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36篇 您的检索式:作者名="Danping Wang"
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1Coinfection with influenza A virus enhances SARS-CoV-2 infectivity显示文摘The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health.Through experimental coinfection with influenza A virus(IAV)and either pseudotyped or live SARS-CoV-2 virus,we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types.Remarkably,in vivo,increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV.Moreover,such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses,likely due to a unique feature of IAV to elevate ACE2 expression.This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection,and thus,prevention of IAV infection is of great significance during the COVID-19 pandemic.Lei Bai Yongliang Zhao Jiazhen Dong Simeng Liang Ming Guo Xinjin Liu Xin Wang Zhixiang Huang Xiaoyi Sun Zhen Zhang Lianghui Dong Qianyun Liu Yucheng Zheng Danping Niu Min Xiang Kun Song Jiajie Ye Wenchao Zheng Zhidong Tang Mingliang Tang Yu Zhou Chao Shen Li Zhou Yu Chen Huan Yan Ke Lan Ke Xu 2021Cell Research2021,31,4:16
2Toric Intraocular Lens vs. Peripheral Corneal Relaxing Incisions to Correct Astigmatism in Eyes Undergoing Cataract Surgery显示文摘Purpose:.To compare toric intraocular lens implantation(ToricIOL).with peripheral corneal relaxing incisions(PCRIs) for astigmatism correction in patients undergoing cataract surgery.Methods: 54 patients(54 eyes) with more than 0.75 diopter(D).of preexisting corneal astigmatism were classified as group A(0.75-1.50D) or group B(1.75-2.50D). The patients were randomized to undergo Toric-IOL or PCRIs in the steep axis with spherical IOL implantation..Log MAR uncorrected visual acuity(Log MAR UCVA), Log MAR best corrected vi sual acuity.(Log MAR BCVA),.error of vector(|EV|), surgery induced refraction correction.(|SIRC |),.and correction rates(CR) were measured 1 month and 6 months postoperatively.Results: At 6 months postoperatively, all 54 eyes had LogMAR BCVA≤0.2. Patients who underwent PCRIs and ToricIOL with Log MAR BCVA≤0.1 showed no significant differences in group A(P=1.00) or in group B(P=0.59). Group A showed no significant differences in Log MAR UCVA(P =0.70), |EV|(P=0.13), |SIRC|(P=0.71), and CR(P=0.56)in patients underwent PCRIs and Toric-IOL. However, group B showed significant differences in Log MAR UCVA(P <0.01), |EV|(P<0.01)), |SIRC|(P<0.01), and CR(P<0.01).The Log MAR UCVA and |EV | between 1 and 6 months showed no significant differences in patients in group A. However, in group B, they are significant differences.Conclusion:.The efficacy and stability of Toric-IOL and PCRIs were equal in low astigmatic patients..Toric-IOL achieved an enhanced effect over PCRIs in higher astigmatic patients.PCRIs had the more refractive regression than Toric-IOL in 6months.Zhiping Liu Xiangyin Sha Xuanwei Liang Zhonghao Wang Jingbo Liu Danping Huang 2014Eye Science2014,29,4:9
3The effect of integrative crop management on root growth and methane emission of paddy rice显示文摘In previous studies, integrative crop management (ICM) improved shoot growth and grain yield of rice (Oryza sativa L.). However, little is known about the effect of ICM on root growth and methane (CH4) emission of paddy rice. In this study, two rice varieties, Wuyunjing 24 and Yongyou 2640, were grown. A field experiment was conducted with three crop management treatments including zero nitrogen fertilization (0N), local farmer practice (LFP), and ICM. Root morphophysiological traits and CH4 emission from the paddy field were investigated. ICM significantly increased mean grain yield by 29.9%, with the effect attributed mainly to an increase in mean total number of spikelets by 26.4% compared to LFP. ICM increased root and shoot biomass, root length, number of roots, root oxidation activity (ROA), root bleeding rate, and root total and active absorbing