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| 1 | IL28B polymorphism and cytomegalovirus predict response to treatment in Egyptian HCV type 4 patients显示文摘AIM:To test whether the status of positive cytomegalovirus(CMV) DNA detection adds to the predictive value of IL28B and to further categorize C/T allele carriers.METHODS:This study included 166 chronic hepatitis C(CHC) patients who received combined interferon and ribavirin therapy for 48 wk,84 spontaneous hepatitis C virus(HCV) resolvers who were positive for IgG anti-HCV antibody and negative for HCV RNA,and 100 healthy subjects who were negative for both HCV antibodies and RNA as controls.Genomic DNA from peripheral blood was used for IL28B rs.12979860 single nucleotide polymorphism(SNP) and CMV DNA detection.A 139 bp fragment containing IL28B SNP was amplified in all subjects by polymerase chain reaction using a specifically designed primer.Then the IL28B rs.12979860 SNP was detected by restriction fragment length polymorphism(RFLP) genotyping.The presence of CMV DNA was tested by amplification of the gB1 gene using nested polymerase chain reaction.The role of CMV and IL28B rs.12979860 SNP genotypes in determining the response rate to combined interferon therapy and clinical status of patients were statistically analyzed.RESULTS:Current data showed that 67% of patients carrying the IL28B 12979860 C/C allele had a sustained viral response(SVR) while the genotypes C/T and TT were associated with lower SVR rates,50% and 48%,respectively.SVR rates for the C/C allele were lower than other HCV genotypes and/or other populations.Genotype CC was associated with the response to interferon(P = 0.025).Genotype C/C was reduced from 48% in controls to 14% in CHC patients suggesting its protective role against progression to chronicity.The majority of spontaneously cleared subjects(86%) were C/C,confirming its protective role.The C/T allele was present in 71% of CHC patients compared with 38% of controls,so the use of IL28B SNP genotyping only in these patients may be of little value as a predictor of response.CMV reactivation occurred in 40% of CHC patients.Co-infection with CMV seriously diminished the response to interferon(IFN) therapy,with SVR rates in C/C genotypes 87.5% in CMV-negative patients and 12.5% in CMV-positive patients(P < 0.0001).SVR rates among C/T carriers were reduced to < 50% in patients with positive CMV DNA while the non-response rate doubled.These data indicate that a supplemental assay for CMV viremia adds to the prognostic value of IL28B genotyping.CONCLUSION:The results suggest that both genetic(i.e.,spontaneous) and therapeutic(IFN-based therapy) arms are complementary in the battle against HCV.CMV DNA testing may be of value to better predict the response to IFN,particularly in IL28B C/T carriers. | Mostafa K El Awady Noha G Bader El Din Ashraf Tabll Yaser El Hosary Ashraf O Abdel Aziz Hesham El Khayat Mohsen Salama Tawfeek H Abdelhafez | 2013 | World Journal of Gastroenterology2013，19，2： | 8 |
| 2 | Ever-increasing diversity of drug-induced pancreatitis显示文摘With over 100000 hospital admissions per annum,acute pancreatitis remains the leading gastrointestinal cause of hospitalization in the United States and has farreaching impact well beyond.It has become increasingly recognized that druginduced pancreatitis(DIP),despite accounting for less than 3%of all cases,represents an important and growing though often inconspicuous cause of acute pancreatitis.Nevertheless,knowledge of DIP is often curtailed by the limited availability of evidence needed to implicate given agents,especially for nonprescription medications.Indeed,the majority of available data is derived from case reports,case series,or case control studies.Furthermore,the mechanism of injury and causality for many of these drugs remain elusive as a definitive correlation is generally not established(<10%of cases).Several classification systems have been proposed,but no single system has been widely adopted,and