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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Molecular and Physiological Analysis of Growth-Limiting Drought Stress in Brachypodium distachyon Leaves显示文摘干旱容忍的草 Brachypodium distachyon 是为适度的草和谷物庄稼的新兴的模型种。为了为干旱探索这种的实用性,学习,一在 vivo 可再现干旱试金被开发。弄干的自发的土壤在叶尺寸导致了 45% 减小,并且这主要由于在细胞扩大的减少,而细胞分割由干旱仍然保持大部分未受影响。调查观察的叶生长减小的分子的基础,第三片 Brachypodium 叶在三个地区被把,也就是增长,扩大,和成熟地区,并且使分析遭到了到 transcriptome,基于一个整个染色体的并列数组。这条途径允许我们加亮不同的发展的叶地区的侧面不同地回答到干旱的那 transcriptome。涉及干旱忍耐的几基因和功能的过程被识别。transcriptome 数据在增长地区建议增加的精力可获得性,与甾醇合成的一条起来规定一起,那可以影响膜流动性。这个信息可以被用来改进适度的谷物的忍耐到干旱,它无疑是今天并且在不久的将来的农业面对的主要环境挑战之一。 | Wim Verelst Edoardo Bertolini Stefanie De Bodt Klaas Vandepoele Marlies Demeulenaere Mario Enrico pè Dirk Inzé | 2013 | Molecular Plant2013，6，2： | 6 |
| 3 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 4 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 5 | Near-infrared fluorescence guided esophageal reconstructive surgery: A systematic review显示文摘BACKGROUND After an esophagectomy, the stomach is most commonly used to restore continuity of the upper gastrointestinal tract. These esophago-gastric anastomoses are prone to serious complications such as leakage associated with high morbidity and mortality. Graft perfusion is considered to be an important predictor for anastomotic integrity. Based on the current literature we believe Indocyanine green fluorescence angiography(ICGA) is an easy assessment tool for gastric tube(GT) perfusion, and it might predict anastomotic leakage(AL).AIM To evaluate feasibility and effectiveness of ICGA in GT perfusion assessment and as a predictor of AL.METHODS This study was designed according to the PRISMA guidelines and registered in the PROSPERO database. PubMed and EMBASE were independently searched by 2 reviewers for studies presenting data on intraoperative ICGA GT perfusion assessment during esophago-gastric reconstruction after esophagectomy.Relevant outcomes such as feasibility, complications, intraoperative surgical changes based on ICGA findings, quantification attempts, anatomical data and the impact of ICGA on postoperative anastomotic complications, were collected by 2 independent researchers. The quality of the included articles was assessed based on the Methodological Index for Non-Randomized Studies. The 19 included studies presented data on 1192 esophagectomy patients, in 758 patients ICGA was used perioperative to guide esophageal reconstruction.RESULTS The 19 included studies for qualitative analyses all described ICGA as a safe and easy method to evaluate gastric graft perfusion. AL occurred in 13.8% of the entire cohort, 10% in the ICG guided group and 20.6% in the control group(P <0.001). When poorly perfused cases are excluded from the analyses, the difference in AL was even larger(AL well-perfused group 6.3% vs control group 20.5%, P <0.001). The AL rate in the group with an altered surgical plan based on the ICG image was 6.5%, similar to the well perfused group(6.3%) and significantly less than the poorly perfused group(47.8%)(P < 0.001), suggesting that the technique is able to identify and alter a potential bad outcome.CONCLUSION ICGA is a safe, feasible and promising method for perfusion assessment. The lower AL rate in the well perfused group suggest that a good fluorescent signal predicts a good outcome. | Elke Van Daele Yves Van Nieuwenhove Wim Ceelen Christian Vanhove Bart P Braeckman Anne Hoorens Jurgen Van Limmen Oswald Varin Dirk Van de Putte Wouter Willaert Piet Pattyn | 2019 | World Journal of Gastrointestinal Oncology2019，11，3： | 3 |
| 6 | Performance, structure, and mechanism of CeO 2 in HCl oxidation to Cl 2显示文摘 | Amol P. Amrute Cecilia Mondelli Maximilian Moser Gerard Novell-Leruth Núria López Dirk Rosenthal Ramzi Farra Manfred E. Schuster Detre Teschner Timm Schmidt Javier Pérez-Ramírez | 2011 | Journal of Catalysis2011，，： | 2 |
| 7 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 8 | Click chemistry as an efficient synthetic tool for the preparation of novel conjugated polymers显示文摘 | Dirk J V C David O R P Strijdonck G P E | 2005 | Chemistry Common2005，，34： | 1 |
| 9 | Bmil and cell of origin determinants of brain tumor phe- notype 显示文摘 | Dirks P | 2007 | Cancer Ce112007，12，4： | 1 |
| 10 | The deformational history of the Larsemann Hills,Prydz Bay:the importance of the Pan-African (500 Ma) in East Antarctica显示文摘 | Dirks P H G M Carson C J Wilson C J L | 1993 | Antarctic Science1993，5，2： | 1 |
| 11 | Cryptochromes and neuronal-activity markers colocalize in the retina of migratory birds during magnetic orientation显示文摘 | Mouritsen H Janssen-Bienhold J Liedvogel M Feenders G Stalleicken J Dirks P Weiler R | | 0，，： | 1 |
| 12 | Glioma migration: clues from the biology of neural progenitor cells and embryonic CNS cell migration显示文摘 | Dirks P B | 2001 | J Neuro Oncol2001，53，2： | 1 |
| 13 | The repair of trust: A dynamic bilateral perspective and multilevel conceptualization显示文摘 | Kim P H Dirks K T and Cooper C D | 2009 | Academy of Management Review2009，34，3： | 1 |
| 14 | Compressional and extensional tectonics in low-medium pressure granulites from the Larsemann Hills,East Antarctica 显示文摘 | Dirks P H G M Hand M | 1995 | Geol Mag1995，132，2： | 1 |
| 15 | IQGAP1 protein specifies amplifying cancer cells in glioblastoma multiforme显示文摘 | BALENCI L CLARKE I D DIRKS P B | 2006 | Cancer Res2006，66，18： | 1 |
| 16 | Stable coexistence of grandidierite and kornerupine during medium pressure granulite facies metamorphism 显示文摘 | Hand M Dirks P H G M | 1995 | Mineral Mag1995，59，： | 1 |
| 17 | Analysis ofvascuhture for liver surgical planning显示文摘 | Dirk S Bemhard P Aaadrea S | 2002 | lEEE Tramacfons on Medical Imaging2002，21，11： | 1 |
| 18 | Compressional and extensional tectonics in low-medium pressure granulites from the Larsemann Hills,East Antarctica显示文摘 | Carson C J Dirks P H G M Hand M | 1995 | Geol Mag1995，132，： | 1 |
| 19 | The repair of trust : A dy-namic bilateral perspective and multilevel conceptualization显示文摘 | Kim P H Dirks K T Cooper C D | 2009 | Academy of Management Review2009，34，3： | 1 |
| 20 | Cancer stem cells: an evolving concept显示文摘 | Nguyen L V Vanner R Dirks P | 2012 | Nature Reviews Cancer2012，12，2： | 1 |
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