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| 1 | Distortion of memory Vδ2 γδ T cells contributes to immune dysfunction in chronic HIV infection显示文摘γ δT 房间是在天生的豁免起重要作用对传染疾病的辩护首要。人的免疫不全病毒(HIV ) 感染破坏在 Vδ 之间的平衡; 1 T 房间和 Vδ在 γ 之中的 2 T 房间和原因机能障碍; δT 房间。然而,生物机制和这混乱的临床的后果要求进一步的调查。在这研究,我们执行了显型的全面分析和记忆 γ 的功能; δ在有 HIV 感染的中国个人的队的 T 房间。我们在记忆 Vδ 发现了一个动态变化; 2γ δT 房间,扭曲了向一激活并且严重地区分了受动器记忆显型 T EMRA Vδ 2γ δT 房间,可以说明 Vδ 的机能障碍, 2γ δ在 HIV 疾病的 T 房间。另外,我们发现那 IL-17-producing γ δT 房间显著地与快疾病前进在感染 HIV 的病人被增加并且断然与 HLA 医生 +γ 相关; δT 房间和 CD38 +HLA 医生 +γ δT 房间。这建议表明小径的 IL-17 涉及 γ δT 房间激活和 HIV 致病。我们的调查结果提供新奇卓见进 Vδ 的角色; 2 T 房间在 HIV 致病期间并且代表与这些房间考虑有免疫力的治疗的一个健全基础。 | Zhen Li Yanmei Jiao Yu Hu Lianxian Cui Dexi Chen Hao Wu Jianmin Zhang Wei He | 2015 | Cellular & Molecular Immunology2015，12，5： | 7 |
| 2 | Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1显示文摘Our previous studies have shown that infection with the gp120 V3 loop can cause human immunodeficiency virus-1 associated neurocognitive disorders. Curcumin has been shown to improve these effects to some degree, but the precise mechanisms remain unknown. The present study analyzed the neuroprotective effect and mechanism of curcumin in relation to hippocampal neurons. Results showed that 1 nmol/L gp120 V3 loop suppressed the growth of synapses. After administration of 1 μmol/L curcumin, synaptic growth improved. Curcumin is neuroprotective against gp120 V3 loop-induced neuronal damage by inhibiting the activation of L-type calcium currents, relieving intracellular Ca2+ overload, promoting Bcl-2 expression, and inhibiting Bax activation. The effect of curcumin was identical to nimodipine, suggesting that curcumin has the same neuroprotective effects against gp120 V3 loop-induced neuronal damage. | Hongmei Tang Rui Pan Wenli Fang Yanyan Xing Dexi Chen Xiaobao Chen Yuanyuan Yu Junbing Wang Zheng Gong Guoyin Xiong Jun Dong | 2013 | Neural Regeneration Research2013，8，15： | 3 |
| 3 | High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients显示文摘The outbreak of coronavirus disease 2019(COVID-19)caused by the new virus SARS-CoV-2 has been announced as a public health emergency of international concern.1–3 The clinical features of patients with COVID-19 range from common fever and cough to other rare symptoms,such as diarrhea and nausea.This disease can progress quickly,and 2–3%of patients die within a short time,which is generally due to multiple organ failure.4–7 Clinically,COVID-19 patients are classified into mild,moderate,severe,and critical cases.5–7 The immune response against SARS-CoV-2 is probably linked to the severity of disease.Recently,Zheng et al.8 showed that elevated levels of T-cell exhaustion and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients;however,a more comprehensive understanding of the pathology of SARS-CoV-2 infection remains to be delineated.Here,we profiled immune cellular components using mass cytometry(CyTOF)to analyze the peripheral blood mononuclear cells(PBMCs)from patients with differences in disease progression by comparing with the PBMCs from healthy donors(HDs). | Wenjing Wang Bin Su Lijun Pang Luxin Qiao Yingmei Feng Yabo Ouyang Xianghua Guo Hongbo Shi Feili Wei Xiaogang Su Jiming Yin Ronghua Jin Dexi Chen | 2020 | Cellular & Molecular Immunology2020，17，6： | 2 |
| 4 | Development of an In-House Multiplex Nested RT-PCR Method for Detecting Acute HIV-1 Infection in High Risk Populations显示文摘 | Zhiying Liu Wei Li Meng Xu Bo Sheng Zixuan Yang Yanmei Jiao Tong Zhang Danlei Mou Dexi Chen Hao Wu | 2015 | Current HIV Research2015，，： | 1 |
| 5 | Depending on the stage of hepatosteatosis, p53 causes apoptosis primarily through either DRAM ‐induced autophagy or BAX显示文摘 | Kai Liu Jinli Lou Tao Wen Jiming Yin Bin Xu Wei Ding Anna Wang Daojie Liu Chao Zhang Dexi Chen Ning Li | 2013 | Liver Int2013，，10： | 1 |
