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| 1 | Effect of maternal age on the outcomes of in vitro fertilization and embryo transfer(IVF-ET)显示文摘This is a retrospective,observational study to evaluate the effect of maternal age on the outcomes of in vitro fertilization and embryo transfer(IVF-ET).11830 IVF-ET cycles from 10268 women were included.Four groups of different maternal age periods were compared.The groups were 21 30 years old group(4549 cycles),31-35 years old group(4424 cycles),36-40 years old group(2429 cycles),and over 40 years old group(428 cycles).The mean starting dose of Gn and mean total dose of Gn in each cycle were significantly higher(P<0.01),while the mean retrieved oocyte number was significantly lower(P<0.01) in groups of higher maternal age period than those in each of the lower groups.The biochemical pregnancy rate and the clinical pregnancy rate were significantly lower(P<0.01),while the miscarriage rate was significantly higher(P<0.01) in groups of higher maternal age period than those in the lower groups.No difference was found in two-pronuclear zygotes(2PN) rate and good quality embryo rate among different groups.Birth defect rate was also comparable in the born babies in different groups.In the group with patients' age over 40 years old,the pregnancy rate was 26.87%,the clinical pregnancy rate was 19.39%,while the miscarriage rate after clinical pregnancy was 36.14%.To draw the conclusion,patients with higher maternal age had worse IVF outcomes.In women of fertile age,patients between 20 and 30 years old have the best IVF outcomes.Patients over 40 years old have poor IVF outcome and high miscarriage rate,which suggested the necessity of preimplantation genetic screening(PGS). | YAN JunHao WU KeLiang TANG Rong DING LingLing CHEN Zi-Jiang | 2012 | Science China(Life Sciences)2012，55，8： | 23 |
| 2 | ZnO nanofluids-A potential antibacterial agent显示文摘In this work, ZnO nanofluids were produced by a medium mill with a pH value of about 7.2 and characterized by Nano-Sizer and SEM. After milling, ZnO nanofluids were formed with an average particle size of 198.4 nm. The ZnO nanofluids used for testing were stored for different periods (1-, 90- and 120-day) and kept in different conditions (under the light and in the dark). The antibacterial activities of these ZnO nanofluids were evaluated by estimating the reduction ratio of the bacteria treated with ZnO. The results showed that the ZnO nanofluid stored for 120 days under the light had the best antibacterial behavior against Escherichia coli DH5a. SEM images suggest that an interaction between the ZnO particles and the E. coli bacteria cells caused by electrostatic forces might be a mechanism. | Lingling Zhang Yulong Ding Malcolm Povey David York | 2008 | Progress in Natural Science:Materials International2008，18，8： | 13 |
| 3 | Association between large artery atherosclerosis and cerebral microbleeds:a systematic review and meta-analysis显示文摘Objective:The aim of this systematic review and meta-analysis was to provide evidence that biomarkers of large artery atherosclerosis,including arterial stenosis and greater carotid intima-media thickness(cIMT),may serve as clinical markers of subclinical haemorrhage-prone cerebral small vessel disease,reflected by cerebral microbleeds(CMBs).Methods:We searched PubMed,MEDLINE,Web of Science,EMBASE and the Cochrane Library to identify relevant studies published before 1 July 2016.The association between arterial stenosis and CMBs was estimated by the OR and 95%CI.The association of cIMT and CMBs was calculated using the standardised mean difference(SMD).Heterogeneity and publication bias were explored.Results:8 studies including a total of 7160 participants were pooled in the meta-analysis.6 of the included studies were cross-sectional,except that 2 were prospective.We found a significant association between arterial stenosis>50%and the presence of CMBs(OR 1.95,95%CI 1.13 to 3.36,I2=56.1%).A fixed-effects model suggested that patients with CMBs were more likely to have a greater cIMT(SMD 0.20,95%CI 0.11 to 0.28,I2=24.7%).Conclusions:This systematic review and metaanalysis found that there is a relationship between large artery atherosclerosis and CMBs.Future studies are needed to confirm the impact of atherosclerosis on the CMBs,which may have potential therapeutic implications. | Lingling Ding Yuehui Hong Bin Peng | 2017 | Stroke & Vascular Neurology2017，2，1： | 13 |
