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11篇 您的检索式：作者名="David Isenberg"

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		题名	作者	年代	出处	被引量
	1	CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL.	Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed	2018	Cellular & Molecular Immunology2018，15，2：	2
	2	Seeded conversion of recombinant prion protein to a disulfide-bonded oligomer by a reduc tion-oxidation process显示文摘	Sangho Lee David E Isenberg	2003	Nature structural biology2003，10，9：	1
	3	Efficacy and Safety of Transcranial Magnetic Stimulation in the Acute Treatment of Major Depression: A Multisite Randomized Controlled Trial显示文摘	John P. O’Reardon H. Brent Solvason Philip G. Janicak Shirlene Sampson Keith E. Isenberg Ziad Nahas William M. McDonald David Avery Paul B. Fitzgerald Colleen Loo Mark A. Demitrack Mark S. George Harold A. Sackeim	2007	Biological Psychiatry2007，，11：	1
	4	Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47显示文摘	David R Soto-Pantoja Erica V Stein Natasha M Rogers Maryam Sharifi-Sanjani Jeffrey S Isenberg David D Roberts	2013	Expert Opinion on Therapeutic Targets2013，，1：	1
	5	The matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47显示文摘	David D. Roberts Thomas W. Miller Natasha M. Rogers Mingyi Yao Jeffrey S. Isenberg	2012	Matrix Biology2012，，3：	1
	6	Group Polarization A Critical Review and Meta-analysis 显示文摘	David Isenberg	1986	Personality and Socialpsych1986，50，：	1
	7	Group Polarization A Critical Review and Meta-analysis显示文摘	David Isenberg		0，，：	1
	8	The Case for a Pragmatic Assessment of Private Military Companies in Iraq, 显示文摘	David Isenberg A Fistful of Contractors	2004	September2004，，：	1
	9	Systemic lupus erythematosus显示文摘	Larissa Lisnevskaia Grainne Murphy David Isenberg	2014	The Lancet2014，，：	1
	10	Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus显示文摘	Michelle Petri Ana‐Maria Orbai Graciela S. Alarcón Caroline Gordon Joan T. Merrill Paul R. Fortin Ian N. Bruce David Isenberg Daniel J. Wallace Ola Nived Gunnar Sturfelt Rosalind Ramsey‐Goldman Sang‐Cheol Bae John G. Hanly Jorge Sánchez‐Guerrero Ann Clark	2012	Arthritis & Rheumatism2012，，8：	1
	11	The substantial burden of systemic lupus erythematosus on the productivity and careers of patients: a European patient-driven online survey显示文摘	Caroline Gordon David Isenberg Kirsten Lerstr?m Yvonne Norton Enkeleida Nika? Daphnee S. Pushparajah Matthias Schneider	2013	Rheumatology2013，，12：	1

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