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| 1 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 2 | Influence of whole peptidoglycan of bifidobacterium on cytotoxic effectors produced by mouse peritoneal macrophages显示文摘INTRODUCTIONBifidobacteria are physiologically beneficial bacteria which are perdominant in human intestine ,and possess the most important functions .They play an important role in maintaining microbial balance of the intestine .Furthermore , their presence is thought to be an important indication of health of the body [1-4].Whole peptidoglycan ( WPG) is the major component in the cell wall of bifidobacterium ,which is also a biological responsemodifier with nontoxic side dffcets. | Li Sheng Wang~1 Hui Ming Zhu~1 Dian Yuan Zhou~2 Yu Lin Wang~1 Wan Dai Zhang~2 ~1Departrnent of Gastroenterology,Shenzhen Municipal People’s Hospital,Jinan University of Medical Sciences,Shenzhen 518020,Guangdong Province,China ~2Chinese PLA Institute of Digestion,the First Military Medical University,Guangzhou 510515,Guangdong Province,ChinaLi Sheng Wang graduated and obtained Ph.D,from the First Military Medical University in 1998,now working at Department of Gastroenterology,Shenzhen Municipal People’s Hospital.Jinan University of Medical Sciences.having 35 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 15 |
| 3 | Evaluation of health benefit using Ben MAP-CE with an integrated scheme of model and monitor data during Guangzhou Asian Games显示文摘Guangzhou is the capital and largest city(land area:7287 km2)of Guangdong province in South China.The air quality in Guangzhou typically worsens in November due to unfavorable meteorological conditions for pollutant dispersion.During the Guangzhou Asian Games in November 2010,the Guangzhou government carried out a number of emission control measures that significantly improved the air quality.In this paper,we estimated the acute health outcome changes related to the air quality improvement during the 2010 Guangzhou Asian Games using a next-generation,fully-integrated assessment system for air quality and health benefits.This advanced system generates air quality data by fusing model and monitoring data instead of using monitoring data alone,which provides more reliable results.The air quality estimates retain the spatial distribution of model results while calibrating the value with observations.The results show that the mean PM_2.5concentration in November 2010 decreased by 3.5μg/m^3 compared to that in 2009 due to the emission control measures.From the analysis,we estimate that the air quality improvement avoided 106 premature deaths,1869 cases of hospital admission,and 20,026 cases of outpatient visits.The overall cost benefit of the improved air quality is estimated to be 165 million CNY,with the avoided premature death contributing 90%of this figure.The research demonstrates that Ben MAP-CE is capable of assessing the health and cost benefits of air pollution control for sound policy making. | Dian Ding Yun Zhu Carey Jang Che-Jen Lin Shuxiao Wang Joshua Fu Jian Gao Shuang Deng Junping Xie Xuezhen Qiu | 2016 | Journal of Environmental Sciences2016，28，4： | 13 |
