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| 1 | Anisotropic coding metamaterials and their powerful manipulation of differently polarized terahertz waves显示文摘Metamaterials based on effective media can be used to produce a number of unusual physical properties(for example,negative refraction and invisibility cloaking)because they can be tailored with effective medium parameters that do not occur in nature.Recently,the use of coding metamaterials has been suggested for the control of electromagnetic waves through the design of coding sequences using digital elements‘0’and‘1,'which possess opposite phase responses.Here we propose the concept of an anisotropic coding metamaterial in which the coding behaviors in different directions are dependent on the polarization status of the electromagnetic waves.We experimentally demonstrate an ultrathin and flexible polarization-controlled anisotropic coding metasurface that functions in the terahertz regime using specially designed coding elements.By encoding the elements with elaborately designed coding sequences(both 1-bit and 2-bit sequences),the x-and y-polarized waves can be anomalously reflected or independently diffused in three dimensions.The simulated far-field scattering patterns and near-field distributions are presented to illustrate the dual-functional performance of the encoded metasurface,and the results are consistent with the measured results.We further demonstrate the ability of the anisotropic coding metasurfaces to generate a beam splitter and realize simultaneous anomalous reflections and polarization conversions,thus providing powerful control of differently polarized electromagnetic waves.The proposed method enables versatile beam behaviors under orthogonal polarizations using a single metasurface and has the potential for use in the development of interesting terahertz devices. | Shuo Liu Tie Jun Cui Quan Xu Di Bao Liangliang Du Xiang Wan Wen Xuan Tang Chunmei Ouyang Xiao Yang Zhou Hao Yuan Hui Feng Ma Wei Xiang Jiang Jiaguang Han Weili Zhang Qiang Cheng | 2016 | Light(Science & Applications)2016，5，1： | 36 |
| 2 | High precision landing site mapping and rover localization for Chang'e-3 mission显示文摘This paper presents the comprehensive results of landing site topographic mapping and rover localization in Chang’e-3 mission.High-precision topographic products of the landing site with extremely high resolutions(up to 0.05 m)were generated from descent images and registered to CE-2 DOM.Local DEM and DOM with 0.02 m resolution were produced routinely at each waypoint along the rover traverse.The lander location was determined to be(19.51256°W,44.11884°N,-2615.451 m)using a method of DOM matching.In order to reduce error accumulation caused by wheel slippage and IMU drift in dead reckoning,cross-site visual localization and DOM matching localization methods were developed to localize the rover at waypoints;the overall traveled distance from the lander is 114.8 m from cross-site visual localization and 111.2 m from DOM matching localization.The latter is of highest accuracy and has been verified using a LRO NAC image where the rover trajeactory is directly identifiable.During CE-3 mission operations,landing site mapping and rover localization products including DEMs and DOMs,traverse maps,vertical traverse profiles were generated timely to support teleoperation tasks such as obstacle avoidance and rover path planning. | LIU ZhaoQin DI KaiChang PENG Man WAN WenHui LIU Bin LI LiChun YU TianYi WANG BaoFeng ZHOU JianLiang CHEN HongMin | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，1： | 15 |
| 3 | Biofunctional magnesium coated Ti6Al4V scaffold enhances osteogenesis and angiogenesis in vitro and in vivo for orthopedic application显示文摘The insufficient osteogenesis and osseointegration of porous titanium based scaffold limit its further application.Early angiogenesis is important for scaffold survival.It is necessary to develop a multifunctional surface on titanium scaffold with both osteogenic and angiogenic properties.In this study,a biofunctional magnesium coating is deposited on porous Ti6Al4V scaffold.For osseointegration and osteogenesis analysis,in vitro studies reveal that magnesium-coated Ti6Al4V co-culture with MC3T3-E1 cells can improve cell proliferation,adhesion,extracellular matrix(ECM)mineralization and ALP activity compared with bare Ti6Al4V cocultivation.Additionally,MC3T3-E1 cells cultured with magnesium-coated Ti6Al4V show significantly higher osteogenesisrelated genes expression.In vivo studies including fluorochrome labeling,micro-computerized tomography and histological examination of magnesium-coated Ti6Al4V scaffold reveal that new bone regeneration is significantly increased in rabbits after implantation.For angiogenesis