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| 1 | Pathogenesis and management issues for non-alcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease (NAFLD) has, although it is a very common disorder, only relatively recently gained broader interest among physicians and scientists. Fatty liver has been documented in up to 10 to 15 percent of normal individuals and 70 to 80 percent of obese individuals. Although the pathophysiology of NAFLD is still subject to intensive research, several players and mechanisms have been suggested based on the substantial evidence. Excessive hepatocyte triglyceride accumulation resulting from insulin resistance is the first step in the proposed 'two hit' model of the pathogenesis of NAFLD. Oxidative stress resulting from mitochondrial fatty acids oxidation, NF-κB-dependent inflammatory cytokine expression and adipocytokines are all considered to be the potential factors causing second hits which lead to hepatocyte injury, inflammation and fibrosis. Although it was initially believed that NAFLD is a completely benign disorder, histologic follow-up studies have showed that fibrosis progression occurs in about a third of patients. A small number of patients with NAFLD eventually ends up with end-stage liver disease and even hepatocellular carcinoma. Although liver biopsy is currently the only way to confirm the NAFLD diagnosis and distinguish between fatty liver alone and NASH, no guidelines or firm recommendations can still be made as for when and in whom it is necessary. Increased physical activity, gradual weight reduction and in selected cases bariatric surgery remain the mainstay of NAFLD therapy. Studies with pharmacologic agents are showing promising results, but available data are still insufficient to make specific recommendations; their use therefore remains highly individual. | Marko Duvnjak Ivan Leroti Neven Bari Vedran Tomai Lucija Virovi Juki Vedran Velagi | 2007 | World Journal of Gastroenterology2007，13，34： | 74 |
| 2 | Overview and developments in noninvasive diagnosis of nonalcoholic fatty liver disease显示文摘High prevalence of non-alcoholic fatty liver disease (NAFLD) and very diverse outcomes that are related to disease form and severity at presentation have made the search for noninvasive diagnostic tools in NAFLD one of the areas with most intense development in hepatology today.Various methods have been investigated in the recent years,including imaging methods like ultrasound and magnetic resonance imaging,different forms of liver stiffness measurement,various biomarkers of necroinflammatory processes (acute phase reactants,cytokines,markers of apoptosis),hyaluronic acid and other biomarkers of liver fibrosis.Multicomponent tests,scoring systems and diagnostic panels were also developed with the purposes of differentiating non-alcoholic steatohepatitis from simple steatosis or discriminating between various fibrosis stages.In all of the cases,performance of noninvasive methods was compared with liver biopsy,which is still considered to be a gold standard in diagnosis,but is by itself far from a perfect comparative measure.We present here the overview of the published data on various noninvasive diagnostic tools,some of which appear to be very promising,and we address as well some of still unresolved issues in this interesting field. | Neven Bari Ivan Leroti Lea Smiri-Duvnjak Vedran Tomai Marko Duvnjak | 2012 | World Journal of Gastroenterology2012，18，30： | 7 |
| 3 | Genetic polymorphisms in non-alcoholic fatty liver disease:Clues to pathogenesis and disease progression显示文摘The spectrum of non-alcoholic fatty liver disease(NAFLD) ranges from simple steatosis through steatohepatitis to advanced f ibrosis and cirrhosis.Although the reason why only a minority of patients develop progressive forms of disease still remains largely unclear,recent research has identified genetic factors as a possible basis for this variation in disease presentation.Most of the studies have been focused on f inding associations between advanced disease forms and selected single nucleotide polymorphisms in genes encoding various proteins involved in disease pathogenesis.Although there are many limitations regarding the study design and interpretation of published data,further carefully planned studies together with implementation of new genetic technologies will likely bring new insights into disease pathogenesis and potential benefits to the management of patients with NAFLD. | Marko Duvnjak Neven Bari Vedran Tomai Ivan Leroti | 2009 | World Journal of Gastroenterology2009，15，48： | 4 |
| 4 | Is Helicobacter pylori infection a risk factor for disease severity in systemic sclerosis?显示文摘 | Mislav Radi? Du?anka Martinovi? Kaliterna Damir Bonacin Jadranka Morovi? Vergles Josipa Radi? Damir Fabijani? Vedran Kova?i? | 2013 | Rheumatology International2013，，11： | 3 |
