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| 1 | Diarrhoea-predominant irritable bowel syndrome distinguishable by 16S rRNA gene phylotype quantification显示文摘AIM:To study whether selected bacterial 16S ribosomal RNA(rRNA)gene phylotypes are capable of disting- uishing irritable bowel syndrome(IBS). METHODS:The faecal microbiota of twenty volunteers with IBS,subdivided into eight diarrhoea-predominant (IBS-D),eight constipation-predominant(IBS-C)and four mixed symptom-subtype(IBS-M)IBS patients,and fifteen control subjects,were analysed at three time-points with a set of fourteen quantitative real-timepolymerase chain reaction assays.All assays targeted 16S rRNA gene phylotypes putatively associated with IBS,based on 16S rRNA gene library sequence analysis. The target phylotypes were affiliated with Actinobac-teria,Bacteroidetes and Firmicutes.Eight of the target phylotypes had less than 95%similarity to cultured bacterial species according to their 16S rRNA gene sequence.The data analyses were made with repeated-measures ANCOVA-type modelling of the data and principle component analysis(PCA)with linear mixed-effects models applied to the principal component scores. RESULTS:Bacterial phylotypes Clostridium cocleatum 88%,Clostridium thermosuccinogenes 85%,Coprobacillus catenaformis 91%,Ruminococcus bromii-like, Ruminococcus torques 91%,and R.torques 93%were detected from all samples analysed.A multivariate analysis of the relative quantities of all 14 bacterial 16S rRNA gene phylotypes suggested that the intestinal microbiota of the IBS-D patients differed from other sample groups.The PCA on the first principal component(PC1),explaining 30.36%of the observed variation in the IBS-D patient group,was significantly altered from all other sample groups(IBS-D vs control, P=0.01;IBS-D vs IBS-M,P=0.00;IBS-D vs IBS-C, P=0.05).Significant differences were also observed in the levels of distinct phylotypes using relative values in proportion to the total amount of bacteria.A phy- lotype with 85%similarity to C.thermosuccinogenes was quantified in significantly different quantities among the IBS-D and control subjects(-4.08±0.90 vs -3.33±1.16,P=0.04)and IBS-D and IBS-M subjects (-4.08±0.90 vs-3.08±1.38,P=0.05).Furthermore,a phylotype with 94%similarity to R.torques was more prevalent in IBS-D patients'intestinal micro- biota than in that of control subjects(-2.43±1.49 vs -4.02±1.63,P=0.01).A phylotype with 93%simi- larity to R.torques was associated with control sam- ples when compared with IBS-M(-2.41±0.53 vs -2.92±0.56,P=0.00).Additionally,a R.bromii-like phylotype was associated with IBS-C patients in com- parison to control subjects(-1.61±1.83 vs-3.69± 2.42,P=0.01).All of the above mentioned phylotype specific alterations were independent of the effect of time. CONCLUSION:Significant phylotype level alterationsin the intestinal microbiotas of IBS patients were observed,further emphasizing the possible contribution of the gastrointestinal microbiota in IBS. | Anna Lyra Teemu Rinttil Janne Nikkil Lotta Krogius-Kurikka Kajsa Kajander Erja Malinen Jaana Mtt Laura Mkel Airi Palva | 2009 | World Journal of Gastroenterology2009，15，47： | 26 |