studies,magnesium-coated Ti6Al4V improve HUVECs proliferation,adhesion,tube formation,wound-healing and Transwell abilities.HUVECs cultured with magnesium-coated Ti6Al4V display significantly higher angiogenesis-related genes(HIF-1αand VEGF)expression.Microangiography analysis reveal that magnesium-coated Ti6Al4V scaffold can significantly enhance the blood vessel formation.This study enlarges the application scope of magnesium and provides an optional choice to the conventional porous Ti6Al4V scaffold with enhanced osteogenesis and angiogenesis for further orthopedic applications. | Peng Gao Bo Fan Xiaoming Yu Wenwen Liu Jie Wu Lei Shi Di Yang Lili Tan Peng Wan Yulin Hao Shujun Li Wentao Hou Ke Yang Xiaokang Li Zheng Guo | 2020 | Bioactive Materials2020，5，3： | 15 |
| 4 | Progress and Applications of Visual SLAM显示文摘Visual simultaneous localization and mapping (SLAM) provides mapping and self-localization results for a robot in an unknown environment based on visual sensors, that have the advantages of small volume, low power consumption, and richness of information acquisition. Visual SLAM is essential and plays a significant role in supporting automated and intelligent applications of robots. This paper presents the key techniques of visual SLAM, summarizes the current research status, and analyses the new trends of visual SLAM research and development. Finally, specific applications of visual SLAM in restricted environments, including deep space and indoor scenarios, are discussed. | Kaichang DI Wenhui WAN Hongying ZHAO Zhaoqin LIU Runzhi WANG Feizhou ZHANG | 2019 | Journal of Geodesy and Geoinformation Science2019，2，2： | 11 |
| 5 | HER2-Specific T Lymphocytes Kill both Trastuzumab-Resistant and Trastuzumab-Sensitive Breast Cell Lines In Vitro显示文摘Objective: Although the development of trastuzumab has improved the outlook for women with human epidermal growth factor receptor 2 (HER2)-positive breast cancer, the resistance to anti-HER2 therapy is a growing clinical dilemma. We aim to determine whether HER2-specific T cells generated from dendritic cells (DCs) modified with HER2 gene could effectively kill the HER2-positive breast cancer cells, especially the trastuzumab-resistant cells. Methods: The peripheral blood mononuclear cells (PBMCs) from healthy donors, whose HLA haplotypes were compatible with the tumor cell lines, were transfected with reconstructive human adeno-association virus (rhAAV/HER2) to obtain the specific killing activities of T cells, and were evaluated by lactate dehydrogenase (LDH) releasing assay. Results: Trastuzumab produced a significant inhibiting effect on SK-BR-3, the IC50 was 100ng /ml. MDA-MB-453 was resistant to trastuzumab even at a concentration of 10,000 ng/ml in vitro. HER2-specific T lymphocytes killed effectively SK-BR-3 [(69.86±13.41)%] and MDA-MB-453 [(78.36±10.68)%] at 40:1 (effector:target ratio, E:T), but had no significant cytotoxicity against HER2-negative breast cancer cell lines MDA-MB-231 or MCF-7 (less than 10%). Conclusion: The study showed that HER2-specific T lymphocytes generated from DCs modified by rhAAV/HER2 could kill HER2-positive breast cancer cell lines in a HER2-dependent manner, and result in significantly high inhibition rates on the intrinsic trastuzumab-resistant cell line MDA-MB-453 and the tastuzumab-sensitive cell line SK-BR-3. These results imply that this immunotherapy might be a potential treatment to HER2-positive breast cancer. | Xiao-lin Lin Xiao-li Wang BO Ma Jun Jia Ying Yan Li-jun Di Yan-hua Yuan Feng-ling Wan Yuan-li Lu Xu Liang Tao Shen Jun Ren | 2012 | Chinese Journal of Cancer Research2012，24，2： | 5 |
| 6 | Eocene Basins on the SE Tibetan Plateau: Markers of Minor Offset along the Xuelongshan–Diancangshan–Ailaoshan Structural System显示文摘The offset of geological bodies provides robust evidence of displacement along a fault or ductile shear zone. The amount of displacement along the Xuelongshan–Diancangshan–Ailaoshan structural system, southeastern Tibetan Plateau, is uncertain because of the lack of offset geological markers. This NNW–SSE-trending system is developed in three isolated metamorphic complexes and interjacent nonmetamorphosed rocks. They are expected to record similar post-Eocene strain, although their structural patterns should be distinct. Geological mapping in the area between the Xuelongshan and Diancangshan metamorphic complexes has revealed a small Eocene basin, the Madeng Basin, located to the west of the structural system. The sedimentary and volcanic successions of the Madeng Basin are comparable to those of the Jianchuan Basin, which is located to the east of the structural system. Zircon U–Pb geochronological and bulk geochemical data demonstrate that the volcanic rocks of both basins formed during 37–34 Ma and