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| 1 | Gestational diabetes: A clinical update显示文摘Gestational diabetes mellitus(GDM)is increasing in prevalence in tandem with the dramatic increase inthe prevalence of overweight and obesity in women of childbearing age.Much controversy surrounds the diagnosis and management of gestational diabetes,emphasizing the importance and relevance of clarity and consensus.If newly proposed criteria are adopted universally a significantly growing number of women will be diagnosed as having GDM,implying new therapeutic challenges to avoid foetal and maternal complications related to the hyperglycemia of gestational diabetes.This review provides an overview of clinical issues related to GDM,including the challenges of screening and diagnosis,the pathophysiology behind GDM,the treatment and prevention of GDM and the long and short term consequences of gestational diabetes for both mother and offspring. | Ulla Kampmann Lene Ring Madsen Gitte Oeskov Skajaa Ditte Smed Iversen Niels Moeller Per Ovesen | 2015 | World Journal of Diabetes2015，6，8： | 17 |
| 2 | 文化与幼儿教育的欧洲视角:走向自然显示文摘 | Ulla Grob-Mengues 王峥 | 2004 | 学前教育研究2004，，7： | 14 |
| 3 | Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology显示文摘AIM: To evaluate ATP-binding cassette(ABC) transporters in colonic pathophysiology as they had recently been related to colorectal cancer(CRC) development. METHODS: Literature search was conducted on Pub Med using combinations of the following terms: ABC transporters, ATP binding cassette transporter proteins, inflammatory bowel disease, ulcerative, colitis, Crohns disease, colorectal cancer, colitis, intestinal inflammation, intestinal carcinogenesis, ABCB1/P-glycoprotein(P-gp/CD243/MDR1), ABCC2/multidrug resistance protein 2(MRP2) and ABCG2/breast cancer resistance protein(BCRP), Abcb1/Mdr1 a, abcc2/Mrp2, abcg2/Bcrp, knock-out mice, tight junction, membrane lipid function. RESULTS: Recently, human studies reported thatchanges in the levels of ABC transporters were early events in the adenoma-carcinoma sequence leading to CRC. A link between ABCB1, high fat diet and gut microbes in relation to colitis was suggested by the animal studies. The finding that colitis was preceded by altered gut bacterial composition suggests that deletion of Abcb1 leads to fundamental changes of hostmicrobiota interaction. Also, high fat diet increases the frequency and severity of colitis in specific pathogenfree Abcb1 KO mice. The Abcb1 KO mice might thus serve as a model in which diet/environmental factors and microbes may be controlled and investigated in relation to intestinal inflammation. Potential molecular mechanisms include defective transport of inflammatory mediators and/or phospholipid translocation from one side to the other of the cell membrane lipid bilayer by ABC transporters affecting inflammatory response and/or function of tight junctions, phagocytosis and vesicle trafficking. Also, diet and microbes give rise to molecules which are potential substrates for the ABC transporters and which may additionally affect ABC transporter function through nuclear receptors and transcriptional regulation. Another critical role of ABCB1 was suggested by the finding that ABCB1 expression identifies a subpopulation of pro-inflammatory Th17 cells which were resistant to treatment with glucocorticoids. The evidence for the involvement of ABCC2 and ABCG2 in colonic pathophysiology was weak. CONCLUSION: ABCB1, diet, and gut microbes mutually interact in colonic inflammation, a well-known risk factor for CRC. Further insight may be translated into preventive and treatment strategies. | Vibeke Andersen Katrine Svenningsen Lina Almind Knudsen Axel Kornerup Hansen Uffe Holmskov Allan Stensballe Ulla Vogel | 2015 | World Journal of Gastroenterology2015，21，41： | 10 |
