|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Damage evolution and dynamic response of cement asphalt mortar layer of slab track under vehicle dynamic load显示文摘The damage evolution and dynamic performance of a cement asphalt(CA)mortar layer of slab track subjected to vehicle dynamic load is investigated in this paper.Initially,a statistical damage constitutive model for the CA mortar layer is developed using continuous damage mechanics and probability theory.In this model,the strength of the CA mortar elements is treated as a random variable,which follows the Weibull distribution.The inclusion of strain rate dependence affords considering its influence on the damage development and the transition between viscosity and elasticity.Comparisons with experimental data support the reliability of the model.A three-dimensional finite element(FE)model of a slab track is then created with the commercial software ABAQUS,where the devised model for the CA mortar is implemented as a user-defined material subroutine.Finally,a vertical vehicle model is coupled with the FE model of the slab track,through the wheel-rail contact forces,based on the nonlinear Hertzian contact theory.The evolution of the damage and of the dynamic performance of the CA mortar layer with various initial damage is investigated under the train and track interaction.The analysis indicates that the proposed model is capable of predicting the damage evolution of the CA mortar layer exposed to vehicle dynamic load.The dynamic compressive strain,the strain rate,and the induced damage increase significantly with an increase in the initial damage,whereas the dynamic compressive stress exhibits a sharp decrease with the increasing initial damage.Also,it is found that the strain rate dependence significantly influences the damage evolution and the dynamic behavior of the CA mortar layer. | ZHU ShengYang FU Qiang CAI ChengBiao SPANOS Pol D | 2014 | Science China(Technological Sciences)2014，57，10： | 19 |
| 2 | Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons显示文摘Neurotrophins 和他们的受体采用发信号的内涵体播送后退信号。然而,机制后退发信号因为另外的 ligand/receptor 系统糟糕被理解。这里,我们报导 purinergic (P) 2X 3 受体的信号,一条门 ATP 的离子隧道, retrogradely 在背面的根中心(DRG ) 被搬运神经原轴突。我们发现了那 Rab5,小 GTPase,控制早 P2X 3 受体排序进内涵体,当 Rab7 调停时快后退 P2X 3 受体的运输。Intraplantar 注射和 axonal 申请进 α 的 microfluidic 房间;, β -methylene-ATP (α, β -MeATP), P2X 选择收缩筋,提高了 endocytosis 并且后退 P2X 3 受体的运输。α, β激活的 -MeATP-induced Ca 2+ 流入由蛋白质 kinase C 组成的一条小径,病毒的 oncogene 和细胞外的调整信号的蛋白质 kinase (英皇家空军之阶级最低之兵) ,它与 endocytic P2X 3 受体联系了到形成表明内涵体的老鼠肉瘤。类脂化合物椽子的混乱废除了 α, β -MeATP-induced 英皇家空军之阶级最低之兵 phosphorylation, endocytosis 并且后退 P2X 3 受体的运输。而且,有 α 的外部轴突的治疗;, β -MeATP 在 DRG 的房间身体增加了英皇家空军之阶级最低之兵和营地反应元素绑定蛋白质的激活水平神经原和提高的 neuronal 易兴奋性。也的缺陷在 vivo 的基于微导管的 axonal 运输或在 vitro 的 dynein 功能堵住了 α, β -MeATP-induced 后退信号。这些结果显示那 P2X 3 激活受体的信号在主要感觉神经原经由 retrogradely 搬运的内涵体被播送并且为门 ligand 的隧道提供新奇发信号机制。 | Xu-Qiao Chen Bin Wang Chengbiao Wu Jin Pan Bo Yuan Yuan-Yuan Su Xing-Yu Jiang Xu Zhang Lan Bao | 2012 | Cell Research2012，22，4： | 8 |
| 3 | Current advances in using neurotrophic factors to treat neurodegenerative disorders显示文摘Neurotrophic factors are best known for their roles in both development and continued maintenance of the nervous system.Their strong potential to elicit pro-survival and pro-functional responses in neurons of the peripheral and central nervous system make them good drug candidates for treatment of a multitude of neurodegenerative disorders.However,significant obstacles remain and need to be overcome before translating the potential of neurotrophins into the therapeutic arena.This article addresses current efforts and advances in resolving these challenges and provides an overview of roadmaps for future translational research and neurotrophin-based drug developments. | April M Weissmiller Chengbiao Wu | 2012 | Translational Neurodegeneration2012，1，1： | 7 |
