|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A Major QTL, Ghd8, Plays Pleiotropic Roles in Regulating Grain Productivity, Plant Height, and Heading Date in Rice显示文摘瑞斯产量和标题日期是量的特点 loci (QTL ) 控制的二个不同特点。位于米饭收益特点下面的分子的机制的解剖为开发 high-yielding 米饭变化是重要的。这里,我们报导克隆和 Ghd8,有谷物产量上的多种的效果的主要 QTL,标题日期,和植物高度的描述。近的 isogenic 线人口的二个集合为克隆 Ghd8 被开发。Ghd8 被变窄到包含二通常认为的基因的一个 20-kb 区域,哪个编码 CCAAT 盒子有约束力的蛋白质(幸运建筑群) 的 OsHAP3 子单元;这基因被认为是 Ghd8 候选人。互补测试证实了身份和基因的多种的效果;有趣地, Ghd8 的基因效果依赖于它的基因背景。由调整 Ehd1, RFT1,和 Hd3a, Ghd8 在长天的条件下面推迟了 flowering,但是在短天的条件下面支持了 flowering。Ghd8 起来调整的 MOC1,控制 tillering 并且分叉的关键基因;这增加了 tillers 的数字,主要、第二等的分支,因此每植物生产 50% 更多的谷物。在 Arabidopsis 的 Ghd8 的宫外的表示在 10 引起了早 flowering ? 类似于那种的 da 状况由它的相当或相同的事物 AtHAP3b 观察了,什么时候与相比在长天的条件下面野类型;这些调查结果在 Arabidopsis 在 flowering 显示 Ghd8 和 AtHAP3b 的保存功能。我们的结果在米饭产量表明了 Ghd8 的重要角色形成和 flowering,以及它的反面在长天的条件下面在在米饭和 Arabidopsis 之间的 flowering 工作。 | Wen-Hao Yan Peng Wang Hua-Xia Chen Hong-Ju Zhou Qiu-Ping Li Chong-Rong Wang Ze-Hong Ding Yu-Shan Zhang Si-Bin Yu Yong-Zhong Xing Qi-Fa Zhang | 2011 | Molecular Plant2011，4，2： | 127 |
| 2 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 3 | Plant abiotic stress response and nutrient use efficiency显示文摘Abiotic stresses and soil nutrient limitations are major environmental conditions that reduce plant growth,productivity and quality.Plants have evolved mechanisms to perceive these environmental challenges,transmit the stress signals within cells as well as between cells and tissues,and make appropriate adjustments in their growth and development in order to survive and reproduce.In recent years,significant progress has been made on many fronts of the stress signaling research,particularly in understanding the downstream signaling events that culminate at the activation of stress-and nutrient limitation-responsive genes,cellular ion homeostasis,and growth adjustment.However,the revelation of the early events of stress signaling,particularly the identification of primary stress sensors,still lags behind.In this review,we summarize recent work on the genetic and molecular mechanisms of plant abiotic stress and nutrient limitation sensing and signaling and discuss new directions for future studies. | Zhizhong Gong Liming Xiong Huazhong Shi Shuhua Yang Luis R.Herrera-Estrella Guohua Xu Dai-Yin Chao Jingrui Li Peng-Yun Wang Feng Qin Jigang Li Yanglin Ding Yiting Shi Yu Wang Yongqing Yang Yan Guo Jian-Kang Zhu | 2020 | Science China(Life Sciences)2020，63，5： | 94 |
| 4 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 5 | The Genome of Dendrobium officinale Illuminates the Biology of the Important Traditional Chinese Orchid Herb显示文摘 | Liang Yan Xiao Wang Hui Liu Yang Tian Jinmin Lian Ruijuan Yang ShumeiHao Xuanjun Wang Shengchao Yang Qiye Li Shuai Qi Ling Kui Moses Okpekum Xiao Ma Jiajin Zhang Zhaoli Ding Guojie Zhang Wen Wang Yang Dong Jun Sheng | 2015 | Molecular Plant2015，8，6： | 64 |
| 6 | Clustering by Fast Search and Find of Density Peaks with Data Field显示文摘A clustering algorithm named 'Clustering by fast search and find of density peaks' is for finding the centers of clusters quickly. Its accuracy excessively depended on the threshold, and no efficient way was given to select its suitable value, i.e., the value was suggested be estimated on the basis of empirical experience. A new way is proposed to automatically extract the optimal value of threshold by using the potential entropy of data field from the original dataset. For any dataset to be clustered, the threshold can be calculated from the dataset objectively instead of empirical estimation. The results of comparative experiments have shown the algorithm with the threshold from data field can get better clustering results than with the threshold from empirical experience. | WANG Shuliang WANG Dakui LI Caoyuan LI Yan DING Gangyi | 2016 | Chinese Journal of Electronics2016，25，3： | 60 |
