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| 1 | Treatment of acute periprosthetic infections with prosthesis retention: Review of current concepts显示文摘Periprosthetic joint infection(PJI) is a devastating complication after total joint arthroplasty, occurring in approximately 1%-2% of all cases. With growing populations and increasing age, PJI will have a growing effect on health care costs. Many risk factors have been identified that increase the risk of developing PJI, including obesity, immune system deficiencies, malignancy, previous surgery of the same joint and longer operating time. Acute PJI occurs either postoperatively(4 wk to 3 mo after initial arthroplasty, depending on the classification system), or via hematogenous spreading after a period in which the prosthesis had functioned properly. Diagnosis and the choice of treatment are the cornerstones to success. Although different definitions for PJI have been used in the past, most are more or less similar and include the presence of a sinus tract, blood infection values, synovial white blood cell count, signs of infection on histopathological analysis and one ormore positive culture results. Debridement, antibiotics and implant retention(DAIR) is the primary treatment for acute PJI, and should be performed as soon as possible after the development of symptoms. Success rates differ, but most studies report success rates of around 60%-80%. Whether single or multiple debridement procedures are more successful remains unclear. The use of local antibiotics in addition to the administration of systemic antibiotic agents is also subject to debate, and its pro's and con's should be carefully considered. Systemic treatment, based on culture results, is of importance for all PJI treatments. Additionally, rifampin should be given in Staphylococcal PJIs, unless all foreign material is removed. The most important factors contributing to treatment failure are longer duration of symptoms, a longer time after initial arthroplasty, the need for more debridement procedures, the retention of exchangeable components, and PJI caused by Staphylococcus(aureus or coagulase negative). If DAIR treatment is unsuccessful, the following treatment option should be based on the patient health status and his or her expectations. For the best functional outcome, one- or two-stage revision should be performed after DAIR failure. In conclusion, DAIR is the obvious choice for treatment of acute PJI, with good success rates in selected patients. | Jesse WP Kuiper Robin Tjeenk Willink Dirk Jan F Moojen Michel PJ van den Bekerom Sascha Colen | 2014 | World Journal of Orthopedics2014，5，5： | 12 |
| 2 | Helicobacter pylori vac A genotype is a predominant determinant of immune response to Helicobacter pylori CagA显示文摘AIM To evaluate the frequency of Helicobacter pylori(H. pylori) Cag A antibodies in H. pylori infected subjects and to identify potential histopathological and bacterial factors related to H. pylori Cag A-immune response.METHODS Systematic data to H. pylori isolates, blood samples, gastric biopsies for histological and molecular analyses were available from 99 prospectively recruited subjects. Serological profile(anti-H. pylori, anti-Cag A) was correlated with H. pylori isolates(cag A, EPIYA, vac A s/m genotype), histology(Sydney classification) and mucosal interleukin-8(IL-8) m RNA and protein expression. Selected H. pylori strains were assessed for H. pylori Cag A protein expression and IL-8 induction in co-cultivation model with AGS cells.RESULTS Thirty point three percent of microbiologically confirmed H. pylori infected patients were seropositive for Cag A. Majority of H. pylori isolates were cag A gene positive(93.9%) with following vac A polymorphisms: 42.4% vac A s1m1, 23.2% s1m2 and 34.3% s2m2. Anti-Cag AIg G seropositivity was strongly associated with atrophic gastritis, increased mucosal inflammation according to the Sydney score, IL-8 and cag A m RNA expression. V a c A s a n d m p o l y m o r p h i s m s w e r e t h e m a j o r determinants for positive(vac A s1m1) or negative(vac A s2m2) anti-Cag A serological immune response, which also correlated with the in vitro inflammatory potential in AGS cells. In vitro co-cultivation of representative H. pylori strains with AGS cells confirmed functional Cag A translocation, which showed only partial correlation with Cag A seropositivity in patients, supporting vac A as major co-determinant of the immune response.CONCLUSION Serological immune response to H. pylori cag A + strain in H. pylori infected patients is strongly associated with vac A polymorphism, suggesting the crucial role of bacterial factors in immune and clinical phenotype of the infection. | Alexander Link Cosima Langner Wiebke Schirrmeister Wiebke Habendorf Jochen Weigt Marino Venerito Ina Tammer Dirk Schlüter Philipp Schlaermann Thomas F Meyer Thomas Wex Peter Malfertheiner | 2017 | World Journal of Gastroenterology2017，23，26： | 12 |
