|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle显示文摘Background: Exercise promotes numerous phenotypic adaptations in skeletal muscle that contribute to improved function and metabolic capacity. An emerging body of evidence suggests that skeletal muscle also releases a myriad of factors during exercise, termed 'myokines'. The purpose of this study was to examine the effects of high-intensity interval training(HIIT) on the acute regulation of the mRNA expression of several myokines, including the prototypical myokine interleukin-6(IL-6), and recently identified myokines fibronectin type III domain-containing protein 5(FNDC5)(irisin) and meteorin-like protein(METRNL).Methods: Both before and after a 20-day period of twice-daily high-volume HIIT, 9 healthy males(20.5 ± 1.5 years performed a standardized bout of high-intensity interval exercise(HIIE; 5 × 4 min at ~80% pretraining peak power output) with skeletal muscle biopsy samples(vastus lateralis) obtained at rest, immediately following exercise, and at 3 h recovery.Results: Before training, a single bout of HIIE increased IL-6(p < 0.05) and METRNL(p < 0.05) mRNA expression measured at 3 h recovery when compared to rest. Following 20 days of HIIT, IL-6 and FNDC5 mRNA were increased at 3 h recovery from the standardized HIIE bout when compared to rest(both p < 0.05). Resting METRNL and FNDC5 mRNA expression were higher following training(p < 0.05), and there was an overall increase in FNDC5 mRNA post-training(main effect of training, p < 0.05).Conclusion: In human skeletal muscle(1) an acute bout of HIIE can induce upregulation of skeletal muscle IL-6 mRNA both before and after a period of intensified HIIT;(2) Resting and overall FNDC5 mRNA expression is increased by 20 days of HIIT; and(3) METRNL mRNA expression is responsive to both acute HIIE and short-term intense HIIT. Future studies are needed to confirm these findings at the protein and secretion level in humans. | Malcolm Eaton Cesare Granata Julianne Barry Adeel Safdar David Bishop Jonathan P.Little | 2018 | Journal of Sport and Health Science2018，7，2： | 15 |
| 2 | Structural, optical, and electrical properties of phase- controlled cesium lead iodide nanowires显示文摘铯铅碘化物(在它的黑 perovskite 阶段的 CsPbI 3), ,为光电的应用有合适的 bandgap 和高量效率。然而, CsPbI 3 趋于到 crystalize 进一个黄 non-perovskite 阶段,它有差的 optoelectronic 性质,在房间温度。因此,在 CsPbI 3 控制阶段转变为这材料的实际申请是批评的。这里,我们报导一个维的 CsPbI 3 nanowires 和他们的相应结构、光、电的性质的阶段转变的系统的研究。我们通过快速的热熄灭从 non-perovskite 黄阶段显示出 perovskite 黑人阶段 CsPbI 3 nanowires 的形成。transformed 以后黑阶段 CsPbI 3 nanowires 展览与一从 2.78 ~ 1.76 eV 缩小 bandgap 增加了光致发光排放紧张。perovskite nanowires 是光导的并且在房间温度显示出快 photoresponse 和优秀稳定性。这些有希望的光、电的性质为许多 nanoscale optoelectronic 设备使 perovskite CsPbI3 nanowires 吸引人。 | Minliang Lai Qiao Kong Connor G. Bischak Yi Yu Letian Dou Samuel W. Eaton Naomi S. Ginsberg Peidong Yang | 2017 | Nano Research2017，10，4： | 8 |
| 3 | The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells显示文摘 | Sendurai A. Mani Wenjun Guo Mai-Jing Liao Elinor Ng. Eaton Ayyakkannu Ayyanan Alicia Y. Zhou Mary Brooks Ferenc Reinhard Cheng Cheng Zhang Michail Shipitsin Lauren L. Campbell Kornelia Polyak Cathrin Brisken Jing Yang Robert A. Weinberg | 2008 | Cell2008，，4： | 7 |
| 4 | Esophageal tissue engineering:A new approach for esophageal replacement显示文摘A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenosis and other problems.Regenerative medicine approaches facilitate the use of biological constructs to replace or regenerate normal tissue function.We review the literature of esophageal tissue engineering,discuss its implications,compare the methodologies that have been employed and suggest possible directions for the future.Medline,Embase,the Cochrane Library,National Research Register and ClinicalTrials.gov databases were searched with the following search terms:stem cell and esophagus,esophageal replacement,esophageal tissue engineering,esophageal substitution.Reference lists of papers identified were also examined and experts in this field contacted for further information.All full-text articles in English of all potentially relevant abstracts were reviewed.Tissue engineering has involved acellular scaffolds that were either transplanted with the aim of being repopulated by host cells or seeded prior to transplantation.When acellular scaffolds were used to replace patch and short tubular defects they allowed epithelial and partial muscular migration whereas when employed for long tubular defects the results were poor leading to an increased rate of stenosis and mortality.Stenting has been shown as an effective means to reduce stenotic changes and promote cell migration,whilst omental wrapping to induce vascularization of the construct has an uncertain benefit.Decellularized matrices have been recently suggested as the optimal choice for scaffolds,but smart polymers that will incorporate signalling to promote cell-scaffold interaction may provide a more reproducible and available solution.Results in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and epithelial cells on scaffolds prior to implantation is a prerequisite for complete esophageal replacement.Novel approaches need to be designed to allow for peristalsis and vascularization in the engineered esophagus.Although esophageal tissue engineering potentially offers a real alternative to conventional treatments for severe esophageal disease,important barriers remain that need to be addressed. | Giorgia Totonelli Panagiotis Maghsoudlou Jonathan M Fishman Giuseppe Orlando Tahera Ansari Paul Sibbons Martin A Birchall Agostino Pierro Simon Eaton Paolo De Coppi | 2012 | World Journal of Gastroenterology2012，18，47： | 5 |