| 4 | Family and twin studies in inflammatory bowel disease显示文摘在不同家庭组以内检验煽动性的肠疾病(IBD ) 的继承的研究是在 IBD 的遗传的最近的分子的进展的基础。在 Crohn 的疾病(CD ) 的导出的可遗传性比在许多另外的复杂疾病高。IBD 的风险在受不了 ulcerative (UC ) 的一个职业人员乐队的一个 CD 职业人员乐队,而是一度的亲戚的一度的亲戚是最高的,更远的亲戚也在增加的风险。在 IBD 的疾病词语索引率在复合家庭并且在三大欧洲成双的研究被检验了。 | Leena Halme Paulina Paavola-Sakki Ulla Turunen Maarit Lappalainen Martti Frkkil Kimmo Kontula | 2006 | World Journal of Gastroenterology2006，12，23： | 8 |
| 5 | 倾听患者的声音:中国2型糖尿病患者疾病管理访谈分析显示文摘目的了解中国2型糖尿病患者掌握的糖尿病相关知识、获取信息的渠道,并呈现患者管理糖尿病的方法、效果和经验。方法选取38例中国2型糖尿病患者,对其进行一对一半结构式深入访谈,鼓励患者展开疾病叙事。结果①患者首次确诊糖尿病呈现出四种情形和三种心理回应模式;②患者对糖尿病的病症成因尚缺乏了解,但对治疗方法较熟悉;获悉途径从单一到多元渠道分布不均;③多数患者采纳了“服药、运动、饮食”三种基本的管理模式,但对疾病管理实施和效果尚不满意。结论糖尿病改变了患者的生活,疾病管理的本质是配合药物治疗、调整生活方式;患者有强烈的治愈疾病的愿望,但需得到当前社会环境、医疗水平、医患交流以及自我疾病和情绪管理等社会、机构和个人层面的有机配合,从而实现对糖尿病的有效管理和控制。 | 李芳 郭莉萍 Ulla Cornor 黄芳 李俊 刘晶晶 牛颖 乔玉玲 吴朝霞 邹漫云 | 2019 | 中国医学伦理学2019，32，12： | 5 |
| 6 | DGGE法检测稻田蓝细菌及硅藻的遗传多态性显示文摘运用对蓝细菌和硅藻 16SrRNA特异的引物对 ,将稻田土壤中提取的总DNA进行PCR扩增后 ,通过DGGE技术对PCR产物进行分析 .结果表明 ,在水稻生长的不同时期 ,稻田蓝细菌及硅藻种群也在变化 ,田间不同位置蓝细菌及硅藻种类也有所不同 。 | 宋铁英 包晓东 郑伟文 Rasmussen Ulla | 2002 | 厦门大学学报(自然科学版)2002，41，5： | 4 |
| 7 | DGGE法与常规培养法对稻田蓝细菌多态性分析结果比较显示文摘研究运用蓝细菌和硅藻16SrDNA特异引物,将晚季水稻生长后期稻田土壤中提取的总DNA进行PCR扩增后,以DGGE技术对PCR产物进行分析结果表明,14条DGGE带经克隆测序,经NCBI基因库比对得晚季水稻生长后期存在10种蓝细菌,包括4种Leptolyngbya、1种Chamaesiphon、1种Nostoc、1种Oscillatoria、2种Syne-chococcus和1种Chroococcidiopsis。同层不同位置土壤中蓝细菌种群亦有所不同,但每个取样点都有一些特有的蓝细菌种类。用常规方法对同一稻田土壤样品进行分离培养,根据蓝细菌鉴定图谱观察到类似Lyngbya、Oscillatori-a、Chroococcidiopsis及Nostoc的蓝细菌,但显微镜下无法准确分类。比较结果表明采用DGGE法比常规培养法能更准确进行蓝细菌多态性鉴定。 | 宋铁英 林智敏 郑伟文 LOTTA Martensson ULLA Rusmussen | 2005 | 中国生态农业学报2005，13，3： | 4 |
| 8 | Polymorphisms in NF-κB,PXR,LXR,PPARγ and risk of inflammatory bowel disease显示文摘AIM:To investigate the contribution of polymorphisms in nuclear receptors to risk of inflammatory bowel disease(IBD) . METHODS:Genotypes of nuclear factor(NF) -κB(NFKB1) NFκB-94ins/del(rs28362491) ;peroxisome proliferatoractivated receptor(PPAR) -γ(PPARγ) PPARγPro12Ala(rs1801282) and C1431T(rs 3856806) ;pregnane X receptor(PXR) (NR1I2) PXR A-24381C(rs1523127) ,C8055T(2276707) ,and A7635G(rs 6785049) ;and liver X receptor(LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients,495 ulcerative colitis(UC) patients,and 779 healthy controls.Odds ratio(OR) and 95%CI were estimated by logistic regression models. RESULTS:The PXR A7635G variant,the PPARγPro12Ala and LXR T-rs2695121-C homozygous variant genotypes were associated with risk of UC(OR:1.31,95% CI:1.03-1.66,P=0.03,OR:2.30,95%CI:1.04-5.08,P=0.04,and OR:1.41,95%CI:1.00-1.98,P=0.05,respectively) compared to the corresponding homozygous wild-type genotypes.Among never smokers,PXR A7635G and the LXR T-rs1405655-C and T-rs2695121-C variant genotypes were associated with risk of IBD(OR:1.41,95%CI:1.05-1.91,P=0.02,OR:1.63,95%CI:1.21-2.20,P=0.001,and OR:2.02,95%CI:1.36-2.99,P=0.0005,respectively) compared to the respective homozygous variant genotypes.PXR A7635G(rs6785049) variant genotype was associated with a higher risk of UC diagnosis before the age of 40 years and with a higher risk of extensive disease(OR:1.34,95%CI:1.03-1.75 and OR:2.49,95%CI:1.24-5.03,respectively) . CONCLUSION:Common PXR and LXR polymorphisms may contribute to risk of IBD,especially among never smokers. | Vibeke Andersen Jane Christensen Anja Ernst Bent A Jacobsen Anne Tjφnneland Henrik B Krarup Ulla Vogel | 2011 | World Journal of Gastroenterology2011，17，2： | 4 |