| 6 | The p53 Pathway Promotes Efficient Mitochondrial DNA Base Excision Repair in Colorectal Cancer Cells 显示文摘 | Dexi Chen Zhiyong Yu Zlliyi Zhu | 2006 | Cancer Res2006，66，7： | 1 |
| 7 | A B-lectin recep- tor kinase gene conferring rice blast resistance 显示文摘 | Chen Xuewei Shang Junjun Chen Dexi | 2006 | The Plant Jour- nal2006，46，5： | 1 |
| 8 | Mitochondrial DNA base excision repair and mitochondrial DNA mutation in human hepatic HuH-7 cells exposed to stavudine显示文摘 | Yasong Wu Ning Li Tong Zhang Hao Wu Chun Huang Dexi Chen | 2009 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2009，，1： | 1 |
| 9 | Occurrence Regularity and Control of Thrips on Leek显示文摘[Objective] The paper was to clear the species and occurrence regularity of thrips severely occurred in leek field, and to study the main control methods. [Methods] The species of thrips on leek were identified in Sichuan Province, and the damage symptoms, occurrence regularity and control methods of thrips in leek field were studied. [Result] The morphological characteristic of thrips on leek was Frankliniella occidentalis(Pergande). ITS molecular identification results showed that the amplified fragment was 520 bp, which shared the similarity of 99.81% with the base se-quence of F. occidentalis. F. occidentalis concentrated at the height of 80 cm from the ground; in sunny days, the occurrence frequency of F. occidentalis was relatively high during 15:00 and 17:00; rainwater had obvious lethal effect on F. occidentalis, and the lethal rate was 29.30%. Field trial showed that 20% dinotefuran SG and 40% acetamiprid GR had good control effect against F. occidentalis. The control effect of 20% dinotefuran SG 1 500 times dilution was the best, up to 92.56%. [Conclusion] The results will provide effective technical support for large-scale control of thrips in leek field. | Chen Dexi He Zhongquan Guo Yunjian Huang Tengfei Yi Xueqing Liu Huan Lu Daijuan Liu Fuping | 2018 | Plant Diseases and Pests2018，9，3： | 0 |
| 10 | Composite topological nodal lines penetrating the Brillouin zone in orthorhombic AgF_(2)显示文摘It has recently been found that nonsymmorphic symmetries can bring many exotic band crossings.Here,based on symmetry analysis,we predict that materials with time-reversal symmetry in the space group of Pbca(No.61)possess rich symmetry-enforced band crossings,including nodal surfaces,fourfold degenerate nodal lines and hourglass Dirac loops,which appear in triplets as ensured by the cyclic permutation symmetry.We take Pbca AgF_(2) as an example in real systems and studied its band structures with ab initio calculations.Specifically,in the absence of spin-orbit coupling(SOC),besides the above-mentioned band degeneracies,this system features a nodal chain and a nodal armillary sphere penetrating the Brillouin zone(BZ).While with SOC,we find a new configuration of the hourglass Dirac loop/chain with the feature traversing the BZ,which originates from the splitting of a Dirac loop confined in the BZ.Furthermore,guided by the bulk-surface correspondence,we calculated the surface states to explore these bulk nodal phenomena.The evolution of these interesting nodal phenomena traversing the BZ under two specific uniaxial strains is also discussed. | Dexi Shao Huaiqiang Wang Tong Chen Pengchao Lu Qinyan Gu Li Sheng Dingyu Xing Jian Sun | 2019 | npj Computational Materials2019，，1： | 0 |
