivo gene knock-in methodology that enables the targeting of a broad range of mutations and cell types through the insertion of a minigene at an intron of the target gene locus using an intracellularly linearized single homology arm donor.As a proof-of-concept,we focused on a mouse model of prematureaging caused by a dominant point mutation,which is difficult to repair using existing in vivo genome-editing tools.Systemic treatment using our new method ameliorated aging-associated phenotypes and extended animal lifespan,thus highlighting the potential of this methodology for a broad range of in vivo genome-editing applications. | Keiichiro Suzuki Mako Yamamoto Reyna Hernandez-Benitez Zhe Li Christopher Wei Rupa Devi Soligalla Emi Aizawa Fumiyuki Hatanaka Masakazu Kurita Pradeep Reddy Alejandro Ocampo Tomoaki Hishida Masahiro Sakurai Amy NNemeth Estrella Nunez Delicado Josep MCampistol Pierre Magistretti Pedro Guillen Concepcion Rodriguez Esteban Jianhui Gong Yilin Yuan Ying Gu Guang-Hui Liu Carlos Lopez-Otin Jun Wu Kun Zhang Juan Carlos Izpisua Belmonte | 2019 | Cell Research2019，29，10： | 2 |
| 8 | αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model显示文摘Dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular organisms.Their regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with age.During aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016). | Paloma Martinez-Redondo Isabel Guillen-Guillen Noah Davidsohn Chao Wang Javier Prieto Masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong Reyna Hernandez-Benitez Tomoaki Hishida Takashi Lezaki Akihisa Sakamoto Amy NNemeth Yuriko Hishida Concepcion Rodriguez Esteban Kensaku Shojima Ling Huang Maxim Shokhirev Estrella Nunez-Delicado Josep MCampistol Isabel Guillen-Vicente Elena Rodriguez-Inigo Juan Manuel Lopez-Alcorocho Marta Guillen-Vicente George Church Pradeep Reddy Pedro Guillen-Garcia Guang-Hui Liu Juan Carlos Izpisua Belmonte | 2020 | Protein & Cell2020，11，3： | 2 |
| 9 | Study of the adsorption of alkyl-benzene-derived amphiphiles on an asphaltene surface using molecular dynamics simulations显示文摘 | OLGA L ESTRELLA R ARGELIA U | 2001 | Energy & Fuels2001，15，1： | 1 |
| 10 | Inhibitory effect of glucocorticoid on coronary artery endothelial function 显示文摘 | Rogers KM Bonar CA Estrella JL | 2002 | Am J Physiol Heart Circ Physiol2002，283，： | 1 |
| 11 | Securitization and the Efficacy of Monetary Policy显示文摘 | Estrella A | | 0，，： | 1 |
| 12 | Automaiedmutation detection using universal conditions direct sequencing :application to ten muscular dystrophy genes 显示文摘 | Bennett RR* Schneider HE Estrella E | 2009 | BMC Genet2009，10，： | 1 |
| 13 | Fungal cell gigantism during mammalian infection 显示文摘 | Zaragoza O Garcia-Rodas R Nosanchuk JD Cuenca- Estrella M Rodriguez-Tudela JL Casadevall A | 2010 | PLoS Pathog2010，6，10： | 1 |
| 14 | Vascular endothelial cells promote acute plasticity in ependymoglial ceils of the neu- roendocrine brain显示文摘 | De Seranno S Estrella C Loyens A | 2004 | J Neurosci2004，24，10： | 1 |
| 15 | Volatile compounds in dry-cured Serrano ham subjected to high pressure processing. Effect of the packaging material显示文摘 | Ana Rivas-Ca?edo Estrella Fernández-García Manuel Nu?ez | 2009 | Meat Science2009，，2： | 1 |
| 16 | Nutritional, Immunological and Health Status of the Elderly Population Living in Poor Neighbourhoods of Quito, Ecuador显示文摘 | Sempertegui F Estrella B Elmieh N | 2006 | Br J Nutr2006，96，5： | 1 |
| 17 | The behavior of interest rates implied by the term structure of Eurodollar futures显示文摘 | Jegadeesh N Pennacchi G G Estrella A | 1996 | Journal of Money Credit & Banking1996，28，3： | 1 |
| 18 | Technological innovation and the third world multinationals 显示文摘 | Tolentino Paz Estrellae | 1993 | London: Routledge1993，，： | 1 |
| 19 | Immobilized humic substances on an anion exchange resin and their role on the redox biotransformation of contaminants显示文摘 | CERVANTES F J GONZALEZ ESTRELLA J MdRQUEZ A | 2011 | Bioresour Technol2011，102，2： | 1 |
| 20 | Short communication : Influence of microbial inoculation and co - composting material on the evolution of humic - like substances during composting of horticultural wastes 显示文摘 | Vargas - Garcia M adel Carmen Suarez - Estrella F Francisca Lopez M a Jose | 2006 | Process Biochemistry2006，41，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员