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| 1 | Epithelial ovarian cancer:An overview显示文摘Ovarian cancer is the second most common gyneco-logical cancer and the leading cause of death in the United States. In this article we review the diagnosis and current management of epithelial ovarian cancer which accounts for over 95 percent of the ovarian malignancies. We will present various theories about the potential origin of ovarian malignancies. We will discuss the genetic anomalies and syndromes that may cause ovarian cancers with emphasis on Breast cancer type 1/2 mutations. The pathology and pathogenesis of ovarian carcinoma will also be presented. Lastly, we provide a comprehensive overview of treatment strategies and staging of ovarian cancer, conclusions and future directions. | Arpita Desai Jingyao Xu Kartik Aysola Yunlong Qin Chika Okoli Ravipati Hariprasad Ugorji Chinemerem Candace Gates Avinash Reddy Omar Danner Geary Franklin Anachebe Ngozi Guilherme Cantuaria Karan Singh William Grizzle Charles Landen Edward E Partridge Valerie Montgomery Rice E Shyam P Reddy Veena N Rao | 2014 | World Journal of Translational Medicine2014，3，1： | 10 |
| 2 | Discovering the roles of subsurface microorganisms: Progress and future of deep biosphere investigation显示文摘The discovery of the marine 'deep biosphere'-microorganisms living deep below the seafloor-is one of the most significant and exciting discoveries since the ocean drilling program began more than 40 years ago. Study of the deep biosphere has become a research frontier and a hot spot both for geological and biological sciences. Here, we introduce the history of the discovery of the deep biosphere, and then we describe the types of environments for life below the seafloor, the energy sources for the living creatures, the diversity of organisms within the deep biosphere, and the new tools and technologies used in this research field. We will highlight several recently completed Integrated Ocean Drilling Program Expeditions, which targeted the subseafloor deep biosphere within the crust and sediments. Finally, future research directions and challenges of deep biosphere investigation towards uncovering the roles of subsurface microorganisms will be briefly addressed. | WANG FengPing LU ShuLin ORCUTT Beth N XIE Wei CHEN Ying XIAO Xiang EDWARDS Katrina J | 2013 | Chinese Science Bulletin2013，58，4： | 6 |
| 3 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 4 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 5 | Biological treatment of airstreams contaminated with VOCs:an overview 显示文摘 | Edwards G F Nirmalakhandan N | 1996 | Wat Sci Tech1996，34，34： | 2 |
| 6 | Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial显示文摘 | Edward B Garon Tudor-Eliade Ciuleanu Oscar Arrieta Kumar Prabhash Konstantinos N Syrigos Tuncay Goksel Keunchil Park Vera Gorbunova Ruben Dario Kowalyszyn Joanna Pikiel Grzegorz Czyzewicz Sergey V Orlov Conrad R Lewanski Michael Thomas Paolo Bidoli Shaker | 2014 | The Lancet2014，，： | 2 |
| 7 | Efficient photon coupling from a diamond nitrogen vacancy center by integration with silica fiber显示文摘A central goal in quantum information science is to efficiently interface photons with single optical modes for quantum networking and distributed quantum computing.Here,we introduce and experimentally demonstrate a compact and efficient method for the low-loss coupling of a solid-state qubit,the nitrogen vacancy(NV)center in diamond,with a single-mode optical fiber.In this approach,single-mode tapered diamond waveguides containing exactly one high quality NV memory are selected and integrated on tapered silica fibers.Numerical optimization of an adiabatic coupler indicates that near-unity-efficiency photon transfer is possible between the two modes.Experimentally,we find an overall collection efficiency between 16%and 37%and estimate a single photon count rate at saturation above 700 kHz.This integrated system enables robust,alignment-free,and efficient interfacing of single-mode optical fibers with single photon emitters and quantum memories in solids. | Rishi N Patel Tim Schröder Noel Wan Luozhou Li Sara L Mouradian Edward H Chen Dirk R Englund | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 8 | Radial variation in the axial conductivity of Populus and its significance in heat pulse velocity measurement显示文摘 | Edwards W R N R E Booker | 1984 | Journal of Experimental Botany1984，33，153： | 2 |
| 9 | After the smoke has cleared: evaluation of the impact of a new national smoke-free law in New Zealand显示文摘 | Edwards R Thomson G Wilson N | 2008 | Tob Control2008，17，： | 1 |
| 10 | After the smoke has cleared: evaluation of the impact of a new national smoke-free law in New Zealand显示文摘 | Edwards R Thomson G Wilson N | 2008 | Tob Control2008，17，1： | 1 |
| 11 | A new technique for measuring the mechanical properties of thin films 显示文摘 | Shape W N Bin Y Edwards R L | 1997 | Journal of Microelectromech System1997，，6： | 1 |
| 12 | Psychological interventions for women with metastatic breast cancer显示文摘 | Edwards AG Hulbert-Williams N Neal RD | 2008 | Cochrane Database Syst Rev2008，3，00： | 1 |
| 13 | The central role of wear debris in periprosthetic osteolysis显示文摘 | Edward P Panagiotis K Bryan J N | 2006 | Hospital for Special Surgery Journal2006，2，： | 1 |
| 14 | Equidistant Fish-Eye Calibration and Rectification by Vanishing Point Extraction 显示文摘 | Ciara'n Hughes Patrick Denny Martin Glavin and Edward Jones | 2010 | IEEE Transactions on Pattern Analysis and Machine Intelligence2010，32，12： | 1 |
| 15 | Kuhn Algorithm: Ullla- convenient Solver to Complex Polynomial and Transcendental Equations without Initial Value Selection 显示文摘 | Yunliang Long Edward K N Yung | 2002 | International Journal of RF and Microwave Computer-Aided Engineering2002，12，6： | 1 |
| 16 | Do viscous polysaccharides slow absorption by inhibiting diffusion or convection?显示文摘 | Edwards C A Johnson I T Read N W | 1988 | European Journal of Clinical Nutrition1988，42，： | 1 |
| 17 | Development of friable embryogenic callus and cmbryogenic suspension culture systems in cassava (Manihot esculenta Crantz)显示文摘 | Taylor N J Edwards M Kiernan R J | 1996 | Nature Biotech1996，14，： | 1 |
| 18 | Mesoporous TiO2-based photocatalystsfor UV and visible light gas-phase toluene degradation显示文摘 | Bosc F Edwards D Keller N | 2006 | Thin Solid Films2006，495，： | 1 |
| 19 | The silent epidemic a- mong Wisconsin women:chronic obstructive pulmonary disease trends, 1980-2000 显示文摘 | Edwards N M Umland M Ahrens D | 2005 | WMJ2005，104，4： | 1 |
| 20 | Polycyclic aromatic hydrocarbons (PAH's)in the Terrestrial environment-a review显示文摘 | EDWARDS N T | | 0，，4： | 1 |
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