| 4 | Enhanced oxidation and graphitization resistance of polycrystalline diamond sintered with Ti-coated diamond powders显示文摘To improve the oxidation and graphitization resistances of the polycrystalline diamond(PCD), Ti coating was deposited on the diamond powders via magnetic sputtering method, which achieved a uniform Ti C protection barrier in PCD during the sintering process. The phase compositions, microstructures and thermal stability of Ti-PCD were characterized by X-ray diffraction(XRD), Auger electron spectroscopy(AES),scanning electron microscopy(SEM) and thermal gravimetric-differential scanning calorimetry(TG-DSC).The results demonstrate that the oxidation and graphitization resistances of PCD are strengthened due to the existence of Ti C phase, which acts as an effective inhibitor. The as-received inhibitor delays the oxidation and graphitization of PCD, elevating their initial temperature by ~50°C and ~100°C, respectively. During the annealing treatment of Ti-PCD, the priory oxidation of Ti C, which produces Ti O2 as an oxygen barrier, postpones the diamond oxide. Moreover, the Ti C barrier also protects diamond grains from direct contact with cobalt, thus a lower cobalt-catalytic graphitization, and yields to an improved graphitization resistance of PCD. The enhanced oxidation and graphitization resistances of PCD are of significant importance for practical applications to elevated temperatures. | Xiaohua Sha Wen Yue Haichao Zhang Wenbo Qin Dingshun She Chengbiao Wang | 2020 | Journal of Materials Science & Technology2020，36，8： | 6 |
| 5 | Uncoupling neurotrophic function from nociception of nerve growth factor: what can be learned from a rare human disease?显示文摘Nerve growth factor(NGF) is a powerful trophic factor that provides essential support for the survival and differentiation of sympathetic and sensory neurons during development. However, NGF also activates nociceptors contributing significantly to inflammatory pain and neuropathic pain after tissue injury. As such anti-NGF based therapies represent a promising strategy for pain management. Because of dose-dependent serious side effects such as back pain, injection site hyperalgesia, clinical trials of using NGF to treat various disorders such as diabetic neuropathies, chemotherapy-induced and human immunodeficiency virus-associated peripheral neuropathies were all discontinued. Thus far, worldwide clinical applications of NGF in treating patients are very limited except in China. Hereditary sensory autonomic neuropathy type V(HSAN V) is an extremely rare disease. Genetic analyses have revealed that HSAN V is associated with autosomal recessive mutations in NGF. One of the mutations occurred at the 100^(th) position of mature NGF resulting in a change of residue from arginine to tryptophan(R100W). Although those HSAN V patients associated with the NGF^(R100W) mutation suffer from severe loss of deep pain, bone fractures and joint destruction, interestingly patients with the NGF^(R100W) mutation do not show apparent cognitive deficits, suggesting important trophic support function is preserved. We believe that NGF^(R100W) provides an ideal tool to uncouple the two important functions of NGF: trophic versus nociceptive. Studies from investigators including ourselves have indeed confirmed in animal testing that the NGF^(R100W) no longer induced pain. More importantly, the trophic function seemed to be largely preserved in NGF harboring the R100W mutation. On the mechanistic level, we found that the NGF^(R100W) mutation was capable of binding to and signaling through the tyrosine receptor kinase A receptor. But its ability to bind to and activate the 75 kDa neurotrophic factor was significantly diminished. The significance of these findings is at least two folds: 1) the NGF^(R100W) mutation can be used as an alternative to the wildtype NGF to treat human conditions without eliciting pain; and 2) the 75 kDa neurotrophic factor may serve as a novel target for pain management. We will discuss all the details in this mini-review. | Kijung Sung Wanlin Yang Chengbiao Wu | 2019 | Neural Regeneration Research2019，14，4： | 5 |
