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| 1 | Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage显示文摘Background and purpose Signal transducer and activator of transcription 3(STAT3)may contribute to the proinflammation in the central nervous system diseases by modulating the microglial responses.Thus,this study was intended to investigate the effect of STAT3 on microglia-dependent neuroinflammation and functional outcome after experimental subarachnoid haemorrhage(SAH).Methods The SAH model was established by endovascular perforation in the mouse.Real-time PCR(RtPCR)and western blot were used to examine the dynamic STAT3 signalling pathway responses after SAH.To clarify the role of the STAT3 signalling pathway in the microglia-dependent neuroinflammation after SAH,the microglia-specific STAT3 knockout(KO)mice were generated by the Cre-LoxP system.The neurological functions were assessed by Catwalk and Morris water maze tests.Neuronal loss after SAH was determined by immunohistochemistry staining.Microglial polarisation status after STAT3 KO was then examined by RtPCR and immunofluorescence.Results The STAT3 and Janus kinase-signal transducer 2 activated immediately with the upregulation and phosphorylation after SAH.Downstream factors and related mediators altered dynamically and accordingly.Microglial STAT3 deletion ameliorated the neurological impairment and alleviated the early neuronal loss after SAH.To investigate the underlying mechanism,we examined the microglial reaction after STAT3 KO.STAT3 deletion reversed the increase of microglia after SAH.Loss of STAT3 triggered the early morphological changes of microglia and primed microglia from M1 to M2 polarisation.Functionally,microglial STAT3 deletion suppressed the SAH-induced proinflammation and promoted the anti-inflammation in the early phase.Conclusions STAT3 is closely related to the microglial polarisation transition and modulation of microglia-dependent neuroinflammation.Microglial STAT3 deletion improved neurological function and neuronal survival probably through promoting M2 polarisation and anti-inflammatory responses after SAH.STAT3 may serve as a promising therapeutic target to alleviate early brain injury after SAH. | Zhiyuan Vera Zheng Junfan Chen Hao Lyu Sin Yu Erica Lam Gang Lu Wai Yee Chan George K C Wong | 2022 | Stroke & Vascular Neurology2022，7，1： | 3 |
| 2 | Epstein-Barr virus-associated smooth muscle tumors in immunocompromised patients:Six case reports显示文摘BACKGROUND Epstein-Barr virus associated smooth muscle tumor(EBV-SMT)is a rare oncological entity.However,there is an increasing incidence of EBV-SMTs,as the frequency of organ transplantation and immunosuppression grows.EBV-SMT diagnosis relies on histopathology and immunochemical staining to distinguish it from post-transplant lymphoproliferative disorder(PTLD).There is no clear consensus on the treatment of EBV-SMTs.However,surgical resection,chemotherapy,radiation therapy,and immunosuppression reduction have been explored with varying degrees of success.CASE SUMMARY Our case series includes six cases of EBV-SMTs across different age groups,with different treatment modalities,adding to the limited existing literature on this rare tumor.The median latency time between immunosuppression and disease diagnosis is four years.EBV-SMTs present with variable degrees of aggressiveness and seem to have worse clinical outcomes in patients with tumor multiplicity and worse immunocompetency.CONCLUSION It is imperative to continue building on this knowledge and keeping EBV-SMTs on the differential in immunocompromised individuals. | Afshin A Khan Bassam N Estfan Anirudh Yalamanchali Djibril Niang Erica C Savage Clifton G Fulmer Hailey L Gosnell Jamak Modaresi Esfeh | 2022 | World Journal of Clinical Oncology2022，13，6： | 2 |
