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| 1 | Cerebral sinus thrombosis in patients with inflammatory bowel disease: A case report显示文摘Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease of the gastrointestinal tract. The pathophysiology of IBD is probably the result of the complex interaction of genetic susceptibility and environmental influences. There is a well-known risk of thrombosis in patients with IBD. We present the case of a 53-year-old man with ulcerative colitis, who spontaneously developed intracranial sinus thrombosis that was treated with low molecular weight heparin. Literature was searched to assess the frequency and characteristics of cerebral sinus thrombosis in IBD and the role of certain etiopathological factors in such thrombotic patients. | Hasan Umit Talip Asil Yahya Celik Ahmet Tezel Gulbin Dokmeci Nermin Tuncbilek Ufuk Utku Ali Riza Soylu | 2005 | World Journal of Gastroenterology2005，11，34： | 6 |
| 2 | Two Poplar Glycosyltransferase Genes, PdGATL 1.1 and PdGATL1.2, Are Functional Orthologs to PARVUS/AtGATL 1 in Arabidopsis显示文摘包括 PARVUS/AtGATL1,在 Arabidopsis 的几基因在木聚糖合成被含有。然而,在这多糖是木头的一个主要部件的地方,在木质的植物的木聚糖的生合成糟糕被理解。这里,我们描绘二 Populus 基因, PdGATL1.1 和 PdGATL1.2,最靠近的 orthologs 到 Arabidopsis PARVUS/GATL1 基因关于他们在白杨的基因表示,他们在 Arabidopsis 补充 parvus 变化的亚 cellular 本地化,和他们的能力。包括词法变化,在缺点的救的大多数由 parvus 变化引起了的 parvus 异种的二白杨基因的 Overexpression 折叠木部,并且改变了房间墙 monosaccharide 作文。量的 RTPCR 证明 PdGATL1.1 在开发白杨的木部最强烈被表示。相反, PdGATL1.2 在叶,射击尖端,外皮,韧皮部,和木部更一致地被表示,并且 PdGATL1.2 的抄本水平是比在检验的所有纸巾的 PdGATL1.1 的低得多的。亚 cellular 本地化实验证明这二蛋白质对局部性嗯并且与到这些亚 cellular 分隔空间的标记蛋白质居民比较的 Golgi。我们的数据显示 PdGATL1.1 和 PdGATL1.2 是 PARVUS/GATL1 的功能的 orthologs 并且能在木聚糖合成起一个作用,但是可以也在另外的墙聚合物的合成有角色。 | Yingzhen Kong Gongke Zhou Utku Avci Xiaogang Gu Chelsea Jones Yanbin Yin Ying Xu Michael G. Hahn | 2009 | Molecular Plant2009，2，5： | 6 |
| 3 | Coronary artery bypass grafting in the octogenarians: should we intervene, or leave them be?显示文摘ObjectiveCoronary 动脉绕过 grafting (CABG ) 逐渐地在老人口正在增加。我们试图在 80 的年龄和 older.MethodsBetween 2002年1月和2011年12月在病人与长期的幸存一起调查风险因素和 CABG 的结果,在 80 的年龄的 101 个连续病人的一个总数并且更旧在我们的医院里经历了 CABG 的人,在学习被包括。病人被跟随,长期的幸存是病人的 estimated.ResultsThe 平均数年龄是 82.98 ±2.27 年。(63.4%) 64 是男性,(36.6%) 37 是女性。紧急情况外科,持续时间心肺绕过,特别护理单位(ICU ) 停留, inotropic 支持,大动脉的汽球跳动申请,红血球输送的数量和新鲜冻结的血浆输送和通风时期是的 intra 在在医院里死了的病人显著地更高。持续时间心肺绕过(CPB ) 被发现是死亡的一个独立预言者(或:1.18, 95% CI 1.01 − 1.38, P = 0.034 ) 。在里面医院死亡是 16.8% 。Kaplan-Meier 分析在一年揭示了 91.3% 的幸存比率, 82.9% 在三年并且 69.0% 在五 years.ConclusionsPatients 在 80 岁时并且更旧 CABG 过程的候选人能正在牢记他们可以有一个更长的通风时期和特别护理单位停留。这个年龄组的病态和死亡在一个可接受的范围以内被考虑。最小化 CPB 的途径,或离开泵外科的选择,可以是一个预防方法降低死亡的发生。因此, CABG 可以与令人满意的幸存比率在这个年龄组被执行。 | Anil Ozen Ertekin Utku Unal Murat Songur Sinan Sabit Kocabeyoglu Onur Hanedan Metin Yilmaz Basak Soran Turkcan Ferit Cicekcioglu Sadi Kaplan Cemal Levent Birincioglu | 2015 | Journal of Geriatric Cardiology2015，12，2： | 5 |
| 4 | Adipokines and ghrelin in gastric cancer cachexia显示文摘AIM:To investigate the roles of the adipocytokines,ghrelin and leptin in gastric cancer cachexia. METHODS:Resistin,ghrelin,leptin,adiponectin,insulin and insulin-like growth factor(IGF-Ⅰ),were measured in 30 healthy subjects,and 60 gastric cancer patients of which 30 suffered from cancer-induced cachexia and 30 served as a control group. The relationships between hormones,body mass index(BMI) loss ratio,age,gender,and Glasgow Prognostic Score(GPS) were