| 4 | A systematic review of research studies on the estimation of net primary productivity in the Three-River Headwater Region, China显示文摘三河的 Headwater 区域(TRHR ) ,作为中国的水塔知道,为在中国和很多个东南亚洲国家的许多下游的区域是为国家安全兴趣和地区性的持续发展活动的一个重要生态的躲蔽处。TRHR 是有一个唯一,却典型的高山的植被系统的高举起的、冷环境。网络主要生产率(NPP ) 是能反映自然环境变化和碳预算层次的一个关键植被参数和生态的指示物。给唯一的地理环境和 TRHR 的战略地点,许多学者由使用不同方法估计了 TRHR 的 NPP;然而,这些估计为很多个原因极大地变化。迄今为止,没有纸,考察了并且估计在 TRHR 进行的 NPP 评价研究。在这篇论文,(1 ) 因此,我们在以前的研究的系统的评论在 TRHR 总结了 NPP 评价的相关方法和结果;(2 ) 为在 TRHR 估计 NPP 讨论了存在方法的适用性并且加亮最重要的挑战;并且(3 ) 估计了估计的 NPP 结果。最后,在 TRHR 的 NPP 评价的发展方向被勘探。 | SUN Qingling LI Baolin ZHOU Chenghu LI Fei ZHANG Zhijun DING Lingling ZHANG Tao XU Lili | 2017 | Journal of Geographical Sciences2017，27，2： | 8 |
| 5 | Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma显示文摘Glioblastoma(GBM)is an incurable and highly heterogeneous brain tumor,originating from human neural stem/progenitor cells(hNSCs/hNPCs)years ahead of diagnosis.Despite extensive efforts to characterize hNSCs and end-stage GBM at bulk and single-cell levels,the de novo gliomagenic path from hNSCs is largely unknown due to technical difficulties in early-stage sampling and preclinical modeling.Here,we established two highly penetrant hNSC-derived malignant glioma models,which resemble the histopathology and transcriptional heterogeneity of human GBM.Integrating time-series analyses of whole-exome sequencing,bulk and single-cell RNA-seq,we reconstructed gliomagenic trajectories,and identified a persistent NSC-like population at all stages of tumorigenesis.Through trajectory analyses and lineage tracing,we showed that tumor progression is primarily driven by multi-step transcriptional reprogramming and fate-switches in the NSC-like cells,which sequentially generate malignant heterogeneity and induce tumor phenotype transitions.We further uncovered stage-specific oncogenic cascades,and among the candidate genes we functionally validated C1QL1 as a new glioma-promoting factor.Importantly,the neurogenic-to-gliogenic switch in NSC-like cells marks an early stage characterized by a burst of oncogenic alterations,during which transient AP-1 inhibition is sufficient to inhibit gliomagenesis.Together,our results reveal previously undercharacterized molecular dynamics and fate choices driving de novo gliomagenesis from hNSCs,and provide a blueprint for potential early-stage treatment/diagnosis for GBM. | Xiaofei Wang Ran Zhou Yanzhen Xiong Lingling Zhou Xiang Yan Manli Wang Fan Li Chuanxing Xie Yiming Zhang Zongyao Huang Chaoqiong Ding Kaidou Shi Weida Li Yu Liu Zhongwei Cao Zhen-Ning Zhang Shengtao Zhou Chong Chen Yan Zhang Lu Chen Yuan Wang | 2021 | Cell Research2021，31，6： | 8 |
| 6 | Kinetic and thermodynamic studies of the esterification of acidified oil catalyzed by sulfonated cation exchange resin显示文摘This study describes the kinetics and thermodynamics of the esterification of acidified oil with methanol catalyzed by sulfonated cation exchange resins(SCER). The effects of the mass ratio of methanol to acidified oil,reaction temperature,and catalyst loading were studied to optimize the conditions for maximum conversion of free fatty acids(FFAs). The results showed that the optimal conversion rate of FFAs was 91.87% at the mass ratio of methanol to acidified oil of 2.5:1.0,reaction temperature of 65.0 °C,catalyst loading of 5.0 g and reaction time of 8.0 h. The external and internal mass transfer resistances were negligible based on the experimental results and a pseudo-homogeneous kinetic model was proposed for the esterification. The activation energy and thermodynamic parameters including G,S and H were determined. The conversion rates of FFAs obtained from the established model were in good agreement with the experimental data. | Lingling Ma Ying Han Kaian Sun Jie Lu Jincheng Ding | 2015 | Journal of Energy Chemistry2015，24，4： | 8 |