| 9 | Evaluation of a Direct Rapid Immunohistochemical Test (dRIT) for Rapid Diagnosis of Rabies in Animals and Humans显示文摘Presently the gold standard diagnostic technique for rabies is the direct immunofluorescence assay ( dFA) which is very expensive and requires a high level of expertise. There is a need for more economical and user friendly tests, particularly for use in developing countries. We have established one such test called the direct rapid immunohistochemical test (dRIT) for diagnosis of rabies using brain tissue. The test is based on capture of rabies nucleoprotein (N) antigen in brain smears using a cocktail of biotinylated monoclonal antibodies specific for the N protein and color development by streptavidin peroxidase-amino ethyl carbazole and counter staining with haematoxollin. The test was done in parallel with standard FAT dFA using 400 brain samples from different animals and humans. The rabies virus N protein appears under light microscope as reddish brown particles against a light blue background. There was 100 % correlation between the results obtained by the two tests. Also, interpretation of results by dRIT was easier and only required a light microscope. To conclude, this newly developed dRIT technique promises to be a simple, cost effective diagnostic tool for rabies and will have applicability in field conditions prevalent in developing countries. | Shampur Narayan Madhusudana Sundaramurthy Subha Ullas Thankappan Yajaman Belludi Ashwin | 2012 | Virologica Sinica2012，27，5： | 3 |
| 10 | Diagnostic yield and clinical outcomes after capsule endoscopy in 100 consecutive patients with obscure gastrointestinal bleeding显示文摘 | Emilio Estévez Benito González-Conde José Luis Vázquez-Iglesias Maria de los Angeles Vázquez-Millán Sonia Pértega Pedro A. Alonso Joan Clofent Eva Santos José Luis Ulla Eloy Sánchez | 2006 | European Journal of Gastroenterology & Hepatology2006，，8： | 3 |
| 11 | Light Triggers the miRNA-Biogenetic Inconsistency for De-etiolated Seedling Survivability in Arabidopsis thaliana显示文摘The shift of dark-grown seedlings into light causes enormous transcriptome changes followed by a dramatic developmental transition.Here,we show that microRNA(miRNA)biogenesis also undergoes regulatory changes during de-etiolation.Etiolated seedlings maintain low levels of primary miRNAs(pri-miRNAs)and miRNA processing core proteins,such as Dicer-like 1,SERRATE,and HYPONASTIC LEAVES 1,whereas during de-etiolation both pri-miRNAs and the processing components accumulate to high levels.However,the levels of most miRNAs do not notably increase in response to light.To reconcile this inconsistency,we demonstrated that an unknown suppressor decreases miRNA-processing activity and light-induced SMALL RNA DEGRADING NUCLEASE 1 shortens the half-life of several miRNAs in de-etiolated seedlings.Taken together,these data suggest a novel mechanism,miRNA-biogenetic inconsistency,which accounts for the intricacy of miRNA biogenesis during de-etiolation.This mechanism is essential for the survival of de-etiolated seedlings after long-term skotomorphogenesis and their optimal adaptation to ever-changing light conditions. | Suk Won Choi Moon Young Ryu Andras Viczian Hyun Ju Jung Gu Min Kim Agustin LArce Natalia PAchkar Pablo Manavella Ulla Dolde Stephan Wenke Attila Molnar Ferenc Nagy Seok Keun Cho Seong Wook Yang | 2020 | Molecular Plant2020，13，3： | 3 |
| 12 | rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study显示文摘AIM To evaluate the rate of adverse events(AEs) during consecutive gastric and duodenal polypectomies in several Spanish centers. METHODS Polypectomies of protruded gastric or duodenal polyps ≥ 5 mm using hot snare were prospectively included. Prophylactic measures of hemorrhage were allowed in predefined cases. AEs were defined and graded according to the lexicon recommended by the American Society for Gastrointestinal Endoscopy. Patients were followed for 48 h, one week and 1 mo after theprocedure. RESULTS308 patients were included