investigated. RESULTS:Cachexia patients had higher tumor stage and GPS when compared with non-cachexia patients(P < 0.05). Ghrelin,resistin,leptin,adiponectin and IGF-Ⅰ,showed a significant correlation with BMI loss ratio and GPS(P < 0.05). A strong correlation was seen between GPS and BMI loss(R = -0.570,P < 0.0001). Multivariate analysis indicated that BMI loss was significantly independent as a predictor of ghrelin,resistin,leptin and IGF-Ⅰ(P < 0.05). Existence of an important significant relationship between resistin and insulin resistance was also noted. CONCLUSION:These results showed that serum ghrelin,leptin,adiponectin,and IGF-Ⅰ play important roles in cachexia-related gastric cancers. No relationshipwas found between resistin and cancer cachexia. Also,because of the correlation between these parameters and GPS,these parameters might be used as a predictor factor. | Mustafa Kerem Zafer Ferahkose Utku Tonguc Yilmaz Hatice Pasaoglu Ebru Ofluoglu Abdulkadir Bedirli Bulent Salman Tevfik Tolga Sahin Murat Akin | 2008 | World Journal of Gastroenterology2008，14，23： | 4 |
| 5 | Treatment of chronic hepatitis B patients with tyrosinemethionine-aspartate-aspartate mutations显示文摘Lamivudine is an antiviral used for the treatment of chronic hepatitis B. Several studies have reported various mutations that are induced by lamivudine therapy. These mutations in the tyrosine-methionineaspartate-aspartate(YMDD) motif are necessary and sufficient to confer high-level lamivudine resistance. During treatment with lamivudine, mutations develop in the YMDD motif of the hepatitis B virus(HBV) polymerase gene and lamivudine cannot prevent the replication of the mutant form. The virulence strain of developed mutation in the polymerase gene is lower than the original virus and they are susceptible to treatment with some other nucleoside analogs except lamivudine. Entecavir and tenofovir are potent HBV inhibitors and they can be confidently used as first line monotherapies. We read the article written by Tan et al that lamivudine therapy improved the clinical course in HBV patients with natural YMDD mutations. We think that lamivudine use for this patient group is not appropriate. These patients should use YMDD mutant form-effective drugs such as adefovir, tenofovir. | Aylin Calica Utku Oguz Karabay | 2016 | World Journal of Gastroenterology2016，22，4： | 4 |
| 6 | Perturbation of Wood Cellulose Synthesis Causes Pleiotropic Effects in Transgenic Aspen显示文摘在树上的纤维素生合成的基因操作可以提供新奇卓见进树的生长和发展。探索这可能性,一棵白杨的 overexpression 第二等的联系墙的纤维素 synthase (PtdCesA8 ) 基因在转基因的白杨(Populus tremuloides L.) 被尝试并且出人意料地象它的内长的对应物一样导致了 transgene 的 silencing。转基因的白杨植物的主要的轴快速停止成长,并且弱树枝采用了一个哭泣的生长习惯。而且,转基因的植物开始开发了更小的叶子和一个不太广泛的根系统。几乎没象 10% 纤维素一样包含的转基因的白杨植物的第二等的木部(木头) 使正常化与典型地在正常白杨木头发现的 41% 纤维素相比弄干重量。在纤维素的这巨大的减小被木质素(35%) 和非有纤维质的多糖(55%) 的比例的增加在控制植物与 22% 木质素和 36% 非有纤维质的多糖相比伴随。生产的转基因的茎典型崩溃或改变了第二等的墙形态学并且极大地包含了的不规则的木部容器减少了水晶的纤维素的数量。这些结果在维持要求在树上建立垂直生长习惯的力量和结构的正直在第二等的木部以内表明第二等的墙纤维素的基本角色。 | Chandrashekhar R Joshi Shivegowda Thammannagowda Takeshi Fujino Ji-Qing Gou Utku Avci Candace H. Haigler Lisa M. McDonnell Shawn D. Mansfield Bemnet Mengesha Nicholas C. Carpita Darby Harris Seth DeBolt Gary F. Peter | 2011 | Molecular Plant2011，4，2： | 4 |