| 5 | Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME显示文摘AIM To cure typically life-threatening esophagogastric anastomosis in rats, lacking anastomosis healing and sphincter function rescue, in particular. METHODS Because we assume esophagogastric fistulas represent a particular NO-system disability, we attempt to identify the benefits of anti-ulcer stable gastric pentadecapeptide BPC 157, which was in trials for ulcerative colitis and currently for multiple sclerosis, in rats with esophagocutaneous fistulas. Previously, BPC 157 therapies have promoted the healing of intestinal anastomosis and fistulas, and esophagitis and gastric lesions, along with rescued sphincter function. Additionally, BPC 157 particularly interacts with the NOsystem. In the 4 d after esophagogastric anastomosis creation, rats received medication(/kg intraperitoneallyonce daily: BPC 157(10 μg, 10 ng), L-NAME(5 mg), or L-arginine(100 mg) alone and/or combined or BPC 157(10 μg, 10 ng) in drinking water). For rats underwent esophagogastric anastomosis, daily assessment included progressive stomach damage(sum of the longest diameters, mm), esophagitis(scored 0-5), weak anastomosis(m L H2 O before leak), low pressure in esophagus at anastomosis and in the pyloric sphincter(cm H2O), progressive weight loss(g) and mortality. Immediate effect assessed blood vessels disappearance(scored 0-5) at the stomach surface immediately after anastomosis creation. RESULTS BPC 157(all regimens) fully counteracted the perilous disease course from the very beginning(i.e., with the BPC 157 bath, blood vessels remained present at the gastric surface after anastomosis creation) and eliminated mortality. Additionally, BPC 157 treatment in combination with L-NAME nullified any effect of L-NAME that otherwise intensified the regular course. Consistently, with worsening(with L-NAME administration) and amelioration(with L-arginine), either L-arginine amelioration prevails(attenuated esophageal and gastric lesions) or they counteract each other(L-NAME + L-arginine); with the addition of BPC 157(L-NAME + L-arginine + BPC 157), there was a marked beneficial effect. BPC 157 treatment for esophagogastric anastomosis, along with NOS-blocker L-NAME and/or NOS substrate L-arginine, demonstrated an innate NO-system disability(as observed with L-arginine effectiveness). BPC 157 distinctively affected corresponding events: worsening(obtained with L-NAME administration that was counteracted); or amelioration(L-arginine + BPC 157-rats correspond to BPC 157-rats).CONCLUSION Innate NO-system disability for esophagogastric anastomoses, including L-NAME-worsening, suggests that these effects could be corrected by L-arginine and almost completely eliminated by BPC 157 therapy. | Zeljko Djakovic Ivka Djakovic Vedran Cesarec Goran Madzarac Tomislav Becejac Goran Zukanovic Domagoj Drmic Lovorka Batelja Anita Zenko Sever Danijela Kolenc Alen Pajtak Nikica Knez Mladen Japjec Kresimir Luetic Dinko Stancic-Rokotov Sven Seiwerth Predrag Sikiric | 2016 | World Journal of Gastroenterology2016，22，41： | 3 |
| 6 | Can infrared thermography be used to monitor fatigue during exercise? A case study显示文摘Background: Infrared thermographic imaging(IRTG) is a safe and reliable technology used to monitor skin temperature. The main aim of our study was to evaluate the relationship between skin temperature changes and muscle fatigue in order to answer the main research question if IRTG can be used to monitor muscle fatigue.Methods: This was a case study performed on a 23-year-old trained middle distance runner. After warm-up the subject was exercising on the dynamometer for 7.5 min at 120?/s performing only concentric contractions of quadriceps. At the same time IRTG recording of both(exercising and non-exercising) quadriceps was performed.Results: A correlational analysis that was performed in order to quantify the relationship between power and temperature change over time has shown that there is a significant negative correlation between skin temperature increase and power decrease(r = -0.543, p = 0.036) of exercising quadriceps. In linear regression model the exercising quadriceps power could be predicted from skin temperature. No such relationships were noted for the non-exercising limb that served as a control.Conclusion: We believe that correlation between skin temperature change and muscle power output as described in this case study deserves further analysis on the larger sample including subjects of the different ages, health status, and physical abilities in order to create a new tool for monitoring the muscle fatigue. | Vedran Had?i Brane irok Ale? Malner?i? Milan oh | 2019 | Journal of Sport and Health Science2019，8，1： | 2 |
