|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 两例食管癌肉瘤克隆来源的分子生物学分析显示文摘 | 孙孟红 朱雄增 Peter Moeller Christian Herfarth Magnus von Knebel Doeberitz Hans K Schackert Thomas Lehnert Johannes Gebert | 2001 | 中华病理学杂志2001，30，5： | 6 |
| 2 | Identification of differentially expressed genes after partial rat liver ischemia/reperfusion by suppression subtractive hybridization显示文摘AIM: To identify potential diagnostic target genes in early reperfusion periods following warm liver ischemia before irreversible liver damage occurs.METHODS: We used two strategies (SSH suppression subtractive hybridization and hybridization of cDNA arrays)to determine early changes in gene expression profiles in a rat model of partial WI/R, comparing postischemic and adjacent nonischemic liver lobes. Differential gene expression was verified (WT/R; 1 h/2 h) and analyzed in more detail after warm ischemia (1 h) in a reperfusion time kinetics (0, 1, 2 and 6 h) and compared to untreated livers by Northern blot hybridizations. Protein expression was examined on Western blots and by immunohistochemistry for four differentially expressed target genes (Hsp70,Hsp27, Gadd45a and IL-1rl).RESULTS: Thirty-two individual WI/R target genes showing altered RNA levels after confirmation by Northern blot analyzes were identified. Among them, six functionally uncharacteristic expressed sequences and 26 known genes (12 induced in postischemic liver lobes, 14 with higher transcriptional expression in adjacent nonischemic liver lobes). Functional categories of the verified marker genes indicate on the one hand cellular stress and tissue damage but otherwise activation of protective cellular reactions (AP-1 transcription factors, apoptosis related genes, heat shock genes). In order to assign the transcriptional status to the biological relevant protein level we demonstrated that Hsp70, Hsp27, Gadd45a and IL-1rI were clearly up-regulated comparing postischemic and untreated rat livers, suggesting their involvement in the WI/R context.CONCLUSION: This study unveils a WI/R response gene set that will help to explore molecular pathways involved in the tissue damage after WI/R. In addition, these genes especially Hsp70and Gadd45a might represent promising new candidates indicating WI/R liver damage. | Christine Fallsehr Christina Zapletal Michael Kremer Resit Demir Magnus von Knebel Doeberitz Ernst Klar | 2005 | World Journal of Gastroenterology2005，11，9： | 4 |
| 3 | 散发性大肠癌肿瘤相关基因位点杂合性丢失分析显示文摘目的 分析大肠癌组织中抑癌基因及肿瘤相关基因位点的变化与预后的关系。方法 79例大肠癌组织经组织微解剖分离癌组织和正常组织,分别进行11 个染色体上14 个位点的杂合性丢失(lossofheterozygosity,LOH)分析。结果 肿瘤组织中LOH呈现一复杂的征象,5q12 及RB基因位点的LOH 与较好的预后有关。结论 不同的抑癌基因及肿瘤相关基因与大肠癌发生有关。5q12 位点的LOH 与较好预后相关的意义有待今后进一步研究。 | 孙孟红 Gebert J Knebel Doeberitz Mv | 1999 | 中华实验外科杂志1999，16，6： | 3 |
| 4 | Systematic review of genomie integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the lower genital tract显示文摘 | Wentaensen N Vinokurova S von Knebel Doeberitz M | 2004 | Cancer Res2004，64，： | 1 |
| 5 | Perfor- mance of p16INK4a-cytology, HPV mRNA, and HPV DNA testing to identify high grade cervical dysplasia in women with abnormal screening results 显示文摘 | Reuschenbach M Clad A von Knebel Doeberitz C | 2010 | Gynecnl Oncol2010，1119，1： | 1 |
| 6 | Reduction of beta-catenin/T-cell transcription factor signaling by aspirin and indomethacinis caused by an increased stabilization of phosphorylated beta-catenin显示文摘 | Dihlmann S Klein S Doeberitz MV | 2003 | Mol Cancer Ther2003，2，6： | 1 |
| 7 | Biomarkers for cervical cancer screening: the role of p 16 (INKga) to highlight transforming HPV infections 显示文摘 | von Knebel Doeberitz M Reuschenbach M Schmidt D | 2012 | Expert Rev Proteomics2012，9，2： | 1 |
| 8 | Immune Response Against Frameshift-Induced Neopeptides in HNPCC Patients and Healthy HNPCC Mutation Carriers显示文摘 | Yvette Schwitalle Matthias Kloor Susanne Eiermann Michael Linnebacher Peter Kienle Hanns Peter Knaebel Mirjam Tariverdian Axel Benner Magnus von Knebel Doeberitz | 2008 | Gastroenterology2008，，4： | 1 |
| 9 | P16INK4a immunocytoehemistry versus human papillomavirus testing for triage of women with minor cytologic abnormalities: a systematic review and meta-analysis 显示文摘 | Roelens J Reuschenbach M von Knebel Doeberitz M | 2012 | Cancer Cytopathol2012，120，5： | 1 |
| 10 | New markers for cervical dysplasia to visualise the genomic chaos created by aberrant oncogenic Papilloma Virus infections 显示文摘 | von Knebel Doeberitz M | 2002 | Eur J Cancer2002，38，17： | 1 |
| 11 | The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate 13-catenin/ TCF-4 signaling显示文摘 | DIHLMANN S SIERMANN A VON KNEBEL DOEBERITZ M | 2001 | Oncogene2001，20，： | 1 |
| 12 | Wnt/beta-cateninpathway as a molecular target for future anti-cancer therapeutics 显示文摘 | Dihhnann S yon Knebel Doeberitz M | 2005 | Int J Cancer2005，113，4： | 1 |
| 13 | Biomarkers in cervical cancer screening显示文摘 | M. von Knebel Doeberitz N. Wentzensen | 2007 | Disease Markers2007，，4： | 1 |
| 14 | Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract显示文摘 | Wentzensen N Vinokurova S Doeberitz MV | 2004 | Cancer Res2004，64，11： | 1 |
| 15 | Influence of chromosomal intergration on glucocorticoidregulated transcription of growth-stimulating papillomavirus genes E6 and E7 in cervical carcinoma cells显示文摘 | von Knebel Doeberitz M Bauknecht T Bartsch D | 1991 | Proc Natl Acad Sci USA1991，88，4： | 1 |
| 16 | Inhibition of tumorigenicity of cervical cancer cells in nude mice by HPV E6E7 antisense RNA显示文摘 | Von Knebel Doeberitz M Rittmiiller C zur Hausen H | 1992 | Int J Cancer1992，51，： | 1 |
| 17 | Evalua- tion of p16INK4a immunostaining for the detection of high- grade changes in cervical cytology显示文摘 | Tabrizi SN Tan SE von Knebel Doeberitz C | 2015 | Pathology2015，47，4： | 1 |
| 18 | Reversible repression of papillomavirus oncogene expression in cervical carcinoma cells:Consequences for the phenotype and E6-p53 and E7-pRB interactions显示文摘 | Von Knebel Doeberitz M Rittmuller C Aengeneyndt F | 1994 | Virol1994，68，： | 1 |
| 19 | The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate β- catenin/TCF - 4 signaling 显示文摘 | DIHLMANN S SIERMANN A VON KNEBEL DOEBERITZ M | 2001 | Oncogene2001，20，： | 1 |
| 20 | Biomarkers in cervical cancer screening显示文摘 | yon Knebel Doeberitz M | 2007 | Dis Markers2007，23，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员