| 7 | Application of scoring systems with point-of-care ultrasonography for bedside diagnosis of appendicitis显示文摘BACKGROUND: Appendicitis is a common disease requiring surgery. Bedside ultrasound(BUS) is a core technique for emergency medicine(EM). The Alvarado score is a well-studied diagnostic tool for appendicitis. This study aimed to investigate the relationship between patients' symptoms, Alvarado score and ultrasound(US) findings, as performed by emergency physicians(EPs) and radiologists, of patients with suspected appendicitis.METHODS: Three EM specialists underwent the BUS course and core course for appendicitis assessment. Patients suspected of having appendicitis were selected and their Alvarado and modif ied(m) Alvarado scores calculated. The specialists performed the BUS. Then, patients were given a formal US and surgery consultation if necessary. Preliminary diagnoses, admission or discharge from the emergency department(ED) and fi nal diagnosis were documented. The patients were also followed up after discharge from the hospital.RESULTS: The determined cut-off value was 2 for Alvarado and 3 for m Alvarado scores. The sensitivities of the two scores were 100%. Each score was used to rule out appendicitis. The results of EP-performed BUS were as follows: accuracy 70%, sensitivity 0.733, specifi city 0.673, + LR 2.24, and – LR 0.40(95%CI). Radiologists were better than EPs at diagnosing appendicitis and radiologists and EPs were equally strong at ruling out appendicitis by US. When US was combined with Alvarado and m Alvarado scores, EP US+Alvarado/m Alvarado scores ≤3 and radiology US+Alvarado/m Alvarado scores ≤4 perfectly ruled out appendicitis.CONCLUSION: BUS performed by EPs is moderately useful in detecting appendicitis. Combined with scoring systems, BUS may be a perfect tool for ruling out decisions in EDs. | Erden Erol Unluer Rifat Urnal Utku Eser Serkan Bilgin Mehmet Haciyanh Orhan Oyar Haldun Akoglu Arif Karagoz | 2016 | World Journal of Emergency Medicine2016，7，2： | 2 |
| 8 | X-linked juvenile retinoschisis: phenotypic and genetic characterization显示文摘Juvenile X-linked retinoschisis(XLRS, MIM#312700) belongs to a group of the vitreoretinal dystrophies. We aimed to describe the phenotype-genotype correlation of three XLRS cases in juveniles with different novel mutations from the Lithuanian population. The patients demonstrated macular retinoschisis and typical cyst-like cavities on spectral-domain optical coherence tomography(SD-OCT) images. The mean central foveal thickness was 569.7 μm. Two patients presented with peripheral retinoschisis. Flash electroretinogram demonstrated a reduced b/a ratio(<1.0) in all patients. RS1(NM_000330.3) gene coding exons Sanger sequencing was performed. RS1 c.599 G>T(p.R200 L) mutation was detected in one case, showing to be pathogenic in silico analysis. c.(92_97) ins C(p.W33 fs) mutation was identified for another patient, indicating the variant is possibly damaging in silico analysis. The third case was identified with a pathogenic mutation c.422 C>G(p.R141 H), HGMD CM981753. These are the first cases of XLRS in the Lithuanian population confirmed by molecular genotyping. Presented patients had a different genotype but similar phenotypic traits. | Rasa Strupaite Laima Ambrozaityte Loreta Cimbalistiene Rimvydas Asoklis Algirdas Utkus | 2018 | International Journal of Ophthalmology(English edition)2018，11，11： | 2 |
