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| 1 | Novel hepatocellular carcinoma molecules with prognostic and therapeutic potentials显示文摘Hepatocellular carcinoma(HCC), the predominant form of primary liver cancer, is the sixth most common cancer worldwide and the third leading cause of cancerrelated death. The difficulty to diagnose early cancer stages, the aggressive behaviors of HCC, and the poor effectiveness of therapeutic treatments, represent the reasons for the quite similar deaths per year and incidence number. Considering the fact that the diagnosis of HCC typically occurs in the advanced stages of the disease when the therapeutic options have only modest efficacy, the possibility to identify early diagnostic markers could be of significant benefit. So far, a large number of biomarkers have been associated to HCC progression and aggressiveness, but many of them turned out not to be of practical utility. This is the reason why active investigations are ongoing in this field. Given the huge amount of published works aimed at the identification of HCC biomarkers, in this review we mainly focused on the data published in the last year, with particular attention to the role of(1) molecular and biochemical cellular markers;(2) micro-interfering RNAs;(3) epigenetic variations; and(4) tumor stroma. It is worth mentioning that a significant number of the HCC markers described in the present review may be utilized also as targets for novel therapeutic approaches, indicating the tight relation between diagnosis and therapy. In conclusion, we believe that integrated researches among the different lines of investigation indicated above should represent the winning strategies to identify effective HCC markers and therapeutic targets. | Bruna Scaggiante Maryam Kazemi Gabriele Pozzato Barbara Dapas Rosella Farra Mario Grassi Fabrizio Zanconati Gabriele Grassi | 2014 | World Journal of Gastroenterology2014，20，5： | 13 |
| 2 | Acute hepatitis C virus infection in a nurse trainee following a needlestick injury显示文摘Hepatitis C virus(HCV) infection after biological accident(needlestick injury) is a rare event.This report describes the first case of acute HCV infection after a needlestick injury in a female nursing student at Padua University Hospital.The student nurse was injured on the second finger of the right hand when recapping a 23-gauge needle after taking a blood sample.The patient who was the source was a 72-year-old female with weakly positive anti-HCV test results.Three months after the injury,at the second step of followup,a relevant increase in transaminases with a low viral replication activity(350 IU/mL) was observed in the student,indicating HCV infection.The patient tested positive for the same genotype(1b) of HCV as the injured student.A rapid decline in transaminases,which was not accompanied by viral clearance,and persistently positive HCV-RNA was described 1 mo later.Six months after testing positive for HCV,the student was treated with pegylated interferon plus ribavirin for 24 wk.A rapid virological response was observed after 4 wk of treatment,and a sustained virological response(SVR) was evident 6 mo after therapy withdrawal,confirming that the patient was definitively cured.Despite the favourable IL28B gene(rs12979860) CC-polymorphism observed in the patient,which is usually predictive of a spontaneous clearance and SVR,spontaneous viral clearance did not take place;however,infection with this genotype was promising for a sustained virological response after therapy. | Renzo Scaggiante Liliana Chemello Roberto Rinaldi Giovanni Battista Bartolucci Andrea Trevisan | 2013 | World Journal of Gastroenterology2013，19，4： | 11 |