| 4 | Design and demonstration of a next-generation air quality attainment assessment system for PM_(2.5)and O_3显示文摘Due to the increasingly stringent standards, it is important to assess whether the proposed emission reduction will result in ambient concentrations that meet the standards. The Software for Model Attainment Test—Community Edition(SMAT-CE) is developed for demonstrating attainment of air quality standards of O3 and PM2.5. SMAT-CE improves computational efficiency and provides a number of advanced visualization and analytical functionalities on an integrated GIS platform. SMAT-CE incorporates historical measurements of air quality parameters and simulated air pollutant concentrations under a number of emission inventory scenarios to project the level of compliance to air quality standards in a targeted future year. An application case study of the software based on the U.S. National Ambient Air Quality Standards(NAAQS) shows that SMAT-CE is capable of demonstrating the air quality attainment of annual PM2.5and 8-hour O3 for a proposed emission control policy. | Hua Wang Yun Zhu Carey Jang Che-Jen Lin Shuxiao Wang Joshua S.Fu Jian Gao Shuang Deng Junping Xie Dian Ding Xuezhen Qiu Shicheng Long | 2015 | Journal of Environmental Sciences2015，27，3： | 11 |
| 5 | DESIGN AND DEVELOPMENT OF A HIGH PERFORMANCE ANODE FOR CHLORINE-EVOLUTION显示文摘The literatures were analyzed,ingredients were designed»the mono/double layered structures were experimented.It was found that the excellent titanium anodes could be obtained by adding cobalt into the intermediate layer.So an anode material with both high activity and corrosion resistance was developed. | Tang Dian Lin Xuan Cui Xiong Yan Qi | 1996 | Transactions of Nonferrous Metals Society of China1996，6，1： | 8 |
| 6 | Development of an integrated policy making tool for assessing air quality and human health benefits of air pollution control显示文摘有效空气质量管理是批评的保护公共健康免受空气污染的不利影响的伤害。为了评估空气污染的有效性,控制策略, US 环境保护机构(美国 EPA )开发了软件让模型成就测试社区编辑( SMAT-CE )估计排放减小的空气质量成就,并且印射的环境好处和编辑( BenMAP-CE )分别地空气质量改进有益于评估健康和经济的分析节目社区。后来科学的决策要求及时、协调的信息,开发在 SMAT-CE 之间的连接,进一个综合评价平台的 BenMAP-CE 是合乎需要的。探讨这需要,连接 SMAT-CE 到 BenMAP-CE 的一个新模块被开发了并且测试。新模块优化对优秀、人的健康为建议空气污染控制策略有益于的空气的评价。它也实现没有损害精确性,显著地提高计算效率的一个优化数据 gridding 算法。综合软件包裹的性能通过案例研究被表明评估质量和联系经济下午 2.5 的公民级的控制策略有益于的空气。案例研究的结果证明建议排放减小基于 US 国家周围的空气质量标准从 379 ~ 25 减少 nonattainment 地点的数字,从改进公共健康每年多于经济好处的 3340 亿美元导致。在这研究的基于科学的软件工具的集成提高为政策制造者开发有效、优化的排放控制策略的效率。 | Xuezhen QIU Yun ZHU Carey JANG Che-Jen LIN Shuxiao WANG Joshua FU Junping XIE Jiandong WANG Dian DING Shicheng LONG | 2015 | Frontiers of Environmental Science & Engineering2015，9，6： | 6 |
| 7 | Dynamic Balance Control Based on an Adaptive Gain-scheduled Backstepping Scheme for Power-line Inspection Robots显示文摘This paper presents an adaptive gain-scheduled backstepping control(AGSBC) scheme for the balance control of an underactuated mechanical power-line inspection(PLI) robotic system with two degrees of freedom and a single control input.First, a nonlinear dynamic model of the balance adjustment process of the PLI robot is constructed, and then the model is linearized at a nominal equilibrium point to overcome the computational infeasibility of the conventional backstepping technique. Second, to solve generalized stabilization control issue for underactuated systems with multiple equilibrium points,an equilibrium manifold linearized model is developed using a scheduling variable, and then a gain-scheduled backstepping control(GSBC) scheme for expanding the operational area of the controlled system is constructed. Finally, an adaptive mechanism is proposed to counteract the impact of external disturbances. The robust stability of the closed-loop system is ensured by Lyapunov theorem. Simulation results demonstrate the effectiveness and high performance of the proposed scheme compared with other control schemes. | Songyi Dian Lin Chen Son Hoang Ming Pu Junyong Liu | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，1： | 6 |
