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| 1 | Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats显示文摘AIM: To correlate gastric contractility, gastrointestinal transit, and hormone levels in non-pregnant(estrous cycle) and pregnant rats using noninvasive techniques. METHODS: Female rats(n = 23) were randomly divided into(1) non-pregnant,(contractility, n =6; transit, n = 6); and(2) pregnant(contractility, n = 5; transit, n = 6). In each estrous cycle phase or at 0, 7, 14, and 20 d after the confirmation of pregnancy, gastrointestinal transit was recorded by AC biosusceptometry(ACB), and gastric contractility was recorded by ACB and electromyography. After each recording, blood samples were obtained for progesterone and estradiol determination. RESULTS: In the estrous cycle, despite fluctuations of sex hormone levels, no significant changes in gastrointestinal motility were observed. Days 7 and 14 of pregnancy were characterized by significant changes in the frequency of contractions(3.90 ± 0.42 cpm and 3.60 ± 0.36 cpm vs 4.33 ± 0.25 cpm) and gastric emptying(168 ± 17 min and 165 ± 15 min vs 113 ± 15 min) compared with day 0. On these same days, progesterone levels significantly increased compared with control(54.23 ± 15.14 ng/m L and 129.96 ± 30.52 ng/mL vs 13.25 ± 6.31 ng/mL). On day 14, we observed the highest level of progesterone and the lowest level of estradiol compared with day 0(44.3 ± 15.18 pg/mL vs 24.96 ± 5.96 pg/mL). CONCLUSION: Gastrointestinal motility was unaffected by the estrous cycle. In our data, high progesterone and low estradiol levels can be associated with decreased contraction frequency and slow gastric emptying. | Juliana Fernandes Matos Madileine Francely Americo Yuri Karen Sinzato Gustavo Tadeu Volpato Luciana Aparecida Corá Marcos Felipe Freitas Calabresi Ricardo Brandt Oliveira Debora Cristina Damasceno Jose Ricardo Arruda Miranda | 2016 | World Journal of Gastroenterology2016，22，25： | 5 |
| 2 | Safinamide:from molecular targets to a new anti -Parkinson drug 显示文摘 | Caccia C Maj R Calabresi M | 2006 | Neurology2006，67，2： | 1 |
| 3 | Natalizumab re- duces visual loss in patients with relapsing multiple sclerosis 显示文摘 | Baiter LJ Galetta SL Calabresi PA | 2007 | Neurology2007，68，16： | 1 |
| 4 | Some Thoughts on Risk Distribution and the Law of Torts 显示文摘 | Guido Calabresi | 1961 | The Yale Law Journal1961，，70： | 1 |
| 5 | The inci- dence and significance of anti-natalizumab antibodies: results from AFFIRM and SENTINEL显示文摘 | Calabresi PA Giovannoni G Confavreux C | 2007 | Neurology2007，69，14： | 1 |
| 6 | Depletion of pre-beta-high density lipoprotein by human chymase impairs ATP-binding cassette transporter A1-but not scavenger receptor class B type I-mediated lipid efflux to high density lipoprotein显示文摘 | Favari E Lee M Calabresi L | 2004 | J Biol Chem2004，279，： | 1 |
| 7 | Mechanical behavior of a natural soft clay显示文摘 | Callisto L Calabresi G | 1998 | Geotechnique1998，48，49： | 1 |
| 8 | Antiepileptic drugs in migraine: from clinical aspects to cellular mechanisms 显示文摘 | Calabresi P Galletti F Rossi C | 2007 | Trends Pharmacol Sci2007，28，4： | 1 |
| 9 | Natalizumab plus interferon beta-1a for relapsing multiple sclerosis显示文摘 | Rudick RA Stuart WH Calabresi PA | | 0，，： | 1 |
| 10 | Safinamide:from molecular targets to a new anti-Parkinson drug显示文摘 | CACCIA C MAJ R CALABRESI M | 2006 | Neurology2006，67，72： | 1 |
| 11 | Interferon beta results in immediate reduction of contrast-enhanced MRI lesions in multiple sclerosis patients followed by weekly MRI显示文摘 | STONE LA BASH CN | 1997 | Neurology1997，48，5： | 1 |
| 12 | Effects of fenofibrate and sim-vastatin on HDL-related biomarkers in low-HDL patients显示文摘 | Franceschini G Calabresi L Colombo C | 2007 | Atherosclerosis2007，195，2： | 1 |
| 13 | Property Rules, Liability Rules, and Inalienability: One View of the Cathedral 显示文摘 | Guido Calabresi and Douglas Melamed | 1972 | Harvard Law Review1972，，85： | 1 |
| 14 | The molecular basis of lecithin : cholesterol acyltransferase deficiency syndromes: a com- prehensive study of molecular and biochemical findings in 13 unre- lated Italian families 显示文摘 | Calabresi L Pisciotta L Costantin A | 2005 | Arterioscler Thromb Vasc Biol2005，25，9： | 1 |
| 15 | Mechanical Behaviour of a Natural Soft Clay显示文摘 | CALL1STO L CALABRESI G | 1998 | Geotechnique1998，48，4： | 1 |
| 16 | The utility of MRI in suspected MS:report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology显示文摘 | Frohman EM Goodin DS Calabresi PA | | 0，，： | 1 |
| 17 | Mechanical Behaviour of a Natural Soft Clay显示文摘 | CALLISTO L CALABRESI G | 1998 | Geoteehnique1998，48，4： | 1 |
| 18 | Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation,opposing forms of synaptic plasticity显示文摘 | Calabresi P Gubellini P Centonze D | 2000 | J Neurosci2000，20，22： | 1 |
| 19 | PEGylation of Interferon-β-1a显示文摘 | Bernd C. Kieseier Peter A. Calabresi | 2012 | CNS Drugs2012，，3： | 1 |
| 20 | Remarks: The Simple Virtues of the Cathedral 显示文摘 | Guido Calabresi | 1997 | Yale Law Journal1997，，106： | 1 |
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