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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 3 | Let the soil work for us显示文摘 | Elliott E T Coleman D C | 1988 | Ecological Bulletins1988，39，： | 2 |
| 4 | Vascular compression of the airway in children 显示文摘 | MCLAREN C A ELLIOTT M J ROEBUCK D J | 2008 | Paediatr Respir Rev2008，9，2： | 1 |
| 5 | Electron energy distributions in e- beam generated Xe and Ar plasmas 显示文摘 | Elliott C J Greene A E | 1976 | Journal of Applied Physics1976，47，7： | 1 |
| 6 | Fractionation of polyethylene显示文摘 | FRSNCIS P S COOKE R C Jr ELLIOTT J H | 1958 | J Polym Sci1958，31，123： | 1 |
| 7 | Computation of geometric partial differential equations and mean curvature flow 显示文摘 | K Deckelnick G Dziuk C M Elliott | 2005 | Acta Numerica2005，14，： | 1 |
| 8 | Scanning and contact micro-radiographic study of the effect of degree of saturation on the rate of enamel demineralization显示文摘 | GAO X J ELLIOTT J C ANDERSON P | 1991 | J Dent Res1991，70，10： | 1 |
| 9 | A review of sharps injures and preventitire strategies显示文摘 | Trim J C Elliott T S J | 2003 | J Hospit Inf2003，53，： | 1 |
| 10 | Oxy-fuelcombustion technology for coal-fired power genera-tion显示文摘 | Buhre B J P Elliott L K Sheng C D | 2005 | Progress in Energy and Combustion Science2005，31，4： | 1 |
| 11 | Ghost Marketing: Pharmacetical Companies and Ghostwritten Journal Articles显示文摘 | Moffatt B Elliott C | 2007 | Perspect Biol Med2007，50，1： | 1 |
| 12 | Dynamic contact angles (Part Ⅰ) : The effect of impressed motion 显示文摘 | Elliott G E P Riddiford A C | 1967 | Journal of Colloid and Interface Science1967，23，3： | 1 |
| 13 | Oxy-fuel combustion technology for coal-fired power generation显示文摘 | BUHRE B J P ELLIOTT L K SHENG C D GUPTA R P WALL T F | 2005 | Prog Energy Combust2005，31，4： | 1 |
| 14 | Identification and quantification of amines in the equine caecum显示文摘 | BAILEY S R MARR C M ELLIOTT J | 2003 | Research in Veterinary Science2003，74，2： | 1 |
| 15 | Screening and confirmatory determination of ractopamineresidues in calves treated with growth promoting doses of theβ-agonist显示文摘 | Elliott C Thompson C Crooks S H | 1998 | Analyst1998，123，5： | 1 |
| 16 | A Review of Sharps Injures and Preventative Strategies显示文摘 | Trim J C Elliott T S J | 2003 | Journal of Hospital Infection2003，53，4： | 1 |
| 17 | Compands from isatis indigotica显示文摘 | Elliott M C | 1970 | Phytochemistry1970，9，： | 1 |
| 18 | Goals:An approach to motivation and achievement显示文摘 | Elliott E S Dweek C s | 1998 | Joumal of Personality mad Social psychology1998，54，1： | 1 |
| 19 | Triply bridged dinuclear tris (bipyridine)iron(11) complex: synthesis and electrochemical and structural studies 显示文摘 | Serr B R Andersen K A Elliott C M | 1988 | Inorg Chem1988，27，： | 1 |
| 20 | Loss of PTEN Expression by Dermal Fibroblasts Causes Skin Fibrosis 显示文摘 | Parapuram SK Shi-Wen X Elliott C | 2011 | J Invest Dermatol2011，131，10： | 1 |
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