| 8 | Effects of antiviral therapy on hepatitis B virus reactivation and liver function after resection or chemoembolization for hepatocellular carcinoma显示文摘 | Xiang‐Ming Lao Guangyu Luo Liang‐Tao Ye Cheng Luo Ming Shi Dian Wang Rongping Guo Minshan Chen Shengping Li Xiaojun Lin Yunfei Yuan | 2013 | Liver Int2013，，4： | 3 |
| 9 | A Family of Nonnormal Cayley Digraphs | Yan Quan FENG Dian Jun WANG Jing Lin CHEN | 2001 | Acta Mathematica Sinica,English Series2001，17，1： | 3 |
| 10 | Pharmacokinetic and pharmacodynamic evidence for developing an oral formulation of octreotide against gastric mucosal injury显示文摘在 somatostatin 类似物之中, octreotide (10 月) 是通常经由静脉内或下的注射在诊所过去常治疗生长荷尔蒙, gastrin 或胰岛素的增加的分泌物引起的各种各样的疾病的大多数。以便 assesse 开发 10 月的口头的明确的表达的可行性,我们在几个动物模型进行了 10 月的系统的 pharmacokinetic 和 pharmacodynamic 分析。在老鼠的 pharmacokinetic 研究证明 10 月的 intragastric 管理有极其低的 bioavailability (<0.5%) ,但是它能明确地在老鼠胃由于 somatostatin 受体 2 的高表示(SSTR2 ) 散布到胃的 mucosa。pharmacodynamic 研究表明 10 月的 intragastric 管理 dose-dependently 带着胃的溃疡,它比得上那些由 10 月的静脉内的注射完成了的导致 WIRS 的老鼠在老鼠免于胃的 mucosal 损害(GMI ) ,并且这效果被 CYN-154806 的合作管理显著地稀释, SSTR2 的一个对手。在幽门的导致结扎的溃疡老鼠,我们进一步证明那个 10 月显著地减少了胃的酸的分泌物经由下面调整 gastrin 的水平,它为对 GMI 的 10 月的保护的效果负责。总的来说,我们为最重要地开发10月的口头的明确的表达的可行性提供了 pharmacokinetic 和 pharmacodynamic 证据,10月的 pharmacokinetics 和药效学上的 SSTR2 的影响建议10月的口头的明确的表达可能为另外的临床的指示是适用的,在这些肿瘤房间上由于 SSTR2 的 overexpression 包括 neuroendocrine 瘤和垂体腺瘤。 | Xi-nuo LI Tai RAO Yang-fan XU Kang-rui HU Zhang-pei ZHU Hao-feng LI Dian KANG Yu-hao SHAO Bo-yu SHEN Xiao-xi YIN Lin XIE Guang-ji WANG Yan LIANG | 2018 | Acta Pharmacologica Sinica2018，39，8： | 3 |
| 11 | Appropriate choice of collision-induced dissociation energy for qualitative analysis of notoginsenosides based on liquid chromatography hybrid ion trap time-of-flight mass spectrometry显示文摘Liquid chromatography hybrid ion trap/time-of-flight mass spectrometry possesses both the MS^n ability of ion trap and the excellent resolution of a time-of-flight and has been widely used to identify drug metabolites and determine trace multi-components in natural products. Collision energy, one of the most important factors in acquiring MS^n information, could be set freely in the range of 10%–400%. Herein, notoginsenosides were chosen as model compounds to build a novel methodology for the collision energy optimization. Firstly, the fragmental patterns of the representatives for the authentic standards of protopanaxadiol-type and protopanaxatriol-type notoginsenosides were obtained based on accurate MS^2 and MS^3 measurements via liquid chromatography hybrid ion trap/time-of-flight mass spectrometry. The extracted ion chromatograms of characteristic product ions of notoginsenosides in Panax Notoginseng Extract were produced under a series of collision energies and compared to screen the optimum collision energies values for MS^2 and MS^3. The results demonstrated that the qualitative capability of liquid chromatography hybrid ion trap/time-of-flight mass spectrometry was greatly influenced by collision energies, and 50% of MS^2 collision energy was found to produce the highest collision-induced dissociation efficiency for notoginsenosides. Addtionally, the highest collision-induced dissociation efficiency appeared when the collision energy was set at 75% in the MS^3 stage. | WANG Guang-Ji FU Han-Xu XIAO Jing-Cheng YE Wei RAO Tai SHAO Yu-Hao KANG Dian XIE Lin LIANG Yan | 2016 | Chinese Journal of Natural Medicines2016，14，4： | 2 |
