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| 1 | Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?显示文摘Frequent activation of phosphatidylinositol-3 kinases(PI3K)/Akt/m TOR signaling pathway in gastric cancer(GC) is gaining immense popularity with identification of mutations and/or amplifications of PIK3 CA gene or loss of function of PTEN,a tumor suppressor protein,to name a few; both playing a crucial role in regulating this pathway. These aberrations result in dysregulation of this pathway eventually leading to gastric oncogenesis,hence,there is a need for targeted therapy for more effective anticancer treatment. Several inhibitors are currently in either preclinical or clinical stages for treatment of solid tumors like GC. With so many inhibitors under development,further studies on predictive biomarkers are needed to measure the specificity of any therapeutic intervention. Herein,we review the common dysregulation of PI3K/Akt/m TOR pathway in GC and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment. We also summarize the recent developments in identification of predictive biomarkers and propose use of predictive biomarkers to facilitate more personalized cancer therapy with effective PI3K/Akt/m TOR pathway inhibition. | Shikha Satendra Singh Wei Ney Yap Frank Arfuso Shreya Kar Chao Wang Wanpei Cai Arunasalam M Dharmarajan Gautam Sethi Alan Prem Kumar | 2015 | World Journal of Gastroenterology2015，21，43： | 36 |
| 2 | 两种AZT-氟喹诺酮偶联物体外抗HIV-1及抗菌活性的研究显示文摘目的体外测定两种AZT-氟喹诺酮偶联物SRLZ和SROZ的抗HIV-1活性及抗菌活性。方法通过合胞体抑制、HIV-1感染细胞保护、HIV-1 p24抗原测定等方法检测急性感染中化合物对HIV-1实验株、临床分离株的抑制作用和对慢性感染细胞中的病毒复制影响;通过体外金黄色葡萄球菌的抑制实验检测化合物的抗菌活性。结果AZT-氟喹诺酮偶联物SRLZ和SROZ能抑制HIV-1实验株诱导的合胞体形成,减少病毒感染细胞的死亡和抑制病毒在细胞内的复制;SRLZ和SROZ对HIV-1临床分离株也有较好的抑制作用;SRLZ和SROZ对HIV-1的抑制活性与AZT相近;AZT-氟喹诺酮偶联物也能抑制金黄色葡萄球菌,其MIC值与其相应的阳性药物相近。结论SRLZ和SROZ有很好的抗HIV-1活性和抗菌活性。 | 龙晶 Dharmarajan Sriram 张高红 郑永唐 | 2009 | 中国药理学通报2009，25，1： | 2 |
| 3 | Synthesis and antimycobacterial screening of new N-(4-(5-aryl-3-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-pyrazol-1-yl)phenyl)-4-amide derivatives显示文摘This article demonstrates the synthesis, characterization and the study of in vitro antitubercular activities of twenty four new N-(4-(5-aryl-3-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-pyrazol-1-yl)phenyl)-4-amide derivatives(8a–x). The antitubercular activity of the compounds against Mycobacterium tuberculosis H37Rv(MTB) revealed that 2-chloro-N-(4-(5-(4-chlorophenyl)-3-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-pyrazol-1-yl)phenyl)benzamide(8n) is the most promising lead molecule with a MIC of1.56 mg/m L, while the corresponding unsubstituted benzamide derivative(8o) is the next most active molecule with a MIC of 3.13 mg/m L. Interestingly, the pyrazole intermediate 5b containing chlorophenyl and N-acylcarbohydrazide substituents also showed significant activity(MIC = 3.13 mg/m L). Further, the active molecules did not show toxicity against a normal NIH 3T3 cell line, signifying their suitability for further drug development. | Nagabhushana Nayak Jurupula Ramprasad Udayakumar Dalimba Perumal Yogeeswari Dharmarajan Sriram | 2016 | Chinese Chemical Letters2016，27，3： | 2 |
| 4 | Intravenous fluids in acute decompensated heart failure 显示文摘 | Bikdeli B Strait KM Dharmarajan K | 2015 | JACC Heart Fail2015，3，2： | 1 |