| 7 | A randomized controlled clinical trial on the treatment of Thymosin-a1 versus interferon-α in patients with hepatitis B显示文摘INTRODUCTIONChronic hepatitis B virus (HBV) infection is a serious problem because of its world wide distribution and possible adverse sequelae ,such as cirrhosis and hepatocellular carcinoma .The World Health Organization estimates that HBV has infected mord than 350 million people worldwide ,and up to 20% of them will become chromic carricrs and will be at significant risk for cirrhosis and HCC .The ultimate goal of the therapy for chronic hepatitis B is to prevent progression to cirrhosis and to prevent development of HCC. | Jing You Lin Zhuang Bao Zhang Tang Wei Bo Yang Su Ying Ding Wu Li Rong Xue Wu Hong Li Zhang Yan Mei Zhang Shao Ming Yan Lu Zhang ~1Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China ~2Departrnent of Hepatology,Kunming Third Municipal People’s Hospital,Kunming 650041,Yunnan Province,China | 2001 | World Journal of Gastroenterology2001，7，3： | 48 |
| 8 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 9 | In vitro derivation of functional insulin-producing cells from human embryonic stem cells显示文摘为人的胚胎的茎(ES ) 的自强和区别的能力细胞为对待类型 Idiabetes mellitus 为胰腺的贝它细胞的产生使他们成为潜在的来源。这里,我们报导一最新发展了并且有效方法,在aserum免费的系统执行了,区分进生产胰岛素的 cells.Activin A 的导致的人的 ES 房间它在起始的阶段被使用从人的 EScells 导致权威的内胚叶区别,是由权威的内胚叶标记 Sox17 和 Brachyury.Further 的表示检测了, all-trans retinoic 酸( RA )被用来支持胰腺的区别,由早胰腺的抄写因素 pdx1 和 hlxb9 的表示显示了。在成熟 inDMEM/F12 以后有 bFGF 和菸碱的没有浆液的媒介,区分的房间表示了小岛特定的标记象 C 肽,胰岛素,胰高血糖素和 glut2 那样。百分比 ofC-peptide-positive 房间超过了 15% 。由这些房间的胰岛素和 C 肽的分泌物在葡萄糖层次对应于变化。当移植了进肾的囊时, ofStreptozotocin (STZ ) 对待裸体老鼠,这些区分的人的 ES 房间熬过并且维持贝它房间标记基因的表示包括 C 肽, pdx1, glucokinase, nkx6.1, IAPP, pax6and Tcf1。百分之三十只移植裸体老鼠展出了 stableeuglycemia 的明显的恢复;并且改正的显型被支撑超过六个星期。我们的新方法为学习人的胰开发的机制提供一个有希望的试管内区别模特儿并且说明为类型 Idiabetes mellitus 的处理使用人的 ES 房间的潜力。 | Wei Jiang Yan Shi Dongxin Zhao Song Chen Jun Yong Jing Zhang Tingting Qing Xiaoning Sun Peng Zhang Mingxiao Ding Dongsheng Li Hongkui Deng | 2007 | Cell Research2007，17，4： | 38 |
| 10 | Sevoflurane postconditioning reduces myocardial reperfusion injury in rat isolated hearts via activation of PI3K/Akt signaling and modulation of Bcl-2 family proteins显示文摘Sevoflurane postconditioning reduces myocardial infarct size.The objective of this study was to examine the role of the phosphatidylinositol-3-kinase(PI3K)/Akt pathway in anesthetic postconditioning and to determine whether PI3K/Akt signaling modulates the expression of pro-and antiapoptotic proteins in sevoflurane postconditioning.Isolated and perfused rat hearts were prepared first,and then randomly assigned to the following groups:Sham-operation(Sham),ischemia/reperfusion(Con),sevoflurane postconditioning(SPC),Sham plus 100 nmol/L wortmannin(Sham+Wort),Con+Wort,SPC+Wort,and Con+dimethylsulphoxide(DMSO).Sevoflurane postconditioning was induced by administration of sevoflurane(2.5%,v/v) for 10 min from the onset of reperfusion.Left ventricular developed pressure(LVDP),left ventricular end-diastolic pressure(LVEDP),maximum increase in rate of LVDP(+dP/dt),maximum decrease in rate of LVDP(?dP/dt),heart rate(HR),and coronary flow(CF) were measured at baseline,R30 min(30 min of reperfusion),R60 min,R90 min,and R120 min.Creatine kinase(CK) and lactate dehydrogenase(LDH) were measured after 5 min and 10 min reperfusion.Infarct size was determined by triphenyltetrazolium chloride staining at the end of reperfusion.Total Akt and phosphorylated Akt(phospho-Akt),Bax,Bcl-2,Bad,and phospho-Bad were determined by Western blot analysis.Analysis of variance(ANOVA) and Student-Newman-Keuls' test were used to investigate the significance of differences between groups.The LVDP,±dP/dt,and CF were higher and LVEDP was lower in the SPC group than in the Con group at all points of reperfusion(P<0.05).The SPC group had significantly reduced CK and LDH release and decreased infarct size compared with the Con group [(22.9±8)% vs.