| 12 | Cytotoxic T‐lymphocyte associated antigen‐4 gene polymorphisms and primary biliary cirrhosis: A systematic review显示文摘 | Man Li Hao Zheng Tao Li Ping Gao Xiao‐Lin Zhang Dian‐Wu Liu | 2012 | Journal of Gastroenterology and Hepatology2012，，7： | 1 |
| 13 | Study on the preparation of by Mg-Li-Zn alloys electrochemical codeposition from LiCl-KCl-MgCl2-ZnCl2 melts显示文摘 | Yong De Yan Mi Lin Zhang Yun Xue Wei Han Dian Xue Cao Shu Quan Wei | | 0，，12： | 1 |
| 14 | Photonic Bandgap Properties of Atom-lattice Photonic Crystals in Polymer显示文摘The present paper covers the various photonic crystals(PhCs) structures mimicking real atom-lattice structures in electronic crystals by using the femtosecond laser-induced two-photon photopolymerization of SU-8 resin. The bandgap properties were investigated by varying the crystal orientations in <111>, <110> and <100> of diamond-lattice PhCs. The photonic stop gaps were present at λ=3.88 μm in <111> direction, λ=4.01 μm in <110> direction and λ=5.30 μm in <100> direction, respectively. In addition, defects were introduced in graphite-lattice PhCs and the strong localization of photons in this structure with defects at λ=5 μm was achieved. All the above work shows the powerful capability of femtosecond laser fabrication in manufacturing various complicated three-dimensional photonic crystals and of controlling photons by inducing defects in the PhCs samples. | REN Lin WANG Dian SUN Gui-ting NIU Li-gang YANG Han SONG Jun-feng | 2011 | Chemical Research in Chinese Universities2011，27，1： | 1 |
| 15 | Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase a显示文摘 | Jia Sun Yuting Yang Ke Wan Ninghui Mao Tai-Yuan Yu Yi-Chien Lin Diane C DeZwaan Brian C Freeman Jing-Jer Lin Neal FLue Ming Lei | 2011 | Cell Research2011，21，2： | 1 |
| 16 | Rapid and simple detection of sodium thiocyanate in milk using surface‐enhanced Raman spectroscopy based on silver aggregates显示文摘 | Xiang Lin Wu‐Li‐Ji Hasi Xiu‐Tao Lou Shuang Lin Fang Yang Bao‐Shen Jia Yu Cui De‐Xin Ba Dian‐Yang Lin Zhi‐Wei Lu | 2014 | J. Raman Spectrosc2014，，： | 1 |
| 17 | Suitablity of Various Australian Wheat for Chinese-style Steamed Bread显示文摘 | Zuo-Ji Lin Diane M Miskelly and H John Moss | 1990 | J Sci Food Agric1990，，53： | 1 |
| 18 | Modulating effect of Mg-A1-CO3 layered double hydroxides on the thermal stability of PVC resin显示文摘 | Lin Yanjun Qing Dian Evans D G | 2005 | Polymer Degradation and Stability2005，88，2： | 1 |
| 19 | Modulating effect of MgeAleCO3 layered double hydroxides on the thermal stability of PVC resin显示文摘 | Yan Jun Lin Dian Qing Li David G Evans | 2005 | Polymer Degradation and Stability2005，88，： | 1 |
| 20 | Managing uncertainty about treatment decision making in early stage prostate cancer: A randomized clinical trial显示文摘 | Merle H. Mishel Barbara B. Germino Lin Lin Raj S. Pruthi Eric M. Wallen Jaime Crandell Diane Blyler | 2009 | Patient Education and Counseling2009，，3： | 1 |
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