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| 1 | Influence of unrecorded alcohol consumption on liver cirrhosis mortality显示文摘Unrecorded alcohol includes illegally distributed alcohol as well as homemade or surrogate alcohol which is unintended for consumption by humans(e.g.,cosmetics containing alcohol).The highest unrecorded alcohol consumption occurs in Eastern Europe and some of these countries have an over proportional liver cirrhosis mortality.Compounds besides ethanol have been hypothesized as being responsible for this observation.On the other hand,chemical investigations were unable to prove that unrecorded alcohol regularly contains contaminants above toxicological thresholds.However,illegally produced spirits regularly contain higher percentages of alcohol(above 45%by volume),but for considerably less costs compared with licit beverages,potentially causing more problematic patterns of drinking.In this review,it is investigated whether patterns of drinking rather than product composition can explain the liver cirrhosis mortality rates.Statistical examination of World Health Organization country data shows that the originally detected correlation of the percentage of unrecorded alcohol consumption and liver cirrhosis mortality rates disappears when the data is adjusted for the prevalence of heavy episodic drinking.It may be concluded that there is currently a lack of data to demonstrate causality between the composition of illicit spirits(e.g.,higher levels of certain contaminants in home-produced products)and liver toxicity on a population scale.Exceptions may be cases of poisoning with antiseptic liquids containing compounds such as polyhexamethyleneguanidine,which were reported to be consumed as surrogate alcohol in Russia,leading to an outbreak of acute cholestatic liver injury,histologically different from conventional alcoholic liver disease. | Dirk W Lachenmeier Yulia B Monakhova Jürgen Rehm | 2014 | World Journal of Gastroenterology2014，20，23： | 10 |
| 2 | Acute compartment syndrome of the thigh following hip replacement by anterior approach in a patient using oral anticoagulants显示文摘Acute compartment syndrome(ACS) of the thigh following primary total hip arthroplasty(THA) is a highly uncommon complication and has not yet been reported before with regards to the anterior approach through the anterior supine interval. We present a case of a 69-year-old male patient with a history of stroke, who developed ACS of the thigh after elective THA while using therapeutic low molecular weight heparin as bridging for regular oral anticoagulation. ACS pathogenesis, diagnostic tools, treatment and relevant literature are discussed. The patient's ACS was recognized in time and treated by operative decompression with fasciotomy of the anterior compartment. Follow-up did not show any neurological deficit or soft-tissue damage. | Dirk Pieter Hogerzeil Imraan Muradin Eline W Zwitser Joris A Jansen | 2017 | World Journal of Orthopedics2017，8，12： | 8 |
| 3 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 4 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 5 | Activity of phenylalanine ammonialyase, peroxidase and polyphenol oxidase in roots of banana(Musa acuminata AAA, cvs Grande Naine and Yangambi km5) before and after infection with Radophotus similes显示文摘 | Nathalie W Dirk D Rony S | 2006 | Nematology2006，8，2： | 1 |
| 6 | Tumor necrosis factor receptor-associated factor(TRAF)4 is a new binding partner for the p70S6 serine/threonine kinase显示文摘 | Fleckenstein D S Dirks W G Drexler H G | 2003 | Leuk Res2003，27，8： | 1 |
| 7 | Self-Organized Pedestrian Crowd Dynamics:Experiments,Simulations,and Design Solutions显示文摘 | Dirk Helbing Lubos Buzna Anders Johansson T W | | 0，，01： | 1 |
| 8 | Design of a ten-way conical transmission line power combiner显示文摘 | DIRK I L PIETER W PETRIE M | 2007 | IEEE Trans Microw Theory Tech2007，55，2： | 1 |
| 9 | Transposon tagging of male sterility gene in Arabidopsis显示文摘 | Aarts M G Dirks W G Stiekema W T | 1993 | Nature1993，363，： | 1 |
| 10 | Fish and immunoeytoehemistry: towards visualising single target molecules in living ceils 显示文摘 | Tanke H J Dirks R W | 2005 | Current Opinion in Biotechnology2005，16，1： | 1 |
| 11 | Macro faunal community structure and sulfide flux at gas hydrate de posits from the Cascadia convergent margin, NE Pacific显示文摘 | Heiko Sahling Dirk Rickert Raymond W Lee | 2002 | Marine Ecology Progress Series2002，231，： | 1 |
| 12 | A second target for the peptoid Tat/transactivation response element inhibitor CGP64222: inhibitor of human immunodeficiecy virus replication by blocking CXCR4-mediated virus entry显示文摘 | Dirk D Dominique S Myriam W | 2000 | Mol Pharmacol2000，57，1： | 1 |
| 13 | FISH and immunocytochemistry: towards visualizing signal target molecules in living cells 显示文摘 | Hans J Tanke Roeland W Dirks Ton Raap | 2005 | Current Opinion in Biotechnology2005，16，： | 1 |
| 14 | Toll like receptors linking innate and adaptive immune response显示文摘 | Dirk W Tomas W J | 2003 | Veterinary Immunology and Immunopathology2003，91，： | 1 |
| 15 | Multiresolution reproducing kernel particle method for computational fluid dynamics 显示文摘 | Liu W K Sukky J Dirk T S | | International Journal for numericalmethods in fluids0，，： | 1 |
| 16 | Bottom influence on the reflectance of the sea 显示文摘 | DIRKS R W J 1987 | 1987 | International Journal of Remote Sensing1987，8，3： | 1 |
| 17 | Mechanical properties and electrical conductivity of carbon-nanotube filled polyamide-6 and its blends with acrylonitrile/butadiene/styrene 显示文摘 | Olaf M Dirk K Hans W | 2004 | Polymer2004，45，： | 1 |
| 18 | Lattice reduction 显示文摘 | DIRK W DOMINIK S JOAKIM J | 2011 | Signal Processing Magazine IEEE2011，28，3： | 1 |
| 19 | Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin显示文摘 | Quentmeier H Martelli M P Dirks W G | 2005 | Leukemia2005，19，： | 1 |
| 20 | Development of individual three-dimensional bone substitutes using 'selective laser melting' 显示文摘 | Dirk A H Tobias W Matthias W | 2003 | European Journal of Trauma2003，29，4： | 1 |
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