| 7 | The Impact of Large-Scale Reclamation on Hydro-Dynamic Environment--A Case Study of Xinghua Bay显示文摘A hydro-dynamic model is established on basis of MIKE21 FM to simulate the hydro-dynamic characteristics of Xinghua Bay and investigate the influence of reclamation project on the tidal elevation and tidal currents. Tidal elevation data was obtained at the six tide gauge stations around the Xinghua Bay, and another six current stations were established to observe the tidal current velocity and direction. Validation shows that the model-simulated tidal elevation and tidal currents agree well with observations made at different stations. Predictions are made according to the reclamation project proposed in the regional marine planning of Hanjiang Industrial Park around the port in Putian City. The variations of hydro-dynamic factors, such as tide, current velocity and direction and tidal influx are obtained, and the adverse effect of reclamation on marine environment is discussed. It is shown that the tidal level inside the Xinghua Bay during high tide decreases after the reclamation project is completed. The tidal currents during flooding tide generally decrease in the southeast of the reclamation region, with the maximum decreasing amplitude reaching 0.44 m s^(-1). On the other hand, the tidal currents during flooding tide increase around the southeast and southwest corners of the reclamation region. The tidal currents during ebb tide increase around the southeast and southwest corners of the reclamation region, with the maximum increasing amplitude attaining 0.18 m s^(-1). The results in this paper can give some guidance for the marine environment management and the effective utilization of land in Putian. | YU Jing BAO Xianwen DING Yang ZHANG Wei ZHOU Lingling | 2016 | Journal of Ocean University of China2016，15，4： | 5 |
| 8 | NIR light-induced tumor phototherapy using ICG delivery system based on platelet-membrane-camouflaged hollow bismuth selenide nanoparticles显示文摘Near-infrared(NIR)light-triggered photothermal therapy(PTT)is a promising treatment strategy for treating cancer.The combination of nanotechnology and NIR has been widely applied.However,the therapeutic efficacy of the drug-delivery system depends on their ability to avoid phagocytosis of endothelial system,cross the biological barriers,prolong circulation life,localize and rapidly release the therapeutic at target sites.In this work,we designed a platelet membrane(PM)-camouflaged hollow mesoporous bismuth selenide nanoparticles(BS NPs)loading with indocyanine green(ICG)(PM@BS-ICG NPs)to achieve the above advantages.PM-coating has active tumor-targe ting ability which could preve nt drug leakage and provide drug long circulation,causing drug delivery systems to accumulate in tumor sites effectively.Moreover,as a type of the photothermal sensitizers,BS NPs are used as the inner cores to improve ICG stability and are served as scaffolds to enhance the hardness of this drug delivery system.For one hand,the thermal vibration of BS NPs under NIR laser irradiation causes tumor inhibition through hyperthermia.For another hand,this hyperthermia process could damage PM and let ICG rapid release from PM@BS-ICG NPs.The in vitro and in vivo results showed that this biomimetic nano-drug delivery system exhibits obvious antitumor activity which has good application prospect. | Kaili Ding Cuixia Zheng Lingling Sun Xinxin Liu Yanyan Yin Lei Wang | 2020 | Chinese Chemical Letters2020，31，5： | 5 |
| 9 | Loss of Wip1 aggravates brain injury after ischaemia/reperfusion by overactivating microglia显示文摘Background and purpose The inflammatory response mediated by microglia/macrophages is closely related to cerebral ischaemia/reperfusion injury.Wild-type p53-induced protein phosphatase 1(Wip1),a serine/threonine phosphatase,is expressed in various tissues.A growing number of reports have suggested that Wip1 is a negative regulator of inflammation in peripheral tissue;however,its role in the central nervous system(CNS)remains unclear.This study aimed to clarify whether Wip1 can inhibit CNS inflammation by regulating microglia/macrophage functions after ischaemic injury.Methods A model of middle cerebral artery occlusion and reperfusion was established in mice.CNS inflammation was simulated by lipopolysaccharide treatment of primary microglia.Laser speckle imaging was used to monitor regional cerebral blood flow.Behavioural outcomes were assessed with a TreadScan gait analysis system.TTC staining was used to evaluate the infarct volume,and western blotting and immunofluorescence staining were applied to detect the phenotypical transformation of microglia.ELISA was performed to detect the levels of inflammatory factors.Results Wip1 expression was increased after ischaemia/reperfusion.Wip1-knockout(KO)mice displayed more severe brain injury than wild-type mice,as indicated by aggravated motor dysfunction,greater brain infarct volumes and higher expression of inflammatory cytokines(interleukin-6 and tumour necrosis factor alpha)in the brain.We also found that Wip1 depletion increased microglial/macrophage activation in both in vitro and in vivo models,which all showed activation of microglia/macrophages.Lentivirus-Ppm1d reversed the injury induced by Wip1-KO.Conclusions Our results suggest that Wip1 may inhibit neuroinflammation by inhibiting microglial/macrophage activation after brain ischaemia/reperfusion injury. | Feng Yan Xiang Cheng Ming Zhao Shenghui Gong Ying Han Liping Ding Di Wu Yumin Luo Wei Zuo Lingling Zhu Ming Fan Xunming Ji | 2021 | Stroke & Vascular Neurology2021，6，3： | 4 |