| 2 | 超音速火焰喷涂碳化物粒径不同的WC-10Co4Cr涂层在粗细磨粒下的磨损性能显示文摘改进的ASTM G65橡胶轮测试方法可采用220nm二氧化钛颗粒和368μm的砂粒分别在潮湿和干燥条件下使用。在由碳化物粒径不同(传统和亚微米)的两种粉末所制备的WC-CoCr涂层上开展试验,研究碳化物大小和磨损介质特性对涂层磨损性能的影响。采用扫描电镜对同一位置磨损前后的低倍和高倍形貌进行观察,并分析了涂层的磨损机理。结果表明:磨损机理取决于碳化物和磨粒的相对大小。在样品上进行磨损定量分析,通过调整碳化物尺寸可改善磨损性能,测试涂层的一些力学性能用于对比。 | Arash Ghabchi Tommi Varis Erja Turunen Tomi Suhonen S-P Hannula 谢旭霞 | 2010 | 热喷涂技术2010，，4： | 15 |
| 3 | Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome显示文摘AIM:To investigate the correlations between selfreported symptoms of irritable bowel syndrome(IBS) and the gastrointestinal(GI) microbiota composition.METHODS:Fecal samples were collected from a total of 44 subjects diagnosed with IBS.Their symptoms were monitored with a validated inflammatory bowel disease questionnaire adjusted for IBS patients.Thirteen quantitative real-time polymerase chain reaction assays were applied to evaluate the GI microbiota composition.Eubacteria and GI bacterial genera(Bifidobacterium,Lactobacillus and Veillonella),groups(Clostridium coccoides/Eubacterium rectale,Desulfovibrio desulfuricans) and distinct bacterial phylotypes [closest 16S rDNA sequence resemblance to species Bifidobacterium catenulatum,Clostridium cocleatum,Collinsella aerofaciens(C.aerofaciens),Coprococcus eutactus(C.eutactus),Ruminococcus torques and Streptococcus bovis ] with a suspected association with IBS were quantified.Correlations between quantities or presence/absence data of selected bacterial groups or phylotypes and various IBSrelated symptoms were investigated.RESULTS:Associations were observed between subjects' self-reported symptoms and the presence or quantities of certain GI bacteria.A Ruminococcus torques(R.torques)-like(94% similarity in 16S rRNA gene sequence) phylotype was associated with severity of bowel symptoms.Furthermore,among IBS subjects with R.torques 94% detected,the amounts of C.cocleatum 88%,C.aerofaciens-like and C.eutactus 97% phylotypes were significantly reduced.Interesting observations were also made concerning the effect of a subject's weight on GI microbiota with regard to C.aerofaciens like phylotype,Bifidobacterium spp.and Lactobacillus spp.CONCLUSION:Bacteria seemingly affecting the symptom scores are unlikely to be the underlying cause or cure of IBS,but they may serve as biomarkers of the condition. | Erja Malinen Lotta Krogius-Kurikka Janne Nikkil Airi Palva Anna Lyra Anne Jskelinen Teemu Rinttil Terttu Vilpponen-Salmela Atte Johannes von Wright | 2010 | World Journal of Gastroenterology2010，16，36： | 13 |
| 4 | 环境变化背景下北极生物的多样性、分布及其适应性显示文摘生物个体是对气候变化和紫外线B(UV-B)辐射变化产生反应的基础,而且这种反应会在各种时间尺度上发生。北极地区的动物、植物以及微生物种类的多样性从表面上看是低的,而且从北方针叶林到极地荒漠逐渐减少,但其原始物种却很丰富。与这种物种多样性随纬向梯度减少的趋势相反,一些空间分布范围很广的单一优势物神的优势度则呈增长趋势。全球气候变暖可能会减少该地区的物种多样性,并限制到这些物种的分布范围,尤其是在该地区生物分布的北部边缘,一些极地特有的动物和植物种类会面临着灭绝的危险。最有可能侵入苔原地带的物种是那些目前生存在极地外缘的北方地区生物。许多植物都具有自身的特征使它们能够在以下环境中生存;短暂的无冰雪覆盖的生长季节,低的太阳高度角,永久冻结地带及低的土壤温度,贫乏的养分获取条件以及极少的物理扰动。以上这些特征有些可能会限制当地物种对气候变暖的反应,但其最主要的因素是这些物种与那些潜在的入侵物种相比缺乏竞争能力。北极地区陆生动物拥有许多适应特性,这使它们能够适应北极地区剧烈的温度变化。许多动物通过冬眠或迁移来逃避极地地区的恶劣天气和资源短缺。北极地区动物生存的生物环境则相对简单:几乎没有天敌、竞争者、疾病、寄生生物,但同时食物资源也很短缺。极地陆生动物可能对由气候变化带来的温暖而干旱的夏季非常不适应,这种变化将会影响到动物的迁移路线、途中栖息地,并会改变冬季积雪的状况和冻融的循环过程。