(42.4±9.4)%,respectively;P<0.05].The SPC group also had increased the expression of phospho-Akt,Bcl-2,and phospho-Bad,and decreased the expression of Bax.Wortmannin abolished the cardioprotection of sevoflurane postconditioning.Sevoflurane postconditioning may protect the isolated rat heart.Activation of PI3K and modulation of the expression of pro-and antiapoptotic proteins may play an important role in sevoflurane-induced myocardial protection. | Li-na YU Jing YU Feng-jiang ZHANG Mei-juan YANG Ting-ting DING Jun-kuan WANG Wei HE Tao FANG Gang CHEN Min YAN | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，9： | 36 |
| 11 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 12 | Pathological evidence for residual SARS-CoV-2 in pulmonary tissues of a ready-for-discharge patient显示文摘Dear Editor,SARS-CoV-2,a novel coronavirus and causing COVID-19,has given rise to a worldwide pandemic.1,2 So far,tens of thousands of COVID-19 patients have been clinically cured and discharged,but multiple COVID-19 cases showed SARS-CoV-2 positive again in discharged patients,3 which raises an attention for the discharged patients.Also,there is an urgent need to understand the pathogenesis of SARS-CoV-2 infection.Here,we conducted postmortem pathologic study in a ready-fordischarge COVID-19 patient who succumbed to sudden cardiovascular accident.Pathological examination revealed SARSCoV-2-viruses remaining in pneumocytes and virus-caused pathological changes in the lungs.Our study provided new insights into SARS-CoV-2 pathogenesis and might facilitate the improvement of clinical guideline for virus containment and disease management. | Xiao-Hong Yao Zhi-Cheng He Ting-Yuan Li Hua-Rong Zhang Yan Wang Huaming Mou Qiaonan Guo Shi-Cang Yu Yanqing Ding Xindong Liu Yi-Fang Ping Xiu-Wu Bian | 2020 | Cell Research2020，30，6： | 35 |
| 13 | Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes显示文摘 | Xiao-Lei Shi Yimeng Gao YupengYan HuchengMa Lulu Sun Pengyu Huang Xuan Ni Ludi Zhang Xin Zhao Haozhen Ren Dan Hu Yan Zhou Feng Tian Yuan Ji Xin Cheng Guoyu Pan Yi-Tao Ding LijianHui | 2016 | Cell Research2016，26，2： | 31 |
| 14 | Radiofrequency ablation or microwave ablation combined with transcatheter arterial chemoembolization in treatment of hepatocellular carcinoma by comparing with radiofrequency ablation alone显示文摘Objective:To compare radiofrequency ablation(RFA) or microwave ablation(MWA) and transcatheter arterial chemoembolization(TACE) with RFA or MWA monotherapy in hepatocellular carcinoma(HCC).Methods:A prospective,randomized,controlled trial was conducted on 94 patients with HCC ≤7 cm at a single tertiary referral center from June 2008 to June 2010 at the Department of Hepatobiliary Surgery,the Second Affiliated Hospital of Southeast University.The patients were randomly assigned into the TACERFA or TACE-MWA(combined treatment group) and the RFA-alone or MWA-alone groups(control group).The primary end point was overall survival.The secondary end point was recurrence-free survival,and the tertiary end point was adverse effects.Results:Until the time of censor,17 patients in the TACE-RFA or TACE-MWA group had died.The median follow-up time of the patients who were still alive for the TACE-RFA or TACE-MWA group was 47.5±11.3 months(range,29 to 62 months).The 1-,3- and 5-year overall survival for the TACE-RFA or TACE-MWA group was 93.6%,68.1% and 61.7%,respectively.Twenty-five patients in the RFA or MWA group