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| 1 | A review of UHMWPE wear-induced osteolysis:the role for early detection of the immune response显示文摘In a world where increasing joint arthroplasties are being performed on increasingly younger patients,osteolysis as the leading cause of failure after total joint arthroplasty(TJA) has gained considerable attention.Ultra-high molecular weight polyethylene wear-induced osteolysis is the process by which prosthetic debris mechanically released from the surface of prosthetic joints induces an immune response that favors bone catabolism, resulting in loosening of prostheses with eventual failure or fracture. The immune response initiated is innate in that it is nonspecific and self-propagating, with monocytic cells and osteoclasts being the main effectors. To date, detecting disease early enough to implement effective intervention without unwanted systemic side effects has been a major barrier. These barriers can be overcome using newer in vivo imaging techniques and modules linked with fluorescence and/or chemotherapies. We discuss the pathogenesis of osteolysis, and provide discussion of the challenges with imaging and therapeutics. We describe a positron emission tomography imaging cinnamoyl-Phe-(D)-Leu-Phe-(D)-Leu-Phe-Lys module,specific to macrophages, which holds promise in early detection of disease and localization of treatment.Further research and increased collaboration among therapeutic and three-dimensional imaging researchers are essential in realizing a solution to clinical osteolysis in TJA. | Adrese M Kandahari Xinlin Yang Kevin A Laroche Abhijit S Dighe Dongfeng Pan Quanjun Cui | 2016 | Bone Research2016，4，2： | 7 |
| 2 | Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection显示文摘Injuries to the postnatal skeleton are naturally repaired through successive stepsinvolving specific cell types in a process collectively termed “bone regeneration”.Although complex, bone regeneration occurs through a series of well-orchestratedstages wherein endogenous bone stem cells play a central role. In most situations,bone regeneration is successful;however, there are instances when it fails andcreates non-healing injuries or fracture nonunion requiring surgical or therapeuticinterventions. Transplantation of adult or mesenchymal stem cells (MSCs) definedby the International Society for Cell and Gene Therapy (ISCT) as CD105+-CD90+CD73+CD45-CD34-CD14orCD11b-CD79αorCD19-HLA-DR- is beinginvestigated as an attractive therapy for bone regeneration throughout the world.MSCs isolated from adipose tissue, adipose-derived stem cells (ADSCs), aregaining increasing attention since this is the most abundant source of adult stemcells and the isolation process for ADSCs is straightforward. Currently, there isnot a single Food and Drug Administration (FDA) approved ADSCs product forbone regeneration. Although the safety of ADSCs is established from their usagein numerous clinical trials, the bone-forming potential of ADSCs and MSCs, ingeneral, is highly controversial. Growing evidence suggests that the ISCT definedphenotype may not represent bona fide osteoprogenitors. Transplantation of bothADSCs and the CD105- sub-population of ADSCs has been reported to induce bone regeneration. Most notably, cells expressing other markers such as CD146,AlphaV, CD200, PDPN, CD164, CXCR4, and PDGFRα have been shown torepresent osteogenic sub-population within ADSCs. Amongst other strategies toimprove the bone-forming ability of ADSCs, modulation of VEGF, TGF-β1 andBMP signaling pathways of ADSCs has shown promising results. The U.S. FDAreveals that 73% of Investigational New Drug applications for stem cell-basedproducts rely on CD105 expression as the “positive” marker for adult stem cells.A concerted effort involving the scientific community, clinicians, industries, andregulatory bodies to redefine ADSCs using powerful selection markers andstrategies to modulate signaling pathways of ADSCs will speed up thetherapeutic use of ADSCs for bone regeneration. | Quang Le Vedavathi Madhu Joseph M Hart Charles R Farber Eli R Zunder Abhijit S Dighe Quanjun Cui | 2021 | World Journal of Stem Cells2021，13，9： | 2 |