surface area by respectively 24.4%, 25.7%, 17.1%, 9.3%, 18.7%, 29.5%, 12.1%, and 24.7%. The concentrations of malic, succinic, and acetic acids in root exudates were respectively 5.8%, 6.0%, and 10.5% higher in ICM than in LFP. Compared to LFP, ICM significantly decreased the rate of CH4 emission during emission peak stages and reduced total CH4 emission by 17.1%. The root morphophysiological traits were positively and significantly correlated with grain yield, whereas root length, specific root length, ROA, and root total and active absorbing surface area were negatively and significantly correlated with total CH4 emission. These results suggest that ICM could achieve the dual goals of increasing grain yield and reducing the greenhouse gas effect by improving the root morphology and physiological traits of paddy rice.Hao Zhang Hailang Liu Danping Hou Yilei Zhou Mengzhu Liu Zhiqin Wang Lijun Liu Junfei Gu Jianchang Yang 2019The Crop Journal2019,7,4:8
4Chaperone proteins identified from synthetic proteasome inhibitor-induced inclusions in PC12 cells by proteomic analysis显示文摘女伴蛋白质在 Lewy 身体是重要的,但是女伴蛋白质的侧面不完全地被解开。Proteomic 分析被用来为进一步的学习决定蛋白质候选人。这里,从导致代理人的包括识别潜在的女伴蛋白质,我们执行了包括在为 48 h 暴露于 10 M 希腊语的第二十三个字母的 PC12 房间形成了的导致的人工地合成的 proteasome 禁止者(希腊语的第二十三个字母) 的 proteomic 分析。用通过指纹对多重蛋白质数据库寻找了的肽质量的生物化学的分别, 2-D 电气泳动,和鉴定,我们反复从导致希腊语的第二十三个字母的包括识别了八可再现的女伴蛋白质。这些, 58 kDa 葡萄糖调整了蛋白质, 75 kDa 葡萄糖调整了蛋白质,并且钙绑定蛋白质 1 是最新识别了。其它五被报导了是 Lewy 身体的一致部件。这些调查结果建议三潜在的女伴蛋白质可能在 proteasome 抑制下面在 PC12 房间被招募到导致希腊语的第二十三个字母的包括。Xing'an Li Yingjiu Zhang Yihong Hu Ming Chang Tao Liu Danping Wang Yu Zhang Lei Zhang Linsen Hu 2008Acta Biochimica et Biophysica Sinica2008,40,5:4
5Ultraflat, broadband, and highly coherent supercontinuum generation in all-solid microstructured optical fibers with all-normal dispersion显示文摘High flatness, wide bandwidth, and high-coherence properties of supercontinuum(SC) generation in fibers are crucial in many applications. It is challenging to achieve SC spectra in a combination of the properties, since special dispersion profiles are required, especially when pump pulses with duration over 100 fs are employed. We propose an all-solid microstructured fiber composed only of hexagonal glass elements. The optimized fiber possesses an ultraflat all-normal dispersion profile, covering a wide wavelength interval of approximately 1.55 μm. An SC spectrum spanning from approximately 1030 to 2030 nm(corresponding to nearly one octave) with flatness<3 dB is numerically generated in the fiber with 200 fs pump pulses at 1.55 μm. The results indicate that the broadband ultraflat SC sources can be all-fiber and miniaturized due to commercially achievable 200-fs fiber lasers. Moreover, the SC pulses feature high coherence and a single pulse in the time domain, which can be compressed to 13.9-fs pulses with high quality even for simple linear chirp compensation. The Fourier-limited pulse duration of the spectrum is 3.19 fs, corresponding to only 0.62 optical cycles.CHUNLEI HUANG MEISONG LIAO WANJUN BI XIA LI LILI HU LONG ZHANG LONGFEI WANG GUANSHI QIN TIANFENG XUE DANPING CHEN WEIQING GAO 2018Photonics Research2018,6,6:4
6WheatGmap:a comprehensive platform for wheat gene mapping and genomic studies显示文摘Bulked segregant analysis(BSA)is an efficient and low-cost strategy that is widely used to identify causal genes in segregating populations.BSA-based methods,such as BSA sequencing(Wenger et al.,2010),bulked segregant RNA sequencing(BSR-seq)(del Viso et al.,2012),and MutMap(Abe et al.,2012),are powerful tools that can be used for rapidly discovering genetic markers and gene mapping.Although BSA is increasingly being used in wheat(Triticum aestivum)gene mapping efforts,few user-friendly BSA tools have been developed for researchers lacking a strong bioinformatics background.Here,we developed the web-based BSA platform WheatGmap(http://gffzz4d94446f6f524399sk09fpfbqp69n6xwv.ffgz.tsg.suse.edu.cn),which integrates multiple BSA mapping models and large amounts of public data to accelerate gene cloning and functional research and facilitate resource sharing.Lichao Zhang Chunhao Dong Zhongxu Chen Lixuan Gui Cheng Chen Danping Li Zhencheng Xie Qiang Zhang Xueying Zhang Chuan Xia Xu Liu Xiuying Kong Jirui Wang 2021Molecular Plant2021,14,2:4
