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| 1 | Bi-directional Selection in Upland Rice Leads to Its Adaptive Differentiation from Lowland Rice in Drought Resistance and Productivity显示文摘Drought resistance is required in rice breeding to address the challenge of frequent droughts . However, the evolutionary mechanism of rice drought resistance is not fully understood. We investigated the genetic differentiation between upland and lowland rice domesticated in agro-ecosystems with contrasting water-soil conditions using genome-wide SNPs. We estimated morphological differences among upland and lowland rice in drought resistance and productivity through common garden experiments. Upland rice had better drought resistance but poorer productivity. The negative correlations between traits of drought resistance and productivity are attributed to the underlying genetic trade-offs through tight linkages (e.g., DCA1 and OsCesA7) or pleiotropic effects (e.g., LAX1). The genetic trade-offs are comm on and greatly shape the evolutio n of drought resista nee in upland rice . In genomic regions associated with both productivity and drought resistance, signs of balancing selection were detected in upland rice, while signs of directional selection were detected in lowland rice, potentially contributing to their adaptive differentiation. Signs of balancing selection in upland rice resulted from bi-directional selection during its domestication in drought-prone upland agro-ecosystems.Using genome-wide association analysis, we ide ntified several valuable quantitative trait loci associated with drought resista nee, for which highly differentiated genes should be considered candidates. Bi-directional selection breaking tight linkages by accumulating recombination events would be applicable in breeding water-saving and droughtresistance rice. | Hui Xia Zhi Luo Jie Xiong Xiaosong Ma Qiaojun Lou Haibin Wei Jie Qiu Hua Yang Guolan Liu Longjiang Fan Liang Chen Lijun Luo | 2019 | Molecular Plant2019，12，2： | 16 |
| 2 | Retrospective study of mycophenolate mofetil treatment in IgA nephropathy with proliferative pathological phenotype显示文摘 | Liang Yan Zhang Junjun Liu Dongwei Quan Songxia Xing Guolan Liu Zhangsuo | 2014 | Chinese Medical Journal2014，，1： | 7 |
| 3 | Total intravenous anesthesia for cesarean section in a pregnant woman with spinal muscular atrophy显示文摘Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder characterized by progressive degeneration of the anterior horn cell leading to a lower motor neuron lesion.It is characterized by degeneration of alpha neurons in the anterior horn cells of the spinal cord leading to progressive muscle atrophy and premature death,usually from respiratory failure.1 There are four types according to the symptoms (Table 1). | Fang Qiwu Gao Guolan An Jianxiong Liu Caicai Qian Xiaoyan Wen Hui Wu Jianping Wang Yong Doris K.Cope John P. Williams | 2014 | Chinese Medical Journal2014，，18： | 3 |
| 4 | Blue revolution for food security under carbon neutrality: A case from the water-saving and drought-resistance rice显示文摘The increasing concentration of greenhouse gases(GHGs)in Earth's atmosphere leads to global warming,which further causes a series of climate changes and does great harm to both human society and natural ecosystems.Agricultural GHG emissions,mainly in theform of methane(CH4)and nitrous oxide(N2O),areasignificantsourceofGHGs,accountingfor~14%total global GHGs(Zhang et al.,2022).One major source of agricultural GHGs is CH4 emissions from rice paddies,which is responsiblefor~10%-12%ofhuman-inducedCH4emissions(van Groenigen et al.,2013)and contributes~2.40%to the enhanced global warming effect(Zhang et al.,2022).The global warming potential of GHGs emissions from rice systems is roughly four times higher than either wheat or maize(Linquist et al.,2012). | Hui Xia Xianxian Zhang Yi Liu Junguo Bi Xiaosong Ma Anning Zhang Hongyan Liu Liang Chen Sheng Zhou Huan Gao Kai Xu Haibin Wei Guolan Liu Feiming Wang Hongyang Zhao Xingxing Luo Danping Hou Qiaojun Lou Fangjun Feng Liguo Zhou Shoujun Chen Ming Yan Tianfei Li Mingshou Li LeiWang Zaochang Liu Xinqiao Yu HanweiMei Lijun Luo | 2022 | Molecular Plant2022，15，9： | 3 |