| 11 | Inactivation of tumor suppressor TAp63 by hepatitis B virus X protein in hepatocellular carcinoma显示文摘Background: The hepatitis B virus X (HBx) protein plays a critical role in the initiation and progression of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). In the early stage of the disease, HBx facilitates tumor onset by inactivating the tumor suppressor p53. The p53-encoding gene, however, is frequently mutated or deleted as the cancer progresses to the late stage and, under such circumstance, the p53 homolog TAp63 can harness HCC growth by transactivating several important p53-target genes.Methods: To determine whether HBx regulates TAp63, we performed co-immunoprecipitation assay, real-time quantitative polymerase chain reaction, immunoblotting, and flow cytometry analysis in p53-null cancer cell lines, Hep3B and H1299.Results: HBx interacts with the transactivation domain of TAp63, as HBx was co-immunoprecipitated with TAp63 but not with ΔNp63. The interaction between HBx and TAp63 abolished transcriptional activity of TAp63, as evidenced by the reduction of the levels of its target genesp21 andPUMA, consequently leading to restricted apoptosis and augmented proliferation of HCC cells.Conclusion: HBV induces progression of HCC that harbors defective p53 by inhibiting the tumor suppressor TAp63. | Bangxiang Xie Qian Hao Xiang Zhou Dexi Chen | 2022 | Chinese Medical Journal2022，，14： | 0 |
| 12 | Correlation study of relative parameters of intracranial pressure and prognosis of patient with craniocerebral injury显示文摘Objective:To analyze the correlation of the relative parameters of intracranial pressure to the prognosis in patients with craniocerebral injury.Methods:The clinical data of 80 patients with closed craniocerebral injury were retrospectively analyzed,and all of these patients underwent conventional examinations of arterial blood pressure and intracranial pressure.Neumatic DCR system was used to monitor relative parameters of intracranial pressure from patients.According to the score of Glasgow outcome scale(GOS)upon discharge,they were divided into favorable prognosis group(GOSⅢ-Ⅴ,n=46)and unfavorable prognosis group(GOSⅠ-Ⅱ,n=34).The relative parameters of intracranial pressure of two groups were compared so as to analyze the correlation of the prognosis in patients to ICP-related parameters.Results:Pressure reactivity index(PRx)and intracranial pressure(ICP)of favorable prognosis group were significantly higher than those of unfavorable prognosis group(t=12.27,t=5.22,p<0.05).Meanwhile,cerebral perfusion pressure(CPP)and ICP-ABP wave amplitude correlation(IAAC)of favorable prognosis group were significantly lower than those of unfavorable prognosis group(t=14.54,t=14.78,p<0.05).The average age,gender,duration of admission to neurosurgical intensive care unit(NICU)and GCS(Glasgow coma scale)score on admission of the two groups were not statistically significant.Conclusions:The prognosis and ICP-related parameters(such as PRx,ICP,CPP,etc.)in patients with craniocerebral injury are risk factors for the prognosis effect.Therefore,to monitor the above-mentioned indicators has an important clinical value for assessing the prognosis of craniocerebral injury. | Laixing Liu Yixin Deng Fuquan Liu Lei Chen Dexi Li Xiangyi Wang | 2019 | Discussion of Clinical Cases2019，6，4： | 0 |
| 13 | Large Spin Hall Conductivity and Excellent Hydrogen Evolution Reaction Activity in Unconventional PtTe1.75 Monolayer显示文摘Two-dimensional(2D)materials have gained lots of attention due to the potential applications.In this work,we propose that based on first-principles calculations,the(2×2)patterned PtTe_(2)monolayer with kagome lattice formed by the well-ordered Te vacancy(PtTe_(1.75))hosts large and tunable spin Hall conductivity(SHC)and excellent hydrogen evolution reaction(HER)activity.The unconventional nature relies on the A1@1b band representation of the highest valence band without spin–orbit coupling(SOC).The large SHC comes from the Rashba SOC in the noncentrosymmetric structure induced by the Te vacancy.Even though it has a metallic SOC band structure,theℤ_(2)invariant is well defined because of the existence of the direct bandgap and is computed to be nontrivial.The calculated SHC is as large as 1.25×10^(3)h/e(Ωcm)^(−1)at the Fermi level(EF).By tuning the chemical potential from EF−0.3 to EF+0.3 eV,it varies rapidly and monotonically from−1.2×10^(3)to 3.1×10^(3)h/e(Ωcm)^(−1)In addition,we also find that the Te vacancy in the patterned monolayer can induce excellent HER activity.Our results not only offer a new idea to search 2D materials with large SHC,i.e.,by introducing inversion–symmetry breaking vacancies in large SOC systems,but also provide a feasible system with tunable SHC(by applying gate voltage)and excellent HER activity. | Dexi Shao Junze Deng Haohao Sheng Ruihan Zhang Hongming Weng Zhong Fang Xing-Qiu Chen Yan Sun Zhijun Wang | 2023 | Research2023，，3： | 0 |
