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| 1 | 公元前1920年溃决洪水为中国大洪水传说和夏王朝的存在提供依据显示文摘中国传统史学讲述了一个在治理洪水成功后建立夏朝并开启文明史的故事。然而,洪水和夏朝的历史真实性一直存在争议。本文重建了约公元前1920年黄河上游地震引发的滑坡坝体的溃决洪水,为一万年以来地球上发生的最大的内陆洪水之一,可以解释中国传说的大洪水。本文将夏朝的开端确定为约公元前1900年,比传统的认识晚了2~3个世纪。测定结果表明,此年代的黄河流域状态与新石器向青铜器时代大变迁时的状态相吻合,这同时也佐证了初级国家形态——二里头文化是夏朝存在的考古证据的假说。 | 吴庆龙 赵志军 刘莉 Darryl E.Granger 王辉 David J.Cohen 吴小红 叶茂林 Ofer Bar-Yosef 陆斌 张进 张培震 袁道阳 齐乌云 蔡林海 白世彪 陈菁(编译) 李荣富(编译) 刘志(编译) 肖晨光(编译) 周程婷(编译) 毕博(编译) | 2017 | 中国水利2017，，3： | 11 |
| 2 | 宇宙成因核素^(10)Be揭示的北祁连山侵蚀速率特征显示文摘山脉侵蚀速率的大小和时空分布信息是研究山脉构造—气候相互作用和地貌演化的关键切入点,其大小是受气候还是构造控制争论已久。宇宙成因核素10Be方法为从千年至万年尺度上定量研究流域平均侵蚀速率提供了一种先进和快捷的技术手段,为揭示侵蚀速率与现代气候和构造地貌因子的关系并进行相关分析提供了基础。利用该方法对北祁连山近现代侵蚀速率进行了研究。所采集的9个流域现代河沙样品,结合前人数据进行共同分析,结果显示该区侵蚀速率的变化范围为18.7~833 mm/ka,北祁连山中段的侵蚀速率约为323 mm/ka,该区侵蚀速率与降雨量没有明显的对应关系,但与流域平均坡度呈现很好的非线性关系,揭示坡度是该区侵蚀速率的最主要控制因素。通过对比北祁连山地表平均侵蚀速率和该区域的断层垂直滑动速率发现整体上该区域地表侵蚀速率要低于祁连山北缘断层的垂直滑动速率,反映了北祁连山正处于地形抬升和生长的过程之中。 | 胡凯 方小敏 赵志军 Darryl Granger | 2015 | 地球科学进展2015，30，2： | 8 |
| 3 | Review of evolution of tunnel position in anterior cruciate ligament reconstruction显示文摘Anterior cruciate ligament(ACL) rupture is one of the commonest knee sport injuries. The annual incidence of the ACL injury is between 100000-200000 in the United States. Worldwide around 400000 ACL reconstructions are performed in a year. The goal of ACL reconstruction is to restore the normal knee anatomy and kinesiology. The tibial and femoral tunnel placements are of primordial importance in achieving this outcome. Otherfactors that influence successful reconstruction are types of grafts, surgical techniques and rehabilitation programmes. A comprehensive understanding of ACL anatomy has led to the development of newer techniques supplemented by more robust biological and mechanical concepts. In this review we are mainly focussing on the evolution of tunnel placement in ACL reconstruction, focusing on three main categories, i.e., anatomical, biological and clinical outcomes. The importance of tunnel placement in the success of ACL reconstruction is well researched. Definite clinical and functional data is lacking to establish the superiority of the single or double bundle reconstruction technique. While there is a trend towards the use of anteromedial portals for femoral tunnel placement, their clinical superiority over trans-tibial tunnels is yet to be established. | Faizal Rayan Shashi Kumar Nanjayan Conal Quah Darryl Ramoutar Sujith Konan Fares S Haddad | 2015 | World Journal of Orthopedics2015，6，2： | 7 |
| 4 | An improved protocol for the treatment of fulminant myocarditis显示文摘Fulminant myocarditis is a rare form of severe myocarditis that is most commonly caused by viral infection.Fulminant myocarditis is often pathophysiologically indistinguishable from milder forms of acute myocarditis but is categorically defined based on clinical disease progression.Patients may initially present with mild symptoms,such as fever,shortness of breath or heart palpitations,but rapidly progress to severe respiratory distress,arrhythmias,and cardiogenic shock. | Matthew L.Edin Darryl C.Zeldin | 2019 | Science China(Life Sciences)2019，62，3： | 7 |
