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| 1 | Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection显示文摘Injuries to the postnatal skeleton are naturally repaired through successive stepsinvolving specific cell types in a process collectively termed “bone regeneration”.Although complex, bone regeneration occurs through a series of well-orchestratedstages wherein endogenous bone stem cells play a central role. In most situations,bone regeneration is successful;however, there are instances when it fails andcreates non-healing injuries or fracture nonunion requiring surgical or therapeuticinterventions. Transplantation of adult or mesenchymal stem cells (MSCs) definedby the International Society for Cell and Gene Therapy (ISCT) as CD105+-CD90+CD73+CD45-CD34-CD14orCD11b-CD79αorCD19-HLA-DR- is beinginvestigated as an attractive therapy for bone regeneration throughout the world.MSCs isolated from adipose tissue, adipose-derived stem cells (ADSCs), aregaining increasing attention since this is the most abundant source of adult stemcells and the isolation process for ADSCs is straightforward. Currently, there isnot a single Food and Drug Administration (FDA) approved ADSCs product forbone regeneration. Although the safety of ADSCs is established from their usagein numerous clinical trials, the bone-forming potential of ADSCs and MSCs, ingeneral, is highly controversial. Growing evidence suggests that the ISCT definedphenotype may not represent bona fide osteoprogenitors. Transplantation of bothADSCs and the CD105- sub-population of ADSCs has been reported to induce bone regeneration. Most notably, cells expressing other markers such as CD146,AlphaV, CD200, PDPN, CD164, CXCR4, and PDGFRα have been shown torepresent osteogenic sub-population within ADSCs. Amongst other strategies toimprove the bone-forming ability of ADSCs, modulation of VEGF, TGF-β1 andBMP signaling pathways of ADSCs has shown promising results. The U.S. FDAreveals that 73% of Investigational New Drug applications for stem cell-basedproducts rely on CD105 expression as the “positive” marker for adult stem cells.A concerted effort involving the scientific community, clinicians, industries, andregulatory bodies to redefine ADSCs using powerful selection markers andstrategies to modulate signaling pathways of ADSCs will speed up thetherapeutic use of ADSCs for bone regeneration. | Quang Le Vedavathi Madhu Joseph M Hart Charles R Farber Eli R Zunder Abhijit S Dighe Quanjun Cui | 2021 | World Journal of Stem Cells2021，13，9： | 2 |
| 2 | Hyperexpression of bio-logically active human chorionic gonado-tropin usingthe methylotropic yeast,Pichia pastoris显示文摘 | SEN GUPTA C DIGHE R R | 1999 | Mol Endo-crinol1999，22，： | 1 |
| 3 | Biological activity of sin-gle chain chorionic gonadotropin,hCGαβ,is decreasedupon deletion of Wve carboxyl terminal amino acids ofthe alpha subunit without a fecting its receptor binding显示文摘 | SEN GUPTA C DIGHE R R | 2000 | Mol Endocrinol2000，24，： | 1 |
| 4 | Aanlysis of transmit-receive diversity in rayleigh fading显示文摘 | DIGHE P MALLIK R JAMUAR S | 2003 | IEEE Trans on Communications2003，51，4： | 1 |
| 5 | Analysis of transmit-receive diversity in Rayleigh fading显示文摘 | Dighe P A Mallik R K Jamuar S S | 2003 | IEEE Transactions on Communications2003，51，4： | 1 |
| 6 | Insulin receptor signaling in cones显示文摘 | Rajala A Dighe R Agbaga MP | 2013 | J Biol Chem2013，288，19： | 1 |
| 7 | Specific immunoneutralization of FSH leads to apoptotic cell death of the pachytene spermatocytes and spermatogonial cells in the rat 显示文摘 | SHETTY J MARATHE G K DIGHE R R | 1996 | Endocrinology1996，137，： | 1 |
| 8 | A 48-core IA-32 processorin 45 nm CMOS using on-die message-passing and DVFS for per-formance and power scaling显示文摘 | Howard J Dighe S Vangal S R | 2011 | Solid-State Circuits IEEE Journalof2011，46，1： | 1 |
| 9 | Bioequivalence of racemic drugs显示文摘 | DIGHE SV WILLIAMS R | 1992 | J Clin Pharmacol1992，32，10： | 1 |
| 10 | Analysis of transmit- receive diversity in Rayleigh fading显示文摘 | Dighe P A Mallik R K Jamuar S S | 2003 | IEEE Transactions on Communications2003，51，6： | 1 |
| 11 | Boron-lined proportional counters with im- proved neutron sensitivity 显示文摘 | DIGHE P M PRASAD D N PRASAD K R | 2003 | Nuclear Instruments and Methods in Physics Research A2003，496，： | 1 |
| 12 | Analysis of transmit-receive diversity in Rayleigh fading 显示文摘 | Dighe P A Mallik R K Jamuar S S | 2003 | IEEE Transactions on Communications2003，51，4： | 1 |
| 13 | Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway显示文摘 | Meraz M A White J M Sheehan K C Bach E A Rodig S J Dighe A S Kaplan D H Riley J K Greenlund A C Campbell D Carver-Moore K DuBois R N Clark R Aguet M Schreiber R D | | 0，，3： | 1 |
| 14 | Silver-lined proportional counter for detection of pulsed neutrons显示文摘 | DIGHE P M PRASAD K R KATARIA S K | 2004 | Nucl Instr and Meth A2004，523，： | 1 |
| 15 | A 48-core IA-32 processor in 45 nm CMOS using on-die message-passing and DVFS for performance and power scaling显示文摘 | HOWARD J DIGHE S VANGAL S R | 2010 | IEEE Journal of Solid-State Circuits2010，46，1： | 1 |
| 16 | Congenital Hypothyroidism in a Lhasa Apso pup显示文摘 | Muley V D Dighe D G Gaikwad R V | 2008 | Australian veterinary journal2008，65，12： | 1 |
| 17 | Single Chain Human Chorionic Gonadotropin, hCGalpha/beta : Effects of Mutations in the Alpha Subunit on Structure and Bioactivity显示文摘 | Setlur S R Dighe R R | 2007 | Glycoconj J2007，24，1： | 1 |
| 18 | A 48-Core IA- 32 processor in 45 nm CMOS using on-die message- passing and DVFS for performance and power scaling显示文摘 | HOWARD J DIGHE S SRIRAM R | 2011 | IEEE Journal of Solid- State Circuits2011，46，1： | 1 |
| 19 | Analysis of transmit-receive diversity in Rayleigh fading显示文摘 | Dighe P A Mallik R K Jamuar S S | 2003 | IEEE Transactions on Communications2003，51，4： | 1 |
| 20 | β-Endorphin antagonizes the effects ofα-MSH on food intake and body weight显示文摘 | Dutia R Meece K Dighe S | 2012 | Endocrinology2012，153，9： | 1 |
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