| 5 | Development of benzooxazol-2(3 H )-ones derivatives as novel inhibitors of Mycobacterium tuberculosis InhA显示文摘 | Ganesh S. Pedgaonkar Jonnalagadda Padma Sridevi Variam Ullas Jeankumar Shalini Saxena Parthiban Brindha Devi Janupally Renuka Perumal Yogeeswari Dharmarajan Sriram | 2014 | Bioorganic & Medicinal Chemistry2014，，： | 1 |
| 6 | Antioxidants mimic the ability of chorionic gonadotropin to suppress apoptosis in the rabbit corpus luteum in vitro: A novel role for superoxide dismutase in regulating bax expression 显示文摘 | Dharmarajan A M Hisheh S Singh B | 1999 | Endocrinology1999，140，6： | 1 |
| 7 | Chronic kidney disease staging in nursing home and community older a- dults : does the choice of cockcroft-gault, modification of diet in renal disease study, or the chronic kidney disease epide- miology collaboration initiative equations matter? 显示文摘 | Dharmarajan TS Yoo J Russell RO | 2012 | J Am Med Dir Assoc2012，13，2： | 1 |
| 8 | Do acid- lowering agents affect vitamin B12 status in older adults显示文摘 | Dharmarajan TS Kanagala MR Murakonda P | 2008 | J Am Med Dir Assoc2008，9，3： | 1 |
| 9 | Laparoscopic versus open 2-Stage ileal pouch:laparoscopic approach allows for fas-ter restoration of intestinal continuity 显示文摘 | Fajardo AD Dharmarajan S George V | 2010 | J Am Coll Surg2010，211，3： | 1 |
| 10 | Laparoscopic versus open 2-stage ileal pouch:laparoscopic approach allows for faster restoration of intestinal continuity显示文摘 | Fajardo AD Dharmarajan S George V | | 0，，03： | 1 |
| 11 | Anemia increases risk for falls in hospitalized older adults: An evaluation of falls in 362 hospitalized, ambulatory, long - term care, and community patients显示文摘 | Dharmarajan TS Avula S Norkus EP | 2007 | J Am Med Dir Assoc2007，8，32： | 1 |
| 12 | Diagnoses and timing of 30-day readmissions after hospitalization for heart failure, acute my ocardial infarction, or pneumonia显示文摘 | Dharmarajan K Hsieh A F Lin Z | 2013 | Jama2013，309，4： | 1 |
| 13 | Discovery of New Antitubercular Oxazolyl Thiosemicarbazones显示文摘 | DHARMARAJAN SRIRAM PERUMAL YOGEESWARI RATHINASABABATHY THIRUMURUGAN | 2006 | Journal of Medicinal Chemistry2006，49，11： | 1 |
| 14 | Identification of ubiquitin ligases required for skeletal muscle at-roohy 显示文摘 | Bodine SC Latres E Baumhueter S Lai VK Nunez L Clarke BA Poueymirou WT Panaro FJ Na E Dharmarajan K Pan ZQ Valenzuela DM DeChiara TM Stitt TN Yancopoulos GD Glass DJ | 2001 | Science2001，294，5547： | 1 |
| 15 | Do acid-lowering agents affect vitamin Bl2 status in older a- dults? 显示文摘 | Dharmarajan T S Kanagala M R Murakonda P | 2008 | J Am Med Dir Assoc2008，9，3： | 1 |
| 16 | Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide 显示文摘 | Patel A Dharmarajan V Cosgrove MS | 2008 | J Biol Chem2008，283，32： | 1 |
| 17 | Clinically en-larged lateral pelvic lymph nodes do not influence prog-nosis after neoadjuvant therapy and TME in stage HI rec-tal cancer显示文摘 | Dharmarajan S Shuai D Fajardo AD | 2011 | J Gastrointest Surg2011，15，8： | 1 |
| 18 | Ren'al tubular defects from antidepressant use in an older adult: an uncommon but reversible adverse drug effect显示文摘 | Adiga G U Dharmarajan T S | 2006 | Clin Drug Investig2006，26，10： | 1 |
| 19 | Evidence for alternative pathways of granulose cell death in healthy and slightly atretic bovine antral follicles显示文摘 | Van Welzel I L Dharmarajan A M Lavranos T C | 1999 | Endocrinology1999，40，： | 1 |
| 20 | In vivo molecular imaging characterizes pulmonary gene expression during experimental lung transplantation显示文摘 | Dharmarajan S Hayama M Kozlowski J | 2005 | Am J Transplant2005，5，6： | 1 |
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