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| 1 | 溶栓时间(入院到用药时间)的延迟及其对脑卒中治疗时间与预后的影响显示文摘尽管美国心脏协会/美国脑卒中协会关于脑卒中的治疗均提出了倡议,大量急性缺血性脑卒中患者仍然在到达就诊60min后才开始启动组织型纤溶酶原激活剂(阿替普酶)溶栓治疗。该研究旨在描述延迟的原因及其与患者预后之间的关系。 | 刘莉 叶鹏 Kamal N Sheng S Xian Y Matsouaka R Hill MD Bhatt DL Saver JL Reeves MJ Fonarow GC Schwamm LH Smith EE | 2017 | 中华高血压杂志2017，25，4： | 15 |
| 2 | 吉非替尼结合化放疗治疗局部晚期头颈癌显示文摘该文旨在评价表皮生长因子受体抑制剂吉非替尼结合同期放化疗治疗局部晚期头颈癌(LA—HNC)的效果及毒性.研究治疗效果和EGFR基因拷贝数目的关系。方法:Ⅲ-Ⅳ期LA—HNC患者先行卡铂及紫杉醇诱导化疗,再给以5-FU及羟基脲(FHX)同期放化疗。同时给以吉非替尼,持续2a。初步疗效终点为肿瘤临床CR。EGFR基因的拷贝数应用荧光原位杂交确定。 | Cohen EE Haraf DJ Kunnavakkam R | 2010 | 中国口腔颌面外科杂志2010，8，4： | 10 |
| 3 | Estrogen deficiency leads to telomerase inhibition, telomere shortening and reduced cell proliferation in the adrenal gland of mice显示文摘雌激素缺乏调停变老,但是内在的机制尚待充分坚定。我们这里报导 aromatase 的指向的混乱在老鼠引起的雌激素缺乏在 vivo 在肾上腺导致 telomerase 活动的重要抑制。基因表示分析证明当雌激素不在时, telomerase 颠倒 transcriptase (TERT ) 基因表示在肾上腺外皮和肾的萎缩与损害房间增长联合被减少。在 c 工具包积极的干细胞被识别在肾的外皮的实质占据。telomeres 的分析表明那雌激素缺乏比那在肾的外皮导致显著地更短的 telomeres 在野类型(WT ) 控制鼠标。为了推进,建立雌激素的原因的效果,我们在这些雌激素缺乏的动物进行了雌激素代替治疗。为 3 个星期的雌激素的管理在雌激素缺乏的老鼠恢复 TERT 基因表示, telomerase 活动和房间增长。因此,我们第一次,那雌激素缺乏在 vivo 在鼠标的肾上腺引起 TERT 基因表示, telomerase 活动, telomere 维护,和房间增长的抑制的数据表演,建议那 telomerase 抑制并且 telomere 弄短可以调停在肾上腺的房间增长拘捕,因此贡献雌激素在生理的条件下面的导致缺乏的老化。 | Sharyn Bayne Margaret EE Jones He Li Alex R Pinto Evan R Simpson Jun-Ping Liu | 2008 | Cell Research2008，18，11： | 6 |
| 4 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 5 | Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines显示文摘 | Yoke Keong Yong Jun Jie Tan Soek Sin Teh Siau Hui Mah Gwendoline Cheng Lian Ee Hoe Siong Chiong Zuraini Ahmad José Luis Ríos | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 2 |
| 6 | NH ( 2 ) -terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer 显示文摘 | Molina MA Saez R Ramsey EE | 2002 | Clin Cancer Res2002，8，2： | 1 |
| 7 | Protective effect of green tea polyphenlo ( - ) epigallocatechin - 3 - gallate and other antioxidants on lipid peroxidation in gerbil brain homogenates显示文摘 | L EE S R M KJ SUH S I | 2003 | J Phytother Res2003，17，3： | 1 |
| 8 | Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene显示文摘 | ee TY alo P t al | | Nat Genet0，0，4： | 1 |
| 9 | Prognostic factors and outcomes for osteosarcoma: an international collaboration 显示文摘 | Pakos EE Nearchou AD Grimer R J | 2009 | Eur J Cancer2009，45，13： | 1 |
| 10 | What can we learn from rodents about pro- lactin in humans? 显示文摘 | BEN-JONATHAN N LAPENSEE C R LAPENS- EE E W | 2008 | Endoc Rev2008，29，： | 1 |
| 11 | A feedback loop comprising lin-28 and let-7 controls pre-let-7maturation during neural stem-cell commitment 显示文摘 | Rybak A Fuchs H Smirnova L Brandt C Pohl EE Nitsch R etal | 2008 | Nat CellBioi2008，10，8： | 1 |
| 12 | Variation in ICU risk-adjusted mortality:impact of methods of assessment and potential confounders显示文摘 | Kuzniewicz MW Vasilevskis EE Lane R | 2008 | Chest2008，133，6： | 1 |
| 13 | Inducible nitric oxide synthase,nitrotyrosine,and apoptosis in Helicobacter pylori gastritis:effect of antibiotics and antioxidants 显示文摘 | Mannick EE Bravo LE Zarama G Realpe JL Zhang XJ Ruiz B Eonthan ETH Mera R Miller MJL Correa P | 1996 | Cancer Res1996，56，： | 1 |
| 14 | Ami- nolaevulinic acid-induced protoporphyrin Ⅸ pharmacoki- netics in central and peripheral arteries of the rat 显示文摘 | Gabeler EE Sluiter W van Hillegersberg R | 2003 | Photochem Photobio12003，78，： | 1 |
| 15 | Fatty acids induce hcpatocyte senescene in vitro: implications for pathogenesis in NASH显示文摘 | SKOIEN R POWELL EE MELINO M | 2010 | Hepatology2010，52，1： | 1 |
| 16 | Transforming growth factor- beta mRNA and protain in hypertrophic scar tissues and fibroblasts antagonism by IFN alpha and IFN- gamma in vitro and in vivo显示文摘 | Tredget EE Wang R Shen Q | 2000 | J Interferon Cytokine Res2000，20，2： | 1 |
| 17 | The natural history of nonalcoholic steatohepatitis:a follow-up study of forty-two patients for up to 21 years显示文摘 | Powell EE Cooksley WG Hanson R | 1990 | Hepatology1990，11，1： | 1 |
| 18 | Wheat yield progress associated with higher stomata conductance and photosynthetic rate and cooler canopies显示文摘 | Fischer R A Ees D Ayre K D | 1998 | Crop Sci1998，8，6： | 1 |
| 19 | GA TA4 transcription factor is required for ventral morphogenesis and heart tube formation 显示文摘 | Kuo CT Morrisey EE Anandappa R et ol | 1997 | Genes Dev1997，11，8： | 1 |
| 20 | TGF-β mRNA and protein in hypertrophic scartissue and tqbroblasts 显示文摘 | Tredget EE Wang R Shen Q | 2000 | J Interferon Cytokine Res2000，20，2： | 1 |
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