|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Stromal clonogenic precur- sors of hemopoietic and their rank in the hierarchy of mesenchymal stem cells 显示文摘 | Nifontova IN Svinareva DA Drize NJ | 2008 | Bull Exp Biol Med2008，145，4： | 1 |
| 2 | Synergistic inhibitory effects of genistein and tamoxifen on human dysplastic and malignant epithelial breast cells in vitro显示文摘 | Tanos V Brzezinski A Drize O | 2002 | Eur J Obstet Gynecol Reprod Biol2002，102，2： | 1 |
| 3 | Multipotent Mesenchymal Stromal Cells for the Prophylaxis of Acute Graft-versus-Host Disease—A Phase II Study显示文摘 | Larisa A. Kuzmina Natalia A. Petinati Elena N. Parovichnikova Lidia S. Lubimova Elena O. Gribanova Tatjana V. Gaponova Irina N. Shipounova Oxana A. Zhironkina Alexey E. Bigildeev Daria A. Svinareva Nina J. Drize Valery G. Savchenko Massimo Dominici | 2011 | Stem Cells International2011，，： | 1 |
| 4 | Synergistic inhibitory effects of genistein and tamoxifen on human dysplastic and malignant epithelial breast cells in vitro显示文摘 | Tanos V Brzezinski A Drize O | | 0，，02： | 1 |
| 5 | Multipotent Mesenchymal Stromal Cells for the Prophylaxis of Acute Graft-versus-Host Disease—A Phase II Study显示文摘 | Larisa A. Kuzmina Natalia A. Petinati Elena N. Parovichnikova Lidia S. Lubimova Elena O. Gribanova Tatjana V. Gaponova Irina N. Shipounova Oxana A. Zhironkina Alexey E. Bigildeev Daria A. Svinareva Nina J. Drize Valery G. Savchenko Massimo Dominici | 2011 | Stem Cells International2011，，： | 1 |
| 6 | Synergistic inhibitory effects of genistein and tamoxifen on human dysplastic and malignant epithelial breast cells in vitro显示文摘 | Tanos V Brzezinski A Drize O | | 0，，02： | 1 |
| 7 | Gene therapy model for stromal precursor cells of hematopoietic microenvironment显示文摘 | Surin VL Gan OL | 1992 | Leukemia1992，3，： | 1 |
| 8 | 显示文摘 | Eyu S Drize NJ | 1997 | Haematologia( Budap)1997，28，： | 1 |
| 9 | Effect of TNF Expression by Stromal Cells on Hemopoietic and Stromal Precursor Cells in Long-Term Bone Marrow Cultures Derived from TNF-Deficient Mice显示文摘 | I. N. Nifontova N. I. Drize | 2005 | Bulletin of Experimental Biology and Medicine2005，，5： | 1 |
| 10 | Caspase-mediated cleavage converts livin from an antiapoptotic to a proapoptotic factor: implications for drug-resistant melanoma显示文摘 | Ashhab Y Bucholtz V Drize O Kadouri L Lotem M | 2003 | Cancer Res2003，63，19： | 1 |
| 11 | Fibronectin increases both non-dherent cells and CFU-GM while collagen increases adherent cells in human normal long-term bone marrow cultures显示文摘 | Sadovinkova EYU Drize NJ | 1997 | Haematologia-(Budap)1997，28，2： | 1 |
| 12 | Synergistic inhibitory effects of genistein and tamoxlfen on human dysplastic and malignant epithelial breast cells in vitro显示文摘 | Tanos V Brzezinski A Drize O | 2002 | Eur J Obstet Gynecol Reprod Biol2002，102，2： | 1 |
| 13 | Synergistic inhibitory effects of genistein and tamoxifen on human dysplastic and malignant epithelial breast cells in vitro显示文摘 | Tanos V Brzezinski A Drize O | 2002 | Eur J Obstet Gynecol Reprod Biol2002，102，2： | 1 |
| 14 | Synergistic inhibitory effects of genistein and tamoxifen on human dysplastic and malignant epithelial breast cells in vitro显示文摘 | Tanos V Brzezinski A Drize O | 2002 | Eur J Obstet Gynecol Reprod Biol2002，102，2： | 1 |
| 15 | Synergistic inhibitory effects s of genistein and tamoxifen on human dysplastic and malignant epithelial breast cells in vitro 显示文摘 | TANOS V BRZEZINSKI A DRIZE O | 2002 | Eur J Obstet Gynecol Reprod Biol2002，102，2： | 1 |
| 16 | Immunoglobulin G monoclonal human anti-rhesus Rho (D) to prevent rhesus-incompatibility显示文摘 | Olovnikova NI Belkina EV Drize NI | 1997 | Klin Med (Mosk)1997，75，7： | 1 |
