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| 1 | Nitric oxide-releasing aspirin but not conventional aspirin improves healing of experimental colitis显示文摘AIM:To determine the effect of non-selective cyclooxygenase (COX) inhibitors,selective COX-2 inhibitors and nitric oxide (NO)-releasing aspirin in the healing of ulcerative colitis.METHODS:Rats with 2,4,6 trinitrobenzenesulfonic acid (TNBS)-induced colitis received intragastric (ig) treatment with vehicle,aspirin (ASA) (a nonselective COX inhibitor),celecoxib (a selective COX-2 inhibitor) or NO-releasing ASA for a period of ten days.The area of colonic lesions,colonic blood flow (CBF),myeloperoxidase (MPO) activity and expression of proinflammatory markers COX-2,inducible form of nitric oxide synthase (iNOS),IL-1β and tumor necrosis factor (TNF)-α were assessed.The effects of glyceryl trinitrate (GTN),a NO donor,and 2-(4-carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-1H-imidazolyl-1-oxy-3-oxide,onopotassium salt (carboxy-PTIO),a NO scavenger,administered without and with ASA or NO-ASA,and the involvement of capsaicin-sensitive afferent nerves in the mechanism of healing the experimental colitis was also determined.RESULTS:Rats with colitis developed macroscopic and microscopic colonic lesions accompanied by a significant decrease in the CBF,a significant rise in colonic weight,MPO activity and plasma IL-1β and TNF-α levels.These effects were aggravated by ASA and 5-(4-chlorophenyl)-1-(4-methoxyphenyl)3-(trifluoromethyl)-1H-pyrazole (SC-560),but not celecoxib and counteracted by concurrent treatment with a synthetic prostaglandin E 2 (PGE 2) analog.Treatment with NO-ASA dose-dependently accelerated colonic healing followed by a rise in plasma NO x content and CBF,suppression of MPO and downregulation of COX-2,iNOS,IL-1β and TNF-α mRNAs.Treatment with GTN,the NO donor,significantly inhibited the ASA-induced colonic lesions and increased CBF,while carboxy-PTIO or capsaicin-denervation counteracted the NO-ASAinduced improvement of colonic healing and the accompanying increase in the CBF.These effects were restored by co-treatment with calcitonin gene related peptide (CGRP) and NO-ASA in capsaicin-denervated animals.CONCLUSION:NO-releasing ASA,in contrast to ASA,COX-1 inhibitors,and SC-560,accelerated the healing of colitis via a mechanism involving NO mediated improvement of microcirculation and activation of sensory nerves releasing CGRP. | Malgorzata Zwolinska-Wcislo Tomasz Brzozowski Agata Ptak-Belowska Aneta Targosz Katarzyna Urbanczyk Slawomir Kwiecien Zbigniew Sliwowski | 2011 | World Journal of Gastroenterology2011，17，36： | 2 |
| 2 | Helicobacter pylori infection and serum gastrin, ghrelin and leptin in children of Polish shepherds显示文摘 | M. Plonka W. Bielanski S.J. Konturek A. Targosz Z. Sliwowski M. Dobrzanska A. Kaminska E. Sito P.C. Konturek T. Brzozowski | 2005 | Digestive and Liver Disease2005，，2： | 1 |
| 3 | Interaction of non- steroidal anti-inflammatory drugs(NSAIDs) with Helicobacter pylo- fi in the stomach of humans and experimental animals显示文摘 | Brzozowski T Konture kPC Sliwowski Z | 2006 | J Physi- ol Phamaco12006，57，3： | 1 |
| 4 | Prostaglandin! cyclooxygenase pathway in ghrelin - induced gastroprotection against ischemia - reperfusion injury显示文摘 | Brzozowski T Konturek PC Sliwowski Z | 2006 | J Phannacol Exp Ther2006，319，1： | 1 |
| 5 | Helicobacter pylori and its eradication in resacea显示文摘 | SZLACHCIC A SLIWOWSKI Z KARCZEWSKA E | 1999 | J Physiol Pharmacol1999，50，5： | 1 |