| 10 | Impact of Global Warming on Water Resource in Arid Area of Northwest China显示文摘As the unprecedented global warming is under way, the glacier retreat is getting more and more serious. In the inland arid area of Northwest China, due to very scarce precipitation, where there is water, there are oases. And the glacier melt water amounts to 22 % of the total direct supply of the inland river water and is of crucial importance to the survival and development of the oases. In this paper, using both the observed data and the previous research achievements of the glaciers in the inland valley of Northwest China where the oasis depending on the glacier is the only location suitable for human living, the authors describe the glacier retreat trend over the past half century, focusing on discussing the possible impact of the glacier retreat on the melt water runoff that is almost the only water resource efficient to nourish the oases. The authors find that even with increasing amount of water from the glacier with global warming, the water shortage is getting more and more serious and the environment is under a degrading way due to the accelerating economical development. The water shortage is bound to be more serious if the glacier retreat keeps on, especially after the glacier melt water is over its top for the degradedglacier scale. So suggestions are stressed in the end that a new water-saving pattern should be adopted in the area for a sustainable development due to the warming-up induced continuous glacier retreat. | LU Aigang DING Yongjian PANG Hongxi YUAN Lingling HE Yuanqing | 2005 | Journal of Mountain Science2005，2，4： | 3 |
| 11 | Human INO80/YY1 chromatin remodeling complex transcriptionally regulates the BRCA2-and CDKNIA-interacting protein (BCCIP) in cells显示文摘 | Jiaming Su Yi Sui Jian Ding Fuqiang Li Shuang Shen Yang Yang Zeming Lu Fei Wang Lingling Cao Xiaoxia Liu Jingji Jin Yong Cai | 2016 | Protein & Cell2016，7，10： | 3 |
| 12 | Intelligent technologies help operating mobile cabin hospitals effectively cope with COVID-19显示文摘Coronavirus disease 2019(COVID-19)has spread fast,and the number of confirmed cases worldwide reaches 167511,in which 81077 are recorded in China until March 16,2020(WHO,2020a).In response to the situation,the Chinese government has marshalled the full resources and efforts of the country to reduce the COVID-19 morbidity and mortality.As the number of confirmed cases decreases considerably every day,China’s control approach for COVID-19 epidemic has been proven to be agile and productive(National Health Commission,2020;WHO,2020b).Among all interventions,operating Chinese mobile cabin hospitals is considered one of the most effective measures because it holds many patients simultaneously at the outbreak stage;as such,this strategy quickly and effectively contains the spread of the virus(WHO,2020b;Zhang,2020b). | Ying ZHOU Lingling WANG Lieyun DING Zhouping TANG | 2020 | Frontiers of Engineering Management2020，7，3： | 2 |
| 13 | Review on the recent development of Li_(3)VO_(4)as anode materials for lithium-ion batteries显示文摘Among the various anodes,Li_(3)VO_(4)is a potential intercalation kind anode used in lithium-ion batteries(LIBs)that exhibits safer discharge voltage and higher capacity than graphite,a lower voltage plateau than Li_(4)Ti_(5)O_(12),and smaller volume difference in the Li^(+)intercalation/deintercalation process than metals and alloys.However,the comparatively low electronic conductivity,low initial coulombic efficiency(ICE)and serious capacity decay make the Li_(3)VO_(4)anode unviable when it comes to practical implementation.Therefore,this paper reviews the research progress of Li_(3)VO_(4)in recent years,mainly including the strategies of developing different synthesis methods to construct unique morphology,through coating,compositing or elemental doping to increase the ICE,electronic conductivity and the cycle constancy.Moreover,the application of Li_(3)VO_(4)anode materials in other energy storage systems is summarized.Lastly,the development prospect and challenge of Li_(3)VO_(4)anodes are discussed. | Limin Zhu Zhen Li Guochun Ding Lingling Xie Yongxia Miao Xiaoyu Cao | 2021 | Journal of Materials Science & Technology2021，，30： | 2 |
