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| 1 | Chimeric anti-IL-17 full-length monoclonal antibody is a novel potentialcandidate for the treatment of rheumatoid arthritis显示文摘 | Fuliang Bai Hui Tian Zeshan Niu Mingyao Liu Guiping Ren Yinhang Yu Tian Sun Siming Li Deshan Li | 2014 | International Journal of Molecular Medicine2014，，3： | 1 |
| 2 | Antibody Response to COVID-19 Virus--Heilongjiang Province and Gansu Province,China,2020显示文摘What is already known about this topic?Coronavirus disease 2019(COVID-19)has become a global pandemic,while the profile of antibody response against the COVID-19 virus has not been well clarified.What is added by this report?In this study,210 serum samples from 160 confirmed COVID-19 cases with different disease severities were recruited.The IgM,IgA,IgG,and neutralizing antibodies(NAb)against COVID-19 virus were determined.Our findings indicated that four antibodies could be detectable at low levels within 2 weeks of disease onset,then rapidly increasing and peaking from the 3^(rd) to 5^(th) Weeks.NAb decreased between 5^(th) and 9^(th) Weeks,and a higher IgM/IgA level was observed in the groups with mild/moderate severity within 2 weeks(p<0.05),while all 4 types of antibodies were higher in the group with severe/critical severity after 4 weeks(p<0.05).What are the implications for public health practice?Our study on the dynamics of serological antibody responses against COVID-19 virus among COVID-19 patients complements the recognition regarding the humoral immune response to COVID-19 virus infection.The findings will help in the interpretation of antibody detection results for COVID-19 patients and be beneficial for the evaluation of vaccination effects. | Naiying Mao Zhen Zhu Shuangli Zhu Deshan Yu Jun Xu Aili Cui Lei Cao Jinyuan Guo Huiling Wang Dongyan Wang Dongmei Yan Yang Song Qian Yang Zhongyi Jiang Hui Zhang Chang Shu Ming Yang Yanhai Wang Jinbo Xiao Zhenzhi Han Yong Zhang Yan Zhang Wenbo Xu | 2020 | China CDC weekly2020，2，34： | 1 |
| 3 | Outbreak of febrile respiratory illness associated with human adenovirus type 14p1 in G ansu Province, C hina显示文摘 | Guohong Huang Deshan Yu Zhen Zhu Hai Zhao Peng Wang Gregory C. Gray Lei Meng Wenbo Xu | 2013 | Influenza Other Respi Viruses2013，，6： | 1 |
| 4 | miR-222-3p suppresses chondrogenic differentiation of ATDC5 cells by regulating autophagy显示文摘Clinical efforts to repair damaged articular cartilage(AC)currently face major obstacles due to the limited intrinsic repair capacity of the cartilage tissue.Thus,it is essential to understand the molecular mechanisms involved in the chondrogenic differentiation.It is known that miRNAs play a significant role in chondrogenic differentiation.In this study,the expression of miR-222-3p and the level of autophagic activity were investigated during chondrogenic induction in ATDC5 cells.The results showed that miR-222-3p was down-regulated significantly and the level of autophagic activity was enhanced during this process,and there was a negative correlation between them.Moreover,inhibition of miR 222-3p promoted chondrogenic differentiation and inhibited hypertrophic differentiation of ATDC5 cells,as supported by enhancing the gene and protein expression of chondrocyte specific markers of SOX9,aggrecan and collagen type II(Col2a1),but reduced the expression of hypertrophic differentiation marker collagen type X(Col10a1).In contrast,inhibiting autophagic activity decreased chondrogenic differentiation and promoted hypertrophic differentiation of ATDC5 cells. | Yan Jihong Yu Rui Yuan Shuzheng Zhou Deshan | 2021 | 解剖学杂志2021，44，S01： | 0 |
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