| 14 | TP53BP2:Roles in suppressing tumorigenesis and therapeutic opportunities显示文摘Malignant tumor is still a major problem worldwide.During tumorigenesis or tumor development,tumor suppressor p53-binding protein 2(TP53BP2),also known as apoptosis stimulating protein 2 of p53(ASPP2),plays a critical role in p53 dependent and independent manner.Expression of TP53BP2 is highly correlated with the prognosis and survival rate of malignant tumor patients.TP53BP2 can interact with p53,NF-κB p65,Bcl-2,HCV core protein,PP1,YAP,CagA,RAS,PAR3,and other proteins to regulate cell function.Moreover,TP53BP2 can also regulate the proliferation,apoptosis,autophagy,migration,EMT and drug resistance of tumor cells through downstream signaling pathways,such as NF-κB,RAS/MAPK,mevalonate,TGF-β1,PI3K/AKT,aPKC-ι/GLI1 and autophagy pathways.As a potential therapeutic target,TP53BP2 has been attracted more attention.We review the role of TP53BP2 in tumorigenesis or tumor development and the signal pathway involved in TP53BP2,which may provide more deep insight and strategies for tumor treatment. | Yunfei Huo Ke Cao Buxin Kou Mengyin Chai Shuangshuang Dou Dexi Chen Ying Shi Xiaoni Liu | 2023 | Genes & Diseases2023，10，5： | 0 |
| 15 | Hepatitis B Virus Induces Microtubule Stabilization to Promote Productive Infection through Upregulating Microtubule-associated Protein 1S显示文摘Background and Aims:Continuous release and transmission of hepatitis B virus(HBV)is one of the main factors leading to chronic hepatitis B(CHB)infection.However,the mechanism of HBV-host interaction for optimal viral transport is unclear.Hence,we aimed to explore how HBV manipulates microtubule-associated protein 1S(MAP1S)and microtubule(MT)to facilitate its transport and release.Methods:The expression of MAP1S or acetylated MT was investigated by immunofluorescence,RT-PCR,immunoblotting,and plasmid transfection.MAP1S overexpression or knockdown was performed by lentiviral infection or shRNA transfection,respectively.HBV DNA was quantified using q-PCR.Results:Significantly higher level of MAP1S in HepG2215 cells compared with HepG2 cells was detected using RT-PCR(p<0.01)and immunoblotting(p<0.001).Notably,stronger MAP1S expression was observed in the liver tissues of patients with CHB than in healthy controls.MAP1S overexpression or knockdown demonstrated that MAP1S promoted MT acetylation and reduced the ratio of HBV DNA copies inside to outside cells.Further,transfection with the hepatitis B virus X protein(HBx)-expressing plasmids induced significantly higher level of MAP1S than that in controls(p<0.0001),whereas HBVX−mutant-encoding HBV proteins(surface antigen,core protein,and viral DNA polymerase)hardly affected its expression.Conclusions:These results demonstrate that HBx induces the forma tion of stable MTs to promote the release of HBV particles through upregulating MAP1S.Thus,our studies delineate a unique molecular pathway through which HBV manipulates the cytoskeleton to facilitate its own transportation,and indicate the possibility of targeting MAP1S pathway for treatment of patients with CHB. | Yuanyue Guan Bin Sun Shijie Zhang Yuan Zhuang Yanxiang Huang Minghua Lin Rongling Zheng Dexi Chen Ying Shi Yanjun Wang | 2022 | Journal of Clinical and Translational Hepatology2022，10，3： | 0 |
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