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| 1 | Distortion of memory Vδ2 γδ T cells contributes to immune dysfunction in chronic HIV infection显示文摘γ δT 房间是在天生的豁免起重要作用对传染疾病的辩护首要。人的免疫不全病毒(HIV ) 感染破坏在 Vδ 之间的平衡; 1 T 房间和 Vδ在 γ 之中的 2 T 房间和原因机能障碍; δT 房间。然而,生物机制和这混乱的临床的后果要求进一步的调查。在这研究,我们执行了显型的全面分析和记忆 γ 的功能; δ在有 HIV 感染的中国个人的队的 T 房间。我们在记忆 Vδ 发现了一个动态变化; 2γ δT 房间,扭曲了向一激活并且严重地区分了受动器记忆显型 T EMRA Vδ 2γ δT 房间,可以说明 Vδ 的机能障碍, 2γ δ在 HIV 疾病的 T 房间。另外,我们发现那 IL-17-producing γ δT 房间显著地与快疾病前进在感染 HIV 的病人被增加并且断然与 HLA 医生 +γ 相关; δT 房间和 CD38 +HLA 医生 +γ δT 房间。这建议表明小径的 IL-17 涉及 γ δT 房间激活和 HIV 致病。我们的调查结果提供新奇卓见进 Vδ 的角色; 2 T 房间在 HIV 致病期间并且代表与这些房间考虑有免疫力的治疗的一个健全基础。 | Zhen Li Yanmei Jiao Yu Hu Lianxian Cui Dexi Chen Hao Wu Jianmin Zhang Wei He | 2015 | Cellular & Molecular Immunology2015，12，5： | 7 |
| 2 | 激光加工技术在塑料成型加工中的应用研究进展显示文摘激光技术作为一种高能物理加工手段,具有加热速度快、热量集中以及可操作性强等优势,在塑料加工成型领域被广泛应用。本文总结了激光技术在传统塑料焊接机切割中的应用进展,并综述了激光技术在塑料加工新原理、新方法及新装备中的应用。特别分析了激光技术,在提升塑料加工效率、加工质量以及独特加工场合等的先进性。未来进一步强化激光技术和塑料加工技术参数耦合,有望实现更多的塑料加工新途径,实现更多的工业化塑料加工新产业。 | 高晓东 李好义 陈明军 Wang Dexi | 2019 | 橡塑技术与装备2019，45，8： | 6 |
| 3 | Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer显示文摘Given that only a subset of patients with colorectal cancer(CRC)benefit from immune checkpoint therapy,efforts are ongoing to identify markers that predict immunotherapeutic response.Increasing evidence suggests that microbes influence the efficacy of cancer therapies.Fusobacterium nucleatum induces different immune responses in CRC with different microsatellite-instability(MSI)statuses.Here,we investigated the effect of F.nucleatum on anti-PD-L1 therapy in CRC.We found that high F.nucleatum levels correlate with improved therapeutic responses to PD-1 blockade in patients with CRC.Additionally,F.nucleatum enhanced the antitumor effects of PD-L1 blockade on CRC in mice and prolonged survival.Combining F.nucleatum supplementation with immunotherapy rescued the therapeutic effects of PD-L1 blockade.Furthermore,F.nucleatum induced PD-L1 expression by activating STING signaling and increased the accumulation of interferon-gamma(IFN-γ)^(+)CD8^(+)tumor-infiltrating lymphocytes(TILs)during treatment with PD-L1 blockade,thereby augmenting tumor sensitivity to PD-L1 blockade.Finally,patient-derived organoid models demonstrated that increased F.nucleatum levels correlated with an improved therapeutic response to PD-L1 blockade.These findings suggest that F.nucleatum may modulate immune checkpoint therapy for CRC. | Yaohui Gao Dexi Bi Ruting Xie Man Li Jing Guo Hu Liu Xianling Guo Juemin Fang Tingting Ding Huiyuan Zhu Yuan Cao Meichun Xing Jiayi Zheng Qing Xu Qian Xu Qing Wei Huanlong Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 3 |
| 4 | Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1显示文摘Our previous studies have shown that infection with the gp120 V3 loop can cause human immunodeficiency virus-1 associated neurocognitive disorders. Curcumin has been shown to improve these effects to some degree, but the precise mechanisms remain unknown. The present study analyzed the neuroprotective effect and mechanism of curcumin in relation to hippocampal neurons. Results showed that 1 nmol/L gp120 V3 loop suppressed the growth of synapses. After administration of 1 μmol/L curcumin, synaptic growth improved. Curcumin is neuroprotective against gp120 V3 loop-induced neuronal damage by inhibiting the activation of L-type calcium currents, relieving intracellular Ca2+ overload, promoting Bcl-2 expression, and inhibiting Bax activation. The effect of curcumin was identical to nimodipine, suggesting that curcumin has the same neuroprotective effects against gp120 V3 loop-induced neuronal damage. | Hongmei Tang Rui Pan Wenli Fang Yanyan Xing Dexi Chen Xiaobao Chen Yuanyuan Yu Junbing Wang Zheng Gong Guoyin Xiong Jun Dong | 2013 | Neural Regeneration Research2013，8，15： | 3 |
| 5 | Synthetic FXR Agonist GW4064 Prevents Diet-Induced Hepatic Steatosis and Insulin Resistance显示文摘 | Yongjie Ma Yixian Huang Linna Yan Mingming Gao Dexi Liu | 2013 | Pharmaceutical Research2013，，5： | 3 |