气候变化还会改变动物繁殖和发育的季节,并会引来新的竞争者、捕食者、寄生生物以及疾病等。极地微生物也能很好地适应该地区的气候:一些微生物甚至在-39℃的低温下还能进行代谢活动。蓝藻细菌和藻类生物有着很广泛的适应策略,这能够使它们避免(至少可以减少)紫外线的伤害。微生物能够忍受许多环境条件,而且其生长周期很短,这些特点将使它们能很快适应新的生存环境。与此形成对比的是,极地植物和动物很可能通过改变其分布范围而不是积极的生物进化来适应环境的变暧。 | Terry V.Callaghan Lars Olof Bjrn Yuri Chernov Terry Chapin Torben R.Christensen Brian Huntley Rolf A.Ims Margareta Johansson Dyanna Jolly Sven Jonasson Nadya Matveyeva Nicolai Panikov Walter Oechel Gus Shaver Josef Elster Heikki Henttonen Kari Laine Kari Taulavuori Erja Taulavuori Christoph Zckler 何永涛 | 2004 | AMBIO-人类环境杂志2004，33，B11： | 2 |
| 5 | Pa- rameter optimization of HVOF sprayed nanostructured alu- mina and alumina-nickel composite coatings显示文摘 | Erja Turanen Tomini varis Tom E Gustafsson | 2006 | Surf Coat Techn2006，，200： | 1 |
| 6 | Deactivation of ZSM-5 additives in laboratory for realistic testing 显示文摘 | Erja Rautiainen Ricardo Pimento Maria Ludvig | 2009 | Catalysis Today2009，140，： | 1 |
| 7 | Disappearance of malachite green residues in fry of rainbow trout (Oncorhynchus mykiss) after treatment of eggs at the hatching stage 显示文摘 | Kirsi N Tiina K Erja L | 2009 | Aquaculture2009，297，： | 1 |
| 8 | The Fecal Microbiota of Irritable Bowel Syndrome Patients Differs Significantly From That of Healthy Subjects显示文摘 | Anna Kassinen Lotta Krogius-Kurikka Harri M?kivuokko Teemu Rinttil? Lars Paulin Jukka Corander Erja Malinen Juha Apajalahti Airi Palva | 2007 | Gastroenterology2007，，1： | 1 |
| 9 | Optimization of Protein Extraction from Hypcrlcum pefforatum Tissues and Immunob- lotting Detection of Hyp-I at Different Stages of Leaf Development 显示文摘 | Katja Karppinen Erja Taulavuori Anja Hohtola | 2010 | Mol Biotechnol2010，46，： | 1 |
| 10 | Comparison of real - timePCR with SYBR Green I or 5' - nuclease assays and dotblot hybridization with rDNA - targeted oligonueleotide probes in quantification of selected faecal bacteria 显示文摘 | Erja Malinen Anna Kassinen Teemu Rinttila | 2003 | Microbiology2003，149，： | 1 |
| 11 | 在物种水平上生物对气候和紫外线B辐射预期变化的响应显示文摘控制实验表明,不同物种对每个环境因子变化变量产生的响应也存在着差异。植物往往对营养元素的变化反应最为强烈,尤其是氮素的增加。夏季增温实验表明,木本植物对温度的升高表现出了积极的响应,而地衣、苔藓类植物的丰富度却因增温而降低。物种对增温的响应主要受水分有效性和雪覆盖程度控制。在气候保持湿润的情况下,伴随着夏季温度的升高,许多无脊椎动物种群的数量都有所增加。实验表明,CO_2浓度和紫外线B(UV-B)辐射的增加对植物和动物影响较小,但是,一些微生物和真菌却对紫外线B辐射的增加非常敏感,甚至可能会因此产生一些诱导突变而引起流行传染病的爆发。苔原土壤的加温、CO_2浓度的升高以及矿物质营养的改善一般都会增加微生物的活动。在温带气候中,藻类往往比蓝藻细菌更占优势。冬季结冰-解冻过程的增加会导致冻壳的形成,从而会大大降低许多陆生动物的冬季存活率,改变这些动物群体的动态过程。厚的积雪会使驯鹿等植食性动物很难采食到雪下的草类植物,同时也不利于其逃避食肉动物的追捕。而无雪期的提前到来则可能会加速植物的生长。物种对气候变化的响应最初可能出现在亚种这一水平上:一个具有很高遗传/群系多样性的北极植物或动物物种,演化历史已经使其具有一种适应不同环境条件的能力,这将使它们能够很快适应未来的环境变化。本土知识(IK)、航空照片和卫星图像表明一些物种的分布已经发生了变化:北极植被更加趋向灌木化,而且生长也更加旺盛;北极驯鹿的分布范围最近也发生了变化一些原来在树线以南区域活动的害虫和鸟类也在北极被发现。与此相对应,大多数在北极地区进行繁殖鸟类的数量却都在下降。根据一些模型的预测,随着气候的变暖,苔原带鸟类的数量将会大幅度地下降。据物种-气候响应模型预测,由于受到气候变暖的影响,北极地区现有物种在未来的潜在分布范围都将大大缩小和向北退缩,而一些无脊椎动物和微生物则很可能会迅速向北扩展到北极地区。 | Terry V.Callaghan Lars Olof Bjrn Yuri Chernov Terry Chapin Torben R.Christensen Brian Huntley Rolf A.Ims Margareta Johansson Dyanna Jolly Sven Jonasson Nadya Matveyeva Nicolai Panikov Walter Oechel Gus Shaver Josef Elster Ingilbjrg S.Jónsdóttir Kari Laine Kari Taulavuori Erja Taulavuori Christoph Zckler 闫魏 | 2004 | AMBIO-人类环境杂志2004，33，B11： | 1 |