and a single polypectomy was performed in 205. Only 36(11.7%) were on prior anticoagulant therapy. Mean polyp size was 15 ± 8.9 mm(5-60) and in 294 cases(95.4%) were located in the stomach. Hemorrhage prophylaxis was performed in 219(71.1%) patients. Nine patients presented AEs(2.9%), and 6 of them were bleeding(n = 6, 1.9%)(in 5 out of 6 AE, different types of endoscopic treatment were performed). Other 24 hemorrhagic episodes could be managed without any change in the outcome of the endoscopy and, consequently, were considered incidents. We did not find any independent risk factor of bleeding.CONCLUSION Gastroduodenal polypectomy using prophylactic measures has a rate of AEs small enough to consider this procedure a safe and effective method for polyp resection independently of the polyp size and location. | Henry Córdova Lidia Argüello Carme Loras Antonio Naranjo Rodríguez Faust Riu Pons Joan B Gornals David Nicolás-Pérez Xavier Andújar Murcia Luis Hernández Santos Santolaria Carles Leal Carles Pons Enrique Pérez-Cuadrado-Robles Orlando García-Bosch Michel Papo Berger José Luis Ulla Rocha Cristina Sánchez-Montes Gloria Fernández-Esparrach | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 13 | Pneumo-CT assessing response to neoadjuvant therapy in esophageal cancer: Imaging-pathological correlation显示文摘Pneumo-computed tomography (PnCT) is a technique primarily developed and used to study stenotic lesions of the esophagus, gastroesophageal junction and stom-ach for pre-surgical planning. It helps to define both upper and lower borders of neoplasms located in the aforementioned areas. It achieves maximum lumen distension with CO2 highlighting thickened areas of the esophageal wall, thus allowing an accurate quantifica-tion of their extents. Although there are other alterna-tives for distension (oral contrast agents, water and ef-fervescent granules), they may be suboptimal. Patients with locally advanced esophageal cancer have a dismal prognosis despite surgical resection. Therefore, neo-adjuvant treatment strategies using radiation therapy and chemotherapy were developed to improve sur-vival. Neoadjuvant therapy improves esophageal tumor prognosis in a substantial proportion of patients, and the use of imaging techniques is mandatory to detect their response. PnCT combined with virtual endoscopy and multiplanar reconstruction enhances morphologic details in esophageal cancer, and thus would allow animproved assessment of response to neoadjuvant treat-ment. Therefore, more information could be provided to assess the efficacy of pre-surgical treatment. We de-scribe the potential use of PnCT to assess the response to neoadjuvant therapy in esophageal cancer with an imaging pathologic correlation. | Marina Ulla Ernestina Gentile Ezequiel Levy Yeyati Maria L Diez Demetrio Cavadas Ricardo D Garcia-Monaco Pablo R Ros | 2013 | World Journal of Gastrointestinal Oncology2013，5，12： | 3 |
| 14 | Mucosal healing at 3 months predicts long-term endoscopic remission in anti-TNF-treated luminal Crohn’s disease显示文摘 | Clas-G?ran af Bj?rkesten Urpo Nieminen Taina Sipponen Ulla Turunen Perttu Arkkila Martti F?rkkil? | 2013 | Scandinavian Journal of Gastroenterology2013，，5： | 2 |
| 15 | Design of the Novel Protraction Mechanism of Insulin Degludec, an Ultra-long-Acting Basal Insulin显示文摘 | Ib Jonassen Svend Havelund Thomas Hoeg-Jensen Dorte Bjerre Steensgaard Per-Olof Wahlund Ulla Ribel | 2012 | Pharmaceutical Research2012，，8： | 2 |
| 16 | Potential of dry fractionation of wheat bran for the development of food ingredients, part I: Influence of ultra-fine grinding显示文摘 | Youna Hemery Marc Chaurand Ulla Holopainen Anna-Maija Lampi Pekka Lehtinen Vieno Piironen Abdelkrim Sadoudi Xavier Rouau | 2010 | Journal of Cereal Science2010，，1： | 2 |