share the same geochemical features. These data suggest that the Madeng and Jianchuan basins previously constituted a single basin, with the distribution of high-K volcanic rocks in the basins defining an ENE–WSW-trending volcanic belt that shows a limited dextral offset of ≤20 km across the Xuelongshan–Diancangshan–Ailaoshan structural system. Therefore, the northern segment of the structural system records no evidence of large-scale lateral movement/displacement. The results suggest that the Indochina block, which is bounded by the Xuelongshan–Diancangshan–Ailaoshan structural system to the east and the Sagaing Fault to the west, has not extruded southward as a whole but rather has been deformed by pervasive crustal shortening. | LIAO Cheng YANG Tiannan XUE Chuandong LIANG Mingjuan XIN Di XIANG Kun JIANG Lili SHI Pengliang ZHU Wenbin WAN Liangchun TANG Jing YU Jing WU Pinglei | 2020 | Acta Geologica Sinica(English Edition)2020，94，4： | 5 |
| 7 | Mobility control of unmanned aerial vehicle as communication relay in airborne multi-user systems显示文摘In this paper, a model-based adaptive mobility control method for an Unmanned Aerial Vehicle(UAV) acting as a communication relay is presented, which is intended to improve the network performance in airborne multi-user systems. The mobility control problem is addressed by jointly considering unknown Radio Frequency(RF) channel parameters, unknown multi-user mobility, and non-available Angle of Arrival(AoA) information of the received signal. A Kalman filter and a least-square-based estimation algorithm are used to predict the future user positions and estimate the RF channel parameters between the users and the UAV, respectively. Two different relay application cases are considered: end-to-end and multi-user communications. A line search algorithm is proposed for the former, with its stability given and proven, whereas a simplified gradient-based algorithm is proposed for the latter to provide a target relay position at each decision time step, decreasing the two-dimensional search to a one-dimensional search. Simulation results show that the proposed mobility control algorithms can drive the UAV to reach or track the optimal relay position movement, as well as improving network performance. The proposed method reflects the properties of using different metrics as objective network performance functions. | Gaofeng WU Xiaoguang GAO Xiaowei Fu Kaifang WAN Ruohai DI | 2019 | Chinese Journal of Aeronautics2019，32，6： | 4 |
| 8 | A four-component combination derived from Huang-Qin Decoction significantly enhances anticancer activity of irinotecan显示文摘Huang-Qin Decoction(HQD)is a classic prescription for diarrhea in Chinese medicine treatment.Recent studies have demonstrated that HQD and its modified formulation PHY906 could ameliorate irinotecan(CPT-11)induced gastrointestinal(GI)toxicity and enhance its anticancer therapeutic efficacy.Nevertheless,which constituents in HQD are effective is still unclear so far.The study aims to screen out the key bioactive components combination from HQD that could enhance the anticancer effect of CPT-11.First,the potential bioactive constituents were obtained through system pharmacology strategy.Then the bioactivity of each constituent was investigated synthetically from the aspects of NCM460 cell migration,TNF-αrelease of THP-1-derived macrophage and MTT assay in HCT116 cell.The contribution of each constituent in HQD was evaluated using the bioactive index Ei,which taken the content and bioactivity into comprehensive consideration.And then,the most contributing constituents were selected out to form a keycomponent combination.At last,the bioefficacy of the key-component combination was validated in vitro and in vivo.As a result,a key-component combination(HB4)consisting of four compounds baicalin,baicalein,glycyrrhizic acid and wogonin was screened out.In vitro assessment indicated that HB4 could enhance the effect of CPT-11 on inhibiting cell proliferation and inducing apoptosis in HCT116.Furthermore,the in vivo study confirmed that HB4 and HQD have similar pharmacological activity and could both enhance the antitumor effect of CPT-11 in HCT116 xenograft model.Meanwhile,HB4 could also reduce the CPT-11 induced GI toxicity. | XU Dou-Dou HOU Xiao-Ying WANG Ou WANG Di LI Dan-Ting QIN Si-Yuan LV Bo DAI Xiao-Min ZHANG Zun-Jian WAN Jian-Bo XU Feng-Guo | 2021 | Chinese Journal of Natural Medicines2021，19，5： | 3 |