| 17 | Synergistic inhibitory effects of genistein and tamoxffen on human dysplastic and malignant epithelial breast cells in vitro显示文摘 | Tanos V Brzezinski A Drize O | 2002 | Eur J Obstet Gynecol Reprod Biol2002，102，2： | 1 |
| 18 | Radiosensitivity of stromal precursors and mature hematopoietic stromal eells in a eulture显示文摘 | Drize NI Gurevich OA Chertkov IL | 1986 | Radiobiologiia1986，26，3： | 1 |
| 19 | Immunophenotypic characteristics of multipotent mesenchymal stromal cells that affect the efficacy of their use in the prevention of acute graft vs host disease显示文摘BACKGROUND Multipotent mesenchymal stromal cells(MSCs)are widely used in the clinic due to their unique properties,namely,their ability to differentiate in all mesenchymal directions and their immunomodulatory activity.Healthy donor MSCs were used to prevent the development of acute graft vs host disease(GVHD)after allogeneic bone marrow transplantation(allo-BMT).The administration of MSCs to patients was not always effective.The MSCs obtained from different donors have individual characteristics.The differences between MSC samples may affect their clinical efficacy.AIM To study the differences between effective and ineffective MSCs.METHODS MSCs derived from the bone marrow of a hematopoietic stem cells donor were injected intravenously into allo-BMT recipients for GVHD prophylaxis at the moment of blood cell reconstitution.Aliquots of 52 MSC samples that were administered to patients were examined,and the same cells were cultured in the presence of peripheral blood mononuclear cells(PBMCs)from a third-party donor or treated with the pro-inflammatory cytokines IL-1β,IFN and TNF.Flow cytometry revealed the immunophenotype of the nontreated MSCs,the MSCs cocultured with PBMCs for 4 d and the MSCs exposed to cytokines.The proportions of CD25-,CD146-,CD69-,HLA-DR-and PD-1-positive CD4+and CD8+cells and the distribution of various effector and memory cell subpopulations in the PBMCs cocultured with the MSCs were also determined.RESULTS Differences in the immunophenotypes of effective and ineffective MSCs were observed.In the effective samples,the mean fluorescence intensity(MFI)of HLAABC,HLA-DR,CD105,and CD146 was significantly higher.After MSCs were treated with IFN or cocultured with PBMCs,the HLA-ABC,HLA-DR,CD90 and CD54 MFI showed a stronger increase in the effective MSCs,which indicated an increase in the immunomodulatory activity of these cells.When PBMCs were cocultured with effective MSCs,the proportions of CD4+and CD8+central memory cells significantly decreased,and the proportion of CD8+CD146+lymphocytes increased more than in the subpopulations of lymphocytes cocultured with MSC samples that were ineffective in the prevention of GVHD;in addition,the proportion of CD8+effector memory lymphocytes decreased in the PBMCs cocultured with the effective MSC samples but increased in the PBMCs cocultured with the ineffective MSC samples.The proportion of CD4+CD146+lymphocytes increased only when cocultured with the inefficient samples.CONCLUSION For the first time,differences were observed between MSC samples that were effective for GVHD prophylaxis and those that were ineffective.Thus,it was shown that the immunomodulatory activity of MSCs depends on the individual characteristics of the MSC population. | Nataliya Petinati Nikolay Kapranov Yulia Davydova Alexey Bigildeev Olesya Pshenichnikova Dmitriy Karpenko Nina Drize Larisa Kuzmina Elena Parovichnikova Valeriy Savchenko | 2020 | World Journal of Stem Cells2020，12，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员