had died.The median follow-up time of the patients who were still alive for the RFA or MWA group was 47.0±12.9 months(range,28 to 62 months).The 1-,3- and 5-year overall survival for the RFA or MWA group was 85.1%,59.6% and 44.7%,respectively.The patients in the TACE-RFA or TACE-MWA group had better overall survival than the RFA or MWA group [hazard ratio(HR),0.526;95% confidence interval(95% CI),0.334-0.823;P=0.002],and showed better recurrence-free survival than the RFA or MWA group(HR,0.582;95% CI,0.368-0.895;P=0.008).Conclusions:RFA or MWA combined with TACE in the treatment of HCC ≤7 cm was superior to RFA or MWA alone in improving survival by reducing arterial and portal blood flow due to TACE with iodized oil before RFA. | Yongxiang Yi Yufeng Zhang Qiang Wei Liang Zhao Jianbo Han Yan Song Ying Ding Guilan Lu Junmao Liu Huaiying Ding Feng Dai Xiaojun Tang | 2014 | Chinese Journal of Cancer Research2014，26，1： | 29 |
| 15 | Relationship of Helicobacterpylori eradication with gastric cancer and gastric mucosal histological changes: a 10-year follow-up study显示文摘 | Zhou Liya Lin Sanren Ding Shigang Huang Xuebiao Jin Zhu Cui Rongli Meng Lingmei Li Yuan Zhang Li Guo Changji Xue Yan Yan Xiu'e Zhang Jing | 2014 | Chinese Medical Journal2014，，8： | 28 |
| 16 | Epithelioid angiomyolipoma of the liver:Cross-sectional imaging findings of 10 immunohistochemically-verified cases显示文摘AIM:To retrospectively evaluate the computed tomography(CT)/magnetic resonance imaging(MRI) imaging features of epithelioid angiomyolipoma of the liver(Epi-HAML),with pathology as a reference. METHODS:The CT/MRI findings(number,diameter, lobar location,and appearance of lesions)in a series of 10 patients with 12 pathologically proven epithelioid angiomyolipomas of the liver were retrospectively analyzed.The imaging features,including attenuation/ signal intensity characteristics,presence of fat, hypervascular,outer rim,and vessels within lesion, were evaluated and compared with that of non-Epi-HAML in 11 patients(13 lesions).The Fisher exact test was used to compare difference in probability of imaging features between the two types. RESULTS:For 21 patients,CT images of 15 patients and MR images of six patients were available.No patient underwent two examinations.For the 15 patients with a CT scan,all HAML lesions in the two groups(10 Epi-HAML and seven non-Epi-HAML) manifested as hypoattenuation.For the six patients with MRI,all lesions(two Epi-HAML and six non-Epi- HAML)were hypointense on T1WI(fat suppression)and hyperintense on T2WI.There were 10 non-Epi-HAML, but only two Epi-HAML lesions showed the presence offat,which significantly different between the two types (P=0.005).On the dynamic contrast enhancement (DCE)imaging,eight Epi-HAML,and 13 non-Epi lesions manifested as hypervascular.Punctate or curved vessels were displayed in 10 Epi-HAML as well as in nine non-Epi lesions and outer rim enhancement could be found with eight Epi-HAML as well as six non-Epi lesions. CONCLUSION:Little or no presence of adipose tissue was found to be an imaging feature of Epi-HAML,compared with the non-Epi type.In addition, hypervascularity with opacification of central punctiform or filiform vessels on DCE would be a characteristic enhancement pattern for Epi-HAML. | Peng-Ju Xu Yan Shan Fu-Hua Yan Yuan Ji Ying Ding Mei-Lin Zhou | 2009 | World Journal of Gastroenterology2009，15，36： | 24 |