| 5 | The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients. | Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens | 2016 | Bone Research2016，4，2： | 6 |
| 6 | 生命伦理学是对生命的爱显示文摘人类的情感中最重要的是爱,爱是人类超越于不同人们之间的存在力量。爱在世界中普遍存在,并能感受到万物统一的力量。中外文化有各种对爱的理解和定义。生命伦理学是一个系统的反应和讨论过程,它的首要理论是爱。生命伦理讨论爱的理论是全部伦理综合体的部分。文章中列出了亚里士多德、托马斯.阿奎拉、康德等人对'善'的道德基础的分析,着重指出'爱'在实践伦理中的作用。然后分析了在医学伦理学中的积极权利和消极权利,提出怎样才是正确的伦理。最后是对社会公正与集体主义理论的思考,讨论个体和集体伦理。 | Darryl Macer 马晶(译) 孙慕义(校) | 2008 | 中国医学伦理学2008，21，1： | 6 |
| 7 | 婴幼儿胃食管反流相关性咳嗽治疗的初步研究显示文摘目的婴幼儿哮喘的诊断主要基于咳嗽及喘息等临床症状,神经系统功能正常的婴幼儿当出现过度胃食管反流时也可以出现类似症状。目前并无随机对照研究来评价单独使用质子泵抑制剂或联合促动力药在婴幼儿中应用的疗效。本研究的主要目的是证实在呼吸道症状提示哮喘的婴幼儿中的确存在过度胃食管反流。其次,通过随机空白对照试验,探讨使用氨基甲酰甲基胆碱和奥美拉唑治疗过度胃食管反流可否改善呼吸道症状。方法有慢性咳嗽或喘息病史且有病史支持、pH监测异常或胃排空扫描提示胃食管反流的婴幼儿22例,随机分为4个治疗组:安慰剂+安慰剂(PP治疗组)、奥美拉唑+氨基甲酰甲基胆碱(OB治疗组)、奥美拉唑+安慰剂(OP治疗组)、氨基甲酰甲基胆碱+安慰剂(BP治疗组)。通过临床问卷调查、检查和家庭日记以及pH监测数据评估患儿上述治疗前后及奥美拉唑+氨基甲酰甲基胆碱非盲试验后的情况。结果 19例纳入数据统计。PP治疗对胃食管反流或呼吸道症状没有作用,pH监测提示胃食管反流并无减少。然而根据pH监测及家长评估,OB治疗可减少胃食管反流,同时显著减少日间咳嗽,改善呼吸,无不良反应发生。结论对于临床表现提示慢性胃食管反流相关性咳嗽的婴幼儿,使用奥美拉唑和氨基甲酰甲基胆碱治疗是可行的选择。 | Darryl J. Adamko Carina M. Majaesic Adrian B. Jones Christopher Skappak 邓小鹿(译) 姚跃(审校) | 2012 | 中国当代儿科杂志2012，14，5： | 5 |
| 8 | Creation and control of high-dimensional multi-partite classically entangled light显示文摘Vector beams,non-separable in spatial mode and polarisation,have emerged as enabling tools in many diverse applications,from communication to imaging.This applicability has been achieved by sophisticated laser designs controlling the spin and orbital angular momentum,but so far is restricted to only two-dimensional states.Here we demonstrate the first vectorially structured light created and fully controlled in eight dimensions,a new state-of-the-art.We externally modulate our beam to control,for the frst time,the complete set of classical Greenberger-Horne-Zeilinger(GHZ)states in paraxial structured light beams,in analogy with high-dimensional multi-partite quantum entangled states,and introduce a new tomography method to verify their fidelity.Our complete theoretical framework reveals a rich parameter space for further extending the dimensionality and degrees of freedom,opening new pathways for vetorilly structured light in the classical and quantum regimes. | Yjie Shen Iaac Nape Xilin Yang Xing Fu Mali Gong Darryl Naidoo Andrew Forbes | 2021 | Light(Science & Applications)2021，10，5： | 4 |
| 9 | Fulminant myocarditis in adults: a narrative review显示文摘Fulminant myocarditis(FM)is an uncommon syndrome characterized by sudden and severe hemodynamic compromise secondary to acute myocardial inflammation,often presenting as profound cardiogenic shock,life-threatening ventricular arrhythmias and/or electrical storm.FM may be refractory to conventional therapies and require mechanical circulatory support(MCS).The immune system has been recognized as playing a pivotal role in the pathophysiology of myocarditis,leading to an increased focus on immunosuppressive treatment strategies.Recent data have highlighted not only the fact that FM has significantly worse outcomes than non-FM,but that prognosis and management strategies of FM are heavily dependent on histological subtype,placing