| 3 | Diagnosis of obscure gastrointestinal bleeding by intraoperative enteroscopy in 81 consecutive patients显示文摘瞄准:为了由与流血调查一系列选择病人分析 intra 起作用的肠寄生物(IOE ) 的结果和复杂并发症,怀疑了从小肠发源。方法:81 个病人(吝啬的年龄:65 年) 包括 40,男性(49.4%) 和有阴暗胃肠的流血的 41 女性(50.6%) 经历了在 1990 和 2004 之间的 IOE。病人从一个数据库被识别,数据回顾地从病人的图表被选择。所有病人在 IOE 前经历了至少一非诊断的 esophagogastroduodenoscopy,结肠镜检查,标准肠寄生物和否定腹的超声扫描。结果:在病人的中部的最小的血红素水平是 59 + 15 g/L 并且 72.8% 病人以前要求了包装红血球的输送。流血来源在 68 被检测(84%) 病人在 IOE 期间。Angiodysplasiae 在 44 个病人(54.3%) 被发现, 9 个病人(11.1%) 被溃疡在小肠影响。在小肠的一个肿瘤在另外一个被检测 6 个病人。治疗在大多数病人由 argon-plasma-coagulation,外科的缝术或有限切除术组成了。结论:Intra 起作用的肠寄生物仍然为怀疑的小肠流血的诊断被使用。最近的开发象无线的囊内视镜检查法和两倍汽球肠寄生物那样,以后可以导致 IOE 的代替。 | Ralf Jakobs Dirk Hartmann Claus Benz Dieter Schilling Uwe Weickert Axel Eickhoff Klaus Schoenleben Juergen F Riemann | 2006 | World Journal of Gastroenterology2006，12，2： | 5 |
| 4 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 5 | Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa显示文摘 | Marieke J van der Werf Sake J de Vlas Simon Brooker Caspar W.N Looman Nico J.D Nagelkerke J.Dik F Habbema Dirk Engels | 2003 | Acta Tropica2003，，2： | 1 |
| 6 | Developing information net- working further: from PSIRP to PURSUIT显示文摘 | NIKOS F PEKKA N DIRK T | 2010 | Broadband Communi- cations Networks and Systems2010，66，3： | 1 |
| 7 | A software-based highquality MPEG-2 encoder employing scene change detection and adapfve quantization显示文摘 | DIRK F NIELS M PETER H N | 2001 | IEEE ICCE Digest2001，，： | 1 |
| 8 | SAMPEG,a scene adaptive,parallel MPEG-2 software encoder 显示文摘 | DIRK F NIEIS M PETER H N | 2001 | SPIE Visual Communications and Image Processing2001，43，10： | 1 |
| 9 | The prognostic value of IL-8 for cardiac events and restenosis in patients with coronary heart diseases after percutaneous coronary Interven- tion显示文摘 | Dirk H Walter Stephan F Marc S | 2001 | JACC2001，37，3： | 1 |
| 10 | Luminescent afterglow behavior in the M2 Sis N8 : Eu familly (M=Ca, Sr, Ba) 显示文摘 | Koen Van den Eeckhout Philippe F Smet Dirk Poelman | 2011 | Materials2011，，4： | 1 |
| 11 | Hyperbranched polymers prepared via the core-dilution/low addition technique computer simulation of molecular weight distribution and degree of branching 显示文摘 | Ralf H Dirk H Holger F | 1998 | Macromolecules1998，，31： | 1 |
| 12 | The Regional Supply of Venture Capital:Can Syndication Overcome Bottlenecks显示文摘 | Michael F Dirk S | | 0，，01： | 1 |
| 13 | A Mathematical Model for Cooling and Rapid Solidification of Molten Metal Droplets显示文摘 | Dirk B Udo F Klans B | 2002 | International Journal of Thermal Science2002，39，： | 1 |
| 14 | The role of active oxygen species in plant signal transduction显示文摘 | Frank V Eva V James F D Dirk I | 2001 | Plant Science2001，161，3： | 1 |
| 15 | Autoantibodies to asialoglycoprotein receptor ( ASGPR ) measured by a novel ELISA-revival of a disease - activity marker in autoimmune hepatitis 显示文摘 | Gert H Dirk R Eugen F | 2009 | Clin Chim Acta2009，408，12： | 1 |
| 16 | Highway or byway: the meta- bolic role of the GABA shunt in plants显示文摘 | AARON F HILLEL F DIRK W | 2008 | Trends in Plant Science2008，13，1： | 1 |
| 17 | SYBR green-based real-time quantitative PCR assay for detection of West Nile virus circumvents false-negative results due to strain variability显示文摘 | James F P Wolfgang V Dirk P D | 2004 | J Clin Microbiol2004，42，4： | 1 |
| 18 | Molecular eompution RNA solution to chess problem显示文摘 | Dirk F Cukras A R Loptou R J | 2000 | Biochemistry2000，97，4： | 1 |
| 19 | Cancer stem cells-per- spectives on current status and future directions: AACR Workshop on cancer stem cells显示文摘 | Clarke M F Dick J E Dirks P B | 2006 | Cancer Res2006，66，19： | 1 |
| 20 | An algorithm for continuous real-time QT interval monitoring显示文摘 | ERICD H SOPHTA H Z JAMES M L DIRK Q F RICHARD E G JOHN J W SCOTT S K FRANCIS P M | 2006 | Journal of Electrocardiology2006，39，： | 1 |
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