| 14 | Investigation into the nanofluids)显示文摘 | Zhang Lingling Jiang Yunhong Ding Yulong | 2007 | Journal of Nanoparticle Research2007，9，： | 1 |
| 15 | Investigation into the antibacterial behaviour of suspensions of ZnO nanoparticles (ZnO nanofluids)显示文摘 | Lingling Zhang Yunhong Jiang Yulong Ding Malcolm Povey David York | 2007 | Journal of Nanoparticle Research2007，，3： | 1 |
| 16 | Removal of hexavalent chromium by using red mud activated with cetyltrimethylammonium bromide 显示文摘 | Li Deliang Ding Ying Li Lingling | 2015 | Environ Technol2015，36，9： | 1 |
| 17 | Salidroside protects PC12 cells from MPP + -induced apoptosis via activation of the PI3K/Akt pathway显示文摘 | Lingling Zhang Wenjun Ding Huixing Sun Qiong Zhou JingQun Huang Xuefen Li Yonghong Xie Jianzong Chen | 2012 | Food and Chemical Toxicology2012，，8： | 1 |
| 18 | Variations in the starting date of the pre-summer rainy season in South China, 1736-2010显示文摘The starting dates of the pre-summer rainy season during historical times(1736– 1911) in Fuzhou and Guangzhou of South China, were determined and reconstructed on the basis of historical documents in the Yu-Xue-Fen-Cun archive, together with observed features of precipitation during the pre-summer rainy season. In addition, starting dates of the pre-summer rainy season from 1953 in Fuzhou and from 1952 in Guangzhou were reconstructed for the instrumental period. These data allowed for analyses of inter-annual and inter-decadal changes in the starting dates of the pre-summer rainy season in South China over the past 300 years. Results show that the mean starting date of the pre-summer rainy season in South China was the first pentad of May; in addition, periodicities in the starting dates of 2–3 years, 10 years, and 40 years were detected during the period 1736–1911, and of 2–3 years, 10 years, and 22 years during the instrumental period. From 1736 to 1911, the earliest starting dates at Fuzhou and Guangzhou both occurred at the fourth pentad of April, while the latest starting dates were at the sixth pentad of May in Fuzhou and the first pentad of June in Guangzhou. During the instrumental period, the earliest and latest starting dates were at the fourth pentad of April and the first pentad of June, respectively, in both Fuzhou during 1953–2010 and Guangzhou during 1952–2010. The maximum difference between neighboring decades during 1736–1911 was 2.2 and 1.6 pentads in Fuzhou and Guangzhou, respectively, and during the instrumental period it was 2.5 and 2.4 pentads in Fuzhou and Guangzhou, respectively. | DING Lingling GE Quansheng ZHENG Jingyun HAO Zhixin | 2014 | Journal of Geographical Sciences2014，24，5： | 1 |
| 19 | Investigation into the Antibacterial Behaviour of Suspensions of ZnO Nanoparticles (ZnO nanofuids) 显示文摘 | Lingling Zhang Yunhong Jiang Yulong Ding | 2007 | Journal of Nanoparticle Research2007，，9： | 1 |
| 20 | Numerical modeling of the seasonal circulation in the coastal ocean of the Northern South China Sea显示文摘The Finite Volume Community Ocean Model(FVCOM)was adapted to the Northern South China Sea(NSCS)to investigate the seasonality of coastal circulation,as well as along-shelf and cross-shelf transport.In fall and winter,southwestward current dominates the NSCS shelf,while the currenfs direction shifts to northeast in summer.The circulation pattern in spring is more complicated:both southwestward and northeastward currents are detected on the NSCS shelf.The mean shelf circulation pattern in winter does not show the permanent counter-wind South China Sea Warm Current(SCSWC)along the 100-200 m isobaths.Meanwhile,the model results indicate a northeastward current flowing along 50-100 m isobaths in spring.Southwestward along-shelf transport varies from 0.30-1.93 Sv in fall and winter,and it redirects to northeast in summer ranging jfrom 0.44—1.09 Sv.Onshore transport is mainly through the shelf break segment southeast of the Pearl River Estuary. | Yang DING Zhigang YAO Lingling ZHOU Min BAO Zhengchen ZANG | 2020 | Frontiers of Earth Science2020，14，1： | 1 |
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