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| 1 | Management of bacterial and fungal infections in end stage liver disease and liver transplantation: Current options and future directions显示文摘Patients with liver cirrhosis are susceptible to infections due to various mechanisms, including abnormalities of humoral and cell-mediated immunity and occurrence of bacterial translocation from the intestine. Bacterial infections are common and represent a reason for progression to liver failure and increased mortality. Fungal infections, mainly caused by Candida spp., are often associated to delayed diagnosis and high mortality rates. High level of suspicion along with prompt diagnosis and treatment of infections are warranted. Bacterial and fungal infections negatively affect the outcomes of liver transplant candidates and recipients, causing disease progression among patients on the waiting list and increasing mortality, especially in the early posttransplant period. Abdominal, biliary tract, and bloodstream infections caused by Gram-negative bacteria [e.g., Enterobacteriaceae and Pseudomonas aeruginosa(P. aeruginosa)] and Staphylococcus spp. are commonly encountered in liver transplant recipients. Due to frequent exposure to broad-spectrum antibiotics, invasive procedures, and prolonged hospitalizations, these patients are especially at risk of developing infections caused by multidrug resistant bacteria. The increase in antimicrobial resistance hampers the choice of an adequate empiric therapy and warrants the knowledge of the local microbial epidemiology and the implementation of infection control measures. The main characteristics and the management of bacterial and fungal infections in patients with liver cirrhosis and liver transplant recipients are presented. | Elda Righi | 2018 | World Journal of Gastroenterology2018，24，38： | 22 |
| 2 | Impact of new treatment options for hepatitis c virus infection in liver transplantation显示文摘Liver transplant candidates and recipients with hepatitis C virus(HCV)-related liver disease greatly benefit from an effective antiviral therapy. The achievement of a sustained virological response before transplantation can prevent the recurrence of post-transplant HCV disease that occurs universally and correlates with enhanced progression to graft cirrhosis. Previous standard-of-care regimens(e.g.,pegylated-interferon plus ribavirin with or without first generation protease inhibitors,boceprevir and telaprevir) displayed suboptimal results and poor tolerance in liver transplant recipients. A new class of potent direct-acting antiviral agents(DAA) characterized by all-oral regimens with minimal side effects has been approved and included in the recent guidelines for the treatment of liver transplant recipients with recurrent HCV disease. Association of sofosbuvir with ribavirin and/or ledipasvir is recommended in liver transplant recipients and patients with decompensated cirrhosis. Other regimens include simeprevir,daclatasvir,and combination of other DAA. Possible interactions should be monitored,especially in coinfected human immunodeficiency virus/HCV patients receiving antiretrovirals. | Elda Righi Angela Londero Alessia Carnelutti Umberto Baccarani Matteo Bassetti | 2015 | World Journal of Gastroenterology2015，21，38： | 3 |
| 3 | Comorbidity, Hospitalization, and Mortality in COPD: Results from a Longitudinal Study显示文摘 | Claudio Terzano Vittoria Conti Fabio Di Stefano Angelo Petroianni Daniela Ceccarelli Elda Graziani Salvatore Mariotta Alberto Ricci Antonio Vitarelli Giovanni Puglisi Corrado De Vito Paolo Villari Luigi Allegra | 2010 | Lung2010，，4： | 2 |
| 4 | Occurrence of retained placenta is preceded by an inflammatory state and alterations of energy metabolism in transition dairy cows显示文摘Background: Failure to expel fetal membranes within 24 h of calving is a pathological condition defined as retained placenta(RP). The objective of this investigation was to evaluate whether there are alterations in several selected serum variables related to innate immunity and carbohydrate and lipid metabolism that precede occurrence of RP in transition Holstein dairy cows.Methods: One hundred multiparous Holstein dairy cows were involved in the study. Blood samples were collected from the coccygeal vein during the-8 to +4 wks around parturition, once per week before the morning feeding.Six healthy control cows(CON) and 6 cows with RP were selected and serum samples at-8,-4, time of diagnosis of disease, and +4 wks relative to parturition were used for analyses. All