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| 1 | Role of leukotrienes in acute gastric lesions induced by ethanol, taurocholate, aspirin, platelet-activating factor and stress in rats显示文摘 | Stanislaw J. Konturek MD Tomasz Brzozowski PhD Danuta Drozdowicz MSc Gerhard Beck PhD | 1988 | Digestive Diseases and Sciences1988，，7： | 1 |
| 2 | Ischemic preconditioning of remote organs attenuates gastric ischemia–reperfusion injury through involvement of prostaglandins and sensory nerves显示文摘 | Tomasz Brzozowski Peter C. Konturek Stanislaw J. Konturek Robert Pajdo Slawomir Kwiecien Michal Pawlik Danuta Drozdowicz Zbigniew Sliwowski Wieslaw W. Pawlik | 2004 | European Journal of Pharmacology2004，，1： | 1 |
| 3 | Role of gastric acid secretion in progression of acute gastric erosions induced by ischemia–reperfusion into gastric ulcers显示文摘 | Tomasz Brzozowski Peter Ch Konturek Stanislaw J Konturek Danuta Drozdowicz Slawomir Kwiecie? Robert Pajdo Wladyslaw Bielanski Eckhart G Hahn | 2000 | European Journal of Pharmacology2000，，1： | 1 |
| 4 | Healing of chronic gastroduodenal ulcerations by antacids显示文摘 | Prof. Dr. Stanis?aw J. Konturek MD Tomasz Brzozowski PhD Danuta Drozdowicz PhD Artur Dembiński MD Christian Nauert PhD | 1990 | Digestive Diseases and Sciences1990，，9： | 1 |
| 5 | Ischemic preconditioning of remote organs attenuates gastric ischemia–reperfusion injury through involvement of prostaglandins and sensory nerves显示文摘 | Tomasz Brzozowski Peter C. Konturek Stanislaw J. Konturek Robert Pajdo Slawomir Kwiecien Michal Pawlik Danuta Drozdowicz Zbigniew Sliwowski Wieslaw W. Pawlik | 2004 | European Journal of Pharmacology2004，，1： | 1 |
| 6 | Helicobacter pylori infection delays healing of ischaemia-reperfusion induced gastric ulcerations: new animal model for studying pathogenesis and therapy of H. pylori infection显示文摘 | Stanislaw J. Konturek Tomasz Brzozowski Peter C. Konturek Slavomir Kwiecien Elibieta Karczewska Danuta Drozdowicz Jerzy Stachura Eckhart G. Hahn | 2000 | European Journal of Gastroenterology & Hepatology2000，，12： | 1 |
| 7 | Grapefruit-seed extract attenuates ethanol-and stress-induced gastric lesions via activation of prostaglandin, nitric oxide and sensory nerve pathways显示文摘AIM: Grapefruit-seed extract (GSE) containing flavonoids, possesses antibacterial and antioxidative properties but whether it influences the gastric defense mechanism and gastroprotection against ethanol- and stress-induced gastric lesions remains unknown. METHODS: We compared the effects of GSE on gastric mucosal lesions induced in rats by topical application of 100% ethanol or 3.5 h of water immersion and restraint stress (WRS) with or without (A) inhibition of cyclooxygenase (COX)-1 activity by indomethacin and rofecoxib, the selective COX-2 inhibitor, (B) suppression of NO-synthase with L-NNA (20 mg/kg ip), and (C) inactivation by capsaicin (125 mg/kg sc) of sensory nerves with or without intragastric (ig) pretreatment with GSE applied 30 min prior to ethanol or WRS. One hour after ethanol and 3.5 h after the end of WRS, the number and area of gastric lesions were measured by planimetry, the gastric blood flow (GBF) was assessed by H2-gas clearance technique and plasma gastrin levels and the gastric mucosal generation of PGE2, superoxide dismutase (SOD) activity and malonyldialdehyde (MDA) concentration, as an index of lipid peroxidation were determined. RESULTS: Ethanol and WRS caused gastric lesions accompanied by the significant fall in the GBF and SOD activity and the rise in the mucosal MDA content. Pretreatment with GSE (8-64 mg/kg i g) dose-dependently attenuated gastric lesions induced by 100% ethanol and WRS; the dose reducing these lesions by 50% (ID50) was 25 and 36 mg/kg, respectively, and this protective effect was similar to that obtained with methyl PGE2 analog (5 μg/kg i g). GSE significantly raised the GBF, mucosal generation of PGE2, SOD activity and plasma gastrin levels while attenuating MDA content. Inhibition of PGE2 generation with indomethacin or rofecoxib and suppression of NO synthase by L-NNA or capsaicin denervation reversed the GSE-induced protection and the accompanying hyperemia. Co-treatment of exogenous calcitonine gene-related peptide (CGRP) with GSE restored the protection and accompanying hyperemic effects of GSE in rats with capsaicin denervation. CONCLUSION: GSE exerts a potent gastroprotective activity against ethanol and WRS-induced gastric lesions via an increase in endogenous PG generation, suppression of lipid peroxidation and hyperemia possibly mediated by NO and CGRP released from sensory nerves. | Tomasz Brzozowski Peter C Konturek Danuta Drozdowicz Stanislaw J Konturek Oxana Zayachivska Robert Pajdo Slawomir Kwiecien Wieslaw W Pawlik Eckhart G Hahn | 2005 | World Journal of Gastroenterology2005，11，41： | 1 |
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