7Analysis and experimentation of key technologies in service-oriented optical internet显示文摘To satisfy diverse bandwidth-intensive applications envisioned in the internet of the future, research on a distributed optical internet, enabling efficient utilization of geographically distributed resources, has become attractive. The deployment of such a network, however, has its own technical challenges, including network architecture, resource management, and high-speed transmission. To address these issues, a service-oriented-architecture-based distributed optical internet architecture is proposed. Thereafter, key technologies of an optical internet, such as optical multicasting, distributed resource control, and high-speed transmission, are analyzed and investigated. The proposed schemes are verified through experimentation and simulation.JI YueFeng REN DanPing LI Hui LIU XueJun WANG ZhengZhong 2011Science China(Information Sciences)2011,54,2:3
8Vehicle-to-Infrastructure Channel Characterization in Urban Environment at 28 GHz显示文摘Both ultra-reliable low latency and high-data-rate communications are required by connective vehicles. Millimeter wave(mm Wave) with large bandwidth is a key technology to support high-data-rate communications. In this paper, the 28 GHz wideband vehicle-to-infrastructure channel is characterized for the urban environment in a major street in Manhattan. The deployment of the transmitter and the receiver, as well as the traffic models, are selected by considering the recommendation by 3GPP TR 37.885. Ray tracing simulator with calibrated electromagnetic parameters is employed in this work to practically conduct intensive simulations. The 3D environment model is reconstructed from OpenStreetMap. The power delay profile, path loss, root-meansquare delay spread, K-factor and so on, are extracted from the calibrated simulation results. The evolution of the parameters, as well as their statistical properties, are analyzed and modeled. The work of this paper helps the researchers understand the propagation channel for designing mmWave technologies and communication system in a similar scenario.Longhe Wang Bo Ai Danping He Ke Guan Jiayi Zhang Junhyeong Kim Zhangdui Zhong 2019China Communications2019,16,2:3
9DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS-STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis显示文摘Gastrointestinal mucositis is one of the most debilitating side effects of the chemotherapeutic agent irinotecan(CPT-11). Andrographolide, a natural bicyclic diterpenoid lactone, has been reported to possess anti-colitis activity. In this study, andrographolide treatment was found to significantly relieve CPT-11-induced colitis in tumor-bearing mice without decreasing the tumor suppression effect of CPT-11. CPT-11 causes DNA damage and the release of double-stranded DNA(ds DNA) from the intestine, leading to cyclic-GMP-AMP synthase(c GAS)-stimulator of interferon genes(STING)-mediated colitis, which was significantly decreased by andrographolide both in vivo and in vitro. Mechanistic studies revealed that andrographolide could promote homologous recombination(HR) repair and downregulate ds DNA-c GAS-STING signaling and contribute to the improvement of CPT-11-induced gastrointestinal mucositis. These results suggest that andrographolide may be a novel agent to relieve gastrointestinal mucositis caused by CPT-11.Yuanyuan Wang Bin Wei Danping Wang Jingjing Wu Jianhua Gao Haiqing Zhong Yang Sun Qiang Xu Wen Liu Yanhong Gu Wenjie Guo 2022Acta Pharmaceutica Sinica B2022,12,1:3
