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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Comparison of brain natfiuretic pePtide (BNP) and amino-terminal ProBNP for early di- agnosis of heart failure 显示文摘 | EMDIN M PASSINO C PRONTERA C | 2007 | Clin Chem2007，53，7： | 1 |
| 3 | Predietive value of ele- vated neutrophil lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease 显示文摘 | Papa A Emdin M Passino C | 2008 | Clin Chim Aeta2008，395，12： | 1 |
| 4 | beta-Lipoprotein- and LDL-associated serum gamma-glutamyltransferase in patients with coronary atherosclerosis显示文摘 | Paolicchi A Emdin M Passino C | 2006 | Atherosclerosis2006，186，1： | 1 |
| 5 | Additive prognostic value of gamma-glutamyltransferasein coronary artery disease显示文摘 | Emdin M Passino C Michelassi C Donato L Pompella A Pa- olicehi A | 2009 | Int J Cardiol2009，136，： | 1 |
| 6 | Estimation of the power spectral in nonstationary cardiovascular time series: assessing the role of the time-frequency representations (TFR) 显示文摘 | Pola A Macerata A and Emdin M | 1996 | IEEE Trans Biomed Eng1996，43，1： | 1 |
| 7 | β-Lipoprotein- and LDL- associated serum γ-glutamyl transferase in patients with coronary atherosclerosis显示文摘 | Paolicchi A Emdin M Passino C | 2006 | Atherosclerosis2006，186，1： | 1 |
| 8 | Cardiac natriuretic hormones, neuro-hormones, thyroid hormones and cytokines in normal subjects and patients with heart failure显示文摘 | Emdin M Passino C Prontera C | 2004 | Clin Chem Lab Med2004，42，6： | 1 |
| 9 | Comparison of brain natriuretic peptide (BNP) and amio-terminal proBNP for early dia- gnosis of heart failure,显示文摘 | Emdin M Passino C Prontera C | 2007 | Clin Chemistry2007，53，7： | 1 |
| 10 | Diagnostic accuracy and prognostic relevance of the measurement of cardiac natriuretic peptides: a review 显示文摘 | Clerico A Emdin M | 2004 | Clin Chem2004，50，1： | 1 |
| 11 | Gamma-glu-tamyltra nsferase,atherosclerosis, and cardiovascu-lar disease: triggering oxidative stress within theplaque显示文摘 | Emdin M Pompella A Paolicchi A | 2005 | Circulation2005，112，14： | 1 |
| 12 | Permanent atrial fi- brillation affects exercise capacity in chronic heart failure patients显示文摘 | Agostoni P Emdin M Corra U | 2008 | Eur Heart J2008，29，19： | 1 |
| 13 | Old and new biomarkers of heat1 failure显示文摘 | Emdin M Vittorini S Passino C | 2009 | Eur J Heart Fail2009，11，4： | 1 |
| 14 | Comparison of brain natriuretic peptide(BNP) and amino-terminal pro-BNP for early diagnosis of heart failure 显示文摘 | Emdin M Passino C Prontera C | 2007 | Clin Chem2007，53，7： | 1 |
| 15 | Beta-lipoprotein- and LDL-associated serum gamma-glutamyltransferase in patients with coronary atherosclerosis 显示文摘 | Paolicchi A Emdin M Passino C | 2006 | Atherosclerosis2006，186，1： | 1 |
| 16 | Diagnostic accuracy and prognostic relevance of the measurement of cardiac na triuretic peptides显示文摘 | CLERICO A EMDIN M | 2004 | Clin Chem2004，50，： | 1 |
| 17 | The European ST-T database: standard for evaluating systems for the analysis of ST-T changes in ambulatory electrocardiography 显示文摘 | Taddei A Distante G Emdin M | 1992 | European Heart Journal1992，13，： | 1 |
| 18 | Comparison of brain natriuretic peptide(BNP)and amino-terminal Pro BNP for early diagnos is of heart failure显示文摘 | EMDIN M PASSINO C PRONTERA C | | 0，，07： | 1 |
| 19 | Comparison of brain natriuretic peptide (BNP) and amino- terminal ProBNP for early diagnosis of heart failure显示文摘 | Emdin M Passino C Prontera C | 2007 | Clin Chem2007，53，7： | 1 |
| 20 | Diagnostic accuracy and prognostic relevance of the measurement of cardiac natriuretic peptides:a review显示文摘 | Clerico A Emdin M | | 0，，01： | 1 |
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