| 6 | Lactulose mediates suppression of dextran sulfate sodium-induced colon inflammation显示文摘Objective:Assessment of digestion colonic flora lactulose can be induced to produce hydrogen and prove lactulose with a potential anti-inflammatory effects. Methods:We established a mouse model of human ulcerative colitis (UC) by supplying mice with water containing dextran sulfate sodium (DSS). At 7-day, DSS-induced pathogenic outcomes, including loss of body weight, increase of colitis score, pathogenic shortening of colon length, elevated level of TNF-α, IL-1β, malondialdehyde (MDA) and myeloperoxidase (MPO) deficiency in colon lesions, were significantly suppressed by lactulose administration and intraperitoneally injected hydrogen water. Results:After eliminating colon microflora by antibiotics, the anti-inflammatory effects of lactulose were significantly compromised. Histological analysis also revealed that the DSS mediated colonic tissue destruction accompanied by neutrophils infiltration was remarkably suppressed by lactulose and hydrogen water. Conclusion:The present study indicated that lactulose can prevent the development of DSS-induced colitis and alleviate oxidative stress state in colitis. | HAI Yuedong HONG Yu WANG Qi LIU Xudong LI Dexi | 2013 | Journal of Medical Colleges of PLA(China)2013，28，2： | 2 |
| 7 | Genome-wide identification and expression analysis of NIN-like Protein(NLP)genes reveals their potential roles in the response to nitrate signaling in watermelon显示文摘To balance the relationship between high yield and low nitrogen supply,the nitrogen utilization efficiency of watermelon needs to be improved urgently.Nodule inception-like Protein(NLP)transcription factors play a key node role in nitrate response and growth and development of plant,however,comprehensive analysis of the NLP gene family in watermelon is unclear.This study explored the functional classification,evolutionary characteristics,and expression profile of the ClNLP gene family.Three ClNLPs were categorized into three groups according to their gene structure and phylogeny.All of them contained the conserved RWP-RK and PB1 domains.Evolutionary analysis of ClNLPs revealed that ClNLP1 and ClNLP3 underwent strong purified selection.In addition,cis-acting elements related to plant hormones and abiotic stresses were present in the ClNLP promoter.According to tissue-specific analysis ClNLP was widely expressed in roots,stems,leaves,flowers and fruits,and ClNLP1 was significantly induced in the roots of different nitrogen utilization varieties under different nitrate nitrogen supply.The SRTING functional protein association network suggested that ClNLP1 is associated with most genes,such as NRT1.1,NRT2.1,NIA1,and NIR1,and the dual-luciferase reporter assay found that ClNLP1 positively regulates the expression of ClNRT2.1.We speculated that ClNLP1 might play a central role in regulating the response of watermelon to nitrate nitrogen. | Gaopeng Yuan Dexi Sun Yifan Wang Guolin An Weihua Li Wenjing Si Junpu Liu Yingchun Zhu | 2022 | Horticultural Plant Journal2022，8，5： | 2 |
| 8 | High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients显示文摘The outbreak of coronavirus disease 2019(COVID-19)caused by the new virus SARS-CoV-2 has been announced as a public health emergency of international concern.1–3 The clinical features of patients with COVID-19 range from common fever and cough to other rare symptoms,such as diarrhea and nausea.This disease can progress quickly,and 2–3%of patients die within a short time,which is generally due to multiple organ failure.4–7 Clinically,COVID-19 patients are classified into mild,moderate,severe,and critical cases.5–7 The immune response against SARS-CoV-2 is probably linked to the severity of disease.Recently,Zheng et al.8 showed that elevated levels of T-cell exhaustion and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients;however,a more comprehensive understanding of the pathology of SARS-CoV-2 infection remains to be delineated.Here,we profiled immune cellular components using mass cytometry(CyTOF)to analyze the peripheral blood mononuclear cells(PBMCs)from patients with differences in disease progression by comparing with the PBMCs from healthy donors(HDs). | Wenjing Wang Bin Su Lijun Pang Luxin Qiao Yingmei Feng Yabo Ouyang Xianghua Guo Hongbo Shi Feili Wei Xiaogang Su Jiming Yin Ronghua Jin Dexi Chen | 2020 | Cellular & Molecular Immunology2020，17，6： | 2 |