| 6 | Microstructure and tribological properties of W-implanted PVD TiN coatings on 316L stainless steel显示文摘 | Bin Tian Wen Yue Zhiqiang Fu Yanhong Gu Chengbiao Wang Jiajun Liu | 2014 | Vacuum2014，，： | 3 |
| 7 | Mechanical characteristic variation of ballastless track in highspeed railway:effect of train–track interaction and environment loads显示文摘Due to the fact that ballastless tracks in highspeed railways are not only subjected to repeated train–track dynamic interaction loads,but also suffer from complex environmental loads,the fundamental understanding of mechanical performance of ballastless tracks under sophisticated service conditions is an increasingly demanding and challenging issue in high-speed railway networks.This work aims to reveal the effect of train–track interaction and environment loads on the mechanical characteristic variation of ballastless tracks in high-speed railways,particularly focusing on the typical interface damage evolution between track layers.To this end,a finite element model of a double-block ballastless track involving the cohesive zone model for the track interface is first established to analyze the mechanical properties of the track interface under the loading–unloading processes of the negative temperature gradient load(TGL)followed by the same cycle of the positive TGL.Subsequently,the effect of wheel–rail longitudinal interactions on the nonlinear dynamic characteristics of the track interface is investigated by using a vehicle-slab track vertical-longitudinal coupled dynamics model.Finally,the influence of dynamic water pressure induced by vehicle dynamic load on the mechanical characteristics and damage evolution of the track interface is elucidated using a fluid–solid coupling method.Results show that the loading history of the positive and negative TGLs has a great impact on the nonlinear development and distribution of the track interface stress and damage;the interface damage could be induced by the wheel–rail longitudinal vibrations at a high vehicle running speed owing to the dynamic amplification effect caused by short wave irregularities;the vehicle dynamic load could produce considerable water pressure that presents nonlinear spatial–temporal characteristics at the track interface,which would lead to the interface failure under a certain condition due to the coupled dynamic effect of vehicle load and water pressure. | Shengyang Zhu Jun Luo Mingze Wang Chengbiao Cai | 2020 | Railway Engineering Science2020，28，4： | 3 |
| 8 | Constraints of molybdenite Re-Os and scheelite Sm-Nd ages on mineralization time of the Kukaazi Pb-Zn-Cu-W deposit, Western Kunlun, NW China显示文摘The Kukaazi Pb-Zn-Cu-W polymetallic deposit, located in the Western Kunlun orogenic belt, is a newly discovered skarn-type deposit. Ore bodies mainly occur in the forms of lenses and veins along beddings of the Mesoproterozoic metamorphic rocks. Three ore blocks, KⅠ,KⅡ, and KⅢ, have been outlined in different parts of the Kukaazi deposit in terms of mineral assemblages. The KⅠ ore block is mainly composed of chalcopyrite, scheelite,pyrrhotite, sphalerite, galena and minor pyrite, arsenopyrite,and molybdenite, whereas the other two ore blocks are made up of galena, sphalerite, magnetite and minor arsenopyrite and pyrite. In this study, we obtained a molybdenite isochron Re–Os age of 450.5 ± 6.4 Ma(2σ,MSWD = 0.057) and a scheelite Sm–Nd isochron age of 426 ± 59 Ma(2σ, MSWD = 0.49) for the KⅠ ore block.They are broadly comparable to the ages of granitoid in the region. Scheelite grains from the KⅠ ore block contain high abundances of rare earth elements(REE, 42.0–95.7 ppm)and are enriched in light REE compared to heavy REE, with negative Eu anomalies(δEu = 0.13–0.55). They display similar REE patterns and Sm/Nd ratios to those of the coeval granitoids in the region. Moreover, they also have similar Sr and Nd isotopes [ ^(87)Sr/ ^(86)Sr = 0.7107–0.7118;ε_(Nd)(t) =-4.1 to-4.0] to those of such granitoids, implying that the tungsten-bearing fluids in the Kukaazi deposit probably originate from the granitic magmas. Our results first defined that the Early Paleozoic granitoids could lead to economic Mo–W–(Cu) mineralization at some favorable districts in the Western Kunlun orogenic belt and could be prospecting exploration targets. | Chengbiao Leng Yuhui Wang Xingchun Zhang Jianfeng Gao Wei Zhang Xinying Xu | 2018 | Acta Geochimica2018，37，1： | 3 |
| 9 | Progress of Nondestructive Detection Technology on Remanufacturing Coatings显示文摘The defects of remanufacturing coatings,such as micro-cracks,micro-pores,oxide inclusion,and fatigue cracks producing in the service process have great influence on the qualities and lives of remanufacturing coatings.This paper summarizes several methods used for detecting coating defects,including ray method,ultrasonic method,eddy method,magnetic memory method,acoustic emission method.The advantages and limitations of the above methods are also discussed.The detection results by ray method are visualized,and it is easy to achieve qualitative,quantitative and locating detection,but this method has incipient fault and low detecting sensitivity.Ultrasonic detection can exactly locate defects,and it is sensitive to plane defects,but the detection has dead zones,and it is inconvenient to perform qualitative and quantitative measurement.Eddy method detects fast,but it only can detect conductive materials,and is difficult to achieve qualitative,quantitative and locating detection.Magnetic memory method is sensitive to ferromagnetic materials,but it can not detect nonferromagnetic materials and is difficult to attain quantitative measurement.Acoustic emission method has an extensive detection range and high sensitivity,but it has big noise interference,and is hard to achieve qualitative detection.In conclusion,it describes the application prospect of each method for detecting coating. | Kang Jiajie Xu Binshi Wang Haidou Wang Chengbiao | 2012 | 稀有金属材料与工程2012，41，S1： | 2 |
| 10 | Interface damage and its effect on vibrations of slab track under temperature and vehicle dynamic loads 显示文摘 | ZHU Shengyang CAI Chengbiao | 2014 | International Journal of Non - Linear Mechanics2014，，58： | 1 |
| 11 | Prepara-tion of polyclonal antibodies to a derivative of 1-aminohydantion (A HD) and development of an indi-rect competitive ELISA for the detection of nitrofuran-toin residue in water显示文摘 | Wei Liu Chengbiao Zhao Yulan Zhang | | 0，，55： | 1 |
| 12 | Molecular Hydrogels with Esterase-like Activity显示文摘能被申请的分子的 hydrogels 的开发 mimicking bioactive 分子在领域里吸引研究人员的广泛的兴趣自己组装。在这研究,我们基于酸肽的包含 L-histidine 由凉下来热的过程形成了的 naphthylacetic 在几分子的 hydrogels 上报导了。所有 hydrogels 比免费 L-histidine 展出了更高的活动到水解 4-nitrophenyl 醋酸盐(4-NPA ) 可能到期在自我装配的 nanofibers 的表面的 L-histidine 残余的高密度。为了计算 4-NPA 水解作用,评价, Michaelis-Menten 酶动力学模型被做。在这些胶化之中, Nap-GFFYGHY 的胶化拥有做酉旨契约劈开的最高的酶活动,它比控制(免费 L-histidine 和 Nap-GFFYGYY ) 的高约 25 倍。这些结果显示有自我装配的 nanofibers 的分子的 hydrogels 为自我装配的多价的材料的产生有大潜力。 | Chengbiao Yang Huaimin Wang Dongxia Li Ling Wang | 2013 | Chinese Journal of Chemistry2013，31，4： | 1 |
| 13 | A nonlinear and fractional derivative viscoelastic model for rail pads in the dynamic analysis of coupled vehicle-slab track systems显示文摘 | Zhu Shengyang Cai Chengbiao Spanos Pol D | 2015 | Journal of Sound and Vibration2015，335，1： | 1 |
| 14 | A comparative study on the tribological behaviors of nitride and sulfta-nitrided 35CrMo steel lubricated in PAO base oil with MoDTC additive显示文摘 | Wen Yue Xuejie Sun Chengbiao Wang | 2011 | Tribology International2011，，44： | 1 |