10Blue revolution for food security under carbon neutrality: A case from the water-saving and drought-resistance rice显示文摘The increasing concentration of greenhouse gases(GHGs)in Earth's atmosphere leads to global warming,which further causes a series of climate changes and does great harm to both human society and natural ecosystems.Agricultural GHG emissions,mainly in theform of methane(CH4)and nitrous oxide(N2O),areasignificantsourceofGHGs,accountingfor~14%total global GHGs(Zhang et al.,2022).One major source of agricultural GHGs is CH4 emissions from rice paddies,which is responsiblefor~10%-12%ofhuman-inducedCH4emissions(van Groenigen et al.,2013)and contributes~2.40%to the enhanced global warming effect(Zhang et al.,2022).The global warming potential of GHGs emissions from rice systems is roughly four times higher than either wheat or maize(Linquist et al.,2012).Hui Xia Xianxian Zhang Yi Liu Junguo Bi Xiaosong Ma Anning Zhang Hongyan Liu Liang Chen Sheng Zhou Huan Gao Kai Xu Haibin Wei Guolan Liu Feiming Wang Hongyang Zhao Xingxing Luo Danping Hou Qiaojun Lou Fangjun Feng Liguo Zhou Shoujun Chen Ming Yan Tianfei Li Mingshou Li LeiWang Zaochang Liu Xinqiao Yu HanweiMei Lijun Luo 2022Molecular Plant2022,15,9:3
11User Association and Wireless Backhaul Bandwidth Allocation for 5G Heterogeneous Networks in the Millimeter-Wave Band显示文摘The user association and wireless backhaul bandwidth allocation for a two-tier heterogeneous network(Het Net) in the millimeter wave(mm Wave) band is proposed in this article. The two-tier Het Net is built up with a macro base station(MBS) and several small cell SBSs, where the MBS is assumed to be equipped with large-scale antenna arrays but the SBSs only have single-antenna capability and they rely on the wireless link to the MBS for backhaul. The sum of logarithmic user rate, which is established according to the result of multi-user Multiple Input Multiple Output(MIMO) downlink employing Zero-Force Beamforming(ZFBF), is chosen as the network utility for the objective function. And a distributed optimization algorithm based on primal and dual decomposition is used to jointly optimize the user association variable xj,i and the wireless backhaul bandwidth factor β. Simulation results reveal that the distributed optimization algorithm jointly optimizing two variables outperforms the conventional SINR-based user association strategies.zhenxiang su bo ai yichuan lin danping he ke guan ning wang guoyu ma li niu 2018China Communications2018,15,4:2
12Effects of calcination temperature and Li^+ ions doping on structure and upconversion luminescence properties of TiO_2:Ho^(3+)-Yb^(3+) nanocrystals显示文摘Ho^(3+)-Yb^(3+) co-doped and Ho^(3+)-Yb^(3+)-Li^+ tri-doped TiO_2 nanocrystals were prepared using the sol-gel method. Effects of the calcination temperature and Li^+ ions doping on the structure and upconversion luminescence properties of Ho^(3+)-Yb^(3+) co-doped TiO_2 nanocrystals were investigated. The upconversion luminescence of nanocrystals was enhanced with the reduction of the crystal lattice symmetry and the crystallinity improvement of the matrix, which were facilitated by the calcination temperature change and Li^+ ions doping. The lowest lattice symmetry and the best crystallinity of the matrix resulted in the maximum luminescence intensity.Kaishun Zou Guangzong Dong Juncheng Liu Boxu Xu Danping Wang 2019Journal of Materials Science & Technology2019,35,4:1
