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| 1 | A review of UHMWPE wear-induced osteolysis:the role for early detection of the immune response显示文摘In a world where increasing joint arthroplasties are being performed on increasingly younger patients,osteolysis as the leading cause of failure after total joint arthroplasty(TJA) has gained considerable attention.Ultra-high molecular weight polyethylene wear-induced osteolysis is the process by which prosthetic debris mechanically released from the surface of prosthetic joints induces an immune response that favors bone catabolism, resulting in loosening of prostheses with eventual failure or fracture. The immune response initiated is innate in that it is nonspecific and self-propagating, with monocytic cells and osteoclasts being the main effectors. To date, detecting disease early enough to implement effective intervention without unwanted systemic side effects has been a major barrier. These barriers can be overcome using newer in vivo imaging techniques and modules linked with fluorescence and/or chemotherapies. We discuss the pathogenesis of osteolysis, and provide discussion of the challenges with imaging and therapeutics. We describe a positron emission tomography imaging cinnamoyl-Phe-(D)-Leu-Phe-(D)-Leu-Phe-Lys module,specific to macrophages, which holds promise in early detection of disease and localization of treatment.Further research and increased collaboration among therapeutic and three-dimensional imaging researchers are essential in realizing a solution to clinical osteolysis in TJA. | Adrese M Kandahari Xinlin Yang Kevin A Laroche Abhijit S Dighe Dongfeng Pan Quanjun Cui | 2016 | Bone Research2016，4，2： | 7 |
| 2 | Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection显示文摘Injuries to the postnatal skeleton are naturally repaired through successive stepsinvolving specific cell types in a process collectively termed “bone regeneration”.Although complex, bone regeneration occurs through a series of well-orchestratedstages wherein endogenous bone stem cells play a central role. In most situations,bone regeneration is successful;however, there are instances when it fails andcreates non-healing injuries or fracture nonunion requiring surgical or therapeuticinterventions. Transplantation of adult or mesenchymal stem cells (MSCs) definedby the International Society for Cell and Gene Therapy (ISCT) as CD105+-CD90+CD73+CD45-CD34-CD14orCD11b-CD79αorCD19-HLA-DR- is beinginvestigated as an attractive therapy for bone regeneration throughout the world.MSCs isolated from adipose tissue, adipose-derived stem cells (ADSCs), aregaining increasing attention since this is the most abundant source of adult stemcells and the isolation process for ADSCs is straightforward. Currently, there isnot a single Food and Drug Administration (FDA) approved ADSCs product forbone regeneration. Although the safety of ADSCs is established from their usagein numerous clinical trials, the bone-forming potential of ADSCs and MSCs, ingeneral, is highly controversial. Growing evidence suggests that the ISCT definedphenotype may not represent bona fide osteoprogenitors. Transplantation of bothADSCs and the CD105- sub-population of ADSCs has been reported to induce bone regeneration. Most notably, cells expressing other markers such as CD146,AlphaV, CD200, PDPN, CD164, CXCR4, and PDGFRα have been shown torepresent osteogenic sub-population within ADSCs. Amongst other strategies toimprove the bone-forming ability of ADSCs, modulation of VEGF, TGF-β1 andBMP signaling pathways of ADSCs has shown promising results. The U.S. FDAreveals that 73% of Investigational New Drug applications for stem cell-basedproducts rely on CD105 expression as the “positive” marker for adult stem cells.A concerted effort involving the scientific community, clinicians, industries, andregulatory bodies to redefine ADSCs using powerful selection markers andstrategies to modulate signaling pathways of ADSCs will speed up thetherapeutic use of ADSCs for bone regeneration. | Quang Le Vedavathi Madhu Joseph M Hart Charles R Farber Eli R Zunder Abhijit S Dighe Quanjun Cui | 2021 | World Journal of Stem Cells2021，13，9： | 2 |