| 9 | A Comparison Study of Moving Object Index Structures显示文摘The task of selecting the most appropriate method for indexing the data according to application requires a careful comparison study of indices of interests. In particular, we consider object movements by tracing their trajectories within a predefined road network. MV3DR-tree and 3DR-tree constitute our first group indexing the objects moving in free movement scenarios. Besides, Mapping and MON-tree are the second group indexing the locations of objects moving over a network of road. Those access methods mainly organize a group of R-tree in order to index the underlying road network and the object movements. Our goal in this study is to evaluate existing proposals under fair circumstances with respect to storage consumption and spatio-temporal query execution performance. In our comparisons, we discuss the structure's sensibility to query's spatial and/or temporal extent as well as the tradeoff arising between two groups in terms of reliability and disk access performance. We believe that revealing the vulnerabilities of the selected structures, especially Mapping and MON-tree motivates us to design more robust organizations. | Utku Kalay Oya Kalipsiz | 2009 | Journal of Computer Science & Technology2009，24，6： | 2 |
| 10 | Parathyroidcysts: diagnosis and treatment with fine needle aspiration显示文摘 | O Emrah Akar Ugur Toprak Utku Menderes | 2003 | European Journal of Radiology Extra2003，46，4： | 1 |
| 11 | Factors affecting the outcome of decompressive craniectomy for large hemispheric infarctions:a prospective cohort study显示文摘 | Kilincer C Asil T Utku U | 2005 | Acta Neurochir(Wien)2005，147，6： | 1 |
| 12 | Monitoring of increased intracranial pressure resulting from cerebral edema with transcranial Doppler sonography in patients with middle cerebral artery infarction 显示文摘 | Asil T Uzunca I Utku U | 2003 | J Ultrasound Med2003，22，10： | 1 |
| 13 | Comparison of results of ATP Bioluminescence and traditional hygiene swabbing methods for the determination of surface cleanliness at a hospital kitchen 显示文摘 | Hasan Aycicek Utku Oguz Koray Karci | 2006 | International Journal of Hygiene and Environmental Health2006，209，2： | 1 |
| 14 | Monitoring of increased intracranial pressure resulting from cerebral edema with transcranial Doppler sonography in patients with middle cerebral artery infarction显示文摘 | Uzunca I Utku U | 2003 | J UItrasound Med2003，22，： | 1 |
| 15 | Factors affecting the outcome of decompressive craniectomy for large hemispheric infarctions:a prospective cohort study显示文摘 | Kilincer C Asil T Utku U et a1 | 2005 | Acta Neurochir (Wien)2005，147，6： | 1 |
| 16 | Crush syndrome patients after the Marmara earthquake显示文摘 | Demirkiroal O Dikmen Y Utku T | 2003 | Emerg Med J2003，20，3： | 1 |
| 17 | Environmental con tamination during a carbapenem- resistant Acinetobacter bau manii outbreak in an intensive care unit显示文摘 | Aygun G Demirkiran O Utku T | 2002 | J Hosp Infect2002，25，4： | 1 |
| 18 | The efficacy of nonop- erative management in childhood blunt hepatic trauma 显示文摘 | Karkiner A Temir G Utku M | 2005 | Lrlus Travma Acil Cerrahi Derg2005，11，2： | 1 |
| 19 | Crush syndrome patients after the Marmara earthquake显示文摘 | Demirkiran O Dikmen Y Utku T | 2003 | Emerg Med J2003，20，3： | 1 |
| 20 | The efficacy of nonoperative management in childhood blunt hepatic trauma 显示文摘 | Kar kiner A Temir G Utku M | 2005 | Ulus Travma Derg2005，11，2： | 1 |
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