greater emphasis on the role of endomyocardial biopsy in diagnosis.The impact of subtype on severity and prognosis will likewise influence how aggressively the myocarditis is managed,including whether MCS is warranted.Many patients with refractory cardiogenic shock secondary to FM end up requiring MCS,with venoarterial extracorporeal membrane oxygenation demonstrating favorable survival rates,particularly when initiated prior to the development of multiorgan failure.Among the challenges facing the field are the need to more precisely identify immunopathophysiological pathways in order to develop targeted therapies,and the need to better optimize the timing and management of MCS to minimize complications and maximize outcomes. | Santiago Montero Darryl Abrams Enrico Ammirati Florent Huang Dirk WDonker Guillaume Hekimian Cosme García-García Antoni Bayes-Genis Alain Combes Matthieu Schmidt | 2022 | Journal of Geriatric Cardiology2022，19，2： | 3 |
| 10 | ^(26)Al/^(10)Be埋藏测年法及其在我国早期人类遗址年代研究中的应用显示文摘本文介绍基于原地宇生核素26Al和10Be埋藏测年的基本原理:地表石英矿物与次级宇宙射线发生核反应,生成26Al和10Be,两者之比为6.8∶1。若长期暴露于地表的石英被快速深埋,不再接受宇宙射线照射,已积累的宇生放射性核素将随时间流逝而衰减。因26Al比10Be衰变快约一倍,两者之比也将按指数规律随时间衰减,由此可测定埋藏事件的年代。本文并讨论了这一测年新技术的假设前提和限制其应用的多种因素。试用该法于周口店第1地点第7—10层的结果为770±80ka,支持洞穴方解石质谱铀系测年的结果。26Al/10Be埋藏测年法理化基础坚实,独立于其他测年技术,应用范围正值我国年代研究的'盲段',所需样品为广泛分布的石英矿物,应可为我国早期人类演化可信年代系列的建立作出重要贡献。 | 沈冠军 邵庆丰 Darryl E.GRANGER | 2009 | 人类学学报2009，28，3： | 3 |
| 11 | Gynecologic oncologists involvement on ovarian cancer standard of care receipt and survival显示文摘AIM:To examine the influence of gynecologic oncolo-gists(GO) in the United States on surgical/chemotherapeutic standard of care(SOC), and how this translates into improved survival among women with ovarian cancer(OC).METHODS: Surveillance, Epidemiology, and End Result(SEER)-Medicare data were used to identify 11688 OC patients(1992-2006). Only Medicare recipients with an initial surgical procedure code(n = 6714) were included. Physician specialty was identified by linking SEER-Medicare to the American Medical Association Masterfile. SOC was defined by a panel of GOs. Multivariate logistic regression was used to determine predictors of receiving surgical/chemotherapeutic SOCand proportional hazards modeling to estimate the effect of SOC treatment and physician specialty on survival. RESULTS: About 34% received surgery from a GO and 25% received the overall SOC. One-third of women had a GO involved sometime during their care. Women receiving surgery from a GO vs non-GO had 2.35 times the odds of receiving the surgical SOC and 1.25 times the odds of receiving chemotherapeutic SOC(P < 0.01). Risk of mortality was greater among women not receiving surgical SOC compared to those who did [hazard ratio = 1.22(95%CI: 1.12-1.33), P < 0.01], and also was higher among women seen by non-GOs vs GOs(for surgical treatment) after adjusting for covariates. Median survival time was 14 mo longer for women receiving combined SOC. CONCLUSION: A survival advantage associated with receiving surgical SOC and overall treatment by a GO is supported. Persistent survival differences, particularly among those not receiving the SOC, require further investigation. | Sun Hee Rim Shawn Hirsch Cheryll C Thomas Wendy R Brewster Darryl Cooney Trevor D Thompson Sherri L Stewart | 2016 | World Journal of Obstetrics and Gynecology2016，5，2： | 3 |
