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| 1 | Inactivation of PTEN is associated with increased angiogenesis and VEGF overexpression in gastric cancer显示文摘AIM: To investigate the expression of PTEN/MMAC1/TEP1 and vascular endothelial growth factor (VEGF), their roles in biologic behavior and angiogenesis and their association in gastric cancer.METHODS: Immunohistochemical staining was used to evaluate the expression of PTEN, VEGF and microvascular density (MVD) on paraffin-embedded sections in 70 patients with primary gastric cancer and 24 patients with chronic superficial gastritis (CSG). Expression of PTEN, VEGF and MVD were compared with clinicopathological features of gastric cancer. The relationship between expression of PTEN, VEGF and MVD as well as the relationship between PTEN and VEGF expression in caner cells were investigated. RESULTS: PTEN expression significantly decreased (t= 3.98, P<0.01) whereas both VEGF expression and MVD significant increased (t = 4.29 and 4.41, respectively, both P<0.01) in gastric cancer group compared with CSG group. PTEN expression was significantly down-regulated (t=1.95, P<0.05) whereas VEGF expression (t = 2.37, P<0.05) and MVD (t= 3.28, P<0.01) was significantly up-regulated in advanced gastric cancer compared with early-stage gastric cancer. PTEN expression in gastric cancer showed a negative association with lymph node metastasis (t= 3.91, P<0.01), invasion depth (t= 1.95, P<0.05) and age (t= 4.69, P<0.01). MVD in PTEN-negative gastric cancer was significantly higher than that in PTEN-positive gastric cancer (t=3.69, P<0.01), and there was a negative correlation betweenPTEN expression and MVD (γ=-0.363, P<0.05). VEGF expression was positively associated with invasion depth (especially with serosa invasion, t = 4.69, P<0.01), lymph node metastasis (t= 2.31, P<0.05) and TNM stage (t= 3.04, P<0.01). MVD in VEGF-positive gaslyic cancer was significantly higher than that in VEGF-negative gastric cancer (t=4.62, P<0.01), and there was a positive correlation between VEGF expression of and MVD (y = 0.512, P<0.05). VEGF expression in PTEN-negative gaslyic cancer was significantly stronger than that in PTEN-positive gastric cancer (t=2.61, P<0.05), and there was a significantly negative correlation between the expression of VEGF and PTEN (γ=-0.403, P<0.05).CONCLUSION: Our results imply that inactivation of PTEN gene and over-expression of VEGF contribute to the neovascularization and progression of gastric cancer. PTEN-related angiogenesis might be attributed to its up-regulation of VEGF expression. PTEN and VEGF could be used as the markers reflecting the biologic behaviors of tumor and viable targets in therapeutic approaches to inhibit angiogenesis of gastric cancers. | Ye-JiangZhou Yu-XiaXiong Xiao-TingWu DeShi WeiFan TongZhou Yue-ChunLi XiongHuang | 2004 | World Journal of Gastroenterology2004，10，21： | 31 |
| 2 | Gut microbiota-derived short chain fatty acids are potential mediators in gut inflammation显示文摘Gut inflammation is a challenging concern in humans and animals,which disturbs normal growth and leads to severe bowel diseases.Short chain fatty acids(SCFA)are the gut microbiota metabolites produced from fermentation of non-digestible carbohydrates,and have been reported to modulate gut inflammation.SCFA have been implicated as the potential therapeutic bioactive molecules for gut inflammatory diseases,and could be an alternative to antibiotic growth promoters(AGP).In this review,the existing knowledge about the types of SCFA,the related gut microbes producing SCFA,the roles of SCFA in maintaining gut homeostasis,and how SCFA modulate gut inflammation is summarized.The therapeutic application of SCFA in the treatment of inflammatory bowel disease(IBD)is also highlighted | Muhammad Akhtar Yan Chen Ziyu Ma Xiaolong Zhang Deshi Shi Jawaria AKhan Huazhen Liu | 2022 | Animal Nutrition2022，，1： | 8 |
| 3 | DI-3-n-butylphthalide exerts neuroprotective effects by modulating hypoxia-inducible factor 1-alpha ubiquitination to attenuate oxidative stress-induced apoptosis显示文摘DI-3-n-butylphthalide is used to treat mild and moderate acute ischemic stroke.However,the precise underlying mechanism requires further investigation.In this study,we investigated the molecular mechanism of DI-3-n-butylphthalide action by various means.We used hydrogen peroxide to induce injury to PC12cells and RAW264.7 cells to mimic neuronal oxidative stress injury in stroke in vitro and examined the effects of DI-3-n-butylphthalide.We found that DI-3-nbutylphthalide pretreatment markedly inhibited the reduction in viability and reactive oxygen species production in PC12 cells caused by hydrogen peroxide and inhibited cell apoptosis.Furthermore,DI-3-n-butylphthalide pretreatment inhibited the expression of the pro-apoptotic genes Bax and Bnip3.DI-3-nbutylphthalide also promoted ubiquitination and degradation of hypoxia inducible factor 1α,the key transcription factor that regulates Bax and Bnip3 genes.These findings suggest that DI-3-n-butylphthalide exhibits a neuroprotective effect on stroke by promoting hypoxia inducible factor-1α ubiquitination and degradation and inhibiting cell apoptosis. | Shuai Li Jingyuan Zhao Yan Xi Jiaqi Ren Yanna Zhu Yan Lu Deshi Dong | 2023 | Neural Regeneration Research2023，18，11： | 3 |