| 17 | Clinical effects of innovative tuina manipulations on treating cervical spondylosis of vertebral artery type and changes in cerebral blood flow显示文摘OBJECTIVE:To determine the clinical effect,treatment times,and rheoencephalogram changes in vertebral artery type cervical spondylosis patients treated with innovative Tuina manipulations.METHODS:One hundred and twenty six cervical spondylosis patients(vertebral artery type) were randomly divided into test and control groups.Patients in the test group were treated with innovative Tuina manipulations,while those in the control group were treated with the routine Tuina manipulations according to the textbook of Chinese Massage for Acupuncture and Moxibustion majors.The clinical effects,treatment times,clinical symptoms,and cerebral blood flow were measured.RESULTS:The response to the treatment was 100% in the test group and 88.71% in the control group.Patients in the test group required(7 ± 4) treatments before recovery,while those in the control group required(15 ± 7) treatments before recovery(P<0.05).The clinical symptoms exhibited greater improvement in the test group compared to the control group(P<0.05).There were no differences in cerebral blood flow between the two groups.CONCLUSION:Both innovative Tuina manipulations and routine Tuina manipulations produced satisfactory therapeutic results in vertebral artery type cervical spondylosis patients.However,the innovative manipulation was more effective in improving the functional symptoms,although there were no changes in the cerebral blood flow. | Quanmao Ding Mingru Yan Ji Zhou Lu Yang Jiang Guo Jun Wang Zhiyong Shi Yixi Wang Hongsheng Zhao | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 24 |
| 18 | Preliminary results of Thymosin-a1 versus interferon-α treatment in patients with HBeAg negative and serum HBV DNA positive chronic hepatitis B显示文摘INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 and C-myc protein expression in the development of gastric cancer . | Lin Zhuang Jing You Bao Zhang Tang Su Ying Ding Kui Hua Yan Dan Peng Yan Mei Zhang Lu Zhang ~1Department of Hepatology,Kunming Third Municipal Peoples Hospital,Kunming 650041,Yunnan Province,China ~2Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China | 2001 | World Journal of Gastroenterology2001，7，3： | 22 |
| 19 | Effect of maternal age on the outcomes of in vitro fertilization and embryo transfer(IVF-ET)显示文摘This is a retrospective,observational study to evaluate the effect of maternal age on the outcomes of in vitro fertilization and embryo transfer(IVF-ET).11830 IVF-ET cycles from 10268 women were included.Four groups of different maternal age periods were compared.The groups were 21 30 years old group(4549 cycles),31-35 years old group(4424 cycles),36-40 years old group(2429 cycles),and over 40 years old group(428 cycles).The mean starting dose of Gn and mean total dose of Gn in each cycle were significantly higher(P<0.01),while the mean retrieved oocyte number was significantly lower(P<0.01) in groups of higher maternal age period than those in each of the lower groups.The biochemical pregnancy rate and the clinical pregnancy rate were significantly lower(P<0.01),while the miscarriage rate was significantly higher(P<0.01) in groups of higher maternal age period than those in the lower groups.No difference was found in two-pronuclear zygotes(2PN) rate and good quality embryo rate among different groups.Birth defect rate was also comparable in the born babies in different groups.In the group with patients' age over 40 years old,the pregnancy rate was 26.87%,the clinical pregnancy rate was 19.39%,while the miscarriage rate after clinical pregnancy was 36.14%.To draw the conclusion,patients with higher maternal age had worse IVF outcomes.In women of fertile age,patients between 20 and 30 years old have the best IVF outcomes.Patients over 40 years old have poor IVF outcome and high miscarriage rate,which suggested the necessity of preimplantation genetic screening(PGS). | YAN JunHao WU KeLiang TANG Rong DING LingLing CHEN Zi-Jiang | 2012 | Science China(Life Sciences)2012，55，8： | 23 |