| 12 | Treatment of C2 body fracture with unusual distractive and rotational components resulting in gross instability显示文摘Cervical fractures can result in severe neurological compromise and even death. One of the most commonly injured segments is the C2 vertebrae, which most frequently involves the odontoid process. In this report, we present the unusual case of a 28-year-old female who sustained a C2 vertebral body fracture(comminuted transverse fracture through the body and both transverse processes) that had both a significant distractive and rotational component, causing the fracture to be highly unstable. Application of halo bracing was unsuccessful. The patient subsequently required a C1-C4 posterior spinal fusion. Follow-up computer tomography imaging confirmed fusion and the patient did well clinically thereafter. | Darryl Lau Samuel S Shin Rakesh Patel Paul Park | 2013 | World Journal of Orthopedics2013，4，4： | 3 |
| 13 | 生命伦理学挑战和机遇:人类行为学时代显示文摘2 0 0 2年 11月绘制思想图计划在自然杂志上发表 (Nature 42 0 :12 1,2 0 0 2 )。它具有从发展对于跨文化和多学科的生命伦理学的描述性方法 ,到制定代表更多少数人想法和观点的下策的几个目的。为了获得绘制想法的最适当的方法 ,绘制思想图计划设立了个方法组 ,其目的是发展平行的方法 ,建立一个对行为进行描述的全面基本的结构。对于确定第二年计划应该向哪个方向发展和集中精力于何处 ,我们考虑了一些方法组的意见。我们邀请更多的人成为这个计划的参与者。 | Darryl Macer 苏保琪 | 2004 | 医学与哲学2004，25，4： | 2 |
| 14 | piRNAs Initiate an Epigenetic Memory of Nonself RNA in the C. elegans Germline显示文摘 | Masaki Shirayama Meetu Seth Heng-Chi Lee Weifeng Gu Takao Ishidate Darryl Conte Craig C. Mello | 2012 | Cell2012，，1： | 2 |
| 15 | The association of grip strength with cardiovascular diseases and all-cause mortality in people with hypertension:Findings from the Prospective Urban Rural Epidemiology China Study显示文摘Background:Both hypertension and grip strength(GS)are predictors of mortality and cardiovascular disease(CVD),but whether these risk factors interact to affect CVD and all-cause mortality is unknown.This study sought to investigate the associations of GS with the risk of major CVD incidence,CVD mortality,and all-cause mortality in patients with hypertension.Methods:GS was measured using a Jamar dynamometer(Sammons Preston,Bolingbrook,IL,USA)in participants aged 3570 years from 12 provinces included in the Prospective Urban Rural Epidemiology China Study.Cox frailty proportional hazards models were used to examine the associations of GS and hypertension and the outcomes of all-cause mortality and CVD incidence/mortality.Results:Among 39,862 participants included in this study,15,964 reported having hypertension,and 9095 had high GS at baseline.After a median follow-up of 8.9 years(interquartile range,6.79.9 years),1822 participants developed major CVD,and 1250 deaths occurred(388 as a result of CVD).Compared with normotensive participants with high GS,hypertensive patients with high GS had a higher risk of major CVD incidence(hazard ratio(HR)=2.39;95%confidence interval(95%CI):1.863.06;p<0.001)or CVD mortality(HR=3.11;95%CI:1.596.06;p<0.001)but did not have a significantly increased