| 3 | Cell-free DNA integrity for the monitoring of breast cancer:Future perspectives?显示文摘Breast cancer(BC) is the most common cancer and the second cause of death in women worldwide. Therapeutic options are increasing, but the response to treatments is not always efficient and the risk of recurrence covers decades. In this perspective, the need to have a proper follow-up for the therapeutic responses and for anticipating recurrence it is urgent in the clinical setting. Liquid biopsy provides the basic principle for a non-invasive method for the routinely monitoring of BC. However, due to the heterogeneity of tumors during onset and progression, the search for tumor DNA mutations of targeted genes in plasma/serum is a limiting factor. A possible approach overtaking this problem comes from the measurement of cell-free DNA integrity, which is an independent factor from the mutational status and theoretically is representative of all tumors. This review summarizes the state-of-the-art of cell-free DNA integrity researches in BC, the controversies and the future perspective. | Navid Sobhani Daniele Generali Fabrizio Zanconati Marina Bortul Bruna Scaggiante | 2018 | World Journal of Clinical Oncology2018，9，2： | 2 |
| 4 | Improving siRNA bio - distribution and minimizing side effects 显示文摘 | Scaggiante B Dapas B Farra R | 2011 | Curt Drug Metab2011，12，1： | 1 |
| 5 | Dissecting the expression of EEF1 A1/2 genes in human prostate cancer cells:the potential of EEF1 A2 as a hallmark for prostate transformation and progression显示文摘 | Scaggiante B Dapas B Bonin S | | 0，，： | 1 |
| 6 | Dissecting the expression of EEF1A1/2 genes in human prostate cancer cells:the potential of EEF1A2 as a hallmark for prostate transformation and progression显示文摘 | Scaggiante B Dapas B Bonin S | | 0，，01： | 1 |
| 7 | The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade显示文摘 | Grassi G Scaggiante B Farra R | | 0，，12： | 1 |
| 8 | Effects of E2F1–cyclin E1–E2 circuit down regulation in hepatocellular carcinoma cells显示文摘 | Rossella Farra Barbara Dapas Gabriele Pozzato Bruna Scaggiante Francesco Agostini Cristina Zennaro Mario Grassi Natalia Rosso Carlo Giansante Nicola Fiotti Gabriele Grassi | 2011 | Digestive and Liver Disease2011，，12： | 1 |
| 9 | Sperm competition and mode of fertilization in the grass goby Zosterisessor ophiocephalus (Teleostei: Gobiidae) 显示文摘 | Mazzoldi C Petersen C W | 1999 | J Exp Zool1999，283，： | 1 |
| 10 | Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels显示文摘 | Daniele Baiz Gabriele Pozzato Barbara Dapas Rossella Farra Bruna Scaggiante Mario Grassi Laura Uxa Carlo Giansante Cristina Zennaro Gianfranco Guarnieri Gabriele Grassi | 2008 | Biochimie2008，，3： | 1 |
| 11 | Dissecting the expression of EEF1A1/2 genes in human prostate cancer cells: the potential of EEF1A2 as a hallmark for prostate transformation and progression 显示文摘 | Scaggiante B Dapas B Bonin S | 2012 | BrJCancer2012，106，1： | 1 |
| 12 | Improving siRNA bio-dis- tribution and minimizing side effects显示文摘 | Scaggiante B Dapas B Farra R | 2011 | Curr Drug Metab2011，12，1： | 1 |
| 13 | Therapeutic Potential of Nucleic Acid-Based Drugs in Coronary Hyper- Proliferative Vascular Diseases显示文摘 | G. Grassi B. Scaggiante B. Dapas R. Farra F. Tonon G. Lamberti A. Barba S. Fiorentino N. Fiotti F. Zanconati M. Abrami M. Grassi | 2013 | Current Medicinal Chemistry2013，，28： | 1 |
| 14 | The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with dif- ferent differentiation grade 显示文摘 | Grassi G Scaggiante B Farra R | 2007 | Biochimie2007，89，12： | 1 |
| 15 | The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade 显示文摘 | Grassi G Scaggiante B Farra R | 2007 | Biochi- mie2007，89，12： | 1 |
| 16 | The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade 显示文摘 | Grassi G Scaggiante B Farra R | 2007 | Biochimie2007，89，12： | 1 |
| 17 | Aptamers as targeting delivery devices or anti cancer drugs for fighting tumors显示文摘 | Scaggiante B Dapas B Farra R | 2013 | Curr Drug Metab2013，14，5： | 1 |
| 18 | The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade显示文摘 | Grassi G Scaggiante B Farra R Dapas B Agostini F Baiz D | 2007 | Biochimie2007，89，： | 1 |
| 19 | The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade显示文摘 | G. Grassi B. Scaggiante R. Farra B. Dapas F. Agostini D. Baiz N. Rosso C. Tiribelli | 2007 | Biochimie2007，，12： | 1 |
| 20 | The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade 显示文摘 | Grassi G Scaggiante B Farra R | 2007 | Biochimie2007，89，12： | 1 |
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