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| 1 | Immunopathogenesis of inflammatory bowel disease显示文摘Crohn’s disease and ulcerative colitis are chronic relapsing immune mediated disorders that results from an aberrant response to gut luminal antigen in genetically susceptible host. The adaptive immune response that is then triggered was widely considered to be a T-helper-1 mediated condition in Crohn’s disease and T-helper-2 mediated condition in ulcerative colitis. Recent studies in animal models, genome wide association, and basic science has provided important insights in in the immunopathogenesis of inflammatory bowel disease, one of which was the characterization of the interleukin-23/Th-17 axis. | David Q Shih Stephan R Targan | 2008 | World Journal of Gastroenterology2008，14，3： | 44 |
| 2 | Immunopathology of inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD)results from a complex series of interactions between susceptibility genes,the environment,and the immune system.The host microbiome,as well as viruses and fungi,play important roles in the development of IBD either by causing inflammation directly or indirectly through an altered immune system.New technologies have allowed researchers to be able to quantify the various components of the microbiome,which will allow for future developments in the etiology of IBD.Various components of the mucosal immune system are implicated in the pathogenesis of IBD and include intestinal epithelial cells,innate lymphoid cells,cells of the innate(macrophages/monocytes,neutrophils,and dendritic cells)and adaptive(T-cells and B-cells)immune system,and their secreted mediators(cytokines and chemokines).Either a mucosal susceptibility or defect in sampling of gut luminal antigen,possibly through the process of autophagy,leads to activation of innate immune response that may be mediated by enhanced toll-like receptor activity.The antigen presenting cells then mediate the differentiation of na?ve T-cells into effector T helper(Th)cells,including Th1,Th2,and Th17,which alter gut homeostasis and lead to IBD.In this review,the effects of these components in the immunopathogenesis of IBD will be discussed. | Kori L Wallace Li-Bo Zheng Yoshitake Kanazawa David Q Shih | 2014 | World Journal of Gastroenterology2014，20，1： | 45 |
| 3 | Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease显示文摘The thiopurine drugs,6-mercaptopurine(6-MP) and azathioprine,are efficacious in the arsenal of inflammatory bowel disease(IBD) therapy.Previous reports indicate that 6-thioguanine nucleotide(6-TGN) levels correlate with therapeutic efficacy,whereas high 6-methylmercaptopurine(6-MMP) levels are associated with hepatotoxicity and myelotoxicity.Due to their complex metabolism,there is wide individual variation in patient response therein,both in achieving therapeutic drug levels as well as in developing adverse reactions.Several strategies to optimize 6-TGN while minimizing 6-MMP levels have been adopted to administer the thiopurine class of drugs to patients who otherwise would not tolerate these drugs due to side-effects.In this report,we will review different approaches to administer the thiopurine medications,including the administration of 6-mercaptopurine in those unsuccessfully treated with azathioprine;coadministration of thiopurine with allopurinol;co-administration of thiopurine with anti-tumor necrosis factor α;6-TGN administration;desensitization trials;and split dosing of 6-MP. | Kara Bradford David Q Shih | 2011 | World Journal of Gastroenterology2011，17，37： | 6 |
| 4 | Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade显示文摘 | Clifford R Jack David S Knopman William J Jagust Leslie M Shaw Paul S Aisen Michael W Weiner Ronald C Petersen John Q Trojanowski | 2010 | Lancet Neurology2010，，1： | 4 |
| 5 | A case of steroid-dependent myeloid granulocytic sarcoma masquerading as Crohn's disease显示文摘Small bowel tumors and Crohn's disease are common causes of small bowel obstruction.Early stage neoplasms can easily be mistaken for Crohn's disease.Therefore,thorough work-ups including imaging studies and endoscopic evaluation with biopsies are critical for accurate diagnosis.Here we report a case of an otherwise healthy female with progressive onset of multiple,recurrent obstructive symptoms secondary to terminal ileal narrowing who was referred for management of steroid-dependent Crohn's disease.After thorough evaluation,the diagnosis was revised to myeloid granulocytic sarcoma involving the terminal ileum.In this case,a delay in diagnosis can be detrimental for prognosis,as myeloid granulocytic sarcoma is highly predictive of underlying acute myeloid leukemia and needs urgent referral for chemotherapy and/or resection. | Lola Y Kwan Stephan R Targan David Q Shih | 2011 | World Journal of Gastroenterology2011，17，19： | 3 |
| 6 | Grain refinement of magnesium alloys显示文摘 | David H S Ma Q Mark A E | 2005 | Metallurgical and Materials Transactions2005，36，7： | 1 |
| 7 | Influence of design parameters on cogging torque in permanent magnet machines 显示文摘 | Z Q Zhu David Howe | 2000 | IEEE Trans on Energy Converision2000，15，4： | 1 |
| 8 | Organization of organic molecules with inorganic molecular species into nanocomposite biphase arrays 显示文摘 | Huo Q H David I Margolese | 1994 | Chemistry of Materials1994，6，8： | 1 |
| 9 | Grain nucleation and formation in Mg-Zr alloys显示文摘 | Ma Q David H S | 2009 | International Journal of Cast Metals Research2009，22，14： | 1 |
| 10 | Effect ofheparin surface modification in reducing silicone oil adherence to various intraocular lenses显示文摘 | Stelh NA Peng Q David JA | 2001 | J Cataract Refract Surg2001，27，10： | 1 |
| 11 | Neurogenesis-dependent and independent effects of fluoxetine in an animal model of anxiety/depression显示文摘 | David DJ Samuels BA Rainer Q | | 0，，： | 1 |
| 12 | Surfactant control of phases in the synthesis of mesoporous silica-based materials 显示文摘 | Huo Q H David I Margolese | 1996 | Chemistry of Materials1996，8，5： | 1 |
| 13 | T regulatory cells in cancer: recent advances and therapeutic potential显示文摘 | Eyad Elkord Erik M Alcantar-Orozco Simon J Dovedi Dat Q Tran Robert E Hawkins David E Gilham | 2010 | Expert Opinion on Biological Therapy2010，，11： | 1 |
| 14 | Regional carbon dynamics in monsoon Asia and its implications for the global carbon cycle显示文摘 | Tian H Q Melillo J M David W K | 2003 | Global and Planetary Change2003，37，34： | 1 |
| 15 | Generating receptive endometrium in Asherman's syndrome显示文摘 | Caroline E Q David H | 2011 | J Hum Reprod Sci2011，4，1： | 1 |
| 16 | Study on grid connected inverter used in high power wind generation system 显示文摘 | QIANG Z LEWEI Q DAVID C | 2006 | IEEE Industry Applications Society Annual 2006 Conference2006，，： | 1 |
| 17 | Direct torque control of brushless DC drives with reduced torque ripple 显示文摘 | Liu Y Zhu Z Q David H | 2005 | IEEE Transactions on Industry Applications2005，41，2： | 1 |
| 18 | Leidenfrost drops显示文摘 | Anne-Laure B Christophe C David Q | 2003 | Phys Fluids2003，15，6： | 1 |
| 19 | Neurogenesis-de- pendent and -independent effects of fluoxetine in an ani- mal model of anxiety/depression显示文摘 | David DJ Samuels BA Rainer Q | 2009 | Neuron2009，62，4： | 1 |
| 20 | Stability of water/crude oil emulsions based on interracial dilatational rheology显示文摘 | Christophe D David A Anne S Q | 2006 | Journal of Colloid and Interface Science2006，297，2： | 1 |
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