|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 2 | Tripling the capacity of wireless communications using electromagnetic polarization显示文摘 | Andrews M R Mitra P P deCarvalho R | 2001 | nature2001，40，1： | 1 |
| 3 | Effects of EDTA on signal stability during electrochemi- cal detection of acetaminophen 显示文摘 | DECARVALHO R M FREIRE R S RATH S | 2004 | J Pharm Biomed Anal2004，34，5： | 1 |
| 4 | A comparison of whole -body turboSTIR MR imaging and planar 99Tcm-methylene diphosphonate scintigraphy in the examination of patients with suspected skeletal metastases显示文摘 | Eustace S Tello R Decarvalho V | 1997 | AJR1997，169，6： | 1 |
| 5 | Implications of radioactive seed migration to the lungs after prostate brachy therapy显示文摘 | Ankem MK Decarvalho VS Harangozo AM | | 0，，06： | 1 |
| 6 | Aeration simulation of stored grain under variable air ambient conditions显示文摘 | Decarvalho D Martins H Decastromeloe | | 0，，01： | 1 |
| 7 | Modulation of plasma levels and percentages of incorpo- ration of oJ-3PUFAs in egg yolk under the influence of supplementation sources rich in omega 3 to diet of laying hens 显示文摘 | PITA M C G DECARVALHO P R PIBER N E | 2011 | Pak J Nutr2011，10，8： | 1 |
| 8 | A comparison of-whole-body turboSTIR MR imaging and planar99Tcm-methylene diphos-phonate scintigraphy in the examination of patients with suspectedskeletalmetastases 显示文摘 | Eustace S Tello R Decarvalho V | 1997 | A JR1997，169，6： | 1 |
| 9 | Tripling the capacity of wireless communications using electromagnetic polarization 显示文摘 | ANFTRED M R MITRA P P DECARVALHO R | 2001 | Natrue2001，409，： | 1 |
| 10 | Tripling the capacity of wireless communications using electro- magnetic polarization 显示文摘 | Andrews R Mitra P DeCarvalho R | 2001 | Nature2001，409，： | 1 |
| 11 | Subclini- cal photodynamic therapy treatment modifies the brain microenvironment and promotes glioma growth显示文摘 | DECARVALHO AC ZHANG X ROBERTS C | 2007 | Glia2007，55，10： | 1 |
| 12 | Gliosarcoma stem cells undergo glial and mesenchymal differentiation in vivo显示文摘 | deCarvalho AC Nelson K Lemke N | | 0，，02： | 1 |
| 13 | Osteonecrosis of femoral head treatedwith total hip arthroplasty without cement显示文摘 | Piston RW Engh CA Decarvalho PI Suthers K | 1994 | J Bone Joint Surg1994，76，： | 1 |
| 14 | Hormonal profile and endometrial - morphology in letrozole controlled ovarian hyperstimulation in ovulatory infertile patients 显示文摘 | Cortinez A DeCarvalho I Vant man D | 2005 | Fertil Steril2005，83，： | 1 |
| 15 | Tripling the capacity of wireless communications using electromagnetic polarization 显示文摘 | M R Andrews P P Mitra R deCarvalho | 2001 | Nature2001，409，1： | 1 |
| 16 | Tripling the capacity of wireless communications using electromagnetic polarization 显示文摘 | M R Andrews P P Mitra and R deCarvalho | 2001 | Nature2001，409，18： | 1 |
| 17 | Investigation of an onsite wastewater treatment system in sandy soil:Modeling the fate of surfactants显示文摘 | DeCarvalho A J Nielsen A M | 2002 | Environ Toxical Chem2002，21，： | 1 |
| 18 | A comparison of whole-body turboSTIR MR imaging and planar 99mTc-methylene diphosphonate scintingraphy in the examination of patients with suspected skeletal metastases显示文摘 | Eustace S Tello R DeCarvalho V | 1997 | Am J Roentgenol1997，169，6： | 1 |
| 19 | Geraniol-- a flavoring agent with multifunctional effects in protecting the gastric and duodenal mucosa显示文摘 | DeCarvalho K I M Bonamin F DosSantos R C | 2014 | Naunyn Schmiedebergs Arch Pharmacol2014，387，4： | 1 |
| 20 | Airborne particles: chemical characterization and mutagenic activity 显示文摘 | Gundel L A Dalsey J M deCarvalho L R F | 1993 | Environmental Science and Technology1993，27，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员