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| 1 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 2 | MicroRNA profile in neosquamous esophageal mucosa following ablation of Barrett's esophagus显示文摘AIM To investigate the micro RNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett's esophagus.METHODS High throughput screening using Taq Man~ Array Human Micro RNA quantitative PCR was used to determine expression levels of 754 micro RNAs in distal esophageal mucosa(1 cm above the gastro-esophageal junction) from 16 patients who had undergone ablation of non-dysplastic Barrett's esophagus using argon plasma coagulation vs pretreatment mucosa, posttreatment proximal normal non-treated esophageal mucosa, and esophageal mucosal biopsies from 10 controls without Barrett's esophagus. Biopsies of squamous mucosa were also taken from 5 cm above the pre-ablation squamo-columnar junction. Predicted m RNA target pathway analysis was used to investigate the functional involvement of differentially expressed micro RNAs.RESULTS Forty-four micro RNAs were differentially expressed between control squamous mucosa vs post-ablation neosquamous mucosa. Nineteen micro RNAs were differentially expressed between post-ablation neosquamous and post-ablation squamous mucosa obtained from the more proximal non-treated esophageal segment. Twelve microRNAs were differentially expressed in both neosquamous vs matched proximal squamous mucosa and neosquamous vs squamous mucosa from healthy patients. Nine micro RNAs(mi R-424-5p, mi R-127-3p, mi R-98-5p, mi R-187-3p, mi R-495-3p, mi R-34c-5p, mi R-223-5p, mi R-539-5p, mi R-376a-3p, mi R-409-3p) were expressed at higher levels in post-ablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These micro RNAs were also more highly expressed in Barrett's esophagus mucosa than matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in the regulation of cell survival signalling pathways. Three micro RNAs(mi R-187-3p, mi R-135b-5p and mi R-31-5p) were expressed at higher levels in postablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These mi RNAs were expressed at similar levels in preablation Barrett's esophagus mucosa, matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in regulating the expression of proteins that contribute to barrier function.CONCLUSION Neosquamous mucosa arising after ablation of Barrett's esophagus expresses micro RNAs that may contribute to decreased barrier function and micro RNAs that may be involved in the regulation of survival signaling pathways. | Loveena Sreedharan George C Mayne David I Watson Timothy Bright Reginald V Lord Alfiya Ansar Tingting Wang Jakob Kist David StJ Astill Damian J Hussey | 2017 | World Journal of Gastroenterology2017，23，30： | 3 |
| 3 | Diet,obesity and reflux in the etiology of adenocarcinomas of the esophagus and gastic cardia in humans 显示文摘 | Mayne ST Navarro SA | 2002 | J Nutr2002，132，11： | 2 |
| 4 | Caries Patterns in the Primary Dentition: Cluster Analysis of a Sample of 5,169 Arizona Children 5-59 Months of Age显示文摘Aim Cluster analysis was conducted on data from 5,169 United States (U.S.) Arizona children, age's 5-59-months with the goal of delineating patterns of caries in the primary dentition of pre-school children without a priori pattern definitions. Methodology Cluster analyses were conducted using all data for children ages 0-4 years in aggregate: 1) for all subjects, and 2) for subjects without crowned restored teeth. Each of these two sets of analyses consisted of 8 differently specified cluster analyses as a validation procedure. Results The caries patterns identified from the clustering analysis are: 1) smooth surfaces (other than the maxillary incisor), 2) maxillary incisor, 3) occlusal surfaces of first molars, and 4) pit and fissure surfaces of second molars. Conclusion The cluster analysis findings were consistent with results produced by multidimensional scaling. These cross-validated patterns may represent resulting disease conditions from different risks or the timing of various risk factor exposures. As such, the patterns may be useful case definitions for caries risk factor investigations in children under 60 months of age. | Walter J. Psoter David G. Pendrys Douglas E. Morse He-ping Zhang Susan T. Mayne | 2009 | International Journal of Oral Science2009，1，4： | 2 |
| 5 | Development of a European herbage growth model(the EU Grazemore project)显示文摘 | Barrett P D Mayne A S | 2004 | Grassland Science in Europe2004，9，： | 1 |
| 6 | Exact penalty function algorithm with simple updating of the penalty parameter显示文摘 | Pantoja J F A Mayne D Q | 1991 | Journal of Optimization Theory and Applications1991，69，3： | 1 |
| 7 | Centralizing automorphisms of prime rings显示文摘 | Mayne J H | 1976 | Canad Math Bull1976，19，： | 1 |
| 8 | Diet,obesity and reflux in the etiology of adenocarcinomas of the esophagus and gastric cardia in humans显示文摘 | MAYNE S T NAVARRO S A | 2002 | J Nutr2002，132，11： | 1 |
| 9 | Simulation of airflow and heat transfer in small alternators using CFD显示文摘 | Maynes B D J Kee R J Tindall C E | 2003 | IEE Proceedings Electric Power Applications2003，150，2： | 1 |
| 10 | Ground response to dynamic compaction显示文摘 | Mayne P W | 1984 | Journal of Geotechnical Engineering ASCE1984，110，6： | 1 |
| 11 | Ideals and Centralizing mappings in prime rings显示文摘 | Mayne J H | 1982 | Proc Amer Math Soc1982，86，： | 1 |
| 12 | Antisense oligodeoxynucleotide inhibition of tumor necrosis factor-alpha expression is neuroprotective after intracerebral hemorrhage显示文摘 | Mayne M Ni W Yan HJ | 2001 | Stroke2001，32，1： | 1 |
| 13 | Nutrient intake and risk of subtypes of esophageal and gastric cancer显示文摘 | Susan T Mayne 2 Harvey A Risch Robert Dubrow | 2001 | Cancer Epidemiol Biomarkers Prey2001，10，10： | 1 |
| 14 | Moving horizon observers and observer based control 显示文摘 | ICHALSKA H MAYNE D Q | 1995 | IEEE Transactions on Automatic Control1995，40，6： | 1 |
| 15 | Statistical relationships between piezocone measurements and stress history of clays显示文摘 | CHEN B S Y MAYNE P W | 1996 | Canadian Geotechnical Journal1996，33，： | 1 |
| 16 | Evidence of immunomodu- lation in nestling American kestrels exposed to environmentally relevant PBDEs 显示文摘 | Femie KJ Mayne G Shutt JL | 2005 | Environ Pollut2005，138，： | 1 |
| 17 | PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities显示文摘 | Mbikay M Sirois F Mayne J | 2010 | FEBS Lett2010，584，4： | 1 |
| 18 | GrazeGro: a European herbage growth model to predict pasture production in perennial ryegrass swards for decision support 显示文摘 | Barrett P D Laidlaw A S Mayne C S | 2005 | European Journal of Agronomy2005，1，： | 1 |
| 19 | Familial cancer history and lung cancer risk in United States nonsmoking men and women显示文摘 | Mayne ST Buenconsejo J Janerich DT | 1999 | Cancer Epidemiol Biomarkers Prev1999，8，： | 1 |
| 20 | A parameter estimation perspec- tive of continuous time model reference adaptive control 显示文摘 | Goodwin G C Mayne D Q | 1989 | Automatica1989，23，： | 1 |
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