| 7 | Risk factors for musculoskeletal injuries in the military: a qualitative systematic review of the literature from the past two decades and a new prioritizing injury model显示文摘Background: Musculoskeletal injuries(MSkIs) are a leading cause of health care utilization, as well as limited duty and disability in the US military and other armed forces. MSkIs affect members of the military during initial training,operational training, and deployment and have a direct negative impact on overall troop readiness. Currently, a systematic overview of all risk factors for MSkIs in the military is not available.Methods: A systematic literature search was carried out using the PubMed, Ovid/Medline, and Web of Science databases from January 1, 2000 to September 10, 2019. Additionally, a reference list scan was performed(using the “snowball method”). Thereafter, an international, multidisciplinary expert panel scored the level of evidence per risk factor, and a classification of modifiable/non-modifiable was made.Results: In total, 176 original papers and 3 meta-analyses were included in the review. A list of 57 reported potential risk factors was formed. For 21 risk factors, the level of evidence was considered moderate or strong. Based on this literature review and an in-depth analysis, the expert panel developed a model to display the most relevant risk factors identified, introducing the idea of the “order of importance” and including concepts that are modifiable/nonmodifiable, as well as extrinsic/intrinsic risk factors.Conclusions: This is the qualitative systematic review of studies on risk factors for MSkIs in the military that has attempted to be all-inclusive. A total of 57 different potential risk factors were identified, and a new, prioritizing injury model was developed. This model may help us to understand risk factors that can be addressed, and in which order they should be prioritized when planning intervention strategies within military groups. | Stefan Sammito Vedran Hadzic Thomas Karakolis Karen R.Kelly Susan P.Proctor Ainars Stepens Graham White Wes O.Zimmermann | 2022 | Military Medical Research2022，9，4： | 2 |
| 8 | Analysis of International Mergers and Acquisitions in the Pharmaceutical Industry显示文摘 | Bo觩o Mati Vlatka Bilas Vedran Ba i | | 0，，01： | 1 |
| 9 | Measurement of Gait Parameters from Free Moving Subjects Measurement显示文摘 | Igor Lackovic Vedran Bilas | 2000 | 27:121-1312000，27，： | 1 |
| 10 | Current opinions and recommendations on multimodal intraoperative monitoring during spine surgeries显示文摘 | Martin Sutter Vedran Deletis Jiri Dvorak Andreas Eggspuehler Dieter Grob David MacDonald Alfred Mueller Francesco Sala Tetsuya Tamaki | 2007 | European Spine Journal2007，，2： | 1 |
| 11 | Basic methodological principles of multimodal intraoperative monitoring during spine surgeries显示文摘 | Vedran Deletis | 2007 | European Spine Journal2007，，2： | 1 |
| 12 | Intraoperative neurophysiological monitoring of the spinal cord during spinal cord and spine surgery: A review focus on the corticospinal tracts显示文摘 | Vedran Deletis Francesco Sala | 2007 | Clinical Neurophysiology2007，，2： | 1 |
| 13 | BRAIN SHEM MAPPING:Neurophysioligical localization of motor muclei on the floor of the fourth Ventricle显示文摘 | Vedran Deletis Fred J Epstein | 1995 | Neurosurgery1995，37，： | 1 |
| 14 | Persistent expression of activated notch in the developing hypothalamus affects survival of pituitary progenitors and alters pituitary structure显示文摘 | Paven K. Aujla Vedran Bogdanovic George T. Naratadam Lori T. Raetzman | 2015 | Dev. Dyn2015，，： | 1 |
| 15 | Application of a surrogatemodeling to the ship structural design 显示文摘 | PERO P VEDRAN Z BOZO VAZIC | 2014 | Ocean engineering2014，84，： | 1 |
| 16 | lmplicit Social Networking: Discovery of Hidden Relationships, Roles and Communities among Consumers显示文摘 | Vedran Podobnik Ignae Lovrek | 2015 | Procedia Computer Science2015，，60： | 1 |
| 17 | A system identification approach to the modelling of pulsed eddy-current systems 显示文摘 | Dadic Martin Vasic Darko Bilas Vedran | 2005 | NDT&E International2005，38，2： | 1 |
| 18 | Madelung syndrome (Benign lipomatosis): clinical course and treatment 显示文摘 | Vedran Uglesic Predrag Knezevic Morena Milic | 2004 | Scand J Plast Reconstr Surg Hand Surg2004，38，： | 1 |
| 19 | Intraoperative neurophysiology for surgery in and around the brainstem: role of brainstem mapping and corticobulbar tract motor-evoked potential monitoring显示文摘 | Nobuhito Morota Satoshi Ihara Vedran Deletis | 2010 | Child’s Nervous System2010，，4： | 1 |
| 20 | The application of Hilbert-I-luang transform in the analysis of muscle fatigue during cy- clic dynamic contractions 显示文摘 | VEDRAN SRHOJEGEKHER MARIO CIFREK MAR- IO CIFREK | 2011 | Medical and Biological Engineering and Computing2011，49，6： | 1 |
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