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| 1 | Updates in the pathophysiological mechanisms of Parkinson's disease: Emerging role of bone marrow mesenchymal stem cells显示文摘AIM: To explore the approaches exerted by mesenchymal stem cells(MSCs) to improve Parkinson's disease(PD) pathophysiology.METHODS: MSCs were harvested from bone marrowof femoral bones of male rats, grown and propagated in culture. Twenty four ovariectomized animals were classified into 3 groups: Group(1) was control, Groups(2) and(3) were subcutaneously administered with rotenone for 14 d after one month of ovariectomy for induction of PD. Then, Group(2) was left untreated, while Group(3) was treated with single intravenous dose of bone marrow derived MSCs(BM-MSCs). SRY gene was assessed by PCR in brain tissue of the female rats. Serum transforming growth factor beta-1(TGF-β1), monocyte chemoattractant protein-1(MCP-1) and brain derived neurotrophic factor(BDNF) levels were assayed by ELISA. Brain dopamine DA level was assayed fluorometrically, while brain tyrosine hydroxylase(TH) and nestin gene expression were detected by semi-quantitative real time PCR. Brain survivin expression was determined by immunohistochemical procedure. Histopathological investigation of brain tissues was also done.RESULTS: BM-MSCs were able to home at the injured brains and elicited significant decrease in serum TGF-β1(489.7 ± 13.0 vs 691.2 ± 8.0, P < 0.05) and MCP-1(89.6 ± 2.0 vs 112.1 ± 1.9, P < 0.05) levels associated with significant increase in serum BDNF(3663 ± 17.8 vs 2905 ± 72.9, P < 0.05) and brain DA(874 ± 15.0 vs 599 ± 9.8, P < 0.05) levels as well as brain TH(1.18 ± 0.004 vs 0.54 ± 0.009, P < 0.05) and nestin(1.29 ± 0.005 vs 0.67 ± 0.006, P < 0.05) genes expression levels. In addition to, producing insignificant increase in the number of positive cells for survivin(293.2 ± 15.9 vs 271.5 ± 15.9, P > 0.05) expression. Finally, the brain sections showed intact histological structure of the striatum as a result of treatment with BM-MSCs. CONCLUSION: The current study sheds light on the therapeutic potential of BM-MSCs against PD pathophysiology via multi-mechanistic actions. | Hanaa H Ahmed Ahmed M Salem Hazem M Atta Emad F Eskandar Abdel Razik H Farrag Mohamed A Ghazy Neveen A Salem Hadeer A Aglan | 2016 | World Journal of Stem Cells2016，8，3： | 9 |
| 2 | Nonlinear total variation based noise removal algorithms显示文摘 | RUDIN L OSHER S EMAD F | 1992 | Physica D: Nonlinear Phenomena1992，60，14： | 1 |
| 3 | Lateral behavior of plasterboard-clad residential steel frames显示文摘 | Emad F Gad Adrian M Chandler Colin F Duffield Graeme Stark | 1999 | Journal of Structural Engineering1999，125，1： | 1 |
| 4 | Lateral behavior of plasterboard clad residential steel frames显示文摘 | Adrian M Chandler Colin F Duffield | 1999 | Journal of Structural Enginetting1999，125，1： | 1 |
| 5 | Static headspace gas chromatographic method for the determination of low and high boiling residual solvents in Betamethasone valerate显示文摘 | Jayalakshmi Somuramasami Yu-Chien Wei Emad F | 2011 | Journal of Pharmaceutical and Biomedical Analysis2011，54，： | 1 |
| 6 | Viral etiologies of lower respiratory tract infections a- mong Egyptian children under five years of age显示文摘 | Shafik Caroline F Mohareb Emad W Yassin Aymen S | 2013 | BMC Infectious Diseases2013，12，1： | 1 |
| 7 | Thermal con- ductivity of porous SiC composite ceramics derived from paper precursor显示文摘 | Nadejda P Emad A Andreas P F | 2010 | Ceram Int2010，36，7： | 1 |
| 8 | Lateral Behavior of Plasterboard-clad Residential Steel Frames显示文摘 | Emad F Gad Adrian M Chandler Colin F Duffield | 1999 | Journal of Structural Engineering1999，125，1： | 1 |
| 9 | Sonographic gallbladder wall thickness measurement and the prediction of esophageal varices among cirrhotics显示文摘Acute variceal bleeding in patients with liver cirrhosis and portal hypertension(PHT) is the most serious emergency complication among those patients and could have catastrophic outcomes if not timely managed. Early screening by esophago-gastro-duodenoscopy(EGD) for the presence of esophageal varices(EVs) is currently recommended by the practice guidelines for all cirrhotic patients. Meanwhile, EGD is not readily accepted or preferred by many patients. The literature is rich in studies to investigate and validate non-invasive markers of EVs prediction aiming at reducing the unneeded endoscopic procedures. Gallbladder(GB) wall