risk of all-cause mortality(HR=1.24;95%CI:0.921.68;p=0.159).These risks were further increased if hypertensive participants whose GS level was low(major CVD incidence,HR=3.31,95%CI:2.604.22,p<0.001;CVD mortality,HR=4.99,95%CI:2.649.43,p<0.001;and all-cause mortality,HR=1.93,95%CI:1.472.53,p<0.001).Conclusion:The present study demonstrates that low GS is associated with the highest risk of major CVD incidence,CVD mortality,and all-cause mortality among hypertensive patients.High levels of GS appear to mitigate long-term mortality risk among hypertensive patients. | Weida Liu Darryl P Leong Bo Hu Lap AhTse Sumathy Rangarajan Yang Wang Chuangshi Wang Fanghong Lu Yindong Li Salim Yusuf Lisheng Liu Wei Li | 2021 | Journal of Sport and Health Science2021，10，6： | 2 |
| 16 | PEC thermography for imaging multiple cracks from rolling contact fatigue显示文摘 | John Wilson Guiyun Tian Ilham Mukriz Darryl Almond | 2011 | NDT and E International2011，，6： | 2 |
| 17 | The epoxyeicosatrienoic acid-stimulated phosphorylation of EGF-R involves the activation of metalloproteinases and the release of HB-EGF in cancer cells显示文摘 | Li-ming CHENG Jian-gang JIANG Zi-yong SUN Chen CHEN Ryan T DACKOR Darryl C ZELDIN Dao-wen WANG | 2010 | Acta Pharmacologica Sinica2010，31，2： | 2 |
| 18 | Endocrine functions of bone in mineral metabolism regulation显示文摘 | Quarles L Darryl | 2008 | Journal of Clinical Investigation2008，，12： | 2 |
| 19 | 葡萄糖转运体缺陷综合征研究进展显示文摘 | 王东 孙若鹏 王霞 杨如 杨红 Pascual Juan M De Vivo Darryl C | 2004 | 中华儿科杂志2004，42，10： | 2 |
| 20 | Hepatic adenoma mimicking a metastatic lesion on computed tomography-positron emission tomography scan显示文摘Positron emission tomography (PET) using 18F-fluorodeoxyglucose ( 18F-FDG) is an imaging modality which reflects cellular glucose metabolism. Most malignant cells accumulate and trap 18F-FDG, allowing the visualisation of increased uptake. It is hence widely used to differentiate malignant from benign lesions. 'False positive' findings of hepatic lesions have been described in certain instances such as hepatic abscesses, but are rare in cases involving hepatocellular adenomas. To our knowledge, there have been only 7 reports in the English literature documenting PET-avid hepatocellular adenomas; 6 of the 7 reports were published in the last 3 years with the first report by Patel et al. We report the case of a 44-year-old Chinese female patient with a history of cervical adenocarcinoma, referred for a hepatic lesion noted on a surveillance computed tomography (CT) scan. A subsequent CT-PET performed showed a hypermetabolic lesion (standardized uptake value 7.9) in segment Ⅳb of the liver. After discussion at a multidisciplinary hepato-pancreato-biliary conference, the consensus was that of a metastatic lesion from her previous cervical adenocarcinoma, and a resection of the hepatic lesion was performed. Histology revealed features consistent with a hepatocyte nuclear factor-1 α inactivated steatotic hepatocellular adenoma. | Darryl Lim Ser Yee Lee Kiat Hon Lim Chung Yip Chan | 2013 | World Journal of Gastroenterology2013，19，27： | 2 |
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