| 3 | Analysis of laboratory critical value reporting at a large academic medical center 显示文摘 | Dighe A S Rao A Coakley A B | 2006 | Am J Clin Pathol2006，125，： | 1 |
| 4 | Analytical methods validation: Bioavailability, bio-equivalence and pharmacokinetic studies 显示文摘 | SHAH V P MIDHA K K DIGHE S | 1992 | J Pharm Sci1992，81，： | 1 |
| 5 | Analysis of Laboratory CriticalValue Reporting at a Large Academic Medical Center 显示文摘 | Anand S Dighe MD Aijun Rao | 2006 | Am JClin Pathol2006，125，： | 1 |
| 6 | Analysis of labo- ratory critical value reporting at a large academic medical center显示文摘 | Dighe A S Rao A Coakley A B | 2006 | Am J Clin Pathol2006，125，5： | 1 |
| 7 | Aanlysis of transmit-receive diversity in rayleigh fading显示文摘 | DIGHE P MALLIK R JAMUAR S | 2003 | IEEE Trans on Communications2003，51，4： | 1 |
| 8 | Analysis of transmit-receive diversity in Rayleigh fading显示文摘 | Dighe P A Mallik R K Jamuar S S | 2003 | IEEE Transactions on Communications2003，51，4： | 1 |
| 9 | Analytical methods validation: Bioavailability ,bioequivalence and pharmacokinetie studies显示文摘 | SHAH V P MIDHA K K DIGHE S | 1992 | Pharm Res1992，9，4： | 1 |
| 10 | Regulation of the interleukin (IL)-12R beta 2 subunit expression in devdoping T helper 1 (Th1) and Th2 cells显示文摘 | Szabo S J Dighe A S Gubler U | 1997 | J Exp Med1997，185，5： | 1 |
| 11 | Thyroid nodule classification using ultrasound elastography via linear discriminant analysis显示文摘 | Luo S Kim EH Dighe M | 2011 | Ultrasonics2011，51，： | 1 |
| 12 | Survey of critical value reporting and reduction of false-positive critical value results 显示文摘 | Dighe AS Jones JB Parham S | 2008 | Arch Pathol Lab Med2008，132，10： | 1 |
| 13 | Analysis of laboratory criti- cal value reporting at a large academic nledicalcenter显示文摘 | Dighe A S Rao A Coakley A B eta! | 2006 | American Journal of Clinical Pathology''2006，125，5： | 1 |
| 14 | Analytical methods validation: bioavailability, bioequivalence and pharmacokinetic studies显示文摘 | Shah V'P Midha KK Dighe S etal | 1992 | J Pharm Sci1992，81，3： | 1 |
| 15 | Analysis of Transmit-receive Diversity in Rayleigh Fading 显示文摘 | Dighe P A Mallik P K Jamuar S S | 2003 | IEEE Transacations on Communications2003，51，4： | 1 |
| 16 | Survey of critical value repor ting and reduction of fales-positive critical value results显示文摘 | Dighe AS Jones J B Parham S | 2008 | Arch Pathol Lab Med2008，132，10： | 1 |
| 17 | Accuracy of radiological staging in identifying high-risk colon cancer patients suitable for neoadjuvant chemotherapy: a muhieentre experience 显示文摘 | Dighe S Swift I Magill L | 2012 | Colorectal Dis2012，14，4： | 1 |
| 18 | Computerized provider order entry in the clinical laboratory显示文摘 | Baron J M Dighe A S | 2011 | J Pathol Inform2011，，2： | 1 |
| 19 | A 48-core IA-32 processorin 45 nm CMOS using on-die message-passing and DVFS for per-formance and power scaling显示文摘 | Howard J Dighe S Vangal S R | 2011 | Solid-State Circuits IEEE Journalof2011，46，1： | 1 |
| 20 | Chronic hepatic artery occlusion with collateral formation:imaging findings and outcomes显示文摘 | Vaidya S Dighe M Bhargava P | | 0，，05： | 1 |
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