| 9 | Ketogenic diet for human diseases:the underlying mechanisms and potential for clinical implementations显示文摘The ketogenic diet(KD)is a high-fat,adequate-protein,and very-low-carbohydrate diet regimen that mimics the metabolism of the fasting state to induce the production of ketone bodies.The KD has long been established as a remarkably successful dietary approach for the treatment of intractable epilepsy and has increasingly garnered research attention rapidly in the past decade,subject to emerging evidence of the promising therapeutic potential of the KD for various diseases,besides epilepsy,from obesity to malignancies.In this review,we summarize the experimental and/or clinical evidence of the efficacy and safety of the KD in different diseases,and discuss the possible mechanisms of action based on recent advances in understanding the influence of the KD at the cellular and molecular levels.We emphasize that the KD may function through multiple mechanisms,which remain to be further elucidated.The challenges and future directions for the clinical implementation of the KD in the treatment of a spectrum of diseases have been discussed.We suggest that,with encouraging evidence of therapeutic effects and increasing insights into the mechanisms of action,randomized controlled trials should be conducted to elucidate a foundation for the clinical use of the KD. | Huiyuan Zhu Dexi Bi Youhua Zhang Cheng Kong Jiahao Du Xiawei Wu Qing Wei Huanlong Qin | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 10 | Synthesis of bifunctional cationic compound for gene delivery显示文摘 | Tan Ren Guisheng Zhang Dexi Liu | 2001 | Tetrahedron Letters2001，42，： | 1 |
| 11 | Determination of the optical constants of polymer light-emitting diode films from single reflection measurements 显示文摘 | ZHU Dexi SHEN Weidong YE Hui | 2008 | Journal of Physics D: Applied Physics(S0022-3727)2008，41，23： | 1 |
| 12 | Development of an In-House Multiplex Nested RT-PCR Method for Detecting Acute HIV-1 Infection in High Risk Populations显示文摘 | Zhiying Liu Wei Li Meng Xu Bo Sheng Zixuan Yang Yanmei Jiao Tong Zhang Danlei Mou Dexi Chen Hao Wu | 2015 | Current HIV Research2015，，： | 1 |
| 13 | Depending on the stage of hepatosteatosis, p53 causes apoptosis primarily through either DRAM ‐induced autophagy or BAX显示文摘 | Kai Liu Jinli Lou Tao Wen Jiming Yin Bin Xu Wei Ding Anna Wang Daojie Liu Chao Zhang Dexi Chen Ning Li | 2013 | Liver Int2013，，10： | 1 |
| 14 | Hybrid Neural Network Based Gray-Box Approach to Fault Detection of Hybrid Systems 显示文摘 | Wang Wenhui An Dexi Zhou Donghua | 2004 | Springer-Verlag2004，2004，： | 1 |
| 15 | Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways显示文摘 | Dexi Zhou Cheng Huang Zhen Lin Shuxiang Zhan Lingna Kong Chengbo Fang Jun Li | 2014 | Cellular Signalling2014，，2： | 1 |
| 16 | Hydrodynamic plasmid DNA gene therapy model in liver transplantation显示文摘 | George T Yoshihito T Dexi L | 2006 | J Surg Res2006，135，2： | 1 |
| 17 | The p53 Pathway Promotes Efficient Mitochondrial DNA Base Excision Repair in Colorectal Cancer Cells 显示文摘 | Dexi Chen Zhiyong Yu Zlliyi Zhu | 2006 | Cancer Res2006，66，7： | 1 |
| 18 | Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA 显示文摘 | Liu Feng Song YK Liu Dexi | 1999 | Gene Ther1999，6，7： | 1 |
| 19 | A B-lectin recep- tor kinase gene conferring rice blast resistance 显示文摘 | Chen Xuewei Shang Junjun Chen Dexi | 2006 | The Plant Jour- nal2006，46，5： | 1 |
| 20 | A new generation of high-performance PVC alloys显示文摘 | Weng Dexi Andries John Saunders Keith | 2000 | Plast Eng2000，58，3： | 1 |
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