periodic updates are required in light of ongoing pharmacologic expansion.Moreover,infrequently prescribed medications or those available over-thecounter(including herbal and other alternative remedies)are often overlooked as a potential culprit of acute pancreatitis.Herein,we review the ever-increasing diversity of DIP and the potential mechanisms of injury with the goal of raising awareness regarding the nature and magnitude of this entity.We believe this manuscript will aid in increasing both primary and secondary prevention of DIP,thus ultimately facilitating more expedient diagnosis and a decrease in DIPrelated morbidity. | Simcha Weissman Muhammad Aziz Ryan B Perumpail Tej I Mehta Rutwik Patel James H Tabibian | 2020 | World Journal of Gastroenterology2020，26，22： | 8 |
| 3 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 4 | Optical properties of thermally evaporated SnS thin films 显示文摘 | El- Nahass M M Zeyada H M Aziz M S | 2002 | Optical Materials2002，20，： | 2 |
| 5 | 普萘洛尔治疗婴幼儿血管瘤导致1例患儿体温变化显示文摘婴幼儿血管瘤在出生后几个月内迅速增殖,如不及时干预,常常遗留瘢痕、溃疡,更为严重的并发症会导致失明、气道阻塞等。目前的治疗方法包括手术、激光治疗及药物治疗等。普萘洛尔是美国药品食品监督管理局唯一许可的治疗血管瘤的药物,由于其亲脂特性,能够通过血脑屏障,增加中枢神经系统受到影响的风险。该文作者报告1例左前臂、躯干、臀部和鼻尖血管瘤的早产儿,放入保温箱时采用普萘洛尔治疗,结果无法脱离保温箱。 | Burkey BW Jacobs JA Aziz H 张凌 | 2017 | 中国口腔颌面外科杂志2017，15，4： | 2 |
| 6 | Rock fracture toughness determination by the Brazilian test显示文摘 | Guo H Aziz I Schmidt L C | 1993 | Engineering Geology1993，33，2： | 1 |
| 7 | Influence of r-irradiation on the bioconversion of rice straw by Tricho-derma vi ride显示文摘 | Youssef Bothaina M Aziz N H | 1999 | Into Single Cell Protein1999，97，386： | 1 |
| 8 | An overview of sigma-delta converters 显示文摘 | Aziz P M Sorensen H V Van der Spiegel J | 1996 | IEEE Signal Processing Magazine1996，13，1： | 1 |
| 9 | An overview of sigma-delta converters 显示文摘 | Aziz P M Sorensen H V Der Spiegel J V | 1996 | IEEE Signal Processing Magazine1996，68，1： | 1 |
| 10 | Heavy metals removal from water in Malaysia: Post treatment by high quality limestone 显示文摘 | AZIZ H A ADLAN M N ARIFFIN K S | 2008 | Bioresource Technology2008，99，6： | 1 |
| 11 | Visceral hypersensitivity in nonerosive reflux disease 显示文摘 | Knowles C H Aziz Q | 2008 | Gut2008，57，5： | 1 |
| 12 | Polyethersulfone(PES)-silver composite UF membrane:effect of silver loading andPVP molecular weight on membrane morphology andantibacterial activity显示文摘 | Basri H Ismail A F Aziz M | 2011 | Desalination2011，273，： | 1 |
| 13 | Complementation of defective colony - stimulating factor 1 receptor signaling and mitogenesis by Raf and v- Src显示文摘 | Aziz N Cherwinski H McMabon M | 1999 | Mol Cell Biol1999，19，2： | 1 |
| 14 | Adsorption of direct dye on palm ash:Kinetic and equilibrium modeling显示文摘 | AHMAD A A HAMEED B H AZIZ N | 2007 | Journal of Hazardous Materials2007，141，1： | 1 |
| 15 | Laparoscopic endoscopic single-site sur- gery versus conventional laparoscopic surgery for acute appendicitis in an adult population显示文摘 | Aziz H Kukar M Zemon H | 2014 | Am Surg2014，80，1： | 1 |
| 16 | The Kawase approach to retrosellar and upper clival basilar aneurysms 显示文摘 | AZIZ K M VAN LOVEREN H R TEW J M JR | 1999 | Neurosurgery1999，44，6： | 1 |
| 17 | Degradation Mechanism of small molecule-based organic light-emitting devices 显示文摘 | Aziz H Z Popovic Z Hu N X | 1999 | Science1999，283，： | 1 |
| 18 | Exendin-4, a GLP-1 receptor agonist, interacts with proteins and their products of digestion to suppress food intake in rats 显示文摘 | Aziz A Anderson G H | 2003 | Nutritional Neurosciences Bull Exp Biol Med2003，135，6： | 1 |
| 19 | Bowel habits and toilet training in rural and urban dwelling children in a developing country显示文摘 | Aziz S Moiz Fakih H A Di Lorenzo C | 2011 | J Pediatr2011，158，5： | 1 |
| 20 | Design, synthesis and antibacterial activity of fluoroquinolones containing bulky arene- sulfonyl fragment: 2D - QSAR and docking study 显示文摘 | Abdel- Aziz A A Asiri Y A A1- Agamy M H | 2011 | European Journal of Medicinal Chemistry2011，46，11： | 1 |
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