samples were analyzed for lactate, nonesterified fatty acids(NEFA), β-hydroxybutyrate(BHBA), interleukin-1(IL-1), interleukin-6(IL-6), tumor necrosis factor(TNF), haptoglobin(Hp), and serum amyloid A(SAA).Results: Cows with RP had greater concentrations of serum lactate, IL-1, IL-6, TNF, and SAA in comparison with CON cows. Intriguingly, elevated concentrations of all five variables were observed at-8 and-4 wks before the occurrence of RP compared to healthy cows. Cows with RP also had lower DMI and milk production vs CON animals; however milk composition was not affected by RP.Conclusions: Cows with RP showed an activated innate immunity 8 wks prior to diagnosis of disease. Overall results suggest that serum IL-1, IL- 6, and TNF, and lactate can be used as screening biomarkers to indicate cows that might have health issues during the transition period. | Elda Dervishi Guanshi Zhang Dagnachew Hailemariam Suzana M.Dunn Burim N.Ametaj | 2016 | Journal of Animal Science and Biotechnology2016，7，3： | 2 |
| 5 | Microbial production of fructosyltransferases for synthesis of prebiotics显示文摘 | ALFREDO E M ROSANE M P ELDA S S | 2008 | Biotechnology Letters2008，30，11： | 1 |
| 6 | Lactobacillus:the Next Generation of Malolactic Fermentation Starter Cuhures-an Overview显示文摘 | Maret du Toit Lynn Engelbrecht Elda Lerm | 2011 | Food Bioprocess Technol2011，，4： | 1 |
| 7 | Peptide G, containing the binding site of the 67-Kda Laminin receptor, increases and stabilizes laminin binding to cancer cells显示文摘 | Alessandra M Elda T Simona B | 1996 | J Biol Chem1996，27，31： | 1 |
| 8 | CHF5074, a Novel Γ-Secretase Modulator, Restores Hippocampal Neurogenesis Potential and Reverses Contextual Memory Deficit in a Transgenic Mouse Model of Alzheimer’s Disease显示文摘 | Bruno P. Imbimbo Luciana Giardino Sandra Sivilia Alessandro Giuliani Marco Gusciglio Vladimiro Pietrini Elda Del Giudice Antonello D'Arrigo Alberta Leon Gino Villetti Laura Calzà | 2010 | Journal of Alzheimer’s Disease2010，，1： | 1 |
| 9 | Osteopathicmanipulative treatment of congenital talipes equinovarus :A case report显示文摘 | Elda A Andrea T Valentina T | 2013 | Journal of Bodywork & MovementTherapies2013，，13： | 1 |
| 10 | Nimodipine selectively stimulates β-amyloid 1-42 secretion by a mechanism independent of ealeium influx blockage显示文摘 | FABRIZIO F CRISTINA F ELDA D G | 2006 | Neurobiology of Aging2006，27，2： | 1 |
| 11 | Crop-pasture rotation for sustaining the quality and productivity of a Typic Argiudull显示文摘 | Guillermo A Studdert Hernan E Echeverria Elda M Casanovas | 1997 | Soil Science Society of America Journal1997，61，： | 1 |
| 12 | Nevre Growth Factor Cooperates with p185HER2 in Activating Growth of Human Breast Carcinoma Cells显示文摘 | Elda Tagliabue Fabio Castiglioni Cristina Ghirelli | 2000 | J Biol Chem2000，275，8： | 1 |
| 13 | The GABAergic parafacial zone is a medullary slow wave sleep-promo- ting center显示文摘 | Christe|le Anaclet Lofts Ferrari Elda Arrigoni | 2014 | Nat Nenrosei2014，17，9： | 1 |
| 14 | Probucol inhibits ABCAl-mediated cellular lipid efflux 显示文摘 | Elda Favari Ilaria Zanotti Francesca Zimetti | 2004 | J Arterioscler Thromb Vasc Biol2004，24，： | 1 |
| 15 | Compressed Sensing with Coherent and Redundant Dictionaries 显示文摘 | CANDES E ELDAS Y C NEEDELL D | 2011 | Ap-pl Comput Harmon Anal2011，31，： | 1 |
| 16 | Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer显示文摘 | Claudia Piovan Dario Palmieri Gianpiero Di Leva Luca Braccioli Patrizia Casalini Gerard Nuovo Monica Tortoreto Marianna Sasso Ilaria Plantamura Tiziana Triulzi Cristian Taccioli Elda Tagliabue Marilena V. Iorio Carlo M. Croce | 2012 | Molecular Oncology2012，，4： | 1 |
| 17 | Inflammation impairs eNOS activation by HDL in patients with acute coronary syndrome显示文摘 | Monica Gomaraschi Alice Ossoli Elda Favari Maria Pia Adorni Gianfranco Sinagra Luigi Cattin Fabrizio Veglia Franco Bernini Guido Franceschini Laura Calabresi | 2013 | Cardiovascular Research2013，，1： | 1 |
| 18 | The 67 kDa laminin receptor as a prognostic factor in human cancer显示文摘 | Sylvie Ménard Elda Tagliabue Maria Ines Colnaghi | 1998 | Breast Cancer Research and Treatment (-)1998，，1： | 1 |
| 19 | Production of poly (3-hydroxy butyrate) in an airlift bioreactor by Ralstonia eutropha显示文摘 | Lana ZT Elda SS Pradella JGC | 2004 | Biochemical Engineering Journal2004，18，： | 1 |
| 20 | Poly (ethylene glycol)- octafunctionalized polyhedral oligomeric silsesquioxane: synthesis and thermal analysis 显示文摘 | Elda M Milena G M Stephen C | 2007 | Macromolecules2007，40，： | 1 |
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