13Geotectonic evolution of lunar LQ-4 region based on multisource data显示文摘The Sinus Iridum region, the first choice for China's 'Lunar Exploration Project' is located at the center of the lunar LQ-4 area and is the site of Chang'e-3(CE-3)'s soft landing. To make the scientific exploration of Chang'e-3 more targeted and scientific, and to obtain a better macro-level understanding of the geotectonic environment of the Sinus Iridum region, the tectonic elements in LQ-4 region have been studied and the typical structures were analyzed statistically using data from CE-1, Clementine, LRO and Lunar Prospector missions. Also, the mineral components and periods of mare basalt activities in the study area have been ascertained. The present study divides the tectonic units and establishes the major tectonic events and sequence of evolution in the study area based on morphology, mineral constituents,and tectonic element distribution.Jianping Chen Yanbo Xu Xiang Wang Shujun He Danping Yan Shaofeng Liu Yongliao Zou Yongchun Zheng 2014Geoscience Frontiers2014,5,2:1
14Vasorelaxant effect of osthole on isolated thoracic aortic rings in rats显示文摘OBJECTIVE: To investigate the effect of osthole on isolated thoracic aortic rings, and to determine the potential mechanism of action.METHODS: Thoracic aortas were isolated from Wistar rats, and were suspended in tissue organ chambers for vascular tension measurement. The effect of cumulative osthole(10-9, 10-8, 10-7, 10-6, and 10-5 mol/L) on endothelium-intact and endothelium-denuded thoracic aortic rings pre-contracted with phenylephrine(PE, 10-6 mol/L) or KCl(6 × 10-2 mol/L) was recorded. Histomorphological changes of thoracic aorta were analyzed by hematoxylin-eosin. The effects of different osthole concentrations on endothelium-intact aortic rings, which were pre-inhibited with the non-selective nitric oxide synthase inhibitor L-Arg(NO2)-OMe·HCl(3 × 10-4 mol/L), endothelium-derived nitric oxide synthase inhibitor Nω-nitro-L-arginine(3 × 10-4 mol/L), guanylate cyclase inhibitor 1 H-[1,2,4] oxadiazolo [4,3-α]quinoxaline-1-one(10-5 mol/L), cyclooxygenase inhibitor indometacin(10-5 mol/L), and the Ca2+-activated potassium channel inhibitor tetraethylammonium nitrate(10-5 mol/L), and then contracted with PE, were examined. Aortic rings incubated with osthole(10-5 mol/L), phentolamine(10-5 mol/L), or verapamil(10-5 mol/L) in Ca2+-free Krebs-Henseleit solution(KHS) were stimulated with PE or KCl.RESULTS: There was a dose-dependent increase in vasorelaxation of isolated thoracic aortic rings(both with and without endothelium) with increasing osthole concentration. Hematoxylin-eosin staining showed that osthole significantly improved thoracic aorta ring morphology. Compared with the control group, there were also significant differences after incubation with L-Arg(NO2)-OMe ω-nitro-L-arginine, and 1 H-[1,2,4] oxadiazo·lo HCl,N [4,3-α] quinoxaline-1-one(P < 0.05 for all). The relaxation rate of the rings in the osthole group incubated with indometacin and tetraethylammonium nitrate were similar to controls. In Ca2+-free KHS, the PE-induced contraction was similar between the osthole(4.37% ± 0.41%) and control(4.21% ± 1.33%)groups. However, after cumulative CaCl2(0.5, 1, 1.5,2, 2.5, and 3 mmol/L), the Ca2+-induced contraction was significantly inhibited in the osthole and phentolamine groups compared with controls(P < 0.05).After cumulative CaCl2 was added to Ca2+-free KHS(high K+ concentration), the contraction rate was significantly higher than both of the control and the osthole groups(P < 0.05). The contraction rate in the osthole group was higher than the verapamil group(P < 0.05).CONCLUSION: Osthole has a vasorelaxant effect on isolated rat thoracic aortic rings, via inhibition of both receptor-operated and voltage-dependent Ca2+channels in arterial smooth muscle, leading to decreased Ca2+ influx, and via inhibition of nitric oxide release on arterial endothelial cells.Huang Ying Kong Liting Wang Yanping Sun Mingjie Cui Haifeng Zhai Huaqiang LüCheng Fan Danping 2019Journal of Traditional Chinese Medicine2019,39,4:1
15Detrital zircon record of Neoproterozoic active- margin sedimentation in the eastern Jiangnan Orogen, South China显示文摘Wang Wei Zhou Meifu Yan Danping 2013Precambrian Research2013,235,:1
16Origin and tectonic significance of a Meso- zoic multi-layer over-thrust system within the Yangtze Block (South China) 显示文摘Yan Danping Zhou Meffu Song Honglin Wang Xin- wen Malpas J 2003Tectonophysies2003,361,34:1