thickness(GBWT) measurement has been found promising in many published research articles. We aim to highlight the validity of sonographic GBWT measurement in the prediction of EVs based on the available evidence. We searched databases including Cochrane library, Pub Med, Web of Science and many others for relevant articles. GBWT is associated with the presence of EVs in cirrhotic patients with PHT of different etiologies. The cut-off of GBWT that can predict the presence of EVs varied in the literature and ranges from 3.1 mm to 4.35 mm with variable sensitivities of 46%-90.9% and lower cutoffs in viral cirrhosis compared to non-viral, however GBWT > 4 mm in many studies is associated with acceptable sensitivity up to 90%. Furthermore, a relation was also noticed with the degree of varices and portal hypertensive gastropathy.Among cirrhotics, GBWT > 3.5 mm predicts the presence of advanced(grade Ⅲ-Ⅳ) EVs with a sensitivity of 45%, the sensitivity increased to 92% when a cut-off ≥ 3.95 mm was used in another cohort. Analysis of these results should carefully be revised in the context of ascites, hypoalbuminemia and other intrinsic GB diseases among cirrhotic patients. The sensitivity for prediction of EVs improved upon combining GBWT measurement with other non-invasive predictors, e.g., platelets/GBWT. | Mohamed H Emara Mariam Zaghloul Ibrahim F Amer Aya M Mahros Mohammed Hussien Ahmed Mahmoud A Elkerdawy Eslam Elshenawy Abdelrahman M Ahmed Rasheda Tarik I Zaher Mona Talaat Haseeb Emad Hassan Emara Hassan Elbatae | 2023 | World Journal of Hepatology2023，15，2： | 1 |
| 10 | Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms显示文摘 | Emad M El-Omar Charles S Rabkin Marilie D Gammon Thomas L Vaughan Harvey A Risch Janet B Schoenberg Janet L Stanford Susan T Mayne James Goedert William J Blot Joseph F Fraumeni Wong-ho Chow | 2003 | Gastroenterology2003，，5： | 1 |
| 11 | Nonlinear total variation based noise removal algorithms显示文摘 | LEONID I R STANLEY O EMAD F | 1992 | Physica D: Nonlinear Phenomena1992，60，1： | 1 |
| 12 | Nonlinear total variation based noise removal algor'thms显示文摘 | LEONID 1 R STANLEY O EMAD F | 1992 | Physica D Noolin for Ploc- nomena1992，60，4： | 1 |
| 13 | An impoved level set method for incompressible two-phase flows显示文摘 | MARK S EMAD F PETER S | 1998 | Computers&Fluids1998，27，56： | 1 |
| 14 | Advances in endoscopic retrograde cholangiopancreatography cannulation显示文摘Endoscopic retrograde cholangiopancreatography is an important tool in the diagnosis and treatment of pancreatobiliary diseases.A critical step in this procedure is deep cannulation of the bile duct as failure of cannulation generally results in an aborted procedure and failed intervention.Expert endoscopists usually achieve a high rate of successful cannulation while those less experienced typically have a much lower rate and a greater incidence of complications.Prolonged attempts at cannulation can result in significant morbidity to patients,anxiety for endoscopists,unnecessary radiation exposure and inefficient patient care.Here we review the most common endoscopic techniques used to achieve selective biliary cannulation.Pharmacologic aids to cannulation are also discussed briefly in this review. | Emad Qayed Ashley L Reid Field F Willingham Steve Keilin | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，4： | 1 |
| 15 | Spinal dural arteriovenous fistulas:experience with endovascular and surgical ther apy显示文摘 | Emad N Eskandar R Lawrence F | 2002 | J Neurosurg2002，96，2： | 1 |
| 16 | Dietary tryptophan effects on growth performance and blood parameters in broiler chicks显示文摘 | EMAD M KAVEH K JAHANSHIRI F | 2010 | Journal of Animal and Veterinary Advances2010，9，4： | 1 |
| 17 | Conical magnetic bearings with radial and thrust control显示文摘 | Mohamed A M Emad F P | 1992 | IEEE Transactions on Automatic Control1992，37，12： | 1 |
| 18 | Chaotic synchronization of two complex nonlinear oscillators显示文摘 | GAMAL M M EMAD E M AHMED A F | 2009 | ChaosSolitons and Fractals2009，42，8： | 1 |
| 19 | SAMAC : A Cross-Layer Conununication Protocol for Set, sot Networks with Sectored Antennas 显示文摘 | EMAD F VURAL S MURAWSKI R | 2010 | IEEE Transaction on Mobile Computing2010，9，8： | 1 |
| 20 | Later Behavior of Plasterboard-Clad Residential Steel Frames 显示文摘 | Emad F Gad Adrian M Chandler Colin F Duffield | 1999 | Journal of Structural Engineering1999，125，1： | 1 |
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