| 20 | Contributions of climate and human activities to changes in runoff of the Yellow and Yangtze rivers from 1950 to 2008显示文摘Runoffs in the Yellow River and Yangtze River basins,China,have been changing constantly during the last half century.In this paper,data from eight river gauging stations and 529 meteorological stations,inside and adjacent to the study basins,were analyzed and compared to quantify the hydrological processes involved,and to evaluate the role of human activities in changing river discharges.The Inverse Distance Weighted(IDW)interpolation method was used to obtain climatic data coverage from station observations.According to the runoff coefficient equation,the effect of human activities and climate can be expressed by changes in runoff coefficients and changes in precipitation,respectively.Annual runoff coefficients were calculated for the period 1950-2008,according to the correlation between respective hydrological series and regional precipitation.Annual precipitation showed no obvious trend in the upper reaches of the Yellow River but a marked downward trend in the middle and downstream reaches,with declines of 8.8 and 9.8 mm/10 a,respectively.All annual runoff series for the Yellow River basin showed a significant downward trend.Runoff declined by about 7.8 mm/10 a at Sanmenxia and 10.8 mm/10 a at Lijin.The series results indicated that an abrupt change occurred in the late 1980s to early 1990s.The trend of correlations between annual runoff and precipitation decreased significantly at the Yellow River stations,with rates ranging from 0.013/10 a to 0.019/10 a.For the hydrologic series,all precipitation series showed a downward trend in the Yangtze River basin with declines ranging from about 24.7 mm/10 a at Cuntan to 18.2 mm/10 a at Datong.Annual runoff series for the upper reaches of the Yangtze River decreased significantly,at rates ranging from 9.9 to 7.2 mm/10 a.In the middle and lower reaches,the runoff series showed no significant trend,with rates of change ranging from 2.1 to 2.9 mm/10 a.Human activities had the greatest influence on changes in the hydrological series of runoff,regardless of whether the effect was negative or positive.During 1970-2008,human activities contributed to 83% of the reduction in runoff in the Yellow River basin,and to 71% of the increase in runoff in the Yangtze River basin.Moreover,the impacts of human activities across the entire basin increased over time.In the 2000s,the impact of human activities exceeded that of climate change and was responsible for 84% of the decrease and 73% of the increase in runoff in the Yellow River and Yangtze River basins,respectively.The average annual runoff from 1980 to 2008 fell by about 97%,83%,83%,and 91%,compared with 1951-1969,at the Yellow River stations Lanzhou,Sanmenxia,Huayuankou and Lijin,respectively.Most of the reduction in runoff was caused by human activities.Changes in precipitation also caused reductions in runoff of about 3%,17%,17%,and 9% at these four stations,respectively.Falling precipitation rates were the main explanation for runoff changes at the Yangtze River stations Cuntan,Yichang,Hankou,and Datong,causing reductions in runoff of 89%,74%,43%,and 35%,respectively.Underlying surface changes caused decreases in runoff in the Yellow River basin and increases in runoff in the Yangtze River basin.Runoff decreased in arid areas as a result of increased water usage,but increased in humid and sub-humid areas as a result of land reclamation and mass urbanization leading to decreases in evaporation and infiltration. | WANG Yan DING YongJian YE BaiSheng LIU FengJing WANG Jie WANG Jie | 2013 | Science China Earth Sciences2013，56，8： | 21 |
您所在的机构暂未开通此部分的功能，请联系管理员