| 5 | Pathogenesis of Primary Sclerosing Cholangitis and Advances in Diagnosis and Management显示文摘 | John E. Eaton Jayant A. Talwalkar Konstantinos N. Lazaridis Gregory J. Gores Keith D. Lindor | 2013 | Gastroenterology2013，，： | 5 |
| 6 | 湍流扩散多相流显示文摘湍流扩散多相流在许多工程和环境科学实际应用中十分常见.流体相中的湍流和扩散相的随机本质使得湍流扩散多相流中遇到的问题远比单一流体中遇到的湍流现象复杂得多.首先评述了湍流扩散多相流研究中实验技术和数值计算方面的现状、各自的优点与局限性,以及该领域研究中未来面临的挑战.主要关注湍流扩散多相流研究中以下3方面重点内容:颗粒、液滴和气泡的选择性聚积;湍流对流体相和扩散相耦合作用的影响以及颗粒物和气泡的存在对流体相中湍流的调节机制. | Balachandar S Eaton John K 朱伟(译) 任晓川(译) 郑晓静(译) 黄永念(校) | 2010 | 力学进展2010，40，5： | 4 |
| 7 | Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer显示文摘 | Masahito Tachibana Paula Amato Michelle Sparman Nuria Marti Gutierrez Rebecca Tippner-Hedges Hong Ma Eunju Kang Alimujiang Fulati Hyo-Sang Lee Hathaitip Sritanaudomchai Keith Masterson Janine Larson Deborah Eaton Karen Sadler-Fredd David Battaglia David L | 2013 | Cell2013，，6： | 2 |
| 8 | Suppression of colonic cancer by dietary phytic acid 显示文摘 | Graf E Eaton JW | 1993 | Nutr Cancer1993，19，： | 2 |
| 9 | Human and ecological risks of metals in soils under different land-use types in an urban environment of Bangladesh显示文摘Trace metal contamination in soil is of great concern owing to its long persistence in the environment and toxicity to humans and other organisms.Concentrations of six potentially toxic trace metals,Cr,Ni,Cu,As,Cd,and Pb,in urban soils were measured in Dhaka City,Bangladesh.Soils from different land-use types,namely,agricultural field,park,playground,petrol station,metal workshop,brick field,burning sites,disposal sites of household waste,garment waste,electronic waste,and tannery wast,and construction waste demolishing sites,were investigated.The concentration ranges of Cr,Ni,Cu,As,Pb,and Cd in soils were 2.4–1258,8.3–1044,9.7–823,8.7–277,1.8–80,and 13–842 mg kg^-1,respectively.The concentrations of metals were subsequently used to establish hazard quotients(HQs)for the adult population.The metal HQs decreased in the order of As>Cr>Pb>Cd>Ni>Cu.Ingestion was the most vital exposure pathway of studied metals from soils followed by dermal contact and inhalation.The range of pollution load index(PLI)was 0.96–17,indicating severe contamination of soil by trace metals.Considering the comprehensive potential ecological risk(PER),soils from all land-use types showed considerable to very high ecological risks.The findings of this study revealed that in the urban area studied,soils of some land-use types were severely contaminated with trace metals.Thus,it is suggested that more attention should be paid to the potential health risks to the local inhabitants and ecological risk to the surrounding ecosystems. | Md.Saiful ISLAM Md.Kawser AHMED Md.Habibullah Al-MAMUN Dennis Wayne EATON | 2020 | Pedosphere2020，30，2： | 2 |
| 10 | Nitric oxide, the endothelium, pregnancy and preeclampsia显示文摘 | Morris NH Eaton BM Dekker G | 1996 | Br J Obstet Gynaecol1996，103，： | 2 |
| 11 | Stealth cells: Prevention of major histocompatibility complex class II-mediated T-cell activation by cell surface modification 显示文摘 | Murad KL Gosselin EJ Eaton JW | 1999 | Blood1999，94，6： | 2 |
| 12 | The epidemiology of sepsis in the United States from 1979 through 2000显示文摘 | Martin GS Mannino DM Eaton S | | 0，，： | 2 |
| 13 | Cities and growth: Theory and evidence from France and Japan显示文摘 | Jonathan Eaton Zvi Eckstein | 1997 | Regional Science and Urban Economics1997，，4： | 2 |
| 14 | Two-dimensional fluorescence difference gel electrophoretic analysis of Streptococcus mutans biofilms显示文摘 | Rathsam C Eaton RE Simpson CL | 2005 | J Proteome Res2005，4，6： | 1 |
| 15 | Self-reported stress and reproductive health of female lawyers显示文摘 | Schencker MB Eaton M Green R | 1997 | J Occup Environ Med1997，39，： | 1 |
| 16 | Technology, Trade,and Growth: A Unified Framwork显示文摘 | Jonathan and kortum Samuel | 2001 | European Economic Review2001，45，： | 1 |
| 17 | Plasma carboxypeptidases as regulators of the plasminogen system显示文摘 | TAN AK EATON DL | 1995 | J Clin Invest1995，96，5： | 1 |
| 18 | Potential for habituation to a neembased feeding deterrent in Japanese beetles,Popillia japonica显示文摘 | Held D Eaton T Potter D | 2001 | Entomologia Experimentalis et Applicata2001，101，1： | 1 |
| 19 | Administration of exogenous interleukin - 18 and interleukin - 12 prevents the induction of oral tolerance显示文摘 | Eaton A D Xu Damo Garside P | 2003 | Immunologe2003，108，19： | 1 |
| 20 | The catalytic subunit of yeast telomerase显示文摘 | Counter CM Meyerson M Eaton EN | 2003 | Proc Nat Acad Sci USA2003，94，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员