| 5 | Resistance of Barnyard Grass(Echinochloa crusglli) to Quinclorac in Double-harvest Rice Area in Hunan Province of China显示文摘[Objective]The paper was to study the resistance of barnyard grass to quinclorac in double-harvest rice area in Hunan Province of China.[Method]Using whole-plant determination method,the resistance of 36 biotypes of barnyard grass to quinclorac in double-harvest rice area in Hunan Province was studied.[Result]The biotype collected from Lijiaping Town of Shaoyang County was the most susceptible barnyard grass to quinclorac,and the EC50value was 70.253 1 g a.i./hm2,so it was recognized as the sensitive biotype.The biotypes collected from Caowei Town of Yuanjiang County(HN3 and HN4 from direct seeding rice fields)and Zhongyukou Town of Nanxian County presented very high resistance to quinclorac;the EC50values were 1 999.122 5,1 664.544 6 and 1 022.739 5 g a.i./hm2,and their resistance indexes reached 28.46,23.69 and 14.56,respectively,indicating that these three biotypes had high level of resistance to quinclorac.EC50values of about 22 biotypes were ranged from 144.837 3 to 408.289 4 g a.i./hm2,and resistance indexes were ranged from 2.06 to 5.81,indicating that these biotypes had produced resistance to quinclorac.EC50values of other 10 biotypes were ranged from 98.032 6 to 138.660 9 g a.i./hm2,and the resistance indexes were ranged from 1.40 to 1.97,indicating that the sensitivity of barnyard grass in these places was decreasing.[Conclusion]The paper provided guidance for scientific and rational use of quinclorac in paddy fields. | Ma Guolan Liu Ducai Liu Xueyuan Tang Tao Peng Yajun | 2013 | Plant Diseases and Pests2013，4，5： | 1 |
| 6 | Evaluation and Genetic Classification of Rice Germplasm Resources Resistant to Rice Blast显示文摘[Objective]This study aimed to explore rice germplasm resources resistant to rice blast and provide theoretical basis for the modification of rice blastresistant germplasm resources. [Method]The resistance of 120 rice materials to rice blast was identified at three experimental areas. [Result]The resistance of120 experimental materials was at grade 0- 9 to panicle blast in Hainan Province,at grade 0- 9 to seedling blast in Fujian Province and at grade 3- 9 to panicle blast in Guangxi Zhuang Autonomous Region. Analysis of correlations between agronomic traits and rice blast resistance indicated that the resistance of experimental materials could not be simply determined based on agronomic traits. Furthermore,61 published SSR makers closely linked to rice blast were selected and synthesized for genotypic analysis of 120 experimental materials. The results of cluster analysis preliminarily divided 120 germplasms into resistant varieties and susceptible varieties. [Conclusion]These rice germplasm resources are of important value for breeding new materials resistant to rice blast. | Yuanyuan NIE Zhengshuai An Zhen ZHANG Linghua MAO Guolan LIU Manlian YAN Yaohui CAI | 2014 | Agricultural Biotechnology2014，3，2： | 0 |
| 7 | Progress in DNA Aptamers as Recognition Components for Protein Functional Regulation显示文摘Proteins play a central role in all domains of life,and precise regulation of their activity is essential for understanding the related biological processes and therapeutic functions.Nucleic acid aptamers,the molecular recognition components derived from systematic evolution of ligands by exponential enrichment(SELEX),can specifically identify proteins with antibody-like recognition characteristics and help to regulate their activity.This minireview covers the SELEX-based selection of protein-binding aptamers,membrane protein analytical techniques based on aptamer-mediated target recognition,aptamer-mediated functional regulation of proteins,including membrane receptors and non-membrane proteins(thrombin as a model),as well as the potential challenges and prospects regarding aptamer-mediated protein manipulation,aiming to supply some useful information for researchers in this field. | HU Lingling LIU Ke REN Guolan LIANG Jiangong WU Yuan | 2022 | Chemical Research in Chinese Universities2022，38，4： | 0 |
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