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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | Single institution's expe- rience in laparoscopic appendectomy as a suitable therapy for compli- cated appendicitis显示文摘 | Dimitriou I Reckmann B Nephuth O | 2013 | Langenbecks Arch Surg2013，398，1： | 1 |
| 3 | ERK2 but not ERK1 in- duces epithelial-to-mesenchymal transformation via DEF motif-de- pendent signaling events 显示文摘 | Shin S Dimitri C A Yoon S O | 2010 | Mol Cell2010，38，1： | 1 |
| 4 | The role of inflammation in heart failure:new therapeutic approaches显示文摘 | Evangelos O Dimitris T Gerasimos S | | 0，，： | 1 |
| 5 | Shared blood and muscle CD8+ T-cell expansions in inclusion body myositis 显示文摘 | Dimitri D Benveuiste O Dnbnurg O | 2006 | Brain2006，129，4： | 1 |
| 6 | Single institution's experience in laparoscopic appendectomy as a suitable therapy for complicated appendicitis显示文摘 | Dimitriou I Reckmann B Nephuth O | 2013 | Langenbeck''s archives of surgery2013，398，1： | 1 |
| 7 | Inflammatory Disorders and Atherosclerosis: New Therapeutic Approaches显示文摘 | Marietta Charakida Frank O’Neil Stefano Masi Nikolaos Papageorgiou Dimitris Tousoulis | 2011 | Current Pharmaceutical Design2011，，37： | 1 |
| 8 | Singleinstitution's experience in laparoscopic appendecto-my as a suitable therapy for complicated appendici-tis显示文摘 | Dimitriou I Reckmann B Nephuth O | 2013 | Langenbecks Arch Surg2013，398，1： | 1 |
| 9 | Dose-dependent effects of short term atorvastatin treatment on arterial wall properties and on indices of left ventficular remodeling in ischemie heart failure 显示文摘 | Dimitris T Evangelos O Gerasimos S | 2013 | Atherosclerosis2013，227，： | 1 |
| 10 | Studies of electrical and mechanical properties of poly(vinyl chloride)mixed with electri- cally conductive additives显示文摘 | Saad A L G Aziz H A Dimitry O I H | 2004 | Journal of Applied Polymer Sci ence2004，91，3： | 1 |
| 11 | Acetabulum augmentation for Leg-Clave-Perths disease显示文摘 | Dimitriou JK Leonidou O Pettas N | 1997 | Acta Orthop Scand Suppl1997，，： | 1 |
| 12 | Studies of electrical and mechanical properties of poly (vinyl chloride) mixed with electrically conductive additives显示文摘 | Saad A L G Aziz H A Dimitry O I H | 2004 | J Appl Polym Sci2004，91，： | 1 |
| 13 | Ultrasonic assisted- Fenton-like degradation of nitrobenzene at neutral pH using nano- sized oxides of Fe and Cu 显示文摘 | Elshafei G M S Yehia F Z Dimitry O I H | 2014 | Ultrasonics Sonochemistry2014，21，4： | 1 |
| 14 | A surface complexation and ion exchange model of Pband Cd competitive sorption on natural soils显示文摘 | Susana Serrano Peggy A O'Day Dimitri Vlassopoulos | 2009 | Geochimica et Cosmochimica Acta2009，73，3： | 1 |
| 15 | Single institutionts experience in ]Ap&roscopic &ppendectomy &s & suitable ~her&py for complic&ted &ppendicitis显示文摘 | Dimitriou I P~eckmsnn B Nephu~h O | 2013 | L&ngenbeck T s &rchives of surgery2013，598，1： | 1 |
| 16 | Lung function and exhaled nitric oxide levels in infants developing chronic lung disease显示文摘 | Williams O Dimitriou G Hannam S | 2007 | Pediatr Pulmonol2007，42，2： | 1 |
| 17 | Activation of necroptosis in multiple sclerosis 显示文摘 | DIMITRY O YASUSHI I AYAZ N | 2015 | Cell Reports2015，15，10： | 1 |
| 18 | Studies of electrical and mechanical properties of poly(vinyl chloride) mixed with electrically conductiveadditives显示文摘 | Saad A Aziz H Dimitry O | 2004 | Journal of Applied Polymer Science2004，91，3： | 1 |
| 19 | A unified network selection framework using principal component analysis and multi attribute decision making 显示文摘 | DIMITRIS D E PANAGOPOULOS A D MARKAKI O I | 2014 | Wireless Personal Communi- cations2014，74，1： | 1 |
| 20 | Words apart:Standardizing forestry terms and definitions across European biodiversity studies显示文摘Forest biodiversity studies conducted across Europe use a multitude of forestry terms,often inconsistently.This hinders the comparability across studies and makes the assessment of the impacts of forest management on biodiversity highly context-dependent.Recent attempts to standardize forestry and stand description terminology mostly used a top-down approach that did not account for the perspectives and approaches of forest biodiversity experts.This work aims to establish common standards for silvicultural and vegetation definitions,creating a shared conceptual framework for a consistent study on the effects of forest management on biodiversity.We have identified both strengths and weaknesses of the silvicultural and vegetation information provided in forest biodiversity studies.While quantitative data on forest biomass and dominant tree species are frequently included,information on silvicultural activities and vegetation composition is often lacking,shallow,or based on broad and heterogeneous classifications.We discuss the existing classifications and their use in European forest biodiversity studies through a novel bottom-up and top-driven review process,and ultimately propose a common framework.This will enhance the comparability of forest biodiversity studies in Europe,and puts the basis for effective implementation and monitoring of sustainable forest management policies.The standards here proposed are potentially adaptable and applicable to other geographical areas and could be extended to other forest interventions. | Giovanni Trentanovi Thomas Campagnaro Tommaso Sitzia Francesco Chianucci Giorgio Vacchiano Christian Ammer MichałCiach Thomas ANagel Miren del Río Yoan Paillet Silvana Munzi Kris Vandekerkhove Andrés Bravo-Oviedo Andrea Cutini Ettore D'Andrea Pallieter De Smedt Inken Doerfler Dimitris Fotakis Jacob Heilmann-Clausen Jeňýk Hofmeister Jan Hošek Philippe Janssen Sebastian Kepfer-Rojas Nathalie Korboulewsky Bence Kovács Daniel Kozák Thibault Lachat Anders Mårell Radim Matula Martin Mikoláš Björn Nordén PéterÓdor x Marko Perović Elisabeth Pötzelsberger Peter Schall Miroslav Svoboda Flóra Tinya Mariana Ujházyová Sabina Burrascano | 2023 | Forest Ecosystems2023，10，4： | 0 |
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