| 15 | Preparation of polyelonal antibodies to a derivative of 1-aminohydantion (AHD) and development of an indirect competitive ELISA for the seteetion of nitrofurantoin residue in water显示文摘 | LIU Wei ZHAO Chengbiao ZHANG Yulan | 2007 | J Agric Food Chem2007，55，17： | 1 |
| 16 | Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease显示文摘Background In Alzheimer’s Disease(AD),about one-third of the risk genes identified by GWAS encode proteins that function predominantly in the endocytic pathways.Among them,the Ras and Rab Interactor 3(RIN3)is a guanine nucleotide exchange factor(GEF)for the Rab5 small GTPase family and has been implicated to be a risk factor for both late onset AD(LOAD)and sporadic early onset AD(sEOAD).However,how RIN3 is linked to AD pathogenesis is currently undefined.Methods Quantitative PCR and immunoblotting were used to measure the RIN3 expression level in mouse brain tissues and cultured basal forebrain cholinergic neuron(BFCNs).Immunostaining was used to define subcellular localization of RIN3 and to visualize endosomal changes in cultured primary BFCNs and PC12 cells.Recombinant flag-tagged RIN3 protein was purified from HEK293T cells and was used to define RIN3-interactomes by mass spectrometry.RIN3-interacting partners were validated by co-immunoprecipitation,immunofluorescence and yeast two hybrid assays.Live imaging of primary neurons was used to examine axonal transport of amyloid precursor protein(APP)andβ-secretase 1(BACE1).Immunoblotting was used to detect protein expression,processing of APP and phosphorylated forms of Tau.Results We have shown that RIN3 mRNA level was significantly increased in the hippocampus and cortex of APP/PS1 mouse brain.Basal forebrain cholinergic neurons(BFCNs)cultured from E18 APP/PS1 mouse embryos also showed increased RIN3 expression accompanied by early endosome enlargement.In addition,via its proline rich domain,RIN3 recruited BIN1(bridging integrator 1)and CD2AP(CD2 associated protein),two other AD risk factors,to early endosomes.Interestingly,overexpression of RIN3 or CD2AP promoted APP cleavage to increase its carboxyl terminal fragments(CTFs)in PC12 cells.Upregulation of RIN3 or the neuronal isoform of BIN1 increased phosphorylated Tau level.Therefore,upregulation of RIN3 expression promoted accumulation of APP CTFs and increased phosphorylated Tau.These effects by RIN3 was rescued by the expression of a dominant negative Rab5(Rab5S34N)construct.Our study has thus pointed to that RIN3 acts through Rab5 to impact endosomal trafficking and signaling.Conclusion RIN3 is significantly upregulated and correlated with endosomal dysfunction in APP/PS1 mouse.Through interacting with BIN1 and CD2AP,increased RIN3 expression alters axonal trafficking and procession of APP.Together with our previous studies,our current work has thus provided important insights into the role of RIN3 in regulating endosomal signaling and trafficking. | Ruinan Shen Xiaobei Zhao Lu He Yongbo Ding Wei Xu Suzhen Lin Savannah Fang Wanlin Yang Kijung Sung Brian Spencer Robert A.Rissman Ming Lei Jianqing Ding Chengbiao Wu | 2020 | Translational Neurodegeneration2020，9，2： | 1 |
| 17 | Rheological properties of polymer-gel drilling fluids at high temperature andpressure显示文摘 | Bu H a i Sun Jinsheng Wang Chengbiao | 2013 | Chemistry and Technology of Fuels and O ils2013，48，44： | 1 |
| 18 | An edge detectionmethod based on optimized BP neuralnetwork显示文摘 | Li Weiqing Wang Chengbiao etal | 2008 | International Symposium on Information Science and Engineering2008，，2： | 1 |
| 19 | Synergistic effects between sulfurized W-DLC coating and MoDTC lubricating additive for improvement of tribological performance显示文摘 | Wen Yue Chunyue Liu Zhiqiang Fu Chengbiao Wang Haipeng Huang Jiajun Liu | 2013 | Tribology International2013，，： | 1 |
| 20 | One at a time, live tracking of NGF axonal transport using quantum dots 显示文摘 | Bianxiao Cui Chengbiao Wu | 2007 | PNAS2007，104，13： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员