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72篇 您的检索式:作者名="Dighe A"
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1A review of UHMWPE wear-induced osteolysis:the role for early detection of the immune response显示文摘In a world where increasing joint arthroplasties are being performed on increasingly younger patients,osteolysis as the leading cause of failure after total joint arthroplasty(TJA) has gained considerable attention.Ultra-high molecular weight polyethylene wear-induced osteolysis is the process by which prosthetic debris mechanically released from the surface of prosthetic joints induces an immune response that favors bone catabolism, resulting in loosening of prostheses with eventual failure or fracture. The immune response initiated is innate in that it is nonspecific and self-propagating, with monocytic cells and osteoclasts being the main effectors. To date, detecting disease early enough to implement effective intervention without unwanted systemic side effects has been a major barrier. These barriers can be overcome using newer in vivo imaging techniques and modules linked with fluorescence and/or chemotherapies. We discuss the pathogenesis of osteolysis, and provide discussion of the challenges with imaging and therapeutics. We describe a positron emission tomography imaging cinnamoyl-Phe-(D)-Leu-Phe-(D)-Leu-Phe-Lys module,specific to macrophages, which holds promise in early detection of disease and localization of treatment.Further research and increased collaboration among therapeutic and three-dimensional imaging researchers are essential in realizing a solution to clinical osteolysis in TJA.Adrese M Kandahari Xinlin Yang Kevin A Laroche Abhijit S Dighe Dongfeng Pan Quanjun Cui 2016Bone Research2016,4,2:7
2Analysis of laboratory critical value reporting at a large academic medical center 显示文摘Dighe A S Rao A Coakley A B 2006Am J Clin Pathol2006,125,:1
3Analysis of laboratory critical value reporting at a large academic medicalcenter显示文摘Dighe AS Ran A Coakley AB 2006Am J Clin Pathol2006,125,5:1
4Analysis of laboratory critical value reporting at a large academic medical center显示文摘Dighe AS Ran A Coakley AB 2006Am J Clin Pathol2006,125,5:1
5Analysis of labo- ratory critical value reporting at a large academic medical center显示文摘Dighe A S Rao A Coakley A B 2006Am J Clin Pathol2006,125,5:1
6Analysis of transmit-receive diversity in Rayleigh fading显示文摘Dighe P A Mallik R K Jamuar S S 2003IEEE Transactions on Communications2003,51,4:1
7Regulation of the interleukin (IL)-12R beta 2 subunit expression in devdoping T helper 1 (Th1) and Th2 cells显示文摘Szabo S J Dighe A S Gubler U 1997J Exp Med1997,185,5:1
8Identification of T helper and linear B epitope in the hypervariable region of nucleocapsid protein of PPRV and its use in the development of specific antibodies to detect viral antigen显示文摘DECHAMMA H J DIGHE V KUMAR C A 2006Vet Microbiol2006,118,34:1
9Analysis of laboratory criti- cal value reporting at a large academic nledicalcenter显示文摘Dighe A S Rao A Coakley A B eta! 2006American Journal of Clinical Pathology''2006,125,5:1
10Insulin receptor signaling in cones显示文摘Rajala A Dighe R Agbaga MP 2013J Biol Chem2013,288,19:1
11Analysis of Transmit-receive Diversity in Rayleigh Fading 显示文摘Dighe P A Mallik P K Jamuar S S 2003IEEE Transacations on Communications2003,51,4:1
12Modeling stress state dependent damage evolution in a cast Al-Si-Mg aluminum alloy显示文摘HORSTEMEYER M F LATHROP J GOKHALE A M DIGHE M 2000Theo Appl Frac Mech2000,33,:1
13Computerized provider order entry in the clinical laboratory显示文摘Baron J M Dighe A S 2011J Pathol Inform2011,,2:1
14“Pre-pre”and”post-post”analytical error:high-incidence patient safety hazardsinvolving the clinical laboratory显示文摘Laposata M Dighe A 2007Clin Chem Lab Med2007,45,6:1
15Analysis of laboratory critical value reporting at a large academic medical center显示文摘Dighe A S Rao A Coakley AB 2006Am J Clin Pathol2006,125,:1
16Analysis of transmit- receive diversity in Rayleigh fading显示文摘Dighe P A Mallik R K Jamuar S S 2003IEEE Transactions on Communications2003,51,6:1
17Effect of strain rate on damage evolution in a cast Al-Si-Mg base alloy 显示文摘DIGHE M D GOKHALE A M HORSTEMEYER M F MOSHER D A 2000Metallurgical and Materials Transactions A2000,31,:1
18Analysis of transmit-receive diversity in Rayleigh fading 显示文摘Dighe P A Mallik R K Jamuar S S 2003IEEE Transactions on Communications2003,51,4:1
19Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway显示文摘Meraz M A White J M Sheehan K C Bach E A Rodig S J Dighe A S Kaplan D H Riley J K Greenlund A C Campbell D Carver-Moore K DuBois R N Clark R Aguet M Schreiber R D 0,,3:1
20Effect of loading condition and stress state on damage evolution of silicon particles in an A1 Si-Mg-Base cast alloy显示文摘DIGHE M D GOKHALE A M HORSTEMEYER M F 2002Metallurgical and Ma- terials Transactions2002,33,:1
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