| 6 | Role of capsaicin-sensitive sensory nerves in gastroprotection against acid-independent and acid-dependent ulcerogens显示文摘 | Brzozowski T Konturek SJ Sliwowski Z | 1996 | Digestion1996，57，6： | 1 |
| 7 | Ischemic preconditioning of remote organs attenuates gastric ischemia–reperfusion injury through involvement of prostaglandins and sensory nerves显示文摘 | Tomasz Brzozowski Peter C. Konturek Stanislaw J. Konturek Robert Pajdo Slawomir Kwiecien Michal Pawlik Danuta Drozdowicz Zbigniew Sliwowski Wieslaw W. Pawlik | 2004 | European Journal of Pharmacology2004，，1： | 1 |
| 8 | Neural aspects of ghrelin-induced gastroprotection against mucosal injury induced by noxious agents 显示文摘 | Brzozowski T Konturck PC Sliwowski Z | 2006 | J Physiol Pharmacol2006，57，6： | 1 |
| 9 | Probiotic bacteria Esch- erichia coli strain Nissle 1917 attenuates acute gastric lesions induced by stress显示文摘 | Konturek P C Sliwowski Z Koziel J er al | 2009 | J Physiol Pharmacol2009，60，6： | 1 |
| 10 | Role of epidermal growth factor prostaglandin and sulfhydryls in stress-induced gastric lesions显示文摘 | Konturek P K Sliwowski Z Konturek S J | 1990 | Gastroenterology1990，99，： | 1 |
| 11 | Gas- troprotective action of orexin-A against stress-induced gastric damage is mediated by endogenous prostaglandins, sensory affer- ent neuropeptides and nitric oxide显示文摘 | BRZOZOWSKI T KONTUREK PC SLIWOWSKI Z | 2008 | Regul Pept2008，148，13： | 1 |
| 12 | Adaptive cytoprotection by ammonia and urea-urease system in the rat gastric mucosa显示文摘 | Brzozowski T P K Konturek Z Sliwowski | 1995 | J Physiol Pharmacol1995，46，： | 1 |
| 13 | Helicobacter pylori and its eradication in resacea 显示文摘 | Szlachcic A Sliwowski Z Karczewska E | 1999 | J Physiol Pharmacol1999，50，5： | 1 |
| 14 | Implications of reactive oxygen species and cytokines in gastroprotection against stress-induced gastric damage by nitric oxide releasing aspirin显示文摘 | Tomasz Brzozowski Piotr C. Konturek Stanislaw J. Konturek Slawomir Kwiecień Zbigniew Sliwowski Robert Pajdo Alexandra Duda Agata Ptak Eckhart G. Hahn | 2003 | International Journal of Colorectal Disease2003，，4： | 1 |
| 15 | Role of larginine, a substrate for nitric oxide-synthase, in gastroprotection and ulcer healing显示文摘 | Brzozwski T Konturek SJ Sliwowski Z | 1998 | J Gastroenterol1998，32，： | 1 |
| 16 | Role of capsaicinsensitive sensory nerves in gastroprotection against acid-independent and acid-dependent ulcerogens显示文摘 | BRZOZOWSKI T KONTUREK S J SLIWOWSKI Z | 1996 | Digestion1996，57，6： | 1 |
| 17 | Interaction of nonsteroidal anti-inflammatory drugs(NSAID) with Helicobacter pylori in the stomach of humans and experimental animals显示文摘 | Brzozowski T Konturek PC Sliwowski Z | 2006 | J Physiol pharmacol2006，57，3： | 1 |
| 18 | Implications of reactive oxygen species and cytokines in gastroprotection against stress-induced gastric damage by nitric oxide releasing aspirin显示文摘 | Tomasz Brzozowski Piotr C. Konturek Stanislaw J. Konturek Slawomir Kwiecień Zbigniew Sliwowski Robert Pajdo Alexandra Duda Agata Ptak Eckhart G. Hahn | 2003 | International Journal of Colorectal Disease2003，，4： | 1 |
| 19 | Healing of chronic gastric ulcers in diabetic rats treated with native aspirin,nitric oxide (NO) derivative of aspirin and cyclooxygenase (COX) -2inhibitor显示文摘 | Targosz A Sliwowski Z | 2004 | J Physiol Pharmacol2004，55，4： | 1 |
| 20 | Probiotic bacteria Esc- heriehia coli strain Nissle 1917 attenuates acute gastric lesions induced by stress显示文摘 | Konturek PC Sliwowski Z Koziel J | 2009 | J Physiol Pharmaeol2009，606，： | 1 |
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