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| 1 | 上海市市区350例胰腺癌病理特征的初步分析显示文摘目的:初步分析上海市市区常住居民胰腺癌的病理特征。方法:2006年12月—2011年1月在上海市市区开展以人群为基础的大规模胰腺癌病例-对照研究,共收集387例病理切片,由上海市5名资深病理医师对所有病例的病理切片进行复查。根据WHO胰腺肿瘤组织学分类(2010年第4版)进行病理分型。结果:确诊胰腺癌350例(90.4%),病理标本以切除标本为主(311/350,88.9%)。胰腺肿瘤平均直径4cm,198例(56.6%)发生在胰头,组织学类型以导管腺癌最常见(311例,89.0%),其次为胰腺神经内分泌肿瘤15例(4.3%)。组织学分级以Ⅱ/Ⅲ级最多见(252例)。TNM分期:40例为ⅠA期,209例为ⅠB期和ⅡA期,80例为ⅡB期。明确神经侵犯者175例,有淋巴管和(或)静脉内癌栓者56例。病理复查仅发现1例误诊。结论:通过病理复查提高了对上海市市区胰腺癌病理特征的认识。 | 纪元 沈铭昌 金晓龙 朱明华 王虹 倪泉兴 张薇 王婧 孙璐 YU Herbert RISCH Harvey 高玉堂 | 2012 | 肿瘤2012，32，3： | 9 |
| 2 | The future of genetic studies of complex human diseases 显示文摘 | Risch N Merikangas K | 1996 | Science1996，273，5281： | 3 |
| 3 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 4 | A Functional Polymorphism of Toll-Like Receptor 4 Gene Increases Risk of Gastric Carcinoma and Its Precursors显示文摘 | Georgina L. Hold Charles S. Rabkin Wong–Ho Chow Malcolm G. Smith Marilie D. Gammon Harvey A. Risch Thomas L. Vaughan Kenneth E.L. McColl Jolanta Lissowska Witold Zatonski Janet B. Schoenberg William J. Blot N. Ashley G. Mowat Joseph F. Fraumeni Emad M. El | 2007 | Gastroenterology2007，，3： | 2 |
| 5 | Short term effects of atorvatatin on c-reactive protein显示文摘 | Riesen W F Engler H Risch M | 2002 | Eur Heart J2002，23，10： | 1 |
| 6 | Altered DNA re- pair capacity and bleomycin sensitivity as risk markers for non-small cell lung cancer显示文摘 | Rajaee-Behbahani N Schmezer P Risch A | 2001 | Int J Cancer2001，95，2： | 1 |
| 7 | Genetic polymor-phism of CYP genes, alone or in combination, as a risk of tobacco - related cancers 显示文摘 | Helmut Bartsch Urrniila Nair Angle Risch | 2000 | Epidemiotogy Biomarker&Prevention2000，9，1： | 1 |
| 8 | Short term effects of atorvastatin on C-reactive protein显示文摘 | Riesen WF Engler H Risch M | 2002 | Eur Heart J2002，23，： | 1 |
| 9 | Nutrient intake and risk of subtypes of esophageal and gastric cancer显示文摘 | Susan T Mayne 2 Harvey A Risch Robert Dubrow | 2001 | Cancer Epidemiol Biomarkers Prey2001，10，10： | 1 |
| 10 | Leptin, leptin soluble re- ceptor and coronary atherosclerosis 显示文摘 | HOEFLE G SAELY C H RISCH L | 2007 | Eur J Clin Invest2007，37，8： | 1 |
| 11 | Nutrient intake and risk of subtypes of esophageal and gastric cancer显示文摘 | MAYNE S T RISCH H A DUBROW R | 2001 | Cancer Epidemiol Biomark Prev2001，10，10： | 1 |
| 12 | Genetic susceptibility to death from coronary heart disease in a study of twins 显示文摘 | MARENBERG M E RISCH N BERKMAN L F | 1994 | New England Journal of Medi- cine1994，330，15： | 1 |
| 13 | Vertical MOS transistors with 70 nm channel length 显示文摘 | Krautschneider W H Hofmann F | 1996 | IEEE Trans Elec Dev1996，43，9： | 1 |
| 14 | Searching for genetic determ illennium显示文摘 | Risch NJ | 2000 | Nature2000，405，84： | 1 |
| 15 | The predictive characteristics of D-dimer testing in outpatients with suspected venous thromboembolism:a Bayesian approach 显示文摘 | Risch L Monn A Luthy R | 2004 | Clinica Chimica Acta2004，345，： | 1 |
| 16 | Glomerular filtration rate esti mates decrease during high altitude expedition but increase with Lake Louise acute mountain sickness scores 显示文摘 | Pichler J Risch L Hefti U | 2008 | Acta Physiol (Oxf)2008，192，3： | 1 |
| 17 | Rapid screening assay for mutagen sensitivity and DNA repair capacity in human peripheral blood lymphocytes显示文摘 | Schmezer P Rajaee BN Risch A | 2001 | Mutagenesis2001，16，1： | 1 |
| 18 | Genetic polymporphism of CYP genes, alone or in combination, as a risk modifier of tobaccorelated cancer 显示文摘 | Bartsch H Nalr U Risch A | 2009 | Cancer Epidemiology Biomarkers and Prevention2009，9，： | 1 |
| 19 | Genetic polymorphism of CYP genes,alone or in combination,as a risk modifier of tobacco-related cancer显示文摘 | Bartsch H Nair U Risch A | 2000 | Cancer Epidemiology Biomarkers & Prevention2000，，9： | 1 |
| 20 | Short- term effects of atorvatatin on c- reactive protein显示文摘 | Riesen W F Engler H Risch M | 2002 | Eur Heart2002，23，： | 1 |
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