| 9 | Key Technology of Embedded System Implementation for Software-based CNC System显示文摘The software-based computer numerical control(CNC) system includes three types of tasks:periodic real-time tasks,aperiodic real-time tasks,and non-real-time tasks.The tasks are characterized by concurrency,hybridization,and correlation,which make system implementation difficult.The conventional scheduling algorithm can not meet the demands of system implementation in the software-based CNC system completely.The uncertainty factors when running real-time tasks affect control performance by degrading manufacturing accuracy as a result of system resource and processor use restrictions.To address the technical difficulty of embedded system implementation,a novel fuzzy feedback scheduling algorithm based on output jitter of key real-time tasks for a software-based CNC system is proposed.Time characteristics,such as sampling jitter,input-output jitter,and non-schedulability are discussed,followed by quantification through simulations of the impact of time characteristics on manufacturing accuracy.On the basis of this research,the scheduler architecture is designed,and then the algorithm table is calculated.When the system resource changes,the key periodic real-time tasks meet their deadlines by means of dynamically adjusting the task period.The simulated results show that the machining precision rises by an order of magnitude for the proposed scheduler in resource-constrained software-based CNC systems.Moreover,unlike conventional feedback scheduling methods,the algorithm in this paper does not rely on the availability of task execution times and is easy to implement while incurring only a small overhead. | WAN Jiafu LI Di ZHANG Ping | 2010 | Chinese Journal of Mechanical Engineering2010，23，2： | 3 |
| 10 | Geospatial technologies for Chang’e-3 and Chang’e-4 lunar rover missions显示文摘This paper presents a brief overview of the geospatial technologies developed and applied in Chang’e-3 and Chang’e-4 lunar rover missions.Photogrammetric mapping techniques were used to produce topographic products of the landing site with meter level resolution using orbital images before landing,and to produce centimeter-resolution topographic products in near real-time after landing.Visual positioning techniques were used to determine the locations of the two landers using descent images and orbital basemaps immediately after landing.During surface operations,visual-positioning-based rover localization was performed routinely at each waypoint using Navcam images.The topographic analysis and rover localization results directly supported waypoint-to-waypoint path planning,science target selection and scientific investigations.A GIS-based digital cartography system was also developed to support rover teleoperation. | Kaichang Di Zhaoqin Liu Wenhui Wan Man Peng Bin Liu Yexin Wang Sheng Gou Zongyu Yue | 2020 | Geo-Spatial Information Science2020，23，1： | 3 |
| 11 | Landing site topographic mapping and rover localization for Chang’e-4 mission显示文摘This paper presents the techniques and results of landing-site topographic mapping and rover localization using orbital,descent and rover images in the Chang’e-4 mission.High-resolution maps of the landing site are generated from orbital and descent images.Local digital elevation models and digital orthophoto maps with 0.02 m resolution are generated at each waypoint.The location of the lander is determined as(177.588?E,45.457?S)using festure-matching techniques.The cross-site visual localization method is routinely used to localize the rover at each waypoint to reduce error accumulation from wheel slippage and IMU drift in dead reckoning.After the first five lunar days,the rover travels 186.66 m from the lander,according to the cross-site visual localization.The developed methods and results have been directly utilized to support the mission’s operations.The maps and localization information are also valuable for supporting multiple scientific explorations of the landing site. | Zhaoqin LIU Kaichang DI Jian LI Jianfeng XIE Xiaofeng CUI Luhua XI Wenhui WAN Man PENG Bin LIU Yexin WANG Sheng GOU Zongyu YUE Tianyi YU Lichun LI Jia WANG Chuankai LIU Xin XIN Mengna JIA Zheng BO Jia LIU Runzhi WANG Shengli NIU Kuan ZHANG Yi YOU Bing LIU Jiangang LIU | 2020 | Science China(Information Sciences)2020，63，4： | 3 |
| 12 | Surgical treatment for recurrent hepatocellular carcinoma:Current status and challenges显示文摘Primary liver cancer is the sixth most commonly diagnosed cancer and was the third leading cause of cancer deaths worldwide in 2020.It includes hepatocellular carcinoma(HCC)(representing 75%-85%of cases),intrahepatic cholangiocarcinoma(representing 10%-15%of cases),and other rare types.The survival rate of patients with HCC has risen with improved surgical technology and perioperative management in recent years;however,high tumor recurrence rates continue to limit long-term survival,even after radical surgical resection(exceeding 50%recurrence).For resectable recurrent liver cancer,surgical removal[either salvage liver transplantation(SLT)or repeat hepatic