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282篇 您的检索式：作者名="Quarles"

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	题名	作者	年代	出处	被引量
1	The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients.	Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens	2016	Bone Research2016，4，2：	6
2	Endocrine functions of bone in mineral metabolism regulation显示文摘	Quarles L Darryl	2008	Journal of Clinical Investigation2008，，12：	2
3	Genistein stimulates the osteoblastic differentiation via NO/cGMP in bone marrow culture显示文摘	Pan W Quarles LD Song LH Yu YH Jiao C Tang HB Jiang CH Deng HW Li YJ Zhou HH Xiao ZS	2006	中国生物学文摘2006，20，5：	2
4	Cbfal isoform overexpression upregulates osteocalcin gene expression in non-osteoblastic and preosteoblsstic cells显示文摘	Xiao ZS Hinson TK Quarles LD	1999	J Cell Biochem1999，74，4：	1
5	Role of fibroblast growth factor 23 in phosphate homeostasis and pathogenesis of disordered mineral metabolism in chronic kidney disease 显示文摘	Stubbs J Liu S Quarles LD	2007	Semin Dial2007，20，：	1
6	Fibroblast growth factor-23:what we know,what we don't know,and what we need to know显示文摘	Kovesdy CP Quarles LD	2013	Nephrol Dial Transplant2013，28，9：	1
7	, An empirical examination of a model of the turnover Intentions of Information Systems Auditors显示文摘	Quarles Boss	1994	Journal of Applied Business Research1994，10，1：	1
8	2008 endocrine functions of bone in mineral metabo- lism regulation 显示文摘	Quarles LD	2008	J Clin Invest2008，118，：	1
9	The calcimimetic AMG 073 as a potential treatment for secondary hyperparathyroidism of end-stage renal disease 显示文摘	Quarles L D Sherrard D J Adler S	2003	Am J Soc Nephrol2003，14，3：	1
10	Evidence for FGF23 involvement in a bone-kidney axis regulating bone mineralization and systemic phosphate and vitamin D homeostasis显示文摘	Martin A Quarles LD		0，，：	1
11	Eval-uation of yucca saponin on broiler performance andammonia suppression显示文摘	Johnston N L Quarles C L Fagerberg D J	1981	Poultry Science1981，60，10：	1
12	Incidence and risk factors of thromboeytopenia in critically ill trauma patients显示文摘	Hanes SD Quarles DA Boucher BA	1997	Ann Pharmacother1997，31，3：	1
13	Selective deficiency of the 'bone-related' runx2-II unexpectedly preserves osteoblast-mediated skeletogenesis显示文摘	Xiao Z S Hjelmeland A B Quarles L D	2004	Biol Chem2004，279，20：	1
14	Role of fibroblast growth factor 23 in phosphate homeostasis and pathogenesis of disordered mineral metabolism in chronic kidney disease显示文摘	Stubbs J Liu S Quarles LD	2007	Semin Dial2007，20，4：	1
15	Prospective trial of pulseoral versus intravenous calcitriol treatment of hyperparathroidism in ESRD显示文摘	Quarles LD Yohay DA Carroll BA	1994	Kidney Int1994，45，6：	1
16	Relationship of atmospheric ammonia and coccidiosis infection in broilers显示文摘	Quarles C LRanson J AFagerberg D J	1975	Poultry1975，54，：	1
17	Hemodialysisassociated subclavian vein stenosis显示文摘	Schwab SJ Quarles LD Middleton JP	1988	Kidney Int1988，33，6：	1
18	Genistein stimulates the osteoblastic differentiation via NO/cGMP in bone marrow culture显示文摘	Pan W Quarles LD Song LH	2005	J Cell Biochem2005，94，2：	1
19	Calcyclin mediates serum response element(SRE) activation by an osteoblastic extracellular cation-sensing mechanism 显示文摘	Tu Q Pi M Quarles L D	2003	Journal of Bone and Mineral Research2003，18，：	1
20	The superfund program at its 25^th anniversary 显示文摘	John Quarles Michael Steinberg W	2006	Environmental Law Reporter2006，，10：	1

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