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| 1 | Non-transgenic Plant Genome Editing Using Purified Sequence-Specific Nucleases显示文摘Dear Editor, Sequence-specific nucleases,including zinc-finger nucleases,meganucleases,TAL effector nucleases (TALENs),and CRISPR/ Cas systems,have been used to introduce targeted mutations in a wide range of plant species (Voytas,2013;Baltes and Voytas,2015).However,delivery of these nucleases using traditional transformation methods (e.g.,particle bombardment,Agrobacterium or protoplast transformation) may result in undesired genetic alterations due to random insertion of nucleaseencoding DNA intothe host genome. | Song Luo Jin Li Thomas J. Stoddard Nicholas J. Baltes Zachary L. Demorest Benjamin M. Clasen Andrew Coffman Adam Retterath Luc Mathis Daniel F. Voytas Feng Zhang | 2015 | Molecular Plant2015，8，9： | 7 |
| 2 | Contraindications for video capsule endoscopy显示文摘Video capsule endoscopy(VCE) has been applied in the last 15 years in an increasing field of applications. Although many contraindications have been put into perspective, some precautions still have to be considered. Known stenosis of the gastrointestinal tract is a clear contraindication for VCE unless surgery is already scheduled or at least has been considered as an optional treatment modality. In patients with a higher incidence of stenosis, as in an established diagnosis of Crohn's disease, clinical signs of obstruction, prior radiation or surgical small bowel resection, a preceding test with the self-dissolving patency capsule can override this contraindication. Endoscopic placement of the capsule should be considered in patients with swallowing disorders to avoid aspiration. Esophageal or gastric motility disorders may require endoscopic capsule transport or application of prokinetics if the real-time viewer proofs delayed transit. In pregnant women, VCE should be restricted to urgent cases where diagnosis cannot be postponed after delivery, as data on safety are missing. There is theoretical and clinical evidence that patients with implanted cardiac devices such as a pacemaker, cardioverters or left heart assist devices, can safely undergo VCE in spite of still existing contraindication by manufacturers. Children from the age of 2 years have safely undergone VCE. Although video capsules are not proven safe with magnetic resonance imaging(MRI), first single cases of patients incidentally undergoing MRI with an incorporated capsule have been reported, showing susceptibility artifacts but no signs of clinical harm. | Dirk Bandorski Niehls Kurniawan Peter Baltes Reinhard Hoeltgen Matthias Hecker Dominik Stunder Martin Keuchel | 2016 | World Journal of Gastroenterology2016，22，45： | 2 |
| 3 | Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprutein显示文摘 | Baltes S Gastens AM Fedrowitz M | 2007 | Neuropharmacology2007，52，2： | 1 |
| 4 | Cryptococcal cell morphology affects host cell interactions and pathogenicity显示文摘 | Okagaki LH Strain AK Nielsen JN Charlier C Baltes NJ Chr6tien F Heitman J Dromer F Nielsen K | 2010 | PLoS Pathog2010，6，10： | 1 |
| 5 | Iatrogenic radial never injury with cannulate fixation of medial epicondyle fracrure in the pediatric humerus:a repore of 2 case显示文摘 | Marcu DM Balts J McCarty JJ | | 0，，02： | 1 |
| 6 | The role of gender in very old age : Profiles of functioning and everyday life patterns 显示文摘 | Smith J Baltes MM | 1998 | Psychol Aging1998，13，： | 1 |
| 7 | Perceived Controllability of Expected Psychological Change across Adulthood and Old Age显示文摘 | HECKHAUSEN J BALTES P | 1991 | Journal of Gerontology Psychological Sciences1991，46，4： | 1 |
| 8 | Relationships between psychological climate perceptions and work outcomes: a meta - analytic review显示文摘 | Parker CP Baltes BB Young SA | 2003 | J Organi Behav2003，24，4： | 1 |
| 9 | MCM-48-Supported Vanadium Oxide Catalysts, Prepared by the Molecular Designed Dispersion of VO(acac)2: A detailed study of the highly reactive MCM-48 surface and the structure and activity of the deposited VOx显示文摘 | Baltes K Cassiers K Van Der Voort P | 2001 | J Catal2001，197，： | 1 |
| 10 | Micromachined thermally based CMOS microsensors显示文摘 | BALTES H PAUL O BRAND O | 1998 | Proceedings of the IEEE1998，86，8： | 1 |
| 11 | Relationships be- tween psychological climate perceptions and work outcomes:a meta- analytic review 显示文摘 | PARKER C P BALTES B B YOUNG S A | 2003 | Joumal of Organizational Behavior2003，24，4： | 1 |
| 12 | Refractive index drop observed after precision molding of optical elements:A quantitative understanding based on the Tool-Narayanaswamy-Moynihan model显示文摘 | Fotheringham U Baltes A Fischer P | 2008 | Journal of the American Ceramic Society2008，91，3： | 1 |
| 13 | The management of imaging dose during image-guided radiotherapy:report of the AAPM task group 75显示文摘 | Murphy M J Baher J Balte S | 2007 | Med Phys2007，34，10： | 1 |
| 14 | Life-span Development Psychology显示文摘 | Baltes P Reese H Lipsett L | 1980 | An Rev Psychol1980，，31： | 1 |
| 15 | Study of the virulence of Actinobacillus pleuropneumoniae in finishing pigs as a basis for vaccination development显示文摘 | HENNIG-PAUKA I BALTES N JACOBSEN I | 2008 | Berl Munch Tierarztl Wochenschr2008，121，56： | 1 |
| 16 | CMOSmonolithic Microelectrode Array forthe Monitoring of Electrogenic Cells显示文摘 | Heer F Franks W Blau A Taschini S Ziegler C Hierlemann A Baltes B | 2004 | Biosensor & Bioelectronics2004，20，： | 1 |
| 17 | Mison Baiter's Mastering Microsoft Access 2003显示文摘 | Mison Balte | 2003 | USA: Sarns publishing2003，1，： | 1 |
| 18 | Effect of levetiracetam on the pharmacokinetics of adjunctive antiepileptic drugs: a pooled analysis of data from randomized clinical trial 显示文摘 | GIDAL B E BALTES E OTOUL C | 2005 | Epilepsy Research2005，64，1： | 1 |
| 19 | Alteration of thyroid hormone homeostasis by antiepileptic drugs in humans:involvement of glucuronosyl transferase induction显示文摘 | STROLIN BENEDETTI M WHOMSLEY R BALTES E | 2005 | Eur J Clin Pharmacol2005，61，12： | 1 |
| 20 | Wisdom-related knowledge:age/cohort differences in response to life-planning problems显示文摘 | Smith J Baltes P.B | | 0，，03： | 1 |
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