| 3 | High-intensity focused ultrasound:current potential and oncologic applications显示文摘 | Dubinsky T J Cuevas C Dighe M K | 2008 | AJR Am J Roentgenol2008，190，1： | 1 |
| 4 | Ultrasound thyroid elastography using carotid artery pulsation: preliminary study 显示文摘 | Bae U Dighe M Dubinsky T | 2009 | Ultrasound Med2009，26，3： | 1 |
| 5 | Thyroid nodule classification using ultrasound elastography via linear discriminant analysis显示文摘 | Luo S Kim EH Dighe M | 2011 | Ultrasonics2011，51，： | 1 |
| 6 | Ultrasound thyroid elastography using carotid artery pulsation:preliminary study显示文摘 | Bae U Dighe M Dubinsky T | | 0，，06： | 1 |
| 7 | Modeling stress state dependent damage evolution in a cast Al-Si-Mg aluminum alloy显示文摘 | HORSTEMEYER M F LATHROP J GOKHALE A M DIGHE M | 2000 | Theo Appl Frac Mech2000，33，： | 1 |
| 8 | Computerized provider order entry in the clinical laboratory显示文摘 | Baron J M Dighe A S | 2011 | J Pathol Inform2011，，2： | 1 |
| 9 | Chronic hepatic artery occlusion with collateral formation:imaging findings and outcomes显示文摘 | Vaidya S Dighe M Bhargava P | | 0，，05： | 1 |
| 10 | “Pre-pre”and”post-post”analytical error:high-incidence patient safety hazardsinvolving the clinical laboratory显示文摘 | Laposata M Dighe A | 2007 | Clin Chem Lab Med2007，45，6： | 1 |
| 11 | Sonographic and color Doppler findings in aortoarteritis (Takayasu Arteritis)显示文摘 | Chaubal N Dighe M Shah M | 2004 | J Ultrasound Med2004，23，7： | 1 |
| 12 | Sonographic and color Doppler findings in aortoarteritis(Takayasu arteritis)显示文摘 | Chaubal N Dighe M Shah M | 2004 | J Ultrasound Med2004，23，7： | 1 |
| 13 | Effect of strain rate on damage evolution in a cast Al-Si-Mg base alloy 显示文摘 | DIGHE M D GOKHALE A M HORSTEMEYER M F MOSHER D A | 2000 | Metallurgical and Materials Transactions A2000，31，： | 1 |
| 14 | Standardization of fetal ultrasound biometry measurements: improving the quality and consistency of measurements显示文摘 | Sarris I Ioannou C Dighe M el al | 2011 | Ultrasound Obstet Gynecol2011，38，6： | 1 |
| 15 | Boron-lined proportional counters with im- proved neutron sensitivity 显示文摘 | DIGHE P M PRASAD D N PRASAD K R | 2003 | Nuclear Instruments and Methods in Physics Research A2003，496，： | 1 |
| 16 | Preoperative plan- ning for renal cell carcinoma----benefits of 64-slice CT imaging显示文摘 | Dighe M Takayama T Bush WH Jr | 2007 | Int Braz J Urol2007，33，3： | 1 |
| 17 | Gestational trophoblast-ic disease: multimmadality imaging assessment with specialemphasis on spectrum of abnormalities and value of ima-ging in staging and management of disease 显示文摘 | Kani KK Lee JH Dighe M | 2012 | Curr ProblDiagn Radiol2012，41，1： | 1 |
| 18 | Efficacy of thyroid ultrasound elastography in differential diagnosis of small thyroid nodules显示文摘 | Dighe M Luo S Cuevas C | 2013 | Eur J Radiol2013，82，6： | 1 |
| 19 | Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway显示文摘 | Meraz M A White J M Sheehan K C Bach E A Rodig S J Dighe A S Kaplan D H Riley J K Greenlund A C Campbell D Carver-Moore K DuBois R N Clark R Aguet M Schreiber R D | | 0，，3： | 1 |
| 20 | Silver-lined proportional counter for detection of pulsed neutrons显示文摘 | DIGHE P M PRASAD K R KATARIA S K | 2004 | Nucl Instr and Meth A2004，523，： | 1 |
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