| 3 | 显示文摘 | Enrica Gianotti Valeria Dellarocca Erica C Oliveira | 2002 | Studies in Surface Science and Catalysis2002，142，： | 1 |
| 4 | Impact on the quality of lift of patients with arteriovenous malformation during the latent interval between gamma knife radiosurgery and lesion obliteration显示文摘 | Samuel C | 2002 | J Neurosurg2002，97，5： | 1 |
| 5 | Detection and Quantification of the Red Tide Dinoflagellate Karenia brevis by Real-Time Nucleic Acid Sequence-Based Amplification显示文摘 | Erica T Casper John H Paul Matthew C Smith | 2004 | Applied and environmental microbiology2004，70，8： | 1 |
| 6 | Impact on the quality of life of patients with arteriovenous malformation during the latent interval between gamma knife radiosurgery and lesion obliteration显示文摘 | ERICA H SAMUEL C | 2002 | J Neurosurg2002，97，5： | 1 |
| 7 | Inflammation enhances myeloid-derived suppressor cell crosstalk by signaling through Toll-like receptor 4显示文摘 | STEPHANIE K B VIRGINIA K C ERICA M H | 2009 | J Leukoc Biol2009，85，： | 1 |
| 8 | Plasticity of marrow-derived stem cells显示文摘 | Erica L H Li C Diane S K | 2003 | Blood2003，102，： | 1 |
| 9 | Reliable identification of mycobacterial species by PCR-restriction enzyme analysis (PRA)-hsp65 in a reference laboratory and elaboration of a sequence-based extended algorithm of PRAhsp65 patterns显示文摘 | Erica C Lucilaine F Suely Y | 2008 | BMC Microbiology2008，8，48： | 1 |
| 10 | Ultra-high temperature ceramic coatings for oxidation protection of carbon-carbon compo-sites 显示文摘 | Erica L C Ronald E L | 2008 | J Eur Ceram Soc2008，91，5： | 1 |
| 11 | Neuroimaging of ischemia and infarction显示文摘 | Erica C Sa′de Camargo Walter J | 2005 | The Journal of the American Society for Experimental NeuroTherapeutics2005，2，： | 1 |
| 12 | Plasticity of marrow-derived stem cells显示文摘 | HERZOG A ERICA L LI C | 2003 | Blood2003，102，10： | 1 |
| 13 | Circulating [alpha]Klotho influences phosphate handling by controlling FGF23 production显示文摘 | Smith Rosamund C O’Bryan Linda M Farrow Emily G Summers Lelia J Clinkenbeard Erica L Roberts Jessica L Cass Taryn A Saha Joy Broderick Carol Ma Y Linda Zeng Qing Qiang Kharitonenkov Alexei Wilson Jonathan M Guo Qianxu Sun Haijun Allen Matt | 2012 | Journal of Clinical Investigation2012，，12： | 1 |
| 14 | Plasticity of marrow - derived stem cells显示文摘 | ERICA L H LI C DIANE S K | 2003 | Blood2003，102，12： | 1 |
| 15 | Urinary neutrophil gelati- nase - associated lipocalcin in D + HUS : a novel marker of renal injury显示文摘 | Howard T Erica C Avital C | 2006 | Pediatr Nephrol2006，21，7： | 1 |
| 16 | Perforin is a major contributor to NK cell control of tumour metastasis显示文摘 | Mark J Smith Y Erica C | 1999 | J Immunol1999，162，66： | 1 |
| 17 | Body stalk anomaly:adverse maternal outcomes in a series of 21 cases显示文摘 | Botelho C M L Egle C Erica F | 2012 | Prenatal diagnosis2012，32，： | 1 |
| 18 | Neuroimaging of ischemia and infarction显示文摘 | ERICA C Sa DE C WALTER J K | 2005 | Neuro Rx2005，2，： | 1 |
| 19 | Simulta- neous liquid chromatographic determination of lam- otrigine, oxcarbazepine monohydroxy derivative and felbamate in plasma of patients with epilepsy显示文摘 | CONTIN M BALBONI M ERICA C T | 2005 | Jour- nal of Chromatography B2005，828，12： | 1 |
| 20 | Perforin is a major contributor to NK cell control of tumour metastasis显示文摘 | Smith Y Erica C | 1999 | J Immunol1999，162，2： | 1 |
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