| 4 | A flextensional transducer and its algorithmic method of resonant frequency显示文摘A flextensional transducer with an Omega shape and its algorithmic method of the resonant frequency and the shape functions are suggested.The Omega transducer is separated into four parts treated respectively as a thin shell of revolution and the theories of thin shells of revolution and piezoelectricity are used to obtain the energy functional of each part so that the sum of the energy functionals of the four parts is the energy functional of the whole Omega transducer.By substituting the shape functions with undetermined coefficients and the geometrical boundary conditions into the energy functional of the Omega transducer,the resonant frequency of the Omega transducer is firstly determined with the Rayleigh-Ritz method.With the gotten resonant frequency,the constant coefficients of the shape functions are following solved through the Rayleigh-Ritz partial differential equations and the geometrical boundary condition equations.The solving method of the resonant frequency and the shape functions is also extended to the cymbal transducer.Such an analytical method is verified to be feasible by the results of the finite element analysis and experiments.The research indicates that(1) The radial vibration of the piezoelectric ceramic is in phase with the longitudinal vibration of the top of metal cap,and it cut down the reversed phase component in the sound field. The Omega transducer can be a low frequency transducer.(2) The determination method of the resonant frequency and the shape functions give a solution to the optimum designs of the Omega transducer and the cymbal transducer.(3) The determination method of the resonant frequency and the shape functions can also be used in other flextensional transducers or other structures which are composed of thin shells of revolution,so it is universal. | WANG Yuhong WANG Deshi CHENG Jinfang ZHANG Kai | 2013 | Chinese Journal of Acoustics2013，32，2： | 2 |
| 5 | Development of an immunochromatographic lateral-flow test strip for rapid detection of sulfonamides in eggs and chicken muscles显示文摘 | WANG Xiliang LI Kui SHI Deshi | 2007 | J Agric Food Chem2007，55，6： | 1 |
| 6 | Devdopment of solidoxide fuel cells that operate at 500 ℃显示文摘 | Deshi R Richards V L Carter J D | 1999 | J Electrochem Soc1999，146，4： | 1 |
| 7 | Development and validation of an immunochromatographic assay for rapid detection of sulfadiazine in eggs and chickens显示文摘 | WANG Xiliang LI Kui SHI Deshi | 2007 | Journal of Chromatography B2007，847，2： | 1 |
| 8 | Haemophilus parasuis infection activates the NF-κB pathway in PK-15 cells through IκB degradation显示文摘 | Yushan Chen Hui Jin Ping Chen Zili Li Xianrong Meng Mei Liu Shaowen Li Deshi Shi Yuncai Xiao Xiliang Wang Zutao Zhou Dingren Bi Rui Zhou | 2012 | Veterinary Microbiology (-)2012，，1： | 1 |
| 9 | Performance optimiza- tion of forging manipulator during the whole forging stroke 显示文摘 | Liu Deshi Li Gang Guo Xinglin | 2010 | In- telligent Robotics and Applications2010，6425，： | 1 |
| 10 | Bilateral subthalamic nucleus stimulation for Parkiusou's disease显示文摘 | Deshi PK Chhaya NA Bhatt MA | 2003 | Neurol India2003，51，1： | 1 |
| 11 | On-line scheduling of parallel jobs in a list显示文摘 | Deshi Ye Guochuan Zhang | 2007 | Journal of Scheduling2007，，6： | 1 |
| 12 | Rwsist chloromycetin monoelonal antibody preparation and appraisal 显示文摘 | TAN YALI SHI DESHI WANG GUIZHI | 2000 | China takes preeantions against veterinary science newspaper2000，22，： | 1 |
| 13 | On-line scheduling of parallel jobs on two machines显示文摘 | Wun-Tat Chan Francis Y.L. Chin Deshi Ye Guochuan Zhang Yong Zhang | 2006 | Journal of Discrete Algorithms2006，，1： | 1 |
| 14 | Non-cooperative games on multidimensional resource allocation显示文摘 | Deshi Ye Jianhai Chen | 2013 | Future Generation Computer Systems2013，，6： | 1 |
| 15 | Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats显示文摘 | Shuai Zhang Lingli Zheng Deshi Dong Lina Xu Lianhong Yin Yan Qi Xu Han Yuan Lin Kexin Liu Jinyong Peng | 2013 | Food Chemistry2013，，3： | 1 |
| 16 | Dexamethasone suppresses the expression of multiple rat carboxylesterases through transcriptional repression: Evidence for an involvement of the glucocorticoid receptor显示文摘 | Deshi Shi Jian Yang Dongfang Yang Bingfang Yan | 2008 | Toxicology2008，，1： | 1 |
| 17 | Efficient aggregation of mul- tiple classes of information in wireless sensor networks 显示文摘 | Qiu Xiaoling Liu Haiping Li Deshi | 2009 | Sensors2009，9，10： | 1 |
| 18 | Optimization of Multiple Gateway Deployment for Underwater Acoustic Sensor Networks显示文摘 | Jugen Nie Deshi Li Yanyan Han | 2011 | Computer Science and Information Sys- tems2011，8，4： | 1 |
| 19 | Deep carbon cycling during subduction revealed by coexisting diamond-methane-magnesite in peridotite显示文摘Subduction is an important process for transferring materials from the surface into the deep mantle.During subduction,recycled carbon can be released from the subducting slab to the mantle wedge through various decarbonation processes.Both oxidized(CO_(2)/CO_(3)^(2-))and reduced(CH4)carbon-bearing species have been discovered in(ultra)high-pressure(HP-UHP)subduction zones worldwide[1-3].Diamond is a typical index mineral for UHP metamorphism. | Xiaoxia Wang Yilin Xiao Hans-Peter Schertl Nikolay V.Sobolev Yang-Yang Wang He Sun Deshi Jin Dong-Bo Tan | 2023 | National Science Review2023，10，10： | 0 |
| 20 | Views on the Planning for Wangjing New District | Jin Deshi Beijing City Construction and Development Corporation | 1989 | China City Planning Review1989，6，1： | 0 |
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