| 12 | Comparision of the antifungal susceptibility testing subcommittee of the European committee on antibiotic susceptibility testing proposed standard and the Etest with the NCCLS broth microdilution method for voriconazole and caspofungin susceptibility testing of yeast species显示文摘 | Erja C Manuel CE | 2002 | Clin Microbiol2002，40，10： | 1 |
| 13 | A confirmatory analysis of malachite green residues in rainbow trout with liquid chromatographyelectmspray tandem mass spectrometry显示文摘 | Kirsi H Erja LKimmo P | 2007 | Journal of Chromatography B2007，845，： | 1 |
| 14 | A confirmatory analysis of malachite green residues in rainbow trout with liquid chromatography-electrospray tandem mass spectrometry显示文摘 | Kirsi H Erja L Kimmo P | 2007 | J Chrom B2007，845，1： | 1 |
| 15 | Deactivation of ZSM-5 additives in laboratory for realistic testing显示文摘 | Erja Rautiainen Ricardo Pimento Maria Ludvig Carel Pouwels | 2009 | Catalysis Today2009，140，： | 1 |
| 16 | Movement of Generative Cell and Vegetative Nucleus in Tobacco Pollen Tubes is Dependent on Microtubule Cytoskeleton but Independent of the Synthesis of Callose Plugs显示文摘 | Erja L Kaisa M N Helena V | 2002 | Sex Plant Reprod2002，15，： | 1 |
| 17 | A confirmatory analysis of malachitegreen residues in rainbow trout with liquid chromatography electrospraytandem mass spectrometry 显示文摘 | KIRSI H ERJA L KIMMO P | 2007 | J Chrom B2007，845，1： | 1 |
| 18 | Acceleration of frost hardening in vaccinium vitis-idaea by nitrogen fertilization显示文摘 | Kari Taulaxuori Erja Taulavuori Ahti Niinimaa | 2001 | Occologia2001，127，： | 1 |
| 19 | Peripartum Ultrasound-Guided Drainage of Cystic Fetal Sacrococcygeal Teratoma for the Prevention of the Labor Dystocia: A Report of Two Cases显示文摘 | Vedran Stefanovic Erja Halmesm?ki | 2011 | Am J Perinatol Rep2011，，02： | 1 |
| 20 | Paired Border Towns or TwinCities from Finland and China显示文摘This paper discusses cross-border cooperation at the level of urban socio-economic systems. Worldwide, cross-border urban cooperation has in several cases produced socio-economic and political coherence supported by various joint programs and efforts. However, the degree of coherence varies and seldom cre-ates socio-economically and politically tightly integrated 'Twin-Cities' where the state border becomes highly transparent or ob-scure. Focusing on Finlan d and China, our aim is to identify whether the selected border towns represent coherent TwinCities or a more loose type of 'paired border towns'. The study uses an empirical examination of three Finnish towns (Helsinki, Tornio, Imatra) and their neighboring towns in Estonia, Sweden, and Rus-sia as a benchmark. Then, a comparative study is made regarding three Chinese cross-border cities facing Russia, Vietnam and Ka-zakhstan. We highlight the differences in cross-border integration from the viewpoint of shared public sector programs, cross-border enterprise relocation and networking, and integrated social sector in terms of labor market, education and shopping area. | Riitta Kosonen Xu Feng Erja Kettunen | 2008 | Chinese Journal of Population,Resources and Environment2008，6，1： | 0 |
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