resection]remains the most effective therapy that is potentially curative for recurrent HCC.Thus,here,we introduce surgical treatment for recurrent HCC.Areas Covered:A literature search was performed for recurrent HCC using Medline and PubMed up to August 2022.Expert commentary:In general,long-term survival after the reresection of recurrent liver cancer is usually beneficial.SLT has equivalent outcomes to primary liver transplantation for unresectable recurrent illness in a selected group of patients;however,SLT is constrained by the supply of liver grafts.SLT seems to be inferior to repeat liver resection when considering operative and postoperative results but has the major advantage of disease-free survival.When considering the similar overall survival rate and the current situation of donor shortages,repeat liver resection remains an important option for recurrent HCC. | Di Wang Min Xiao Zhen-Miao Wan Xin Lin Qi-Yong Li Shu-Sen Zheng | 2023 | World Journal of Gastrointestinal Surgery2023，15，4： | 2 |
| 13 | Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions显示文摘With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expanding the targeted therapeutic options improved the survival and safety. However, responses to these agents are commonly temporary and incomplete. Moreover, even patients with the same oncogenic driver gene can respond diversely to the same agent. Furthermore, the therapeutic role of immune-checkpoint inhibitors (ICIs) in oncogene-driven NSCLC remains unclear. Therefore, this review aimed to classify the management of NSCLC with driver mutations based on the gene subtype, concomitant mutation, and dynamic alternation. Then, we provide an overview of the resistant mechanism of target therapy occurring in targeted alternations (“target-dependent resistance”) and in the parallel and downstream pathways (“target-independent resistance”). Thirdly, we discuss the effectiveness of ICIs for NSCLC with driver mutations and the combined therapeutic approaches that might reverse the immunosuppressive tumor immune microenvironment. Finally, we listed the emerging treatment strategies for the new oncogenic alternations, and proposed the perspective of NSCLC with driver mutations. This review will guide clinicians to design tailored treatments for NSCLC with driver mutations. | Jia Zhong Hua Bai Zhijie Wang Jianchun Duan Wei Zhuang Di Wang Rui Wan Jiachen Xu Kailun Fei Zixiao Ma Xue Zhang Jie Wang | 2023 | Frontiers of Medicine2023，17，1： | 2 |
| 14 | Inclusion control of automotive spring steel in the basic oxygen furnace and ingot casting process显示文摘The process of automotive spring steel in the basic oxygen furnace and ingot casting(BOF-IC)of Baosteel is described in this paper.High quality spring steel can be obtained through designing reasonable deoxidization and alloying processes,enhancing steel purity and reducing inclusions in steel. | ZHANG Jianchun DI Yongzhong HU Huijun WAN Genjie | 2010 | Baosteel Technical Research2010，4，2： | 2 |
| 15 | The enzyme-amplified amperometric DNA sensor using an electrodeposited polymer redox mediator显示文摘A highly sensitive method for the detection of a breast cancer-associated BRCA-1 gene is reported. The detection is based on a classical sandwich-type assay using horseradish peroxidase (HRP) as a catalytic label and electrodeposited Os2+/3+ conducting polymer (PAA-PVI-Os) as a redox mediator. Target DNA could be detected by the HRP-catalyzed reduction of H2O2, leading to a limit of detection as low as 10 fM. | ZHANG LanYong WAN Ying ZHANG Jiong LI Di WANG LiHua SONG ShiPing FAN ChunHai | 2009 | Science China Chemistry2009，52，6： | 2 |
| 16 | Effect of hypoxia and re-oxygenation on cell invasion and adhesion in human ovarian carcinoma cells显示文摘 | Shi J Wan Y Di W | 2008 | Oncology Reports2008，20，： | 1 |
| 17 | Leukotriene B4-induced changes in vascular permeability are mediatedby neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin) 显示文摘 | Di Gennaro A Kenne E Wan M | 2009 | FASEB J2009，23，6： | 1 |
| 18 | A systematic review and meta-analysis on the safety and efficacy of the frozen elephant trunk technique in aortic arch surgery显示文摘 | Tian DH Wan B Di Eusanio M | | 0，，： | 1 |
| 19 | The downregulation of ErbB3 binding protein 1 (EBP1) is associated with poor prognosis and enhanced cell proliferation in hepatocellular carcinoma显示文摘 | Baoying Hu Yicheng Xiong Runzhou Ni Lixian Wei Dawei Jiang Gang Wang Di Wu Tianxin Xu Fengbo Zhao Mingyan Zhu Chunhua Wan | 2014 | 2014 (1-2)2014，，1： | 1 |
| 20 | Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP)显示文摘 | Lonneke V. Franse Marco Pahor Mauro Di Bari Ronald I. Shorr Jim Y. Wan Grant W. Somes William B. Applegate | 2000 | Journal of Hypertension2000，，8： | 1 |
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