17Minor change in the length of carbon chain has a great influence on the antitumor effect of paclitaxel-fatty alcohol prodrug nanoassemblies:Small roles,big impacts显示文摘Prodrug-based nanoassembly emerges as a hopeful way for the efficient delivery of antitumor drugs,with carrier-free structure and ultra-high drug loading.Carbon chains are widely used to design self-assembling prodrugs.The impacts of the length of carbon chains on the self-assembly stability,drug delivery efficiency and antitumor effect of prodrugs have not been fully elucidated.Here,three paclitaxel prodrugs were synthesized by conjugating paclitaxel with octanol(C_(8)),decanol(C_(10))or dodecanol(C_(12))through disulfide bond.The three prodrugs could form homogeneous nanoparticles,with over 50%drug loading and redox dual-responsivity.Interestingly,the length extension of carbon chains ameliorates the self-assembly and the colloidal stability of prodrugs,thus improving the drug delivery efficiency.The optimal paclitaxel-dodecanol prodrug nanoassemblies exhibit better antitumor efficacy than Taxol and Abraxane.These findings are meaningful for the rational design of advanced nanomedicines in cancer therapy.Xin Wang Lingxiao Li Danping Wang Shiyi Zuo Tian Liu Fudan Dong Xuanbo Zhang Zhonggui He Bingjun Sun Jin Sun 2022Nano Research2022,15,4:1
18A diet-induced type 2 diabetes model in Drosophila显示文摘Dear Editor.Type 2 diabetes has become a global epidemic.It is a disease characterized by insulin resistance and relative insulin deficiency,resulting in hyperglycemia and various physiological and metabolic abnormalities.Besides genetic risk factors,inappropriate life styles,such as lack of physical activity and imbalanced diet,also contribute to the development of type 2diabetes in human(Jia et al.,2019).Animal models of type 2diabetes are of great value to understand its underlying mechanisms as well as to develop and evaluate potential diagnostic and therapeutic options(Kleinert et al.,2018).Danping Chen Jie Yang Zhengyun Xiao Sicong Zhou Liming Wang 2021Science China(Life Sciences)2021,64,2:1
19Comparing tribological behaviors of sulfur- and phosphorus-free organomolybdenum additive with ZDDP and MoDTC显示文摘Lili Yan Wen Yue Chengbiao Wang Danping Wei Bo Xu 2012Tribology International2012,,:1
20Maternal butyrate supplementation affects the lipid metabolism and fatty acid composition in the skeletal muscle of offspring piglets显示文摘Maternal sodium butyrate(SB)intake has important effects on offspring growth and development.This study aimed to investigate the impacts of maternal SB supplementation during gestation and lactation on fatty acid composition and lipid metabolism in the offspring skeletal muscle of pigs.Twenty sows(Yorkshire,parity 2 to 3)were assigned to the control group(diets without SB,n=10)and SB group(diets with 0.1%SB,n=10).The results showed maternal SB supplementation throughout gestation and lactation increased(P<0.05)body weight of offspring piglets at weaning.The concentrations of triglyceride in plasma and milk were enhanced(P<0.05).Maternal SB induced(P<0.05)lipid accumulation with increased expression of peroxisome proliferator activated receptorγ(PPARγ)by enrichment of the acetylation of H3 acetylation K27(H3 K27)in offspring skeletal muscle.Meanwhile,the concentrations of C18:2 n-6,C18:3 n-3,total polyunsaturated fatty acid(PUFA),n-6 PUFA and n-3 PUFA decreased(P<0.05)in skeletal muscle of weaning piglets derived from SB sows.Together,these results showed that maternal SB supplementation could influence offspring growth performance,lipid metabolism and fatty acid composition of the skeletal muscle.Yongsen Zhao Danping Wang Yanping Huang Dangdang Wu Xiaoming Ji Xiaobing Zhou Dong Xia Xiaojing Yang 2021Animal Nutrition2021,,4:1
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