| 17 | Recent applications of ionic liquids in quasi-solid-state lithium metal batteries显示文摘Quasi-solid-state lithium metal batteries are considered as one of the most promising energy storage devices,and the application of ionic liquids(ILs)as a new generation of functionalized electrolyte components in lithium metal batteries has become one of the research focuses.In this review,the very recent research work related to using ILs to develop quasi-solid-state electrolytes and their influences on the performances of quasi-solid-state lithium metal batteries were surveyed and summarized,suggesting that the introduction of ILs can improve the ionic conductivity,broaden the electrochemical stability window,and enhance the electrochemical stability of the selected electrolytes.Moreover,using ILs to prepare high-performance electrodes with unique microstructures and uniform distribution of fillers were also introduced.The composite quasi-solid-state electrolytes were suggested as the mainstream of electrolytes in the future due to the combination of the advantages of inorganic and polymer quasi-solid-state electrolytes,and their development challenges in high energy and high safety quasisolid-state lithium metal batteries were also discussed. | Jiajia Li Fangfang Li Lan Zhang Haitao Zhang Ulla Lassi Xiaoyan Ji | 2021 | Green Chemical Engineering2021，2，3： | 2 |
| 18 | Vadim Fridman Bioelectrocatalysis by redox enzymes at modified electrodes显示文摘 | Frieder W Scheller Ulla Wollenberger | 2002 | Reviews in Molecular Biotechnology2002，，82： | 2 |
| 19 | 传输系统中的时钟同步技术显示文摘网络同步和时钟产生是高速传输系统设计的重要方面。为了通过降低发射和接收错误来提高网络效率,必须使系统的各个阶段都要使用的时钟的质量保持特定的等级。网络标准定义同步网络的体系结构及其在标准接口上的预期性能,以保证传输质量和传输设备的无缝集成。有大量的同步问题,系统设计人员在建立系统体系结构时必须十分清楚。本文论述了时钟恶化的各种来源,如抖动和漂移。本文还讨论了传输系统中时钟恶化的原因和影响,并分析了标准要求,提出了各种实现技巧。 | Ullas Kumar | 2004 | 电子设计技术 EDN CHINA2004，11，12： | 2 |
| 20 | Gallbladder cancer with tumor thrombus in the superior vena cava显示文摘BACKGROUND:Gastrointestinal cancers,especially pancreatobiliary cancers,are frequently associated with or are complicated by thromboembolic phenomena due to hypercoagulability and/or altered venous drainage,especially of the abdomen and lower limbs.This report describes an unusual and interesting case of gallbladder carcinoma developing a viable tumor thrombus in the superior vena cava(SVC)with resultant SVC obstruction,while on gefitinibbased anti-epidermal growth factor receptor(EGFR)therapy.METHODS:A 60-year-old woman was incidentally diagnosed to have gallbladder cancer on cholecystectomy.She had disease recurrence and received systemic chemotherapy followed by gefitinib-based anti-EGFR therapy.Subsequently,while on gefitinib-based therapy,she presented with clinical signs and symptoms suggestive of SVC thrombosis.RESULTS:A whole body PET scan revealed a metabolically active tumor thrombus in the SVC,besides other sites of metabolically active disease inclusive of the lung parenchyma, lymph nodes and abdomen.She was treated with antithrombotics and external beam radiotherapy directed to the SVC thrombus leading to symptomatic relief.She continues to survive on the day of writing this report.CONCLUSIONS:This rare complication,though theoretically possible,is unreported because of the short overall survival of advanced gallbladder cancer patients.This highlights that with the availability of better chemotherapeutic/biotherapeutic agents for increasing in the lifespan of cancer patients,we may come across such cases more frequently in the future. | Sandeep Batra Dinesh Chandra Doval Ullas Batra Pandalanghat Suresh Amit Dhiman Vineet Talwar | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，3： | 2 |
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