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| 1 | Adiponectin downregulation is associated with volume overload-induced myocyte dysfunction in rats显示文摘目的: Adiponectin 被报导了在在体积的病理学的室的改变,而是 adiponectin 的角色期间施加保护的效果导致超载的心失败遗体不清楚。在这研究,我们在心脏的 myocyte 上调查了 adiponectin 的效果在 rats.Methods 的可收缩的机能障碍追随者体积超载: 体积超载被 infrarenal 主动脉静脉 cava 通过手术在老鼠导致管。老鼠是在 2- 的静脉内地管理的 adenoviral adiponectin, 6 星期、 9 星期的后面的管。adiponectin, adiponectin 受体(AdipoR1/R2 和 T-cadherin ) 和 AMPK 活动的蛋白质表示用西方的污点分析被测量。孤立的室的 myocytes 在管以后的 12 个星期被准备检验 myocytes 和细胞内部的 Ca 2+ transient.Results 的可收缩的表演: A-V 管在浆液和心肌的 adiponectin 层次导致了重要减小,心肌的 adiponectin 受体(AdipoR1/R2 和 T-cadherin ) 层次,以及心肌的 AMPK 活动。与这些变化一致,孤立的 myocytes 在房间弄短和细胞内部的 Ca 2+ 展出了重要消沉短暂。adenoviral adiponectin 的管理显著地增加了浆液 adiponectin 层次并且阻止了 myocyte 在管老鼠的可收缩的机能障碍。而且,有 recombinant adiponectin 的孤立的 myocytes 的预告的处理(2.5 μ g/mL ) 显著地在管老鼠改进了他们的可收缩的性能,但是没在控制或 adenoviral 有效果管理 adiponectin 的 rats.Conclusion : 这些结果表明在 adiponectin downregulation 和体积之间的积极关联导致超载的室的改变。Adiponectin 在体积起一个保护的作用导致超载的心失败。 | Li-li WANG Dori MILLER Desiree WANDERS Gayani NANAYAKKARA Rajesh AMIN Robert JUDD Edward E MORRI-SON Ju-ming ZHONG | 2016 | Acta Pharmacologica Sinica2016，37，2： | 4 |
| 2 | Effect of anaerobiosis on aspects of avocado fruit ripening显示文摘 | Dori S Burdon J N Lomaniec E | 1995 | Acta Horticulturae1995，379，： | 1 |
| 3 | Defining translational research : Implications for training 显示文摘 | DORIS MCGARTLAND RUBIO ELLIE E SCHOENBAUM LINDA S LEE | 2010 | Academic Medicine2010，85，3： | 1 |
| 4 | Field of needs: the genetics of stroke 显示文摘 | Boerwinkle E Doris PA Fornage M | 1999 | Circulation1999，99，： | 1 |
| 5 | Best cases from the AFIP:congenital intracranial teratoma显示文摘 | SANDOW B A DORY C E AGUIAR M A | 2004 | Radiographics2004，24，4： | 1 |
| 6 | A Modular Software ProcessMini-Assessment Method显示文摘 | Karl E Wiegers Doris C Sturzenberger | 2000 | JEEE Software2000，2000，： | 1 |
| 7 | Hypoxia links ATR and p53 through replication Arrest显示文摘 | DENKO N C DORIE M J | 2002 | Mol Cell Biol2002，22，6： | 1 |
| 8 | Modes of Theorizing in Strategic Human Resource Management:Tests of Universalistic,Contingency,and Configurational Performance Predic-tions 显示文摘 | Delery J E Dory D H | 1996 | Academy of Management Journal1996，39，4： | 1 |
| 9 | Free amino acid content of chicken muscle from broilers and hens显示文摘 | Julius H M Dawson L E Doris H B | 1965 | Jouenal of Food Science1965，30，3： | 1 |
| 10 | Modes of theorizing in strategic human resource management : tests of universalistic, contingency, and configurational performance predictons显示文摘 | Delery J E Dory D H | 1996 | Academy of Management Journal1996，39，4： | 1 |
| 11 | Modes of theorizing in strategic human resource management: Tests ofuniversalistic, contingency, and configurational performance predictions 显示文摘 | Delery J E Dory H D | 1996 | Academy of Management Journal1996，39，1： | 1 |
| 12 | National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications显示文摘 | Hannah Blencowe Simon Cousens Mikkel Z Oestergaard Doris Chou Ann-Beth Moller Rajesh Narwal Alma Adler Claudia Vera Garcia Sarah Rohde Lale Say Joy E Lawn | 2012 | The Lancet2012，，9832： | 1 |
| 13 | Modes of Theorizing in Strategic Human Resource Management : Tests of Universalistic, Contingency, and Configurational Perspectives 显示文摘 | Delery J E Dory D H | 1996 | Academy of Management Journal1996，39，4： | 1 |
| 14 | Differential expression of cytokines and chemokines in human monocytes induced by lipid formulations of amphotericin B显示文摘 | Simitsopoulou M Roilides E Doris J | 2005 | Antimicrob Agents Chemother2005，49，4： | 1 |
| 15 | Glass for high performance optics and laser technology 显示文摘 | Doris E Wolfgang S | 1991 | J Non-Cryst Solids1991，129，： | 1 |
| 16 | High-throughput multiplex SNP genotyping with MALDI-TOF mass spectrometry,practice,problem and promise显示文摘 | Bray M S Boerwinkle E Doris P A | 2001 | Hum Mutant2001，17，： | 1 |
| 17 | The post-harvest ripening of water stressed banana fruit显示文摘 | Burdon J N Dori S Lomaniec E | 1994 | Journal of Hort Sci1994，69，5： | 1 |
| 18 | The Development of Dtaxonomy of Career Competencies for Professional Women 显示文摘 | Hackett G Betz N E Dory M S | 1985 | Sex Roles1985，，12： | 1 |
| 19 | Fructose sweetness:a new dimension显示文摘 | Dory T E | 1976 | Cereal Foods world1976，2，2： | 1 |
| 20 | Modes of Theorizing in Strategic Human Resource Management: Tests of Unlversalistlc, Contingency and Conflgurational Performance Predictions显示文摘 | Delery J E Dory D H | 1996 | Academy of Management Journal1996，39，4： | 1 |
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