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| 1 | Carbon storage and net primary productivity in Canadian boreal mixedwood stands显示文摘Canadian boreal mixedwood forests are extensive,with large potential for carbon sequestration and storage;thus,knowledge of their carbon stocks at different stand ages is needed to adapt forest management practices to help meet climate-change mitigation goals.Carbon stocks were quantified at three Ontario boreal mixedwood sites.A harvested stand,a juvenile stand replanted with spruce seedlings and a mature stand had total carbon stocks(±SE)of 133±13 at age 2,130±13 at age 25,and 207±15 Mg C ha^-1 at age 81 years.At the clear-cut site,stocks were reduced by about 40%or 90 Mg C ha^-1 at harvest.Vegetation held 27,34 and 62%of stocks,while detritus held 34,29 and 13%of stocks at age 2,25 and 81,respectively.Mineral soil carbon stocks averaged 51 Mg C ha^-1,and held 38,37 and 25%of stocks.Aboveground net primary productivity(±SE)in the harvested and juvenile stand was 2.1±0.2 and 3.7±0.3 Mg C ha^-1 per annum(p.a.),compared to 2.6±2.5 Mg C ha^-1 p.a.in the mature stand.The mature canopies studied had typical boreal mixedwood composition and mean carbon densities of 208 Mg C ha^-1,which is above average for managed Canadian boreal forest ecosystems.A comparison of published results from Canadian boreal forest ecosystems showed that carbon stocks in mixedwood stands are typically higher than coniferous stands at all ages,which was also true for stocks in vegetation and detritus.Also,aboveground net primary productivity was typically found to be higher in mixedwood than in coniferous boreal forest stands over a range of ages.Measurements from this study,together with those published from the other boreal forest stands demonstrate the potential for enhanced carbon sequestration through modified forest management practices to take advantage of Canadian boreal mixedwood stand characteristics. | Nicholas J.Payne D.Allan Cameron Jean-Denis Leblanc Ian K.Morrison | 2019 | Journal of Forestry Research2019，30，5： | 4 |
| 2 | Intranasal rapamycin ameliorates Alzheimerlike cognitive decline in a mouse model of Down syndrome显示文摘Background:Down syndrome(DS)individuals,by the age of 40s,are at increased risk to develop Alzheimer-like dementia,with deposition in brain of senile plaques and neurofibrillary tangles.Our laboratory recently demonstrated the disturbance of PI3K/AKT/mTOR axis in DS brain,prior and after the development of Alzheimer Disease(AD).The aberrant modulation of the mTOR signalling in DS and AD age-related cognitive decline affects crucial neuronal pathways,including insulin signaling and autophagy,involved in pathology onset and progression.Within this context,the therapeutic use of mTOR-inhibitors may prevent/attenuate the neurodegenerative phenomena.By our work we aimed to rescue mTOR signalling in DS mice by a novel rapamycin intranasal administration protocol(InRapa)that maximizes brain delivery and reduce systemic side effects.Methods:Ts65Dn mice were administered with InRapa for 12 weeks,starting at 6 months of age demonstrating,at the end of the treatment by radial arms maze and novel object recognition testing,rescued cognition.Results:The analysis of mTOR signalling,after InRapa,demonstrated in Ts65Dn mice hippocampus the inhibition of mTOR(reduced to physiological levels),which led,through the rescue of autophagy and insulin signalling,to reduced APP levels,APP processing and APP metabolites production,as well as,to reduced tau hyperphosphorylation.In addition,a reduction of oxidative stress markers was also observed.Discussion:These findings demonstrate that chronic InRapa administration is able to exert a neuroprotective effect on Ts65Dn hippocampus by reducing AD pathological hallmarks and by restoring protein homeostasis,thus ultimately resulting in improved cognition.Results are discussed in term of a potential novel targeted therapeutic approach to reduce cognitive decline and AD-like neuropathology in DS individuals. | Antonella Tramutola Chiara Lanzillotta Eugenio Barone Andrea Arena Ilaria Zuliani Luciana Mosca Carla Blarzino D.Allan Butterfield Marzia Perluigi Fabio Di Domenico | 2018 | Translational Neurodegeneration2018，7，1： | 3 |
| 3 | Evidence of oxidative damage in Alzheimer’s disease brain: central role for amyloid β-peptide显示文摘 | D.Allan Butterfield Jennifer Drake Chava Pocernich Alessandra Castegna | 2001 | Trends in Molecular Medicine2001，，12： | 2 |
| 4 | Standards for ecologically successful river restoration显示文摘 | M.A.PALMER E.S.BERNHARDT J. D.ALLAN P.S.LAKE G.ALEXANDER S.BROOKS J.CARR S.CLAYTON C. N.DAHM J.FOLLSTAD SHAH D. L.GALAT S. G.LOSS P.GOODWIN D.D.HART B.HASSETT R.JENKINSON G.M.KONDOLF R.LAVE J.L.MEYER T.K.O’DONNELL L.PAGANO E.SUDDUTH | 2005 | Journal of Applied Ecology2005，，2： | 2 |
| 5 | Fetal cardiac abnormalities identified prior to 14?weeks’ gestation显示文摘 | I. C.Huggon T.Ghi A. C.Cook N.Zosmer L. D.Allan K. H.Nicolaides | 2002 | Ultrasound Obstet Gynecol2002，，1： | 2 |
| 6 | Likelihood ratio for trisomy 21 in fetuses with tricuspid regurgitation at the 11 to 13 + 6‐week scan显示文摘 | S.Faiola E.Tsoi I. C.Huggon L. D.Allan K. H.Nicolaides | 2005 | Ultrasound Obstet Gynecol2005，，1： | 2 |
| 7 | Antisense directed at the Aβ region of APP decreases brain oxidative markers in aged senescence accelerated mice显示文摘 | H.Fai Poon Gururaj Joshi Rukhsana Sultana Susan A Farr William A Banks John E Morley Vittorio Calabrese D.Allan Butterfield | 2004 | Brain Research2004，，1： | 1 |
| 8 | Standards for ecologically successful river restoration显示文摘 | M.A.PALMER E.S.BERNHARDT J. D.ALLAN P.S.LAKE G.ALEXANDER S.BROOKS J.CARR S.CLAYTON C. N.DAHM J.FOLLSTAD SHAH D. L.GALAT S. G.LOSS P.GOODWIN D.D.HART B.HASSETT R.JENKINSON G.M.KONDOLF R.LAVE J.L.MEYER T.K.O’DONNELL L.PAGANO E.SUDDUTH | 2005 | Journal of Applied Ecology2005，，2： | 1 |
| 9 | Evidence of oxidative damage in Alzheimer’s disease brain: central role for amyloid β-peptide显示文摘 | D.Allan Butterfield Jennifer Drake Chava Pocernich Alessandra Castegna | 2001 | Trends in Molecular Medicine2001，，12： | 1 |
| 10 | 斜拉桥的经济设计显示文摘 | D.Allan Firmage 邹立中 | 1983 | 国外桥梁1983，，1： | 1 |
| 11 | Lipid peroxidation and protein oxidation in AD brain显示文摘 | D.Allan Christopher M | | 0，，11： | 1 |
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